Folate bioavailability from breads and a meal assessed with a human stable-isotope area under the curve and ileostomy model

American Journal of Clinical Nutrition

Volumn 92, Issue 3, 2010, Pages 532-538

  Öhrvik, Veronica E ^a   Büttner, Barbara E ^b   Rychlik, Michael ^b   Lundin, Eva ^c   Witthöft, Cornelia M ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; STABLE ISOTOPE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BLOOD SAMPLING; BREAD; FEMALE; HUMAN; ILEOSTOMY; MALE; MEAL; RANDOMIZED CONTROLLED TRIAL; BLOOD; CEREAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET; DIET SUPPLEMENTATION; INTESTINE ABSORPTION; ISOTOPE LABELING; MIDDLE AGED;

ADULT; AGED; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BREAD; CEREALS; CROSS-OVER STUDIES; DIET; FEMALE; FOLIC ACID; FOOD, FORTIFIED; HUMANS; ILEOSTOMY; INTESTINAL ABSORPTION; ISOTOPE LABELING; MALE; MIDDLE AGED;

EID: 77956639998     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.2009.29031     Document Type: Article

References (29)

1. Sanderson P, McNulty H, Mastroiacovo P, et al. Folate bioavailability: UK Food Standards Agency workshop report. Br J Nutr 2003;90:473-9.
2. Wright AJA, Finglas PM, Dainty JR, et al. Differential kinetic behavior and distribution for pteroylglutamic acid and reduced folates: a revised hypothesis of the primary site of PteGlu metabolism in humans. J Nutr 2005;135:619-23.
3. Kelly P, McPartlin J, Goggins M, Weir DG, Scott JM. Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr 1997;65:1790-5. (Pubitemid 27240695)
4. Selhub J, Morris MS, Jacques PF, Rosenberg IH. Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. Am J Clin Nutr 2009;89:702S-6S.
5. Pentieva K, McNulty H, Reichert R, et al. The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men. J Nutr 2004;134:580-5.
6. Witthöft CM, Arkbåge K, Johansson M, et al. Folate absorption from folate-fortified and processed foods using a human ileostomy model. Br J Nutr 2006;95:181-7. (Pubitemid 43250726)
7. Witthöft C, Strålsjö L, Berglund G, Lundin E. A human model to determine folate bioavailability from food: a pilot study for evaluation. Scand J Nutr 2003;47:6-18. (Pubitemid 36538427)
8. Konings EJM, Troost FJ, Castenmiller JJM, Roomans HHS, van den Brandt PA, Saris WHM. Intestinal absorption of different types of folate in healthy subjects with an ileostomy. Br J Nutr 2002;88:235-42.
9. 2]folic acid. J Nutr 1997;127:2321-7.
10. Fenech M, Noakes M, Clifton P, Topping D. Aleurone flour is a rich source of bioavailable folate in humans. J Nutr 1999;129:1114-9. (Pubitemid 29250158)
11. Prinz-Langenohl R, Brönstrup A, Thorand B, Hages M, Pietrzik K. Availability of food folate in humans. J Nutr 1999;129:913-6.
12. Wright AJA, Finglas PM, Dainty JR, et al. Single oral doses of C-13 forms of pteroylmonoglutamic acid and 5-formyltetrahydrofolic acid elicit differences in short-term kinetics of labeled and unlabeled folates in plasma: potential problems in interpretation of folate bioavailability studies. Br J Nutr 2003;90:363-71.
13. Lin Y, Dueker SR, Follett JR, et al. Quantitation of in vivo human folate metabolism. Am J Clin Nutr 2004;80:680-91.
14. Pfeiffer CM, Rogers LM, Bailey LB, Gregory JF. Absorption of folate from fortified cereal-grain products and of supplemental folate consumed with or without food determined using a dual-label stable-isotope protocol. Am J Clin Nutr 1997;66:1388-97.
15. Finglas PM, Witthöft CM, Vahteristo L, et al. Use of an oral/intravenous dual-label stable-isotope protocol to determine folic acid bioavailability from fortified cereal grain foods in women. J Nutr 2002;132:936-9. (Pubitemid 34493556)
16. Tamura T, Stokstad EL. Availability of food folate in man. Br J Haematol 1973;25:513-32.
17. Buchholz BA, Arjomand A, Dueker SR, Schneider PD, Clifford AJ, Vogel JS. Intrinsic erythrocyte labeling and attomole pharmacokinetic tracing of 14C-labeled folic acid with accelerator mass spectrometry. Anal Biochem 1999;269:348-52.
18. Kim TH, Yang J, Darling PB, O'Connor DL. A large pool of available folate exists in the large intestine of human infants and piglets. J Nutr 2004;134:1389-94.
19. Jeejeebhoy KN, Ramanath P, Mehan KP, et al. A simple method of estimating folic acid absorption (a modified faecal excretion method). J Nucl Med 1967;8:40-9.
20. Jastrebova J, Witthöft C, Grahn A, Svensson U, Jägerstad M. HPLC determination of folates in raw and processed beetroots. Food Chem 2003;80:579-88. (Pubitemid 36149744)
21. Öhrvik V, Öhrvik H, Tallkvist J, Witthöft C. Folates in bread: retention during bread-making and in vitro bioaccessibility. Eur J Nutr (Epub ahead of print 4 February 2010).
22. Freisleben A, Schieberle P, Rychlik M. Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays. J Agric Food Chem 2002;50:4760-8. (Pubitemid 34856142)
23. Mönch S, Netzel M, Netzel G, Rychlik M. Quantitation of folates and their catabolites in blood plasma, erythrocytes, and urine by stable isotope dilution assays. Anal Biochem 2010;398:150-60.
24. Tozer T, Rowland M. Introduction to pharmacokinetics and pharmacodynamics. Baltimore, MD: Lippincott Williams & Wilkins, 2006.
25. Öhrvik J. Nonparametric methods in crossover trials. Biom J 1998;40:771-89.
26. 13C- labeled [6S]-5-formyltetrahydrofolic acid. Am J Clin Nutr 2009;90:116-23.
27. Gregory JF, Quinlivan EP. In vivo kinetics of folate metabolism. Annu Rev Nutr 2002;22:199-220.
28. 3H and 5-formyltetrahydrofolate (folinic acid). J Clin Invest 1971;50:455-62.
29. Pietrzik K, Hages M, Remer T. Methodological aspects in vitamin bioavailability testing. J Micronutr Anal 1990;7:207-22.