Poloxamer 407 microspheres for orotransmucosal drug delivery. Part I: Formulation, manufacturing and characterization

International Journal of Pharmaceutics

Volumn 399, Issue 1-2, 2010, Pages 71-79

  Albertini, B ^a   Passerini, N ^a   Di Sabatino, M ^a   Monti, D ^b   Burgalassi, S ^b   Chetoni, P ^b   Rodriguez, L ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Formulation design; Microparticles; Mucoadhesion; Poloxamers 407; Release; Solid state

Indexed keywords

ATENOLOL; GELUCIRE; MICROSPHERE; POLOXAMER;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ANALYSIS; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG MANUFACTURE; DRUG RELEASE; DRUG SOLUBILITY; DRUG STORAGE; INFRARED SPECTROSCOPY; MUCOADHESION; PRIORITY JOURNAL; SOLID STATE; SUSTAINED DRUG RELEASE; VISCOSITY; X RAY DIFFRACTION;

ADMINISTRATION, ORAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; HUMANS; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MOUTH MUCOSA; PARTICLE SIZE; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; POLOXAMER; POWDER DIFFRACTION; SALIVA; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE PROPERTIES; TABLETS; VISCOSITY; X-RAY DIFFRACTION;

EID: 77956884762     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.08.004     Document Type: Article

References (28)

1. Ahuja N., Katare O.P., Singh B. Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers. Eur. J. Pharm. Biopharm. 2007, 65:26-38.
2. Albertini B., Passerini N., Pattarino F., Rodriguez L. New spray congealing atomizer for the microencapsulation of highly concentrated solid and liquid substances. Eur. J. Pharm. Biopharm. 2008, 69:348-357.
3. Albertini B., Passerini N., Di Sabatino M., Vitali B., Brigidi P., Rodriguez L. Polymer-lipid based mucoadhesive microspheres prepared by spray congealing for the vaginal delivery of Econazole nitrate. Eur. J. Pharm. Sci. 2009, 36:591-601.
4. Alexandridis P., Hatton T.A. Poly(ethylene oxide)-poly(propylene oxide)-poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. Colloids Surf. A: Physicochem. Eng. Aspects 1995, 96:1-46.
5. Bromberg L., Alakhov V. Effects of polyether-modified poly(acrylic acid) microgels on doxorubicin transport in human intestinal epithelial Caco-2 cell layers. J. Control. Release 2003, 88:11-22.
6. Brüsewitz C., Schendler A., Funke A., Wagner T., Lipp R. Novel poloxamer-based nanoemulsions to enhance the intestinal absorption of active compounds. Int. J. Pharm. 2007, 329:173-181.
7. Cafaggi S., Leardi R., Parodi B., Caviglioli G., Russo E., Bignardi G. Preparation and evaluation of a chitosan salt-poloxamer 407 based matrix for buccal drug delivery. J. Control. Release 2005, 102:159-169.
8. Caplar V., Mikotic-Mihun Z., Hofman H., Kuftinec J., Kajfez F. Atenolol. Analytical Profiles of Drug Substances 1984, vol. 13:1-25. Academic Press, New York.
9. Desigaux L., Gourden C., Bello-Roufai M., Richard P., Oudrhiri N., Lehen P., Escande D., Polard H., Pitard B. Nonionic amphiphilic block copolymers promote gene tranfer to the lung. Hum. Gen. Ther. 2005, 16:821-829.
10. Dhiman M., Yedurkar P., Sawant K.K. Formulation, characterization, and in vitro evaluation of bioadhesive gels containing 5-fluorouracil. Pharm. Dev. Technol. 2008, 13:15-25.
11. Dumortier G., Grossiord J.L., Agnely F., Chaumeil J.C. A review of poloxamer 407 pharmaceutical and pharmacological characteristics. Pharm. Res. 2006, 2:2709-2728.
12. Escobar-Chávez J.J., López-Cervantes M., Naïk A., Kalia Y.N., Quintanar-Guerrero D., Ganem-Quintanar A. Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations. J. Pharm. Pharm. Sci. 2006, 9:339-358.
13. Giannola L.I., De Caro V., Giandalia G., Siragusa M.G., Tripodo C., Florena A.M., Campisi G. Release of naltrexone on buccal mucosa: permeation studies, histological aspects and matrix system design. Eur. J. Pharm. Biopharm. 2007, 67:425-433.
14. Jones D.S., Bruschi M.L., de Freitas O., Gremiao M.P.D., Guimaraes Lara E.H., Andrews G.P. Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamers 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity. Int. J. Pharm. 2009, 372:49-58.
15. Kockisch S., Rees G.D., Young S.A., Tsibouklis J., Smart J.D. Polymeric microspheres for drug delivery to the oral cavity: an in vitro evaluation of mucoadhesive potential. J. Pharm. Sci. 2003, 92:1614-1623.
16. Lin H., Gebhardt M., Bian S., Kwon K.A., Shim C.K., Chung S.J., Kim D.D. Enhancing effect of surfactants on fexofenadine HCl transport across the human nasal epithelial cell monolayer. Int. J. Pharm. 2007, 330:23-31.
17. Mackaplow M.B., Zarraga I.E., Morris J.F. Rotary spray congealing of asuspenction: Effect of disk speed and dispersed particle properties. J. Microencapsul. 2006, 23:793-809.
18. Monti, D., Burgalassi, S., Rossato, M.S., Albertini, B., Passerini, N., Rodriguez, L., Chetoni, P., Poloxamer 407 microspheres for orotransmucosal drug delivery. Part II: in vitro and in vivo evaluation, Int. J. Pharm., submitted for publication.
19. Morishita M., Barichello J.M., Takayama K., Chiba Y., Tokiwa S., Nagai T. Pluronic F-127 gels incorporating highly purified unsaturated fatty acids for buccal delivery of insulin. Int. J. Pharm. 2001, 212:289-293.
20. Mundargi R.C., Patil S.A., Agnihotri S.A., Aminabhavi T.M. Evaluation and controlled release characteristics of modified xanthan film for transdermal delivery of atenolol. Drug Dev. Ind. Pharm. 2007, 33:79-90.
21. Oh K.T., Bronich T.K., Kabanov A.V. Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic block copolymers. J. Control. Release 2004, 94:411-422.
22. Passerini N., Albertini B., Gonzalez-Rodriguez M.L., Cavallari C., Rodriguez L. Preparation and characterization of ibuprofen-polaxamer 188 granules obtained by melt granulation. Eur. J. Pharm. Sci. 2002, 15:71-78.
23. Passerini N., Perissutti B., Moneghini M., Voinovich D., Albertini B., Cavallari C., Rodriguez L. Characterization of carbamazepine-gelucire 50/13 microparticles prepared by a spray-congealing process using ultrasound. J. Pharm. Sci. 2002, 91:699-707.
24. Passerini N., Qi S., Albertini B., Grassi M., Rodriguez L., Craig D.Q.M. Solid lipid microparticles produced by spray congealing: influence of the atomizer on microparticle characteristics and mathematical modeling of the drug release. J. Pharm. Sci. 2010, 99:916-931.
25. Santos C.A., Jacob J.S., Hertzog B.A., Freedman B.D., Press D.L., Harnpicharnchai P., Mathiowitz E. Correlation of two bioadhesion assays: the everted sac technique and the CAHN microbalance. J. Control. Release 1999, 61:113-122.
26. Senel S., Hincal A.A. Drug permeation enhancement via buccal route: possibilities and limitations. J. Control. Release 2001, 72:133-144.
27. Shin S.C., Kim J.Y. Enhanced permeation of triamcinolone acetonide through the buccal mucosa. Eur. J. Pharm. Biopharm. 2000, 50:217-220.
28. Vogelpoel H., Welink J., Amidon G.L., Junginger H.E., Midha K.K., Möller H., Olling M., Shah V.P., Barends D.M. Biowaiver monographs for immediate release solid oral dosage forms based on biopharmaceutics classification system (BCS) literature data: verapamil hydrochloride, propranolol hydrochloride, and atenolol. J. Pharm. Sci. 2004, 93:1945-5196.