Up-regulation of GAT-1, GAT-3 in genetic epileptic rat hippocampus

Chinese Pharmacological Bulletin

Volumn 26, Issue 5, 2010, Pages 629-633

  Mao, Xiao Yuan ^a   Yu, Jun Ling ^a   Min, Dong Yu ^a   Guo, Feng ^a   Liu, Rui ^a   Wu, Kun Can ^a   Zhang, Yu Xuan ^a   Xie, Ni ^a   Cai, Ji Qun ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Epilepsy; GAT 1; GAT 3; Immunohistochemistry; RT PCR; Tremor rat; Western blot

Indexed keywords

MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN GAT 1; PROTEIN GAT 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPILEPSY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SEIZURE; UPREGULATION; WESTERN BLOTTING;

EID: 77956809775     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Hu J, Quick M W. Substrate-mediated regulation of γ-aminobutyric acid transporter 1 in rat brain [J]. Neuropharmacology, 2008, 54(2):309-18.
2. Chiu C S, Brickley S, Jensen K, et al. GABA transporter deficiency causes tremor, ataxia nervousness and increased GABA-induced tonic conductance in cerebellum [J]. J Neurosci, 2005, 25(12):3234-45. (Pubitemid 40463559)
3. Enna S J, McCarson K E. The role of GABA in the mediation and perception of pain [J]. Adv Pharmacol, 2006, 54:1-27.
4. Nagatomo K, Ueda Y, Doi T, et al. Functional role of GABA transporters for kindling development in GLAST KO mice [J]. Neurosci Res, 2007, 57(2):319-21. (Pubitemid 46177294)
5. Pan J W, Cavus I, Kim J, et al. Hippocampal extracellular GABA correlates with metabolism in human epilepsy [J]. Metab Brain Dis, 2008, 23(4):457-68.
6. Meldrum B S, Rogawski M A. Molecular targets for antiepileptic drug development [J]. Neurotherapeutics, 2007, 4(1):18-61. (Pubitemid 46107329)
7. Kulig K, Szwaczkiewicz M. The role of structure activity relationship studies in the search for new GABA uptake inhibitors [J]. Mini Rev Med Chem, 2008, 8(12):1214-23.
8. Dalby N O. Inhibition of gamma-aminobutyric acid uptake: anatomy, physiology and effects against epileptic seizures [J]. Eur J Pharmacol, 2003, 479(1-3):127-37.
9. Sun F, Cai J Q, Xie N, Wang Q H. Abnormal expression of GLT-1, EAAC1 in cortex and hippocampus of spontaneously epileptic rats [J]. Chin Pharmacol Bull, 2009, 25(5):617-20.
10. Yu J L, Chen Z X, Mao X Y, et al. Determination of Glutamate and GABA in tremor rat by HPLC [J]. Chin Pharmacol Bull, 2009, 25(11):1530-3.
11. Kitada K, Akimitsu T, Shigematsu Y, et al. Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system [J]. J Neurochem, 2000, 74(6):2512-9. (Pubitemid 30314228)
12. Imamura S, Tanaka S, Akaike K, et al. Hippocampal transection attenuates kainic acid-induced amygdalar seizures in rats [J]. Brain Res, 2001, 897(1-2):93-103. (Pubitemid 32244356)
13. Sperk G, Schwarzer C, Heilman J, et al. Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures [J]. Hippocampus, 2003, 13(7):806-15. (Pubitemid 37407967)
14. Mathem G W, endoza D M, Lozada A, et al. Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy [J]. Neurology, 1999, 52(3):453-72.