Chapter 2 Biological Aspects of Aporphinoid Alkaloids

Alkaloids: Chemistry and Biology

Volumn 53, Issue C, 1999, Pages 57-117

  Ríos, José Luis ^a   Máñez, Salvador ^a   Giner, Rosa M ^a   Recio, M Carmen ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956695140     PISSN: 10994831     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1099-4831(08)60060-7     Document Type: Chapter

References (180)

1. Guinaudeau H., Lebocuf M., and Cavé A. Lloydia 38 (1975) 275
2. Guinaudeau H., Lebocuf M., and Cavé A. J. Nat. Prod. 42 (1979) 133
3. Guinaudeau H., Leboeuf M., and Cavé A. J. Nat. Prod. 42 (1979) 325
4. Guinaudeau H., Lebocuf M., and Cavé A. J. Nat. Prod. 46 (1983) 761
5. Guinaudeau H., Lebocuf M., and Cavé A. J. Nat. Prod. 47 (1984) 565
6. Shamma M., and Guinaudeau H. Nat. Prod. Rep. 1 (1984) 201
7. Shamma M., and Guinaudeau H. Nat. Prod. Rep. 2 (1985) 227
8. Shamma M., and Guinaudeau H. Nat. Prod. Rep. 3 (1986) 345
9. Bentley K.W. Nat. Prod. Rep. 4 (1987) 677
10. Bentley K.W. Nat. Prod. Rep. 5 (1988) 265
11. Guinaudeau H., Lebocuf M., and Cavé A. J. Nat. Prod. 51 (1988) 1025
12. Bentley K.W. Nat. Prod. Rep. 6 (1989) 405
13. Bentley K.W. Nat. Prod. Rep. 7 (1990) 245
14. Bentley K.W. Nat. Prod. Rep. 8 (1991) 339
15. Bentley K.W. Nat. Prod. Rep. 9 (1992) 365
16. Bentley K.W. Nat. Prod. Rep. 10 (1993) 449
17. Bentley K.W. Nat. Prod. Rep. 11 (1994) 555
18. Guinaudeau H., Lebocuf M., and Cavé A. J. Nat. Prod. 57 (1994) 1033
19. Bentley K.W. Nat. Prod. Rep. 12 (1995) 419
20. Bentley K.W. Nat. Prod. Rep. 13 (1996) 127
21. Bentley K.W. Nat. Prod. Rep. 14 (1997) 387
22. Harborne J.B. Nat. Prod. Rep. 6 (1989) 85
23. Harborne J.B. Nat. Prod. Rep. 3 (1986) 323
24. Lajide L., Escoubas P., and Mizutani J. J. Agric. Food Chem. 41 (1993) 669
25. Harborne J.B. Nat. Prod. Rep. 10 (1993) 327
26. Shamma M., and Guinaudeau H. Tetrahedron 40 (1984) 4795
27. Cavé A., Leboeuf M., and Waterman P.G. In: Pelletier S.W. (Ed). Alkaloids: Chemical and Biological Perspectives 5 (1987), John Wiley & Sons, New York 133
28. Guinaudeau H., and Bruneton J. In: Dey P.M., and Harborne J.B. (Eds). Methods in Plant Biochemistry 8 (1993), Academic Press, London 373
29. Shamma M. In: Phillipson J.D., Roberts M.F., and Zenk M.H. (Eds). The Chemistry and Biology of Isoquinoline Alkaloids (1985), Springer Verlag, Berlin 142
30. Bracher F. Pharm. Ztg. Wiss. 3 (1992) 109
31. Tojo E. J. Nat. Prod. 52 (1989) 909
32. Shamma M. The Isoquinoline Alkaloids. Chemistry and Pharmacology (1972), Academic Press, New York
33. Shamma M., and Moniot J.L. Isoquinoline Alkaloids Research 1972-1977 (1978), Plenum Press, New York
34. Ríos J.L., Simcón S., and Villar A. Fitoterapia 60 (1989) 387
35. Alexander S.P.H., and Peters J.A. 1998 Receptor & Ion Channel Nomenclature Supplement: Dopamine Receptors. Trends Pharmacol. Sci. 19 Suppl. 29 (1998)
36. Seeman P., and Van Tol H.H.M. Trends Pharmacol. Sci. 15 (1994) 264
37. Pulvirenti L., and Koob G.F. Trends Pharm. Sci. 15 (1994) 374
38. Neumeyer J.L. In: Phillipson J.D., Roberts M.F., and Zenk M.H. (Eds). The Chemistry and Biology of Isoquinoline Alkaloids (1985), Springer Verlag, Berlin 146
39. Gao Y., Ram V.J., Campbell A., Kula N.S., Baldessarini R.J., and Neumeyer J.L. J. Med. Chem. 33 (1990) 39
40. Martin L.P., Cox R.F., and Waszczak B.L. Neuropharmacol. 29 (1990) 135
41. Schaus J.M., Titus R.D., Foreman M.M., Mason N.R., and Truex L.L. J. Med. Chem. 33 (1990) 600
42. Gao Y., Zong R., Campbell A., Kula N.S., Baldessarini R.J., and Neumeyer J.L. J. Med. Chem. 31 (1988) 1392
43. Booth R.G., Baldessarini R.J., Kula N.S., Gao Y., Zong R., and Neumeyer J.L. Mol. Pharmacol. 38 (1990) 92
44. Baldessarini R.J., Kula N.S., Zong R., and Neumeyer J.L. Eur. J. Pharmacol. 254 (1994) 199
45. Neumeyer J.L., Arana G.W., Ram V.J., Kula N.S., and Baldessarini R.J. J. Med. Chem. 25 (1982) 990
46. Ogidigben M., Chu T.C., and Potter D.E. J. Pharmacol. Exp. Ther. 267 (1993) 822
47. Baldessarini R.J., Kula N.S., Gao Y., Campbell A., and Neumeyer J.L. Neuropharmacology 30 (1991) 97
48. Neumeyer J.L., Arana G.W., Ram V.J., and Baldessarini R.J. Acta Pharm. Suec. (Suppl. 2) 11 (1983)
49. Banzatti C., Carfagna N.N., Commisso R., Heidempergher F., Pegrassi L., and Melloni P. J. Med. Chem. 31 (1988) 1466
50. Protais P., Arbaoui J., Bakkali E.H., Bermejo A., and Cortes D. J. Nat. Prod. 58 (1995) 1475
51. Neumeyer J.L., Gao Y., Kula N.S., and Baldessarini R.J. J. Med. Chem. 34 (1991) 24
52. Kula N.S., Baldessarini R.J., Kekabian J.W., and Neumeyer J.L. Cell. Mol. Neurobiol. 14 (1994) 185
53. Seeman P., and Van Tol H.H.M. Eur. J. Pharmacol. 233 (1993) 173
54. Baldessarini R.J., Campbell A., Ben-Jonathan N., Ellingboe J., Zong R., and Neuneyer J.L. Neurosci. Lett. 176 (1994) 269
55. Protais P., Cortes D., Pons J.L., López S., Villaverde M.C., and Castedo L. Experientia 48 (1992) 27
56. Campbell A., Baldessarini R.J., Gao Y., Zong R., and Neumeyer J.L. Psychopharmacology 88 (1990) 158
57. Baldessarini R.J., Marsh E.D., Kula N.S., Zong R., Gao Y., and Neumeyer J.L. Biochem. Pharmacol. 40 (1990) 417
58. Campbell A., Baldessarini R.J., and Neumeyer J.L. Psychopharmacology 111 (1993) 351
59. Campbell A., Yeghiayan S., Baldessarini R.J., and Neumeyer J.L. Psychopharmacology 103 (1991) 323
60. Más M., Fumcro B., and Pérez-Rodríguez I. Eur. J. Pharmacol. 280 (1995) 331
61. Nemcroff C.B., Kilts C.D., Levant B., Bissette G., Campbell A., and Baldessarini R.J. Neuropsychopharmacol. 4 (1991) 27
62. Aizenstein M.L., da Silva-Planeta C., DeLucia R., and da Silva C.S. Pharmacol. Biochem. Behav. 53 (1996) 335
63. Zetler G. Arch. Int. Pharmacodyn. 296 (1988) 255
64. Shäfer H.L., Shäfer H., Schneider W., and Elstner E.F. Arzneim. Forsch./Drug Res. 45 (1995) 124
65. Weischer M.L., and Okpanyi S.N. Z. Phytother. 15 (1994) 257
66. Ríos De las Heras J.L., Martínez-Mir I., and Rubio E. Pharmazie 45 (1990) 443
67. Ivorra M.D., Lugnier C., Schott C., Catret M., Noguera M.A., Anselmi E., and D'Ocón M.P. Br. J. Pharmacol. 106 (1992) 387
68. Ivorra M.D., Chuliá S., Lugnier C., and D'Ocón M.P. Eur. J. Pharmacol. 231 (1993) 165
69. Chuliá S., Morcau J., Naline E., Noguera M.A., Ivorra M.D., D'Ocón M.P., and Advenier C. Br. J. Pharmacol. 119 (1996) 1305
70. Madrero Y., Elorriaga M., Martínez S., Noguera M.A., Cassels B.K., D'Ocón M.P., and Ivorra M.D. Br. J. Pharmacol. 119 (1996) 1563
71. Yu S.M., Ko F.N., Chueh S.C., Chen J., Chen S.C., Chen C.C., and Teng C.M. Eur. J. Pharmacol. 252 (1994) 29
72. Chuliá S., Ivorra M.D., Cavé A., Cortes D., Noguera M.A., and D'Ocón M.P. J. Pharm. Pharmacol. 47 (1995) 647
73. Chuliá S., Noguera M.A., Ivorra M.D., Cortes D., and D'Ocón M.P. Pharmacology 50 (1995) 380
74. Orallo F., Fernández-Alzueta A., Loza M.I., Vivas N., Badía A., Campos M., Honrubia M.A., and Cadavid M.I. Br. J. Pharmacol. 110 (1993) 943
75. Orallo F., Fernández-Alzueta A., Campos-Toimil M., and Calleja J.M. Br. J. Pharmacol. 114 (1995) 1419
76. Chen C.C., Huang Y.L., Ou J.C., Su M.J., Yu S.M., and Teng C.M. Planta Med. 57 (1991) 406
77. Teng C.M., Yu S.M., Ko F.N., Chen C.C., Huang Y.L., and Huang T.F. Br. J. Pharmacol. 104 (1991) 651
78. Yu S.M., Hsu S.Y., Ko F.N., Chen C.C., Huang Y.L., Huang T.F., and Teng C.M. Br. J. Pharmacol. 106 (1992) 797
79. Yu S.M., Lee S.S., Hou Y.S., and Teng C.-M. Naunyn-Schmiedeberg's Arch. Pharmacol. 349 (1994) 637
80. Mustafa M.R., Mohamad R., and Achike F. FASEB J. 11 (1997) A1536
81. Guh J.H., Ko F.N., Yu S.M., Wu Y.C., and Teng C.M. Eur. J. Pharmacol. 279 (1995) 33
82. Chen W.Y., Ko F.N., Wu Y.C., Lu S.-T., and Teng C.M. J. Pharm. Pharmacol. 46 (1994) 380
83. Lemos V.S., Thomas G., and Barbosa Filho J.M. J. Ethnopharmacol. 40 (1993) 141
84. Sotníková R., Kettmann V., Kostálová D., and Táborská E. Meth. Find. Exp. Clin. Pharmacol. 19 (1997) 589
85. Shoji N., Umeyama A., Saito N., Iuchi A., Takemoto T., Kajiwara A., and Ohizumi Y. J. Nat. Prod. 50 (1987) 773
86. Cannon J.G., Moe S.T., and Long J.P. Chirality 3 (1991) 19
87. Cannon J.G., Raghupathi R., and Moe S.T. J. Med. Chem. 36 (1993) 1316
88. Cannon J.G., Flaherty P.T., Ozkutlu U., and Long J.P. J. Med. Chem. 38 (1995) 1841
89. Hedberg M.H., Johansson A.M., Nordvall G., Yliniemela A., Li H.B., Martin A.R., Hjorth S., Unelius L., Sundell S., and Hacksell U. J. Med. Chem. 38 (1995) 647
90. Hedberg M.H., Linnanen Jansen J.M., Nordvall G., Hjorth S., Unelius L., and Johansson A.M. J. Med. Chem. 38 (1996) 3503
91. Hedberg M.H., Jansen J.M., Nordvall G., Hjorth S., Unelius L., and Johansson A.M. J. Med. Chem. 39 (1996) 3491
92. Hasrat J.A., De Backer J.-P., Vauquelin G., and Vlietinck A.J. Phytomedicine 4 (1997) 59
93. Hasrat J.A., De Bruyne T., De Backer J.-P., Vauquelin G., and Vlietinck A.J. J. Pharm. Pharmacol. 49 (1997) 1145
94. Speisky H., Squella J.A., and Núñez-Vergara J.L. Planta Med. 57 (1991) 519
95. Hue B., Le Corronc H., Kuballa B., and Anton R. Pharm. Pharmacol. Lett. 3 (1994) 169
96. Lin C.H., Chang G.J., Su M.J., Wu Y.C., Teng C.M., and Ko F.N. Br. J. Pharmacol. 113 (1994) 275
97. Lin C.H., Yang C.M., Ko F.N., Wu Y.C., and Teng C.M. Br. J. Pharmacol. 113 (1994) 1464
98. Cortes D., Torrero M.Y., D'Ocón M.P., Candenas M.L., Cavé A., and Hudi A.H.A. J. Nat. Prod. 53 (1990) 503
99. Anselmi E., Fayos G., Blasco R., Candenas L., Cortes D., and D'Ocón P. J. Pharm. Pharmacol. 44 (1992) 337
100. Ivorra M.D., Martínez F., Serrano A., and D'Ocón P. J. Pharm. Pharmacol. 45 (1993) 439
101. Loza I., Orallo E., Verde I., Gil-Longo J., Cadavid I., and Calleja J.M. Planta Med. 59 (1993) 299
102. Mustafa M.R., Mohamad R., Din L., and Wahid S. Phytother. Res. 9 (1995) 555
103. Chen K.S., Ko F.N., Teng C.M., and Wu Y.C. J. Nat. Prod. 59 (1996) 531
104. Yu S.M., Kang Y.F., Chen C.C., and Teng C.M. Br. J. Pharmacol. 108 (1993) 1055
105. Chang K.C., Lo H.M., Lin F.Y., Tseng Y.Z., Ko F.N., and Teng C.M. J. Cardiovasc. Pharmacol. 26 (1995) 169
106. Tsai T.J., Lin R.H., Chang C.C., Chen Y.M., Chen C.F., Ko F.N., and Teng C.M. Nephron 70 (1995) 91
107. Abdalla S., Alkhalil S.S., and Afifi F. Gen. Pharmacol. 22 (1991) 253
108. Lin C.H., Ko F.N., Wu Y.C., Lu S.T., and Teng C.M. Eur. J. Pharmacol. 237 (1993) 109
109. Kang J.J., Cheng Y.W., and Fu W.M. Jpn. J. Pharmacol. 76 (1998) 207
110. Kang J.J., and Cheng Y.W. Planta Med. 64 (1998) 18
111. Chiou C.M., Kang J.J., and Lee S.S. J. Nat. Prod. 61 (1998) 46
112. Miôík V., Bezáková L., Máleková L., and Koôtálová D. Planta Med. 61 (1995) 372
113. Yu S.M. Biochem. J. 303 (1994) 289
114. Wang B.H., Lu Z.X., and Polya G.M. Planta Med. 63 (1997) 494
115. Miski M., Shen X., Cooper R., Gillum A.M., Fischer D.K., Miller R.W., and Higgins T.J. Bioorg. Med. Chem. Lett. 5 (1995) 1519
116. Zhang Y.H., Shin J.S., Lee S.S., Kim S.H., and Lee M.K. Planta Med. 63 (1997) 362
117. Speisky H., Cassels B.K., Lissi E., and Videla L.A. Biochem. Pharmacol. 41 (1991) 1575
118. Cederbaum A.I., Kukielka E., and Speisky H. Biochem. Pharmacol. 44 (1992) 1765
119. Bannach R., Valenzuela A., Cassels B.K., Núñez-Vergara L.J., and Speisky H. Cell. Biol. Toxicol. 12 (1996) 89
120. Kringstein P., and Cederbaum A.I. Free Rad. Biol. Med. 18 (1995) 559
121. Marti L.A., Ríos Anez J.L., Payá M., and Alcaraz M.J. Free Rad. Biol. Med. 12 (1992) 287
122. Úbeda A., Montesinos C., Payá M., Terencio C., and Alcaraz M.J. Free Rad. Res. Commun. 18 (1993) 167
123. Úbeda A., Montesinos C., Payá M., and Alcaraz M.J. Free Rad. Biol. Med. 15 (1993) 159
124. Cassels B.K., Asencio M., Conget P., Speisky H., Videla L.A., and Lissi E.A. Pharmacol. Res. 31 (1995) 103
125. Hu J., Speisky H., and Cotgreave I.A. Biochem. Pharmacol. 50 (1995) 1635
126. Chen C.C.Y., Huang L., Ou J.C., Su M.J., Yu S.M., and Teng C.M. Planta Med. 57 (1991) 406
127. Yu S.I., Chen C.C., Ko F.N., Huang Y.L., Huang T.F., and Teng C.M. Biochem. Pharmacol. 43 (1992) 323
128. Chen C.C., Lin C.F., Huang Y.L., Ko F.N., and Teng C.M. J. Nat. Prod. 58 (1995) 1423
129. Chen I.S., Wu S.J., Lin Y.C., Tsai I.L., Seki H., Ko F.N., and Teng C.M. Phytochemistry 36 (1994) 237
130. Chen I.S., Chen J.J., Tsai I.L., Chang Y.L., and Teng C.M. Planta Med. 61 (1995) 537
131. Chen K.S., Ko F.N., Teng C.M., and Wu Y.C. Planta Med. 62 (1996) 133
132. Teng C.M., Hsueh C.M., Chang Y.L., Ko F.N., Lee S.S.K.C., and Liu S. J. Pharm. Pharmacol. 49 (1997) 706
133. Chen K.S., Wu Y.C., Teng C.M., Ko F.N., and Wu T.S. J. Nat. Prod. 60 (1997) 645
134. Schmeda-Hirschmann G., Loyola J.I., Sierra J., Retalmal R., and Rodríguez J. Phytother. Res. 6 (1992) 184
135. Schmeda-Hirschmann G., Loyola J.I., Rodríguez J., and Dutra-Behrens M. Phytother. Res. 8 (1994) 49
136. Fernández-Alzueta A., Verde I., Loza M.I., Orallo F., and Cadavid M. Rev. Farmacol. Clin. Exp. (Suppl.) P148 (1992)
137. Young M.L., Su M.J., Wu M.H., and Chen C.C. Br. J. Pharmacol. 113 (1994) 69
138. Su M.J., Nieh Y.C., Huang H.W., and Chen C.C. Naunyn-Schmiedeberg's Arch. Pharmacol. 349 (1994) 42
139. Chang G.Y., Wu M.H., Wu Y.C., and Su M.J. Br. J. Pharmacol. 118 (1996) 1571
140. Villar A., Ríos J.L., and Mares M. Farm. Tijdschr. Belg. 61 (1984) 299
141. Villar A., Ríos J.L., Recio M.C., Cortes D., and Cavé A. Planta Med. 52 (1986) 556
142. Villar A., Mares M., Ríos J.L., Cantón E., and Gobernado M. Pharmazie 42 (1987) 248
143. Simeón S.J.L., and Ríos Villar A. Pharmazie 45 (1990) 442
144. Hsu C., and Chen C. Holzforschung 45 (1991) 325
145. Paulo M.Q., Barbosa-Fihlo J.M., Lima E.O., Maia R.F., Barbosa R.C., and Kaplan M.A. J. Ethnopharmacol. 36 (1992) 39
146. Montanha J.A., Amoros M., Boussie J., and Girre L. Planta Med. 61 (1995) 419
147. Lin L.Z., Hu S.F., Zaw K., Angerhofer C.K., Chai H., Pezzuto J.M., Cordell G.A., Lin J., and Zheng D.M. J. Nat. Prod. 57 (1994) 1430
148. Likhitwitayawuid K., Angerhofer C.K., Chai H., Pezzuto J.M., and Cordell G.A. J. Nat. Prod. 56 (1993) 1468
149. Morello A., Lipchenca I., Cassels B.K., Speisky H., Aldunate J., and Repetto Y. Compar. Biochem. Physiol. C-Pharmacol. Toxicol. Endocrinol. 107 (1994) 367
150. Mahiou V., Roblot F., Hocquemiller R., Cavé A., Dearias A.R., Inchausti A., Yaluff G., Fournet A., and Angelo A. J. Nat. Prod. 57 (1994) 890
151. Wu C., Duh Y.S.Y.-C., Wang K., Chen K.S., and Yang T.H. J. Nat. Prod. 53 (1990) 1327
152. Ruangrungsi N., Riverpiboon A., Lange G.L., Lee M., Decicco C.P., Picha P., and Preechanukool K. J. Nat. Prod. 50 (1987) 891
153. Wu Y.C., Chen C.H., Yang T.H., Lu S.T., McPhail D.R., McPhail A.T., and Lee K.H. Phytochemistry 28 (1989) 2191
154. Wu Y.C., Chang G.Y., Duh C.Y., and Wang S.K. Phytochemistry 33 (1993) 497
155. Wu Y.C., Liou Y.F., Lu S.T.C., Chen H., Chang J.J., and Lee K.H. Planta Med. 55 (1989) 163
156. Suffness M., and Cordell G.A. In: Brossi A. (Ed). The Alkaloids 25 (1989), Academic Press, New York 1
157. Boup-Grochtmann I., and Kingston D.G.I. J. Nat. Prod. 45 (1982) 102
158. Wijeratne E.M.K., Gunatilaka A.A.L., Kingston D.G.I., Haltiwanger R.C., and Eggleston D.S. Tetrahedron 51 (1995) 7877
159. Chen I.S., Chen J.J., Duh C.Y., Tsai I.L., and Chang C.T. Planta Med. 63 (1997) 154
160. Chen I.S., Ishikawa T., Duh C.Y., Tsai I.L., and Chang C.T. Planta Med. 62 (1996) 528
161. Morita H., Matsumoto K., Takeya K., Itokawa H., and Itaka Y. Chem. Pharm. Bull. 41 (1993) 1418
162. Harrigan G.G., Gunatilaka A.A.L., Kingston D.G.I., Chan G.W., and Johnson R.K. J. Nat. Prod. 57 (1994) 68
163. Woo S.H., Reynolds M.C., Sun N.J., Cassady J.M., and Snapka R.M. Biochem. Pharmacol. 54 (1997) 467
164. Chen G., Todorov D.K., and Zeller W.J. Cancer Lett. 62 (1992) 173
165. Chen G., and Zeller W.J. Anticancer Res. 13 (1993) 219
166. Seifert F., Todorov D.K., Hutter K.J., and Zeller W.J. J. Cancer. Res. Clin. Oncol. 122 (1996) 707
167. You M., Wickramaratne D.B.M., Silva G.L., Chai H., Chagwedera T.E., Farnsworth N.R., Cordell G.A., Kinghorn A.D., and Pezzuto J.M. J. Nat. Prod. 58 (1995) 598
168. Ivanovska N., and Philipov S. Phytother. Res. 10 (1996) 62
169. Ivanovska N., Philipov S., and Georgieva P. Pharmacol. Res. 35 (1997) 267
170. Ivanovska N., and Philipov S. Meth. Find. Exp. Clin. Pharmacol. 19 (1997) 579
171. González-Cabello R., Speisky H., Bannach R., Valenzuela A., Feher J., and Gergely P. J. Invest. Allerg. Clin. Immunol. 4 (1994) 139
172. Lanhers C., Joyeux M., Soulimani R., Fleurentin J., Sayag M., Mortier F., Younos C., and Pelt J.M. Planta Med. 57 (1991) 110
173. Backhouse N., Delporte C., Givernau M., Cassels B.K., Valenzuela A., and Speisky H. Agents Actions 42 (1994) 114
174. Ahnfelt-Rome I., Haagen Nielsen O., Christensen A., Langholz E., Binder V., and Riis P. Gastroenterology 98 (1990) 1162
175. Gotteland M., Jiménez I., Brunser O., Guzman L., Romero S., Cassels B.K., and Speisky H. Planta Med. 63 (1997) 311
176. Fedorak R.N., Empey L.R., and Walker K. Gastroenterology 102 (1992) 1229
177. Tadaki S., Nozaka T., Yamada S., Ishino A., Morimoto I., Tanaka A.J., and Kunitomo I. J. Pharmacobio-Dyn. 15 (1992) 501
178. Nozaka T., Watanabe F., Tadaki S., Ishino M., Morimoto J., Kunitomo J., Ishii H., and Natori S. Mutat. Res. 240 (1990) 267
179. Moreno P.R.H., Vargas V.M.F., Andrade H.H.R., Henriques A.H., and Henriques J.A.P. Mutat. Res. 260 (1991) 145
180. Tavares D.C., and Takahashi C.S. Mutat. Res. 321 (1994) 139