Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA

Cell Cycle

Volumn 9, Issue 15, 2010, Pages 3126-3134

  Babayeva, Nigar D ^a   Wilder, Phillip J ^a   Shiina, Masaaki ^b   Mino, Koshiki ^a   Desler, Michelle ^a   Ogata, Kazuhiro ^b   Rizzino, Angie ^a   Tahirov, Tahir H ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Crystal structure; Ets domain; Ets1; Protein DNA complex; Stromelysin 1

Indexed keywords

PALINDROMIC DNA; PROTEIN P53; STROMELYSIN; TRANSCRIPTION FACTOR ETS 1;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; EXON; EXPRESSION VECTOR; POINT MUTATION; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE;

EID: 77956793453     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.14.12257     Document Type: Article

References (49)

1. Seth A, Watson DK. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer 2005; 41:2462-78. (Pubitemid 41540623)
2. Gallant S, Gilkeson G. ETS transcription factors and regulation of immunity. Arch Immunol Ther Exp (Warsz) 2006; 54:149-63. (Pubitemid 44257335)
3. Donaldson LW, Petersen JM, Graves BJ, McIntosh LP. Secondary structure of the ETS domain places murine Ets-1 in the superfamily of winged helix-turn-helix DNA-binding proteins. Biochemistry 1994; 33:13509-16.
4. Nye JA, Petersen JM, Gunther CV, Jonsen MD, Graves BJ. Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif. Genes Dev 1992; 6:975-90.
5. Leprince D, Gegonne A, Coll J, de Taisne C, Schneeberger A, Lagrou C, et al. A putative second cell-derived oncogene of the avian leukaemia retrovirus E26. Nature 1983; 306:395-7. (Pubitemid 14242756)
6. Nunn MF, Seeburg PH, Moscovici C, Duesberg PH. Tripartite structure of the avian erythroblastosis virus E26 transforming gene. Nature 1983; 306:391-5. (Pubitemid 14242755)
7. Hagman J, Grosschedl R. An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene. Proc Natl Acad Sci USA 1992; 89:8889-93.
8. Jonsen MD, Petersen JM, Xu QP, Graves BJ. Characterization of the cooperative function of inhibitory sequences in Ets-1. Mol Cell Biol 1996; 16:2065-73.
9. Lim F, Kraut N, Framptom J, Graf T. DNA binding by c-Ets-1, but not v-Ets, is repressed by an intramolecular mechanism. EMBO J 1992; 11:643-52.
10. Petersen JM, Skalicky JJ, Donaldson LW, McIntosh LP, Alber T, Graves BJ. Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an alpha helix. Science 1995; 269:1866-9.
11. Wasylyk C, Kerckaert JP, Wasylyk B. A novel modulator domain of Ets transcription factors. Genes Dev 1992; 6:965-74.
12. Lee GM, Donaldson LW, Pufall MA, Kang HS, Pot I, Graves BJ, et al. The structural and dynamic basis of Ets-1 DNA binding autoinhibition. J Biol Chem 2005; 280:7088-99. (Pubitemid 40341265)
13. Garvie CW, Pufall MA, Graves BJ, Wolberger C. Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships. J Biol Chem 2002; 277:45529-36. (Pubitemid 36159163)
14. Wotton D, Ghysdael J, Wang S, Speck NA, Owen MJ. Cooperative binding of Ets-1 and core binding factor to DNA. Mol Cell Biol 1994; 14:840-50. (Pubitemid 24013144)
15. Sun W, Graves BJ, Speck NA. Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins. J Virol 1995; 69:4941-9.
16. Gu TL, Goetz TL, Graves BJ, Speck NA. Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1). Mol Cell Biol 2000; 20:91-103.
17. Goetz TL, Gu TL, Speck NA, Graves BJ. Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2. Mol Cell Biol 2000; 20:81-90.
18. Kim WY, Sieweke M, Ogawa E, Wee HJ, Englmeier U, Graf T, et al. Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains. EMBO J 1999; 18:1609-20. (Pubitemid 29127073)
19. Wai PY, Mi Z, Gao C, Guo H, Marroquin C, Kuo PC. Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. J Biol Chem 2006; 281:18973-82. (Pubitemid 44035400)
20. Sato M, Morii E, Komori T, Kawahata H, Sugimoto M, Terai K, et al. Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues. Oncogene 1998; 17:1517-25. (Pubitemid 28472756)
21. Garvie CW, Hagman J, Wolberger C. Structural studies of Ets-1/Pax5 complex formation on DNA. Mol Cell 2001; 8:1267-76. (Pubitemid 34084998)
22. Venanzoni MC, Robinson LR, Hodge DR, Kola I, Seth A. ETS1 and ETS2 in p53 regulation: spatial separation of ETS binding sites (EBS) modulate protein: DNA interaction. Oncogene 1996; 12:1199-204.
23. Wasylyk C, Gutman A, Nicholson R, Wasylyk B. The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins. EMBO J 1991; 10:1127-34. (Pubitemid 21905574)
24. Baillat D, Begue A, Stehelin D, Aumercier M. ETS-1 transcription factor binds cooperatively to the palindromic head to head ETS-binding sites of the stromelysin-1 promoter by counteracting autoinhibition. J Biol Chem 2002; 277:29386-98.
25. Buttice G, Kurkinen M. A polyomavirus enhancer A-binding protein-3 site and Ets-2 protein have a major role in the 12-O-tetradecanoylphorbol-13-acetate response of the human stromelysin gene. J Biol Chem 1993; 268:7196-204.
26. Basuyaux JP, Ferreira E, Stehelin D, Buttice G. The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner. J Biol Chem 1997; 272:26188-95.
27. Tuck SP, Crawford L. Characterization of the human p53 gene promoter. Mol Cell Biol 1989; 9:2163-72.
28. Baillat D, Leprivier G, Regnier D, Vintonenko N, Begue A, Stehelin D, et al. Stromelysin-1 expression is activated in vivo by Ets-1 through palindromic head-to-head Ets binding sites present in the promoter. Oncogene 2006; 25:5764-76.
29. Reisman D, Eaton E, McMillin D, Doudican NA, Boggs K. Cloning and characterization of murine p53 upstream sequences reveals additional positive transcriptional regulatory elements. Gene 2001; 274:129-37.
30. Baillat D, Laitem C, Leprivier G, Margerin C, Aumercier M. Ets-1 binds cooperatively to the palindromic Ets-binding sites in the p53 promoter. Biochem Biophys Res Commun 2009; 378:213-7.
31. Sternlicht MD, Lochter A, Sympson CJ, Huey B, Rougier JP, Gray JW, et al. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell 1999; 98:137-46.
32. Vu TH, Werb Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev 2000; 14:2123-33.
33. Malemud CJ, Goldberg VM. Future directions for research and treatment of osteoarthritis. Front Biosci 1999; 4:762-71.
34. Nelson AR, Fingleton B, Rothenberg ML, Matrisian LM. Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol 2000; 18:1135-49.
35. Zucker S, Cao J, Chen WT. Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment. Oncogene 2000; 19:6642-50.
36. Johansson N, Ahonen M, Kahari VM. Matrix metalloproteinases in tumor invasion. Cell Mol Life Sci 2000; 57:5-15.
37. Kirstein M, Sanz L, Quinones S, Moscat J, Diaz-Meco MT, Saus J. Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene. J Biol Chem 1996; 271:18231-6.
38. Quinones S, Buttice G, Kurkinen M. Promoter elements in the transcriptional activation of the human stromelysin-1 gene by the inflammatory cytokine, interleukin 1. Biochem J 1994; 302:471-7.
39. Lamber EP, Vanhille L, Textor LC, Kachalova GS, Sieweke MH, Wilmanns M. Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization. EMBO J 2008; 27:2006-17.
40. Desiraju GR, Steiner T. The weak hydrogen bond in structural chemistry and biology. International Union of Crystallography Monographs on Crystallography 1999; 9. Oxford University Press, New York.
41. Pufall MA, Lee GM, Nelson ML, Kang HS, Velyvis A, Kay LE, et al. Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science 2005; 309:142-5.
42. Cowley DO, Graves BJ. Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition. Genes Dev 2000; 14:366-76.
43. Brünger ATAP, Clore GM, DeLano WL, Gros P, Grosse-Kunstleve RW, Jiang JS, et al. Crystallography and NMR system (CNS): a new software system for macromolecular structure determination. Acta Crystallogr Sect D 1998; 54:905-21.
44. Vassylyev DG, Vassylyeva MN, Perederina A, Tahirov TH, Artsimovitch I. Structural basis for transcription elongation by bacterial RNA polymerase. Nature 2007; 448:157-62.
45. DeLano WL. (2002). The PyMOL Molecular Graphics System DeLano Scientific, San Carlos CA, USA. http://www.pymol.org.
46. Kopp JL, Wilder PJ, Desler M, Kim JH, Hou J, Nowling T, et al. Unique and selective effects of five Ets family members, Elf3, Ets1, Ets2, PEA3 and PU.1, on the promoter of the type II transforming growth factor-beta receptor gene. J Biol Chem 2004; 279:19407-20.
47. Wiebe MS, Nowling TK, Rizzino A. Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity. J Biol Chem 2003; 278:17901-11.
48. Ma YG, Rosfjord E, Huebert C, Wilder P, Tiesman J, Kelly D, et al. Transcriptional regulation of the murine k-FGF gene in embryonic cell lines. Dev Biol 1992; 154:45-54.
49. Kopp JL, Wilder PJ, Desler M, Kinarsky L, Rizzino A. Different domains of the transcription factor ELF3 are required in a promoter-specific manner and multiple domains control its binding to DNA. J Biol Chem 2007; 282:3027-41.