Ibogaine produces neurodegeneration in rat, but not mouse, cerebellum. Neurohistological biomarkers of Purkinje cell loss

Annals of the New York Academy of Sciences

Volumn 801, Issue , 1996, Pages 217-226

  Scallet, A C ^a   Ye, X ^a   Rountree, R ^a   Nony, P ^a   Ali, S F ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALBINDIN; GLIAL FIBRILLARY ACIDIC PROTEIN; IBOGAINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CEREBELLUM; CONFERENCE PAPER; CONTROLLED STUDY; DENDRITE; DRUG DEPENDENCE; DRUG MECHANISM; HISTOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICROTOME; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PERIKARYON; PURKINJE CELL; RAT;

ANIMALIA;

EID: 0030463962     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb17444.x     Document Type: Conference Paper

References (27)

1. SHEPPARD, S. G. 1994. A preliminary investigation of ibogaine: case reports and recommendations for further study. J. Subst. Abuse Treat. 11: 379-385.
2. DEECHER, D. C., M. TEITLER, D. M. SODERLUND, W. G. BORNMANN, M. E. KUEHNE & S. D. GLICK. 1992. Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies. Brain Res. 571: 242-247.
3. 3H]MK-801 binding to the NMDA receptor complex. Psychopharmacology 114: 672-674.
4. MASH, D. C., J. K. STALEY, J. P. PABLO, A. M. HOLOHEAN, J. C. HACKMAN & R. A. DAVIDOFF. 1995. Properties of ibogaine and its principal metabolite (12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex. Neurosci. Lett. 192: 53-56.
5. POPIK, P., R. T. LAYER & P. SKOLNIK. 1995. 100 years of ibogaine: neurochemical and pharmacological actions of a putative anti-addictive drug. Pharmacol. Rev. 47: 235-253.
6. SCALLET, A. C., C. R. CLONINGER & E. OTHMER. 1976. The management of chronic hysteria: a review and double-blind trial of electrosleep and other relaxation methods. Dis. Nerv. Syst. 37: 3347-3353.
7. CAPPENDIJK, S. L., D. FEKKES & M. R. DZOLJIC. 1994. The inhibitory effect of norharman on morphine withdrawal syndrome in rats: comparison with ibogaine. Behav. Brain Res. 65: 117-119.
8. FRANCES, B., R. GOUT, J. CROS & J. M. ZAJAC. 1992. Effects of ibogaine on naloxone-precipitated withdrawal in morphine-dependent mice. Fundam. Clin. Pharmacol. 6: 327-332.
9. GLICK, S. D., K. ROSSMAN, S. STEINDORF, I. M. MAISONNEUVE & J. N. CARLSON. 1991. Effects and aftereffects of ibogaine on morphine self-administration in rats. Eur. J. Pharmacol. 195: 341-345.
10. GLICK, S. D., C. A. GALLAGHER, L. B. HOUGH, K. L. ROSSMAN & I. M. MAISONNEUVE. 1992. Differential effects of ibogaine pretreatment on brain levels of morphine and (+)-amphetamine. Brain Res. 588: 173-176.
11. GLICK, S. D., K. ROSSMAN, N. C. RAO, I. M. MAISONNEUVE & J. N. CARLSON. 1992. Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor. Neuropharmacology 31: 497-500.
12. MAISONNEUVE, I. M., R. W. KELLER, JR. & S. D. GLICK. 1991. Interactions between ibogaine, a potential anti-addictive agent, and morphine: an in vivo microdialysis study. Eur. J. Pharmacol. 199: 35-42.
13. MAISONNEUVE, I. M., K. L. ROSSMAN, R. W. KELLER, JR. & S. D. GLICK. 1992. Acute and prolonged effects of ibogaine on brain dopamine metabolism and morphine-induced locomotor activity in rats. Brain Res. 575: 69-73.
14. SHARPE, L. & J. JAFFE. 1991. Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine dependent rat. NIDA Res. Monogr. 105: 477.
15. BRODERICK, P. A., F. T. PHELAN, F. ENG & R. T. WECHSLER. 1994. Ibogaine modulates cocaine responses which are altered due to environmental habituation: in vivo microvoltammetric and behavioral studies. Pharmacol. Biochem. Behav. 49: 711-728.
16. CAPPENDIJK, S. L. & M. R. DZOLJIC. 1993. Inhibitory effects of ibogaine on cocaine self-administration in rats. Eur. J. Pharmacol. 241: 261-265.
17. MAISONNEUVE, I. M. & S. D. GLICK. 1992. Interactions between ibogaine and cocaine in rats: in vivo microdialysis and motor behavior. Eur. J. Pharmacol. 212: 263-266.
18. SERSHEN, H., A. HASHIM, L. HARSING & A. LAJTHA. 1992. Ibogaine antagonizes cocaine-induced locomotor stimulation in mice. Life Sci. 50: 1079-1086.
19. SERSHEN, H., A. HASHIM & A LAJTHA. 1994. Ibogaine reduces preference for cocaine consumption in C57BL/6By mice. Pharmacol. Biochem. Behav. 47: 13-19.
20. GLICK, S. D., K. ROSSMAN, S. WANG, N. DONG & R. W. KELLER, JR. 1993. Local effects of ibogaine on extracellular levels of dopamine and its metabolites in nucleus accumbens and striatum: interactions with d-amphetamine. Brain Res. 628: 201-208.
21. MAISONNEUVE, I. M., R. W. KELLER, JR., S. D. GLICK. 1992. Interactions of ibogaine and d-amphetamine: in vivo microdialysis and motor behavior in rats. Brain Res. 579: 87-92.
22. SERSHEN, H., L. G. HARSING, JR., A. HASHIM & A. LAJTHA. 1992. Ibogaine reduces amphetamine-induced locomotor stimulation in C57BL/6By mice, but stimulates locomotor activity in rats. Life Sci. 51: 1003-1011.
23. O'HEARN, E. & M. E. MOLLIVER. 1993. Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Neuroscience 55: 303-310.
24. O'HEARN, E., D. B. LONG & M. E. MOLLIVER. 1993. Ibogaine induces glial activation in parasagittal zones of the cerebellum. Neuroreport 4: 299-302.
25. SCALLET, A. C. 1995. Quantitative morphometry for neurotoxicity assessment. In Neurotoxicology: Approaches and Methods. L. W. Chang & W. Slikker, Eds.: 99-132. Academic Press. San Diego, CA.
26. STERNBERGER, L. A. 1982. Immunocytochemistry. 2nd edit. Wiley. New York.
27. NADLER, J. V. & D. A. EVENSON. 1983. Use of excitatory amino acids to make axon-sparing lesions of the hypothalamus. Methods Enzymol. 103: 393-400.