메뉴 건너뛰기




Volumn 15, Issue 4, 2010, Pages 579-586

Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; FOSCARNET; GANCICLOVIR; ANTIVIRUS AGENT; DNA DIRECTED DNA POLYMERASE;

EID: 77956803865     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: 10.3851/IMP1565     Document Type: Article
Times cited : (16)

References (30)
  • 1
    • 0033956562 scopus 로고    scopus 로고
    • Natural history and outcome of new AIDS-related cytomegalovirus retinitis diagnosed in the era of highly active antiretroviral therapy
    • Jacobson MA, Stanley H, Holtzer C, Margolis TP, Cunningham ET. Natural history and outcome of new AIDS-related cytomegalovirus retinitis diagnosed in the era of highly active antiretroviral therapy. Clin Infect Dis 2000; 30:231-233.
    • (2000) Clin Infect Dis , vol.30 , pp. 231-233
    • Jacobson, M.A.1    Stanley, H.2    Holtzer, C.3    Margolis, T.P.4    Cunningham, E.T.5
  • 2
    • 0347285458 scopus 로고    scopus 로고
    • Herpesvirus infections in transplant recipients: Current challenges in the clinical management of cytomegalovirus and Epstein-Barr virus infections
    • Razonable RR, Paya CV. Herpesvirus infections in transplant recipients: current challenges in the clinical management of cytomegalovirus and Epstein-Barr virus infections. Herpes 2003; 10:60-65.
    • (2003) Herpes , vol.10 , pp. 60-65
    • Razonable, R.R.1    Paya, C.V.2
  • 3
    • 0033957722 scopus 로고    scopus 로고
    • New strategies for prevention and therapy of cytomegalovirus infection and disease in solid-organ transplant recipients
    • Sia IG, Patel R. New strategies for prevention and therapy of cytomegalovirus infection and disease in solid-organ transplant recipients. Clin Microbiol Rev 2000; 13:83-121. (Pubitemid 30039345)
    • (2000) Clinical Microbiology Reviews , vol.13 , Issue.1 , pp. 83-121
    • Sia, I.G.1    Patel, R.2
  • 4
    • 0021807545 scopus 로고
    • Metabolic activation of the nucleoside analog 9-[(2-hydroxy-1- (hydroxymethyl) ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus
    • Biron KK, Stanat SC, Sorrell JB, et al. Metabolic activation of the nucleoside analog 9-[(2-hydroxy-1- (hydroxymethyl) ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus. Proc Natl Acad Sci U S A 1985; 82:2473-2477.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 2473-2477
    • Biron, K.K.1    Stanat, S.C.2    Sorrell, J.B.3
  • 5
    • 0030480275 scopus 로고    scopus 로고
    • Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cells
    • Cihlar T, Chen MS. Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cells. Mol Pharmacol 1996; 50:1502-1510.
    • (1996) Mol Pharmacol , vol.50 , pp. 1502-1510
    • Cihlar, T.1    Chen, M.S.2
  • 6
    • 0027110881 scopus 로고
    • A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
    • Sullivan V, Talarico CL, Stanat SC, Davis M, Coen DM, Biron KK. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature 1992; 359:85.
    • (1992) Nature , vol.359 , pp. 85
    • Sullivan, V.1    Talarico, C.L.2    Stanat, S.C.3    Davis, M.4    Coen, D.M.5    Biron, K.K.6
  • 7
    • 0026085287 scopus 로고
    • Foscarnet: A review of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with cytomegalovirus retinitis
    • Chrisp P, Clissold SP. Foscarnet. A review of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with cytomegalovirus retinitis. Drugs 1991; 41:104-129. (Pubitemid 21920729)
    • (1991) Drugs , vol.41 , Issue.1 , pp. 104-129
    • Chrisp, P.1    Clissold, S.P.2
  • 8
    • 0030788134 scopus 로고    scopus 로고
    • Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease
    • Chou S, Marousek G, Guentzel S, et al. Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease. J Infect Dis 1997; 176:786-789.
    • (1997) J Infect Dis , vol.176 , pp. 786-789
    • Chou, S.1    Marousek, G.2    Guentzel, S.3
  • 9
    • 0030960868 scopus 로고    scopus 로고
    • Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients
    • Erice A, Gil-Roda C, Perez JL, et al. Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients. J Infect Dis 1997; 175:1087-1092.
    • (1997) J Infect Dis , vol.175 , pp. 1087-1092
    • Erice, A.1    Gil-Roda, C.2    Perez, J.L.3
  • 10
    • 0034686916 scopus 로고    scopus 로고
    • Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants
    • Limaye AP, Corey L, Koelle DM, Davis CL, Boeckh M. Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants. Lancet 2000; 356:645-649. (Pubitemid 30627592)
    • (2000) Lancet , vol.356 , Issue.9230 , pp. 645-649
    • Limaye, A.P.1    Corey, L.2    Koelle, D.M.3    Davis, C.L.4    Boeckh, M.5
  • 11
    • 0036137356 scopus 로고    scopus 로고
    • High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy
    • Limaye AP, Raghu G, Koelle DM, et al. High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy. J Infect Dis 2002; 185:20-27.
    • (2002) J Infect Dis , vol.185 , pp. 20-27
    • Limaye, A.P.1    Raghu, G.2    Koelle, D.M.3
  • 12
    • 0030991256 scopus 로고    scopus 로고
    • High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes
    • Smith IL, Cherrington JM, Jiles RE, et al. High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes. J Infect Dis 1997; 176:69-77.
    • (1997) J Infect Dis , vol.176 , pp. 69-77
    • Smith, I.L.1    Cherrington, J.M.2    Jiles, R.E.3
  • 13
    • 0038574429 scopus 로고    scopus 로고
    • Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus
    • Chou S, Lurain NS, Thompson KD, Miner RC, Drew WL. Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. J Infect Dis 2003; 188:32-39.
    • (2003) J Infect Dis , vol.188 , pp. 32-39
    • Chou, S.1    Lurain, N.S.2    Thompson, K.D.3    Miner, R.C.4    Drew, W.L.5
  • 14
    • 0032169622 scopus 로고    scopus 로고
    • A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture
    • Cihlar T, Fuller MD, Mulato AS, Cherrington JM. A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture. Virology 1998; 248:382-393.
    • (1998) Virology , vol.248 , pp. 382-393
    • Cihlar, T.1    Fuller, M.D.2    Mulato, A.S.3    Cherrington, J.M.4
  • 15
    • 14744270979 scopus 로고    scopus 로고
    • Human cytomegalovirus resistance to antiviral drugs
    • DOI 10.1128/AAC.49.3.873-883.2005
    • Gilbert C, Boivin G. Human cytomegalovirus resistance to antiviral drugs. Antimicrob Agents Chemother 2005; 49:873-883. (Pubitemid 40327699)
    • (2005) Antimicrobial Agents and Chemotherapy , vol.49 , Issue.3 , pp. 873-883
    • Gilbert, C.1    Boivin, G.2
  • 16
    • 0031775862 scopus 로고    scopus 로고
    • Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments
    • Cihlar T, Fuller M, Cherrington J. Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments. J Virol 1998; 72:5927-5936.
    • (1998) J Virol , vol.72 , pp. 5927-5936
    • Cihlar, T.1    Fuller, M.2    Cherrington, J.3
  • 17
    • 35848968504 scopus 로고    scopus 로고
    • Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens
    • Chou S, Marousek GI, Van Wechel LC, Li S, Weinberg A. Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens. Antimicrob Agents Chemother 2007; 51:4160-4162.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 4160-4162
    • Chou, S.1    Marousek, G.I.2    Van Wechel, L.C.3    Li, S.4    Weinberg, A.5
  • 18
    • 31144436564 scopus 로고    scopus 로고
    • Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to foscarnet
    • Tchesnokov EP, Gilbert C, Boivin G, Gotte M. Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to foscarnet. J Virol 2006; 80:1440-1450.
    • (2006) J Virol , vol.80 , pp. 1440-1450
    • Tchesnokov, E.P.1    Gilbert, C.2    Boivin, G.3    Gotte, M.4
  • 19
    • 0033996648 scopus 로고    scopus 로고
    • A standardized plaque reduction assay for determination of drug susceptibilities of cytomegalovirus clinical isolates
    • Landry ML, Stanat S, Biron K, et al. A standardized plaque reduction assay for determination of drug susceptibilities of cytomegalovirus clinical isolates. Antimicrob Agents Chemother 2000; 44:688-692.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 688-692
    • Landry, M.L.1    Stanat, S.2    Biron, K.3
  • 20
    • 0031281931 scopus 로고    scopus 로고
    • Expression of the catalytic subunit (UL54)and the accessory protein (UL44) of human cytomegalovirus DNA polymerase in a coupled in vitro transcription/translation system
    • DOI 10.1006/prep.1997.0781
    • Cihlar T, Fuller MD, Cherrington JM. Expression of the catalytic subunit (UL54) and the accessory protein (UL44) of human cytomegalovirus DNA polymerase in a coupled in vitro transcription/translation system. Protein Expr Purif 1997; 11:209-218. (Pubitemid 27498910)
    • (1997) Protein Expression and Purification , vol.11 , Issue.2 , pp. 209-218
    • Cihlar, T.1    Fuller, M.D.2    Cherrington, J.M.3
  • 21
    • 33745610047 scopus 로고    scopus 로고
    • Three-dimensional modeling of cytomegalovirus DNA polymerase and preliminary analysis of drug resistance
    • Shi R, Azzi A, Gilbert C, Boivin G, Lin SX. Three-dimensional modeling of cytomegalovirus DNA polymerase and preliminary analysis of drug resistance. Proteins 2006; 64:301-307.
    • (2006) Proteins , vol.64 , pp. 301-307
    • Shi, R.1    Azzi, A.2    Gilbert, C.3    Boivin, G.4    Lin, S.X.5
  • 22
    • 33745841864 scopus 로고    scopus 로고
    • Crystal structure of the herpes simplex virus 1 DNA polymerase
    • Liu S, Knafels JD, Chang JS, et al. Crystal structure of the herpes simplex virus 1 DNA polymerase. J Biol Chem 2006; 281:18193-18200.
    • (2006) J Biol Chem , vol.281 , pp. 18193-18200
    • Liu, S.1    Knafels, J.D.2    Chang, J.S.3
  • 23
    • 33747838537 scopus 로고    scopus 로고
    • CUPSAT: Prediction of protein stability upon point mutations
    • DOI 10.1093/nar/gkl190
    • Parthiban V, Gromiha MM, Schomburg D. CUPSAT: prediction of protein stability upon point mutations. Nucleic Acids Res 2006; 34:W239-W242. (Pubitemid 44529771)
    • (2006) Nucleic Acids Research , vol.34 , Issue.WEB. SERV. ISS
    • Parthiban, V.1    Gromiha, M.M.2    Schomburg, D.3
  • 24
    • 0020027799 scopus 로고
    • Pyrophosphate analogues as inhibitors of DNA polymerases of cytomegalovirus, herpes simplex virus and cellular origin
    • Eriksson B, Oberg B, Wahren B. Pyrophosphate analogues as inhibitors of DNA polymerases of cytomegalovirus, herpes simplex virus and cellular origin. Biochim Biophys Acta 1982; 696:115-123.
    • (1982) Biochim Biophys Acta , vol.696 , pp. 115-123
    • Eriksson, B.1    Oberg, B.2    Wahren, B.3
  • 25
    • 0030043162 scopus 로고    scopus 로고
    • Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS
    • Baldanti F, Underwood MR, Stanat SC, et al. Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS. J Virol 1996; 70:1390-1395.
    • (1996) J Virol , vol.70 , pp. 1390-1395
    • Baldanti, F.1    Underwood, M.R.2    Stanat, S.C.3
  • 26
    • 11844275363 scopus 로고    scopus 로고
    • How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients
    • Springer KL, Chou S, Li S, et al. How evolution of mutations conferring drug resistance affects viral dynamics and clinical outcomes of cytomegalovirus-infected hematopoietic cell transplant recipients. J Clin Microbiol 2005; 43:208-213.
    • (2005) J Clin Microbiol , vol.43 , pp. 208-213
    • Springer, K.L.1    Chou, S.2    Li, S.3
  • 27
  • 28
    • 0035369086 scopus 로고    scopus 로고
    • Structure of the replicating complex of a pol alpha family DNA polymerase
    • Franklin MC, Wang J, Steitz TA. Structure of the replicating complex of a pol alpha family DNA polymerase. Cell 2001; 105:657-667.
    • (2001) Cell , vol.105 , pp. 657-667
    • Franklin, M.C.1    Wang, J.2    Steitz, T.A.3
  • 29
    • 0038421037 scopus 로고    scopus 로고
    • Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids
    • Bestman-Smith J, Boivin G. Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids. J Virol 2003; 77:7820-7829.
    • (2003) J Virol , vol.77 , pp. 7820-7829
    • Bestman-Smith, J.1    Boivin, G.2
  • 30
    • 34547734892 scopus 로고    scopus 로고
    • DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions
    • Andrei G, Fiten P, Froeyen M, et al. DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions. Antivir Ther 2007; 12:719-732.
    • (2007) Antivir Ther , vol.12 , pp. 719-732
    • Andrei, G.1    Fiten, P.2    Froeyen, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.