The effect of obesity on testicular function by insulin-like factor 3, inhibin B, and leptin concentrations in obese adolescents according to pubertal stages

Clinical Biochemistry

Volumn 43, Issue 15, 2010, Pages 1236-1240

  Taneli, Fatma ^a   Ersoy, Betul ^a   Özhan, Bayram ^a   Çalkan, Mehmet ^a   Yilmaz, Ömer ^a   Dinç, Gönül ^a   Genç, Abdulkadir ^a   Taneli, Can ^a  

^a CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

Human; Iinsulin like 3 (Leydig cell) protein; Inhibin; Leptin; Obesity; Puberty; Testes

Indexed keywords

ESTRADIOL; FOLLITROPIN; INHIBIN B; INSULIN LIKE FACTOR 3; LEPTIN; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTIS PEPTIDE HORMONE; TESTOSTERONE; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FOLLITROPIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; LEYDIG CELL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; OBESITY; PRIORITY JOURNAL; PUBERTY; SCHOOL CHILD; TESTIS FUNCTION; TESTIS SIZE;

ADOLESCENT; BODY MASS INDEX; CASE-CONTROL STUDIES; CHILD; HUMANS; INHIBINS; INSULIN; LEPTIN; LUTEINIZING HORMONE; MALE; OBESITY; PROTEINS; PUBERTY; TESTIS; TESTOSTERONE;

EID: 77956745598     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2010.07.026     Document Type: Article

References (32)

1. McMillen I.C., Rattanatray L., Duffield J.A., et al. The early origins of later obesity: pathways and mechanisms. Adv Exp Med Biol 2009, 646:71-81.
2. Lee Y.S. Consequences of childhood obesity. Ann Acad Med Singapore 2009, 38:75-77.
3. James P.T., Rigby N., Leach R. International Obesity Task Force. The obesity epidemic, metabolic syndrome and future preventive strategies. Eur J Cardiovasc Prev Rehabil 2004, 11:3-8.
4. Pauli E.M., Legro R.S., Demers L.M., Kunselman A.R., Dodson W.C., Lee P.A. Diminished paternity and gonadal function with increasing obesity in men. Fertil Steril 2008, 90:346-351.
5. Foresta C., Di Mambro A., Pagano C., Garolla A., Vettor R., Ferlin A. Insulin-like factor 3 as a marker of testicular function in obese men. Clin Endocrinol 2009, 71:722-726.
6. Ferlin A., Pepe A., Gianesello L., et al. New roles for INSL3 in adults. Ann N Y Acad Sci 2009, 1160:215-218.
7. Foresta C., Bettella A., Vinanzi C., et al. Insulin-like factor 3: a novel circulating hormone of testis origin in humans. J Clin Endocrinol Metab 2004, 89:5952-5958.
8. Ferlin A., Garolla A., Rigon F., Caldogno L.R., Lenzi A., Foresta C. Changes in serum insulin like 3 during normal male puberty. J Clin Endocrinol Metab 2006, 91:3426-3431.
9. Winters S.J., Wang C., Abdelrahaman E., Hadeed V., Dyky M.A., Brufsky A. Inhibin B levels in healthy young adult men and prepubertal boys: is obesity the cause for the contemporary decline in sperm count because of fewer Sertoli cells?. J Androl 2006, 27:560-564.
10. Lewis K., Lee P.A. Endocrinology of male puberty. Curr Opin Endocrinol Diab Obes 2009, 16:5-9.
11. Chada M., Prusa R., Bronsky J., et al. Inhibin B, follicle stimulating hormone, luteinizing hormone and testosterone during childhood and puberty in males: changes in serum concentrations in relation to age and stage of puberty. Physiol Res 2003, 52:45-51.
12. Radicioni A.F., Anzuini A., De Marco E., Nofroni I., Castracane V.D., Lenzi A. Changes in serum inhibin B during normal male puberty. Eur J Endocrinol 2005, 152:403-409.
13. Suomi A.M., Main K.M., Kaleva M., et al. Hormonal changes in 3month-old cryptorchid boys. Endocrinol Metab 2006, 91:953-958.
14. Mah P.M., Wittert G.A. Obesity and testicular function. Mol Cell Endocrinol 2010, 316:180-186.
15. Ishikawa T., Fujioka H., Ishimura T., Takenaka A., Fujisawa M. Expression of leptin and leptin receptor in the testis of fertile and infertile patients. Andrologia 2007, 39:22-27.
16. Marshall W.A., Tanner J.M. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970, 45:13-23.
17. 2000 United States CDC Growth Charts (March, 2008). Available at http://www.cdc.gov/nchs/about/major/nhanes/growthcharts/clinical_charts.htm.
18. Feng S., Ferlin A., Truong A., et al. INSL3/RXFP2 signaling in testicular descent. Ann N Y Acad Sci 2009, 1160:197-204.
19. Wikström A.M., Bay K., Hero M., Andersson A.M., Dunkel L. Serum insulin-like factor 3 levels during puberty in healthy boys and boys with klinefelter syndrome. J Clin Endocrinol Metab 2006, 91:4705-4708.
20. Bay K., Virtanen H.E., Hartung S., et al. The Nordic cryptorchidism Study group, Toppari J. Insulin like factor 3 levels in cord blood and serum from children: Effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism. J Clin Endocrinol Metab 2007, 92:4020-4027.
21. Andersson A.M., Juul A., Petersen J.H., Muller J., Groome N.P., Skakkebaek N.E. Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels. J Clin Endocrinol Metab 1997, 82:3976-3981.
22. Raivio T., Perheentuba A., McNeilly A.S., et al. Biphasic increase in serum inhibin B during puberty: a longitudinal study of healthy Finnish boys. Pediatr Res 1998, 44:552-556.
23. Radicioni A.F., Anzuini A., De Marco E., Nofroni I., Castracane V.D., Lenzi A. Changes in serum inhibin B during normal male puberty. Eur J Endocrinol 2005, 152:403-409.
24. Aggerholm A.S., Thulstrup A.M., Toft G., Ramlau-Hansen C.H., Bonde J.P. Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile?. Fertil Steril 2008, 90:619-626.
25. Fu J.F., Dong G.P., Liang L., Jiang Y.J., Chen L.Q., Dayan C. Early activation of the inhibin B/FSH axis in obese Tanner Stage G1PH1 boys. Clin Endocrinol 2006, 65:327-332.
26. Jensen T.K., Andersson A.M., Jorgensen N., et al. Body mass index in relation to semen quality and reproductive hormones among 1, 558 Danish men. Fertil Steril 2004, 82:863-870.
27. Wu F.C., Tajar A., Pye S.R., et al. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab 2008, 93:2737-2745.
28. Mohr B.A., Bhasin S., Link C.L., O'Donnell A.B., McKinlay J.B. The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study. Eur J Endocrinol 2006, 155:443-452.
29. Globerman H., Shen-Orr Z., Karnieli E., Aloni Y., Charuzi I. Inhibin B in men with severe obesity and after weight reduction following gastroplasty. Endocr Res 2005, 31:17-26.
30. Isidori A.M., Caprio M., Strollo F., et al. Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab 1999, 84:3673-3680.
31. Pasquali R., Patton L., Gambineri A. Obesity and infertility. Curr Opin Endocrinol Diab Obes 2007, 14:482-487.
32. Zorn B., Osredkar J., Meden-Vrtovec H., Majdic G. Leptin levels in infertile male patients are correlated with inhibin B, testosterone and SHBG but not with sperm characteristics. Int J Androl 2007, 30:439-444.