Y124 at the peripheral anionic site is important for the reactivation of nerve agent-inhibited acetylcholinesterase by H oximes

Biochemical Pharmacology

Volumn 80, Issue 9, 2010, Pages 1427-1436

  Luo, Chunyuan ^a   Chambers, Carolyn ^a   Pattabiraman, Nagarajan ^a   Tong, Min ^a   Tipparaju, Prasanthi ^a   Saxena, Ashima ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Bovine acetylcholinesterase; Cyclosarin; Molecular modeling; Oxime reactivation; Peripheral anionic site; VR

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 [2,4 BIS(HYDROXYIMINOMETHYL)PYRIDINIO] 1' (4 CARBAMOYLPYRIDINIO)DIMETHYL ETHER DIIODIDE; 1,1' METHYLENEBIS(4 HYDROXYIMINOMETHYLPYRIDINIUM) DICHLORIDE; ACETYLCHOLINESTERASE; ICD 585; OXIME; PRALIDOXIME; UNCLASSIFIED DRUG; Y124 ENZYME; CHEMICAL WARFARE AGENT; CHOLINESTERASE INHIBITOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFICACY; ENZYME INHIBITION; ENZYME REACTIVATION; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; ANIMAL; BOVINAE; CELL LINE; DRUG EFFECTS; ENZYME ACTIVATION; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; TOXICITY;

ACETYLCHOLINESTERASE; ANIMALS; CATTLE; CELL LINE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; ENZYME ACTIVATION; HUMANS; OXIMES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956647349     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.07.020     Document Type: Article

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