Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers

Journal of Medicinal Chemistry

Volumn 53, Issue 18, 2010, Pages 6773-6777

  Melchiorre, Michele ^a   Del Lungo, Martina ^b   Guandalini, Luca ^a   Martini, Elisabetta ^a   Dei, Silvia ^a   Manetti, Dina ^a   Scapecchi, Serena ^a   Teodori, Elisabetta ^a   Sartiani, Laura ^b   Mugelli, Alessandro ^b   Cerbai, Elisabetta ^b   Romanelli, Maria Novella ^a  

^a Synthesis and Study of Biologically Active Heterocycles   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; CARDIOVASCULAR AGENT; CILOBRADINE; CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 1; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 2; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 4; IVABRADINE; N,N BIS[4 (7,8 DIMETHOXY 2 OXO 1,3 DIHYDROBENZO[D]AZEPIN 3 YL)BUT 2 ENYL] 2 (3,4 DIMETHOXYPHENYL)PROPANAMINE; UNCLASSIFIED DRUG; ZATEBRADINE; BENZAZEPINE DERIVATIVE; HCN1 PROTEIN, HUMAN; HCN1 PROTEIN, MOUSE; HCN2 PROTEIN, HUMAN; HCN2 PROTEIN, MOUSE; HCN4 PROTEIN, HUMAN; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; ION CHANNEL; ISOPROTEIN; MUSCLE PROTEIN; N,N-BIS(4-(7,8-DIMETHOXY-2-OXO-1,3-DIHYDROBENZO(D)AZEPIN-3-YL)BUT-2-ENYL)-2-(3,4-DIMETHOXYPHENYL)PROPANAMINE; POTASSIUM CHANNEL; PROPYLAMINE;

ARTICLE; CELL STRAIN HEK293; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MEMBRANE CHANNEL; POTASSIUM CURRENT; REACTION ANALYSIS; SODIUM CURRENT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DRUG EFFECTS; GUINEA PIG; HEART RATE; IN VITRO STUDY; MOUSE; PATCH CLAMP TECHNIQUE; STEREOISOMERISM; STIMULATION; SYNTHESIS;

ANIMALS; BENZAZEPINES; CELL LINE; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; GUINEA PIGS; HEART RATE; HUMANS; ION CHANNELS; MICE; MUSCLE PROTEINS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PROPYLAMINES; PROTEIN ISOFORMS; STEREOISOMERISM; STIMULATION, CHEMICAL; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; IN VITRO TECHNIQUES;

EID: 77956779715     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1006758     Document Type: Article

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