Acute and chronic administration of ibogaine to the rat results in astrogliosis that is not confined to the cerebellar vermis

Annals of the New York Academy of Sciences

Volumn 801, Issue , 1996, Pages 205-216

  O'Callaghan, James P ^a,c   Rogers, Tina S ^b   Rodman, Larry E ^b   Page, John G ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; GLIAL FIBRILLARY ACIDIC PROTEIN; IBOGAINE; NEUROFILAMENT PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ASTROCYTOSIS; BRAIN; BRAIN CORTEX; BRAIN STEM; CELL DEGENERATION; CEREBELLUM; CEREBELLUM VERMIS; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; FEMALE; HIPPOCAMPUS; HISTOPATHOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; OLFACTORY BULB; PURKINJE CELL; RAT; SEX DIFFERENCE;

ANIMALIA;

EID: 0030447380     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb17443.x     Document Type: Conference Paper

References (20)

1. O'HEARN, E. & M. E. MOLLIVER. 1993. Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Neuroscience 55: 303-310.
2. O'HEARN, E., D. B. LONG & M. E. MOLLIVER. 1993. Ibogaine induces glial activation in parasagittal zones of the cerebellum. NeuroReport 4: 299-302.
3. GLICK, S. D., K. ROSSMAN, N. C. RAO, I. M. MAISONNEUVE & J. N. CARLSON. 1992. Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor. Neuropharmacology 31: 497-500.
4. MARTIN, P. M. & J. P. O'CALLAGHAN. 1995. A direct comparison of GFAP immunocytochemistry and GFAP concentration in various regions of ethanol-fixed rat and mouse brain. J. Neurosci. Methods 58: 181-192.
5. O'CALLAGHAN, J. P. 1991. Quantification of glial fibrillary acidic protein: comparison of slot-immunobinding assays with a novel sandwich ELISA. Neurotoxicol. Teratol. 13: 275-281.
6. BURNETTE, W. N. 1981. "Western blotting:" electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein. Anal. Biochem. 112: 195-203.
7. SONSALLA, P. K. & R. E. HEIKKILA. 1988. Neurotoxic effects of MPTP and methamphetamine in several strains of mice. Prog. Neurol. Biol. Psychiatry 12: 345-352.
8. GIOVANNI, A., B-A. SIEBER, R. E. HEIKKILA & P. K. SONSALLA. 1994. Studies on species sensitivity to the dopaminergic neurotoxin MPTP. Part 1: systemic administration. J. Pharmacol. Exp. Ther. 270: 1000-1007.
9. MILLER, D. B. & J. P. O'CALLAGHAN. 1994. Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse. J. Pharmacol. Exp. Ther. 270: 752-760.
10. MILLER, D. B. & J. P. O'CALLAGHAN. 1996. Neurotoxicity of d-amphetamine in the C57BL/6J and CD-1 mouse: interactions with stress and the adrenal system. Ann. N. Y. Acad. Sci. This volume.
11. DLUZEN, D. E., J. L. MCDERMOTT & B. LIU. 1996. Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release. J. Neurochem. 66: 658-666.
12. SONSALLA, P. K. & R. E. HEIKKILA. 1986. The influence of dose and dosing interval on MPTP-induced dopaminergic neurotoxicity in mice. Eur. J. Pharmacol. 129: 339-345.
13. ALI, S. F., X. M. MENG & J. P. O'CALLAGHAN. 1994. Neurotoxicity of ibogaine in CD mice. Soc. Neurosci. Abstr. 20 (Part 2): 1650.
14. CAMPBELL, D. B. 1995. The use of toxicokinetics for safety assessment of drugs acting in brain. Mol. Neurobiol. 11: 193-216.
15. NORTON, W. T., D. A. AQUINO, I. HOZUMI, F-C. CHIU & C. F. BROSNAN. 1992. Quantitative aspects of reactive gliosis: a review. Neurochem. Res. 17: 877-885.
16. O'CALLAGHAN, J. P. 1993. Quantitative features of reactive gliosis following toxicant-induced damage of the CNS. Ann. N. Y. Acad. Sci. 679: 195-210.
17. O'CALLAGHAN, J. P., K. F. JENSEN & D. B. MILLER. 1995. Quantitative aspects of drug and toxicant-induced astrogliosis. Neurochem. Int. 26: 115-124.
18. HOFFMAN, P. N. & D. W. CLEVELAND. 1988. Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific β-tubulin isotype. Proc. Natl. Acad. Sci. USA 85: 4530-4533.
19. WEST, J. R. & S. L. DEWEY. 1984. Mossy fiber sprouting in the fascia dentata after unilateral entorhinal lesions: quantitative analysis using computer-assisted image processing. Neuroscience 13: 377-384.
20. WONG, J. & M. M. OBLINGER. 1990. A comparison of peripheral and central axotomy effects on neurofilament and tubulin gene expression in rat dorsal root ganglion neurons. J. Neurosci. 10: 2215-2222.