Chapter 3 Pharmacology of Ibogaine And Ibogaine-Related Alkaloids

Alkaloids: Chemistry and Biology

Volumn 52, Issue C, 1999, Pages 197-231

  Popik, Piotr ^a   Skolnick, Phil ^b  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956700035     PISSN: 10994831     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0099-9598(08)60027-9     Document Type: Chapter

References (202)

1. Lecomte A. Arch. Med. Navale 2 (1864) 264
2. Goutarel R., Gollnhofer O., and Sillans R. Psyched. Mono. Essays 6 (1993) 71
3. H. S. Lotsof, U S Patent 4,499,096 (1985).
4. H. S. Lotsof, U S Patent 4,587,243 (1986).
5. H. S. Lotsof, U S Patent 4,857,523 (1989).
6. H. S. Lotsof, U S Patent 5,026,697 (1991).
7. Lotsof H.S. Bull. MAPS 5 (1995) 16
8. Kaplan C.D., Ketzer E., de Jong J., and de Vries M. Soc. Neurosc. Bull. 6 (1993) 6
9. Sisko B. Bull. MAPS IV (1993) 15
10. Popik P., and Glick S.D. Drugs Future 21 (1996) 1109
11. Popik P., Layer R.T., and Skolnick P. Pharmacol. Rev. 47 (1995) 235
12. Taylor W.I. In: Manske R.H.F. (Ed). "The Alkaloids: Chemistry and Physiology" 8 (1965), Academic Press, New York, London 203
13. Taylor W.I. In: Manske R.H.F. (Ed). "The Alkaloids: Chemistry and Physiology" 9 (1968), Academic Press, New York, London 79
14. Schultes R.E., and Hofmann A. In: Schultes R.E., and Hofmann A. (Eds). "The Botany and Chemistry of Hallucinogens" (1980), Charles C Thomas, Springfield 235
15. Fernandez J.W. "Bwiti - an ethnography of religious imagination in Africa." (1982), Princeton Press, Princeton, NJ
16. Pope Jr. H.G. Econ. Bot. 23 (1969) 174
17. Van Beek T.A., de Smidt C., and Verpoorte R. J. Ethnopharmacol. 14 (1985) 315
18. Baillon H. Bull. Mens. Soc. Lin. de Paris 1 (1889) 782
19. Dybovsky J., and Landrin E. C. R. Acad. Sci. 133 (1901) 748
20. Haller A., and Heckel E. C. R. Acad. Sci. 133 (1901) 850
21. Lambert M., and Heckel E. C. R. Acad. Sci. 133 (1901) 1236
22. Lambert M. Arch. Int. Pharmacodyn. 10 (1902) 101
23. Phisalix M.C. C. R. Soc. Biol. 53 (1901) 1077
24. Pouchet G., and Chevalier J. Bull. Gen. Ther. 149 (1905) 211
25. Rothlin E., and Raymond-Hamet M. C. R. Soc. Biol. 127 (1938) 592
26. Raymond-Hamet M., and Rothlin E. Arch. Int. Pharmacodyn. Ther. 63 (1939) 27
27. Raymond-Hamet M. C. R. Soc. Biol. 134 (1940) 541
28. Raymond-Hamet M. C. R. Soc. Biol. 133 (1940) 426
29. Raymond-Hamet M. C. R. Acad. Sci. 211 (1940) 285
30. Raymond-Hamet M. C. R. Soc. Biol. 135 (1941) 176
31. Raymond-Hamet M. C. R. Acad. Sci. 212 (1941) 768
32. Raymond-Hamet M., and Vincent D. C. R. Soc. Biol. 154 (1960) 2223
33. Naranjo C. Clin. Toxicol. 2 (1969) 209
34. De Sio F. Med. Sport 23 (1970) 362
35. H. S. Lotsof, U S Patent 5,152,994 (1992).
36. Regan L.R. Justicia (1992) September, 1
37. Touchette N. Nature Med. 1 (1995) 288
38. FDA Advisory CMTE. In: Clarke E., Frederick C., and Balog K. (Eds). "The NDA Pipeline." (1993), F-D-C Reports, Inc., Chevy Chase, MD V-76
39. Sharpe L.G., and Jaffe J.H. NeuroReport 1 (1990) 17
40. Touchette N. J. NIH Res. 5 (1993) 50 November)
41. Buie J. Psych. Times XI 7 (1994) 44
42. Sanchez-Ramos J., and Mash D. Bull. MAPS 4 (1994) 11
43. Sheppard S.G. J. Subsl. Abuse Treat. 11 (1994) 379
44. B. E. Judd, Ibogaine, Psychotherapy, and the Treatment of Substance-related Disorders. The Eighth International Conference on Drug-Related Harm. (1994).
45. Ali S.F., Chetty S.C., Meng X.M., Newport G.D., and Slikker W. J. Neurochem. 65 (1995) S172
46. Landrin A. Bull. Sci. Pharmacol. 11 (1905) 319
47. Taylor W.I. J. Am. Chem. Soc. 79 (1957) 3298
48. Büchi G., Coffen D.L., Kocsis K., Sonnet P.E., and Ziegler F.E. J. Am. Chem. Soc. 88 (1966) 3099
49. Rosenmund P., Haase W.H., Bauer J., and Frische R. Chem. Ber. 180 (1975) 1871
50. Wenkert E., Cochran D.W., Gottlieb H.E., and Hagaman E.W. Helv. Chim. Acta 59 (1976) 2437
51. Seltzman H.H., Odear D.F., Carroll F.I., and Wyrick D. J. Chem. Soc., Chem. Commun. (1992) 1757
52. Seltzman H.H., Odear D.F., and Lauderman C.P. J. Labeled Compd. Radiopharm. 34 (1994) 367
53. Budavari S., O'Neil M., Smith A., Heckelman P.E., and Kinneary J.F. "The Merck Index. An Encyclopedia of Chemicals, Drugs and Biologicals,". 12th Ed. (1996), Merck & Co., Inc., Whitehouse Station, NJ
54. Cartoni G.P., and Giarusso A. J. Chromatogr. 71 (1972) 154
55. Kelley J.M., and Adamson R.H. Pharmacology 10 (1973) 28
56. Repke D.B., Artis D.R., Nelson J.T., and Wong E.H. J. Org. Chem. 59 (1994) 2164
57. Dhahir H.I., Jain N.C., and Forney R.B. J. Forensic Sci. 16 (1971) 103
58. Dhahir H.I., Jain N.C., and Thornton J.I. J. Forensic Sci. 12 (1972) 309
59. Bertol E., Mari F., and Froldi R. J. Chromatogr. 117 (1976) 239
60. Dhahir H.I. Diss. Abstr. Int. 32/04-B (1971) 2311
61. Zetler G., Singbarth G., and Schlosser L. Pharmacology 7 (1972) 237
62. Gallagher C.A., Hough L.B., Keefner S.M., Seyed Mozaffari A., Archer S., and Glick S.D. Biochem. Pharmacol. 49 (1995) 73
63. Hearn W.L., Pablo J., Hime G.W., and Mash D.C. J. Anal. Toxicol. 19 (1995) 427
64. Alburges M.E., Foltz R.L., and Moody D.E. J. Anal. Toxicol. 19 (1995) 381
65. Ley F.R., Jeffcoat A.R., and Thomas B. J. Chromatogr. A 723 (1996) 101
66. Pearl S.M., Hough L.B., Boyd D.L., and Glick S.D. Pharmacol. Biochem. Behav. 57 (1997) 809
67. Hough L.B., Pearl S.M., and Glick S.D. Life Sci. 58 (1996) PL119
68. Glick S.D., Rossman K., Steindorf S., Maisonneuve I.M., and Carlson J.N. Eur. J. Pharmacol. 195 (1991) 341
69. Maisonneuve I.M., Rossman K.L., Keller Jr. R.W., and Glick S.D. Brain Res. 575 (1992) 69
70. Sershen H., Hashim A., and Lajtha A. Pharmacol. Biochem. Behav. 47 (1994) 13
71. Maisonneuve I.M., Keller R.W., and Glick S.D. Eur. J. Pharmacol. 199 (1991) 35
72. Layer R.T., Skolnick P., Bertha C.M., Kuehne M.E., and Popik P. Eur. J. Pharmacol. 309 (1996) 159
73. Mash D., Staley J.K., Baumann M.H., Rothman R.B., and Hearn W.L. Life Sci. 57 (1995) PL45
74. Glick S.D., Rossman K., Rao N.C., Maisonneuve I.M., and Carlson J.N. Neuropharmacology 31 (1992) 497
75. Chen G., and Bohner B. J. Pharmacol. Exp. Ther. 123 (1958) 212
76. Sershen H., Hashim A., Harsing L., and Lajtha A. Life Sci. 50 (1992) 1079
77. Luxton T., Parker L.A., and Siegel S. Prog. Neuro-Psych. Biol. Psych. 20 (1996) 857
78. Kesner R.P., Jackson-Smith P., Henry C., and Amann K. Pharmacol. Biochem. Behav. 51 (1995) 103
79. Page J.G., Rodan L.E., Franell D.R., and Martin J.F. NIDA Contract Report SRI-CBE-94-002-7486 (1994)
80. Maisonneuve I.M., Visker K.E., Mann G.L., Bandarage U.K., Kuehne M.E., and Glick S.D. Eur. J. Pharmacol. 336 (1997) 123
81. Sershen H., Harsing Jr. L.G., Hashim A., and Lajtha A. Life Sci. 51 (1992) 1003
82. Maisonneuve I.M., Keller Jr. R.W., and Glick S.D. Brain Res. 579 (1992) 87
83. Maisonneuve I.M. Diss. Abst. Int. (1992) 1
84. Maisonneuve I.M., and Glick S.D. Eur. J. Pharmacol. 212 (1992) 263
85. Broderick P.A., Phelan F.T., and Berger S.P. In: Harris L.S. (Ed). "NIDA Research Monograph No. 119. Problems of Drug Dependence" (1992), U.S. Government Printing Office, Washington, DC 285
86. Broderick P.A., Phelan F.T., Eng F., and Wechsler R.T. Pharmacol. Biochem. Behav. 49 (1994) 711
87. Pearl S.M., Johnson D.W., and Glick S.D. Psychopharmacology 121 (1995) 470
88. Glick S.D., Maisonneuve I.M., and Pearl S.M. Brain Res. 749 (1997) 340
89. Glick S.D., Pearl S.M., Cai J., and Maisonneuve I.M. Brain Res. 713 (1996) 294
90. Singbarth G., Zetler G., and Schlosser L. Neuropharmacology 12 (1973) 239
91. French E.D., Dillon K., and Ali S.F. Life Sci. 59 (1996) PL199
92. Helsley S., Fiorella D., Rabin R.A., and Winter J.C. Pharmacol. Biochem. Behav. 58 (1997) 37
93. O'Hearn E., and Molliver M.E. Neuroscience 55 (1993) 303
94. S. L. Costache "Pharmacological attenuation of the tremorigenic effects of ibogaine." Unpublished M.S. thesis. Albany Medical College, Albany, NY, 1995.
95. Zetler G. Neuropharmacology 22 (1983) 757
96. Glick S.D., Kuehne M.E., Raucci J., Wilson T.E., Larson D., Keller R.W., and Carlson J.N. Brain Res. 657 (1994) 14
97. Glick S.D., Kuehne M.E., Maisonneuve I.M., Bandarage U.K., and Molinari H.H. Brain Res. 719 (1996) 29
98. King S.M., and Tunnicliff G. Biochem. Int. 20 (1990) 821
99. Roberts E., Wong E., Svenneby G., and Degener P. Brain Res. 152 (1978) 614
100. Trouvin J.H., Jacqmin P., Rouch C., Lesne M., and Jacquot C. Eur. J. Pharmacol. 140 (1987) 303
101. Schneider J.A., and Sigg E.B. Ann. NY Acad. Sci. 66 (1957) 765
102. Gershon S., and Lang W.J. Arch. Int. Pharmacodyn. Ther. 135 (1962) 31
103. Benwell M.E.M., Holtora P.E., Moran R.J., and Balfour D.J.K. Br. J. Pharmacol. 117 (1996) 743
104. Onaivi E.S., Ali S.F., and Chakrabarti A. Ann. N. Y. Acad. Sci. 844 (1998) 227
105. Cappendijk S.L.T., and Dzoljic M.R. Eur. J. Pharmacol. 241 (1993) 261
106. Vocci F.J., and London E.D. Ann. N. Y. Acad. Sci. 820 (1996) 29
107. Presented to the Food and Drug Administration's Drug Advisory Committee, #26,1993
108. R. S. Mansbach, R. L. Balster, M. Gregory, and E. Soenghen, "NIDA Contract Report" SA92.16, (1992).
109. Dworkin S.I., Gleeson S., Meloni D., Koves T.R., and Martin T.J. Psychopharmacology 117 (1995) 257
110. Lee Y.W., Rezvani A.H., and Overstreet D.H. Soc. Neurosci. Abstr. 20 (1994) 1608
111. Rezvani A.H., Overstreet D.H., and Leef Y.W. Pharmacol. Biochem. Behav. 52 (1995) 615
112. Rezvani A.H., Mash D., Overstreet D.H., Hearn W.L., and Lee Y.W. Alcohol. Clin. Exp. Res. 19 (1995) 15A
113. Rezvani A.H., Overstreet D.H., Yang Y., Maisonneuve I.M., Bandarage U.K., Kuehne M.E., and Glick S.D. Pharmacol. Biochem. Behav. 58 (1997) 615
114. Aceto M.D., Bowman E.R., and Harris L.S. NIDA Res. Monogr. 95 (1990) 578
115. Dzoljic E.D., Kaplan C.D., and Dzoljic M.R. Arch. Int. Pharmacodyn. 294 (1988) 64
116. Cappendijk S.L.T., Fekkes D., and Dzoljic M.R. Behav. Brain Res. 65 (1994) 117
117. Sharpe L.G., and Jaffe J.H. NIDA Res. Monogr. 105 (1991) 477
118. Frances B., Gout R., Cros J., and Zajac J.M. Fundam. Clin. Pharmacol. 6 (1992) 327
119. Popik P., Layer R.T., Fossom L., Benveniste M., Getter-Douglas B., Witkin J.M., and Skolnick P. J. Pharmacol. Exp. Ther. 275 (1995) 753
120. Schneider J.A., and McArthur M. Experientia 12 (1956) 323
121. Bhargava H.N., Cao Y.J., and Zhao G.M. Brain. Res. 752 (1997) 234
122. Cao Y.J., and Bhargava H.N. Brain Res. 752 (1997) 250
123. Bagal A.A., Hough L.B., Nalwalk J.W., and Glick S.D. Brain Res. 741 (1996) 258
124. Pearl S.M., Herrickdavis K., Teitler M., and Glick S.D. Brain Res. 675 (1995) 342
125. Badio B., Padgett W.L., and Daly J.W. Mol. Pharmacol. 51 (1997) 1
126. Kostowski W., Rewerski W., and Piechocki T. Pharmacology 7 (1972) 259
127. Schechter M.D., and Gordon T.L. Eur. J. Pharmacol. 249 (1993) 79
128. Schechter M.D. Life Sci. 60 (1997) PL83
129. Palumbo P.A., and Winter J.C. Pharmacol. Biochem. Behav. 43 (1992) 1221
130. Witkin J.M., Brave S., French D., and Geterdouglass B. J. Pharmacol. Exp. Ther. 275 (1995) 1267
131. Helsley S., Rabin R.A., and Winter J.C. Life Sci. 60 (1997) PL147
132. Parker L.A., Siegel S., and Luxton T. Exp. Clin, Psychopharm. 3 (1995) 344
133. Moroz I., Parker L.A., and Siegel S. Exp. Clin. Psychopharm. 5 (1997) 119
134. Parker L.A., and Siegel S. Learn. Motiv. 27 (1996) 170
135. Blackburn J.R., and Szumlinski K.K. Soc. Neurosci. Abstr. 21 (1995) 1467
136. Popik P. Life Sci. 59 (1996) PL379
137. Schneider J.A., and Rinehart R.K. Arch. Int. Pharmacodyn. Ther. CX (1957) 92
138. Hajo-Tello N., Dupont C., Wepierre J., Cohen Y., Miller R., and Godfraind T. Arch. Int. Pharmacodyn. Ther. 276 (1985) 35
139. Hajo N., Dupont C., and Wepierre J. J. Pharmacol. 12 (1981) 441
140. Binienda Z., Beaudoin M.A., Thorn B.T., Prapurna D.R., Johnson J.R., Fogle C.M., Slikker W., and Ali S.F. Ann. N. Y. Acad. Sci. 844 (1998) 265
141. Mandrile E.L., and Bongiorno de Pflrter G.M. Acta. Farm. Bonaerense 4 (1985) 49
142. Naranjo C. "The Healing Journey. New Approaches to Consciousness." (1973), Pantheon, New York
143. Von Schmid P.B. Arzneim.-Forsch. 17 (1967) 485
144. Sloviter R.S., Drust E.G., Damiano B.P., and Connor J.D. J. Pharmacol. Exp. Ther. 214 (1980) 231
145. Farnsworth N.R. Science 162 (1968) 1086
146. Delourme-Houde J. Ann. Pharm. Fr. 4 (1946) 30
147. O'Hearn E., Long D.B., and Molliver M.E. Neuroreport 4 (1993) 299
148. O'Hearn E., Zhang P., and Molliver M.E. Neuroreport 6 (1995) 1611
149. O'Hearn E., and Molliver M.E. J. Neurosci. 1 (1997) 8828
150. O'Hearn E., and Molliver M.E. Soc. Neurosci. Abstr. 23 (1997) 2308
151. Scallet A.C., Ye X., Rountree R., Nony P., and Ali S.F. Ann. NY Acad. Sci. 801 (1996) 217
152. Scallet A.C., Ye X., and Ali S.F. Ann. N. Y. Acad. Sci. 801 (1996) 227
153. Molinari H.H., Maisonneuve I.M., and Glick S.D. Brain Res. 737 (1996) 255
154. Helsley S., Dlugos C.A., Pentney R.J., Rabin R.A., and Winter J.C. Brain Res. 759 (1997) 306
155. O'Callaghan J.P., Rodman L.E., Rogers T.S., Terril J.B., and Page J.G. Soc. Neurosci. Abstr. 20 (1994) 1650
156. O'Callaghan J.P., Rogers T.S., Rodman L.E., and Page J.G. Ann. N. Y. Acad. Sci. 801 (1996) 205
157. Vilner B.J., Bandarage U.K., Kuehne M.E., Bertha C.M., and Bowen W.D. In: Harris L.S. (Ed). "Problems of Drug Dependence. Proceedings of the 59th Annual Scientific Meeting, NIDA Res. Monograph." (1997), U.S. Government Printing Office, Washington, DC
158. O'Hearn E., and Molliver M.E. Soc. Neurosci. Abstr. 21 (1995) 1340
159. Popik P., Layer R.T., and Skolnick P. Psychopharmacology 114 (1994) 672
160. J. W. Olney, U S Patent 5,629,307 (1997).
161. Chen K., Kokate T.G., Yamagishi S., Carroll F.I., and Rogawski M.A. Soc. Neurosci. Abstr. 21 (1995) 1105
162. Chen K., Kokate T.G., Donevan S.D., Carroll F.I., and Rogawski M.A. Neuropharmacology 35 (1996) 423
163. Mash D.C., Douyon R., Hearn W.L., Sambol N.C., and Sanchezramos J. Biol. Psychiat. 37 (1995) 652
164. Whitaker P.M., and Seeman P. J. Pharm. Pharmacol. 29 (1977) 506
165. Deecher D.C., Teitler M., Soderlund D.M., Bornmann W.G., Kuehne M.E., and Glick S.D. Brain Res. 571 (1992) 242
166. Sweetnam P.M., Lancaster J., Snowman A., Collins J., Perschke S., Bauer C., and Ferkany J. Psychopharmacology 118 (1995) 369
167. Staley J.K., Ouyang Q., Pablo J., Hearn W.L., Flynn D.D., Rothman R.B., Rice K.C., and Mash D.C. Psychopharmacology 127 (1996) 10
168. Messer C., and Rudnick G. Soc. Neurosci. Abstr. 21 (1995) 1383
169. Glick S.D., Rossman K., Wang S., Dong N., and Keller Jr. R.W. Brain Res. 628 (1993) 201
170. Ali S.F., Newport G.D., Slikker W., Rothman R.B., and Baumann M.H. Soc. Neurosci. Abstr. 21 (1995) 2107
171. Ali S.F., Newport G.D., Slikker Jr. W., Rothman R.B., and Baumann M.H. Brain Res. 737 (1996) 215
172. Reid M.S., Hsu K., Souza K.H., Broderick P.A., and Berger S.P. J. Neural. Transm. 103 (1996) 967
173. Baumann M.H., Rothman R.B., and Ali S.F. Ann. N. Y. Acad. Sci. 844 (1998) 252
174. Sershen H., Hashim A., and Lajtha A. Brain Res. Bull. 36 (1995) 587
175. Sershen H., Hashim A., and Lajtha A. Pharmacol. Biochem. Behav. 53 (1996) 863
176. Harsing L.G., Sershen H., and Lajtha A. J. Neur. Trans. 96 3 (1994) 215
177. Sershen H., Hashim A., and Lajtha A. Neurochem. Res. 19 (1994) 1463
178. Sershen H., Hashim A., and Lajtha A. Brain Res. Bull. 40 (1996) 63
179. Glick S.D., Gallagher C.A., Hough L.B., Rossman K.L., and Maisonneuve I.M. Brain Res. 588 (1992) 173
180. Pearl S.M., Maisonneuve I.M., and Glick S.D. Neuropharmacology 35 (1996) 1779
181. Maisonneuve I.M., Mann G.L., Deibel C.R., and Glick S.D. Psychopharmacology 129 (1997) 249
182. Rabin R.A., and Winter J.C. Eur. J. Pharmacol. 316 (1996) 343
183. Codd E.E. Life Sci. 57 (1995) PL315
184. Pablo J.P., and Mash D.C. Neuroreport 9 (1998) 109
185. Whitaker P.M., and Seeman P. Psychopharmacology 59 (1978) 1
186. Whitaker P.M., and Seeman P. Proc. Natl. Acad. Sci. USA 75 (1978) 5783
187. Long R.F., and Lessin A.W. Biochem. J. 82 (1962) 4P
188. Sershen H., Hashim A., and Lajtha A. Brain Res. Bull. 42 (1997) 161
189. Miller R.C., and Godfraind T. Eur. J. Pharmacol. 96 (1983) 251
190. Schneider A.S., Nagel J.E., and Mah S.J. Eur. J. Pharmacol. 317 (1996) R1
191. Mash D., Staley J.K., Pablo J.P., Holohean A.M., Hackman J.C., and Davidoff R.A. Neurosci. Lett. 192 (1995) 53
192. Pablo J., Staley J.K., Holohean A.M., Hackman J.C., Davidoff R.A., and Mash D.C. Soc. Neurosci. Abstr. 21 (1995) 1264
193. Bowen W.D., Vilner B.J., Williams W., Bertha C.M., Kuehne M.E., and Jacobson A.E. Eur. J. Pharmacol. 279 (1995) R1
194. Mach R.H., Smith C.R., and Childers S.R. Life Sci. 57 (1995) PL57
195. Bowen W.D., Vilner B.J., Bandarage U.K., and Kuehne M.E. Soc. Neurosci. Abstr. 22 (1996) 2006
196. Rabin R.A., and Winter J.C. Brain Res. 731 (1996) 226
197. Cretet E., Prioux-Guyonneau M., Jacquot C., Sentenac H., and Wepierre J. Arch. Pharmacol. 313 (1980) 119
198. Binienda Z., Johnson J., Thorn B., and Ali S.F. Soc. Neurosci. Abstr. 23 (1997) 1227
199. Bunag R.D., and Walaszek E.J. Ann. N. Y. Acad. Sci. 104 (1968) 437
200. Alburges M.E., and Hanson G.R. Soc. Neurosci. Abstr. 23 (1997) 2408
201. House R.V., Thomas P.T., and Bhargava H.N. Pharmacology 51 (1995) 56
202. Itzhak Y., and Ali S.F. Soc. Neurosci. Abstr. 21 (1995) 2108