Selection and optimization of MCF-7 cell line for screening selective inhibitors of 11β-hydroxysteroid dehydrogenase 2

Cell Biochemistry and Function

Volumn 28, Issue 6, 2010, Pages 440-447

  Kim, Chi Hyun ^a   Cho, Young Sik ^b  

^a Korea Basic Science Institute (KBSI)   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

11 hydroxysteroid dehydrogenase type 2; Cortisol; Cortisone; Homogeneous time resolved fluorescence cortisol assay; MCF 7

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; GLUCOCORTICOID; GLYCYRRHETINIC ACID;

ARTICLE; BONE CELL; BREAST CELL; CANCER CELL CULTURE; COLON; CORTICOSTEROID METABOLISM; ENZYME ACTIVITY; FEASIBILITY STUDY; FLUORESCENCE ANALYSIS; GENE OVEREXPRESSION; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ASSAYS; ENZYME INHIBITORS; HUMANS; HYDROCORTISONE;

EID: 77956799682     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1674     Document Type: Article

References (30)

1. Stimson RH, Walker BR. Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome. Minerva Endocrinol 2007; 32: 141-159.
2. Yona S, Gordon S. Inflammation: Glucocorticoids turn the monocyte switch. Immunol Cell Biol 2007; 85: 81-82.
3. Walker BR, Andrew R. Tissue production of cortisol by 11betahydroxysteroid dehydrogenase type 1 and metabolic disease. Ann N Y Acad Sci 2006; 1083: 165-184.
4. Schibler U, Brown SA. Enlightening the adrenal gland. Cell Metab 2005; 2: 278-281.
5. Chrousos GP, Kino T. Intracellular glucocorticoid signaling: A formerly simple system turns stochastic. Sci STKE 2005; 2005: Pe48.
6. Andrews RC, Herlihy O, Livingstone DE, Andrew R, Walker BR. Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance. J Clin Endocrinol Metab 2002; 87: 5587-5593.
7. Zennaro MC, Caprio M, Feve B. Mineralocorticoid receptors in the metabolic syndrome. Trends Endocrinol Metab 2009; 20: 444-451.
8. Cooper MS, Bujalska I, Rabbitt E, et al. Modulation of 11betahydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: An autocrine switch from glucocorticoid inactivation to activation. J Bone Miner Res 2001; 16: 1037-1044.
9. Ricketts ML, Verhaeg JM, Bujalska I, Howie AJ, Rainey WE, Stewart PM. Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues. J Clin Endocrinol Metab 1998; 83: 1325-1335.
10. Bland R, Worker CA, Noble BS, et al. Characterization of 11betahydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines. J Endocrinol 1999; 161: 455-464.
11. Yakirevich E, Morris DJ, Tavares R, et al. Mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type II expression in renal cell neoplasms: A tissue microarray and quantitative RT-PCR study. Am J Surg Pathol 2008; 32: 874-883.
12. Chapman KE, Seckl JR. 11beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function. Neurochem Res 2008; 33: 624-636.
13. Schroth M, Plank C, Rauh M, Dorr HG, RascherW, Dotsch J. Pediatric renal allograft transplantation does not normalize the increased cortisol/ cortisone ratios of chronic renal failure. Eur J Endocrinol 2006; 154: 555-561.
14. van Uum SH, Hermus AR, Smits P, Thien T, Lenders JW. The role of 11 beta-hydroxysteroid dehydrogenase in the pathogenesis of hypertension. Cardiovasc Res 1998; 38: 16-24.
15. Wang Q, Zhang P, Gao HB. Luteinizing hormone induces expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells. Reprod Biol Endocrinol 2009; 7: 39.
16. Quinkler M, Zehnder D, Lepenies J, et al. Expression of renal 11betahydroxysteroid dehydrogenase type 2 is decreased in patients with impaired renal function. Eur J Endocrinol 2005; 153: 291-299.
17. Krozowski Z. The 11beta-hydroxysteroid dehydrogenases: Functions and physiological effects. Mol Cell Endocrinol 1999; 151: 121-127.
18. Brown RW, Chapman KE, Kotelevtsev Y, et al. Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2. Biochem J 1996; 313(Pt 3): 1007-1017.
19. Cho YS, Kim CH, Cheon HG. Cell-based assay for screening 11betahydroxysteroid dehydrogenase 1 inhibitors. Anal Biochem 2009; 392: 110-116.
20. Wang DY, Lu Q, Walsh SL, et al. Development of a high-throughput cell-based assay for 11beta-hydroxysteroid dehydrogenase type 1 using BacMam technology. Mol Biotechnol 2008; 39: 127-134.
21. Carballo-Jane E, Pandit S, Santoro JC, et al. Skeletal muscle: A dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation. J Steroid Biochem Mol Biol 2004; 88: 191-201.
22. Farman N, Bocchi B. Mineralocorticoid selectivity: Molecular and cellular aspects. Kidney Int 2000; 57: 1364-1369.
23. Benediktsson R, Calder AA, Edwards CR, Seckl JR. Placental 11 betahydroxysteroid dehydrogenase: A key regulator of fetal glucocorticoid exposure. Clin Endocrinol (Oxf) 1997; 46: 161-166.
24. Quinkler M, Zehnder D, Eardley KS, et al. Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria. Circulation 2005; 112: 1435-1443.
25. Draper N, Stewart PM. 11Beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action. J Endocrinol 2005; 186: 251-271.
26. Korbonits M, Bujalska I, Shimojo M, et al. Expression of 11 betahydroxysteroid dehydrogenase isoenzymes in the human pituitary: Induction of the type 2 enzyme in corticotropinomas and other pituitary tumors. J Clin Endocrinol Metab 2001; 86: 2728-2733.
27. Lipka C, Mankertz J, Fromm M, et al. Impairment of the antiproliferative effect of glucocorticosteroids by 11beta-hydroxysteroid dehydrogenase type 2 overexpression in MCF-7 breast-cancer cells. Horm Metab Res 2004; 36: 437-444.
28. Tagawa N, Ikariko N, Fukumura K, Kobayashi Y. Development of an enzyme-linked immunosorbent assay for serum 11-dehydrocorticosterone in rat and mouse. Biol Pharm Bull 2007; 30: 403-409.
29. Niwa T, Kobayashi T, Sun P, Goto J, Oyama H, Kobayashi N. An enzyme-linked immunometric assay for cortisol based on idiotype- anti-idiotype reactions. Anal Chim Acta 2009; 638: 94-100.
30. Li W, Gao L, Wang Y, Duan T, Myatt L, Sun K. Enhancement of cortisol-induced 11beta-hydroxysteroid dehydrogenase type 1 expression by interleukin 1beta in cultured human chorionic trophoblast cells. Endocrinology 2006; 147: 2490-2495.