Shaping the micromechanical behavior of multi-phase composites for bone tissue engineering

Acta Biomaterialia

Volumn 6, Issue 9, 2010, Pages 3448-3456

  Ranganathan, Shivakumar I ^a   Yoon, Diana M ^b   Henslee, Allan M ^a   Nair, Manitha B ^b   Smid, Christine ^a   Kasper, F Kurtis ^b   Tasciotti, Ennio ^a   Mikos, Antonios G ^b   Decuzzi, Paolo ^a,c   Ferrari, Mauro ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b Rice University   (United States)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Biocomposite; Elastic properties; Particle shape; Scaffold

Indexed keywords

BIOMECHANICS; BONE; ELASTIC MODULI; FRACTURE; FUNCTIONS; MECHANICAL STABILITY; PLATELETS; REINFORCEMENT; RESINS; SCAFFOLDS (BIOLOGY); STIFFNESS; TISSUE REGENERATION;

BIOCOMPOSITE; BONE TISSUE ENGINEERING; ELASTIC PROPERTIES; MECHANICAL STIFFNESS; MICROMECHANICAL BEHAVIOUR; MULTIPHASE COMPOSITES; PARTICLE SHAPE; RATIONAL DESIGN; THIN PLATELETS; VOLUME CONCENTRATION;

COMPOSITE MATERIALS;

POLY(PROPYLENE FUMARATE); POLYMER; SILICON; UNCLASSIFIED DRUG; FUMARIC ACID DERIVATIVE; GLYCOLIC ACID DERIVATIVE; HYDROXYAPATITE; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; POLYPROPYLENE;

ANISOTROPY; ARTICLE; BONE TISSUE; CELL REGENERATION; EXPERIMENTAL TEST; GEOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; MASS SPECTROMETRY; MATHEMATICAL MODEL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; THROMBOCYTE; TISSUE ENGINEERING; BONE; CHEMISTRY; DRUG EFFECTS; MECHANICS; PHYSIOLOGY; POROSITY; PROCEDURES; TISSUE SCAFFOLD; YOUNG MODULUS;

ANISOTROPY; BONE AND BONES; DURAPATITE; ELASTIC MODULUS; FUMARATES; GLYCOLATES; HUMANS; LACTIC ACID; MECHANICAL PHENOMENA; POLYGLYCOLIC ACID; POLYPROPYLENES; POROSITY; SILICON; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 77956719859     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.03.029     Document Type: Article

References (45)

1. Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-6.
2. Mistry AS, Mikos AG. Tissue engineering strategies for bone regeneration. Adv Biochem Eng Biotechnol 2005;94:1-22.
3. Kavlock KD, Pechar TW, Hollinger JO, Guelcher SA, Goldstein AS. Synthesis and characterization of segmented poly (esterurethane urea) elastomers for bone tissue engineering. Acta Biomater 2007;3:475-84.
4. Nair MB, Babu SS, Varma HK, John A. A triphasic ceramic-coated porous hydroxyapatite for tissue engineering application. Acta Biomater 2008;4:173-81.
5. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005;26:5474-91.
6. Sanz-Herrer JA, García-Aznar JM, Doblaré M. On scaffold designing for bone regeneration: a computational multiscale approach. Acta Biomater 2009;5:219-29.
7. Liebschner Michael AK. Biomechanical considerations of animal models used in tissue engineering of bone. Biomaterials 2004;25:1697-714.
8. Cowin SC. Tissue growth and remodeling. Annu Rev Biomed Eng 2004;6:77-107.
9. Claes LE, Heigele CA. Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J Biomech 1999;32:255-66.
10. Epari DR, Kassi J-P, Schell H, et al. Timely fracture-healing requires optimization of axial fixation stability. J Bone Joint Surg Am 2007;89:1575-85.
11. Rezwan K, Chen QZ, Blaker JJ, et al. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006;27:3413-31.
12. Kretlow JD, Mikos AG. From material to tissue: biomaterial development, scaffold fabrication, and tissue engineering. AIChE J 2008;54:3048-67.
13. Hong Z, Zhang P, He C, et al. Nano-composite of poly (L-lactide) and surface grafted hydroxyapatite: mechanical properties and biocompatibility. Biomaterials 2005;26:6296-304.
14. Thomson RC, Yaszemski MJ, Powers JM, et al. Hydroxyapatite fiber reinforced poly (α-hydroxy ester) foams for bone regeneration. Biomaterials 1998;19:1935-43.
15. Kasaga T, Yoshio O, Masayuki N, et al. Preparation and mechanical properties of polylactide acid composites containing hydroxyapatite fibres. Biomaterials 2001;22:9-23.
16. Cai X, Tong H, Shen XY, et al. Preparation and characterization of homogeneous chitosan-polylactic acid/hydroxyapatite nanocomposite for bone tissue engineering and evaluation of its mechanical properties. Acta Biomater 2009;5:2693-703.
17. Jose MV, Thomas V, Johnson KT, Dean DR, Nyairo E. Aligned PLGA/HA nanofibrous nanocomposite scaffolds for bone tissue engineering. Acta Biomater 2009;5:305-15.
18. Lu HH, El-Amin SF, Scott KD, et al. Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cells in vitro. J Biomed Mater Res A 2003;64 A: 465-74.
19. Khan M, Dhirendra DS, Katti S, et al. Novel polymer-synthesized ceramic composite-based system for bone repair: an in vitro evaluation. J Biomed Mater Res A 2004;69 A: 728-37.
20. Shi XF, Sitharaman B, Pham QP, et al. Fabrication of porous ultra-short singlewalled carbon nanotube nanocomposite scaffolds for bone tissue engineering. Biomaterials 2007;28:4078-90.
21. Shi X, Hudson JL, Spicer PP, et al. Injectable nanocomposites of single-walled carbon nanotubes and biodegradable polymers for bone tissue engineering. Biomacromolecules 2006;7:2237-42.
22. Shi XT, Wang YJ, Ren L, et al. Novel mesoporous silica-based antibiotic releasing scaffold for bone repair. Acta Biomater 2009;5:1697-707.
23. Ferrari M. Composite homogenization via the equivalent poly-inclusion approach. Compos Eng 1994;4:37-45.
24. Mori T, Tanaka K. Average stress in matrix and average elastic energy of materials with misfitting inclusions. Acta Metall 1973;21:571-4.
25. Marzari N, Ferrari M. Textural and micromorphological effects on the overall elastic response of macroscopically anisotropic composites. J Appl Mech 1992;59:269-75.
26. Eshelby JD. The determination of the elastic field of an ellipsoidal inclusion and related problems. Proc R Soc Lond A 1957;241:376-96.
27. Mura T. Micromechanics of defects in solids. Dordrecht: Kluwer; 1987.
28. Ranganathan SI, Ostoja-Starzewski M. Universal elastic anisotropy index. Phys Rev Lett 2008;101:055504-1-4-4.
29. Ranganathan SI, Decuzzi P, Wheeler LT, et al. Geometrical anisotropy in biphase particle reinforced composites. J Appl Mech 2010;77:41017-20.
30. Shung AK, Timmer MD, Jo S, et al. Kinetics of poly (propylene fumarate) synthesis by step polymerization of diethyl fumarate and propylene glycol using zinc chloride as a catalyst. J Biomater Sci Polymer Edn 2002;13:95-108.
31. Timmer MD, Ambrose CG, Mikos AG. Evaluation of thermal-and photocrosslinked biodegradable poly (propylene fumarate)-based networks. J Biomed Mater Res A 2003;66:811-8.
32. Kasper FK, Tanahashi K, Fisher JP, et al. Synthesis of poly (propylene fumarate). Nat Protoc 2009;4:518-25.
33. Fisher JP, Dean D, Mikos AG. Photocrosslinking characteristics and mechanical properties of diethyl fumarate/poly (propylene fumarate) biomaterials. Biomaterials 2002;23:4333-43.
34. Suggs LJ, Shive MS, Garcia CA, et al. In vitro cytotoxicity and in vivo biocompatibility of poly (propylene fumarate-co-ethylene glycol) hydrogels. J Biomed Mater Res 1999;46:22-32.
35. Temenoff JS, Athanasiou KA, Le Baron RG, et al. Effect of poly (ethylene glycol) molecular weight on tensile and swelling properties of oligo (poly (ethylene glycol) fumarate) hydrogels for cartilage tissue engineering. J Biomed Mater Res 2002;59:429-37.
36. Suggs LJ, Krishnan RS, Garcia CA, et al. In vitro and in vivo degradation of poly (propylene fumarate-coethylene glycol) hydrogels. J Biomed Mater Res 1998;42:312-20.
37. Tasciotti E, Liu X, Bhavane R, et al. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nat Nanotechnol 2008;3:151-7.
38. Canham LT. Bioactive silicon structure fabrication through nanoetching techniques. Adv Mater 1995;7:1033-7.
39. Anderson SHC, Elliott H, Wallis DJ, et al. Dissolution of different forms of partially porous silicon wafers under stimulated physiological conditions. Phys Status Solidi A 2003;197:331-5.
40. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-7.
41. Schmid J, Wallkamm B, Hammerle CH, et al. The significance of angiogenesis in guided bone regeneration. A case report of a rabbit experiment. Clin Oral Implants Res 1997;8:244-8.
42. Ding SY, Himmel ME. The maize primary cell wall microfibril: a new model derived from direct visualization. J Agr Food Chem 2006;54:597-606.
43. Menig R, Meyers MH, Meyers MA, et al. Quasi-static and dynamic mechanical response of Haliotis rufescens (abalone) shells. Acta Mater 2000;48:2383-98.
44. Tesch W, Eidelman N, Roschger P, et al. Graded microstructure and mechanical properties of human crown dentin. Calcif Tissue Int 2001;69:147-57.
45. Landis WJ. The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix. Bone 1995;16:533-44.