Serotonin transporter gene-linked polymorphic region (5-HTTLPR) and diurnal cortisol: A sex by genotype interaction

Biological Psychology

Volumn 85, Issue 2, 2010, Pages 344-346

  Wankerl, Matthis ^a   Zyriax, Birgit Christiane ^b   Bondy, Brigitta ^c   Hinkelmann, Kim ^b   Windler, Eberhard ^b   Otte, Christian ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Cortisol; HPA axis; Serotonin transporter gene linked polymorphic region (5 HTTLPR); Sex effects; Stress

Indexed keywords

HYDROCORTISONE; SEROTONIN TRANSPORTER;

ADULT; AGED; ALLELE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; FEMALE; GENDER; GENE INTERACTION; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; PRIORITY JOURNAL; PROMOTER REGION; STRESS;

ADULT; AGED; ALLELES; ANALYSIS OF VARIANCE; CIRCADIAN RHYTHM; FEMALE; GENOTYPE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; SALIVA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX FACTORS; STRESS, PSYCHOLOGICAL; TIME FACTORS;

EID: 77956761907     PISSN: 03010511     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsycho.2010.07.007     Document Type: Article

References (30)

1. Alexander N., Kuepper Y., Schmitz A., Osinsky R., Kozyra E., Hennig J. Gene-environment interactions predict cortisol responses after acute stress: implications for the etiology of depression. Psychoneuroendocrinology 2009, 34:1294-1303.
2. Beck A. The evolution of the cognitive model of depression and its neurobiological correlates. The American Journal of Psychiatry 2008, 165:969-977.
3. Bethea C., Lu N., Gundlah C., Streicher J. Diverse actions of ovarian steroids in the serotonin neural system. Frontiers in Neuroendocrinology 2002, 23:41-100.
4. Caspi A., Hariri A., Holmes A., Uher R., Moffitt T. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. The American Journal of Psychiatry 2010, 167:509-527.
5. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H.L., McClay J. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 301:386-389.
6. Chen M., Joormann J., Hallmayer J., Gotlib I. Serotonin transporter polymorphism predicts waking cortisol in young girls. Psychoneuroendocrinology 2009, 34:681-686.
7. De Kloet E., Joëls M., Holsboer F. Stress and the brain: from adaptation to disease. Nature Reviews Neuroscience 2005, 6:463-475.
8. Goodyer I., Bacon A., Ban M., Croudace T., Herbert J. Serotonin transporter genotype, morning cortisol and subsequent depression in adolescents. The British Journal of Psychiatry 2009, 195:39-45.
9. Gotlib I., Joormann J., Minor K., Hallmayer J. HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression. Biological Psychiatry 2008, 63:847-851.
10. Heim C., Ehlert U., Hellhammer D. The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 2000, 25:1-35.
11. Hinkelmann K., Moritz S., Botzenhardt J., Riedesel K., Wiedemann K., Kellner M. Cognitive impairment in major depression: association with salivary cortisol. Biological Psychiatry 2009, 66:879-885.
12. Hu X., Oroszi G., Chun J., Smith T., Goldman D., Schuckit M. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcoholism: Clinical and Experimental Research 2005, 29:8-16.
13. Kendler K., Kuhn J., Vittum J., Prescott C., Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Archives of General Psychiatry 2005, 62:529-535.
14. Klink R., Robichaud M., Debonnel G. Gender and gonadal status modulation of dorsal raphe nucleus serotonergic neurons. Part I: effects of gender and pregnancy. Neuropharmacology 2002, 43:1119-1128.
15. Klink R., Robichaud M., Debonnel G. Gender and gonadal status modulation of dorsal raphe nucleus serotonergic neurons Part II. Regulatory mechanisms. Neuropharmacology 2002, 43:1129-1138.
16. Kudielka B., Kirschbaum C. Sex differences in HPA axis responses to stress: a review. Biological Psychology 2005, 69:113-132.
17. Mueller A., Brocke B., Fries E., Lesch K.P., Kirschbaum C. The role of the serotonin transporter polymorphism for the endocrine stress response in newborns. Psychoneuroendocrinology 2010, 35:289-296.
18. Muhtz C., Zyriax B.C., Klähn T., Windler E., Otte C. Depressive symptoms and metabolic risk: effects of cortisol and gender. Psychoneuroendocrinology 2009, 34:1004-1011.
19. Ochedalski T., Subburaju S., Wynn P., Aguilera G. Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity. Journal of Neuroendocrinology 2007, 19:189-197.
20. O'hara R., Schröder C., Mahadevan R., Schatzberg A., Lindley S., Fox S. Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol. Molecular Psychiatry 2007, 12:544-555.
21. Otte C., Hart S., Neylan T., Marmar C., Yaffe K., Mohr D. A meta-analysis of cortisol response to challenge in human aging: importance of gender. Psychoneuroendocrinology 2005, 30:80-91.
22. Otte C., Marmar C., Pipkin S., Moos R., Browner W., Whooley M. Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: the heart and soul study. Biological Psychiatry 2004, 56:241-247.
23. Pruessner J., Kirschbaum C., Meinlschmid G., Hellhammer D. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 2003, 28:916-931.
24. Risch N., Herrell R., Lehner T., Liang K.Y., Eaves L., Hoh J. Interaction between the serotonin transporter gene (5-HTTLPR) stressful life events, and risk of depression: a meta-analysis. The Journal of the American Medical Association 2009, 301:2462-2471.
25. Spitzer R., Kroenke K., Williams J. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study primary care evaluation of mental disorders. patient health questionnaire. The Journal of the American Medical Association 1999, 282:1737-1744.
26. Uher R., McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Molecular Psychiatry 2008, 13:131-146.
27. Uher R., McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Molecular Psychiatry 2010, 15:18-22.
28. Wüst S., Kumsta R., Treutlein J., Frank J., Entringer S., Schulze T. Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion. Psychoneuroendocrinology 2009, 34:972-982.
29. Way B., Taylor S. The serotonin transporter promoter polymorphism is associated with cortisol response to psychosocial stress. Biological Psychiatry 2010, 67:487-492.
30. Wendland J., Martin B., Kruse M., Lesch K.P., Murphy D. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Molecular Psychiatry 2006, 11:224-226.