Mechanisms of amphipathic helical peptide denaturation by guanidinium chloride and urea: A molecular dynamics simulation study

Journal of Computer-Aided Molecular Design

Volumn 24, Issue 10, 2010, Pages 829-841

  Mehrnejad, Faramarz ^a   Khadem Maaref, Mahmoud ^b   Ghahremanpour, Mohammad Mehdi ^a   Doustdar, Farahnoosh ^c  

^a AZARBAIJAN SHAHID MADANI UNIVERSITY   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Alpha helical peptide; Guanidinium chloride; Hydrogen bond; Hydrophobic interaction; Osmolytes; Urea

Indexed keywords

CHAINS; CHLORINE COMPOUNDS; HYDROGEN BONDS; HYDROPHOBICITY; METABOLISM; MOLECULAR DYNAMICS; PEPTIDES; SURFACE CHEMISTRY;

ALPHA HELICAL PEPTIDE; AMPHIPATHIC; DYNAMICS SIMULATION; GUANIDINIUM CHLORIDES; HELICAL PEPTIDE; HELICAL STRUCTURES; HYDROPHOBIC INTERACTIONS; MD SIMULATION; OSMOLYTES; SIMULATION STUDIES;

UREA;

GUANIDINE; UREA;

ARTICLE; CALCULATION; CONTROLLED STUDY; HYDRATION; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; SIMULATION;

EID: 77956879386     PISSN: 0920654X     EISSN: 15734951     Source Type: Journal    
DOI: 10.1007/s10822-010-9377-x     Document Type: Article

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