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Volumn , Issue , 2010, Pages 625-649

Clinical studies of drug-drug interactions: Design and interpretation

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EID: 77956576179     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-0840-7_24     Document Type: Chapter
Times cited : (26)

References (108)
  • 2
    • 33644861762 scopus 로고    scopus 로고
    • Inhibition constants, inhibitor concentrations and the prediction of inhibitory drug drug interactions: Pitfalls, progress and promise
    • Bachmann KA (2006) Inhibition constants, inhibitor concentrations and the prediction of inhibitory drug drug interactions: pitfalls, progress and promise. Curr Drug Metab 7:1-14.
    • (2006) Curr Drug Metab , vol.7 , pp. 1-14
    • Bachmann, K.A.1
  • 3
    • 18844410849 scopus 로고    scopus 로고
    • Predicting inhibitory drug-drug interactions and evaluating drug interaction reports using inhibition constants
    • Bachmann KA and Lewis JD (2005) Predicting inhibitory drug-drug interactions and evaluating drug interaction reports using inhibition constants. Ann Pharmacother 39:1064-1072.
    • (2005) Ann Pharmacother , vol.39 , pp. 1064-1072
    • Bachmann, K.A.1    Lewis, J.D.2
  • 6
    • 0026009994 scopus 로고
    • Caffeine and theophylline as adenosine receptor antagonists in humans
    • Biaggioni I, Paul S, Puckett A and Arzubiaga C (1991) Caffeine and theophylline as adenosine receptor antagonists in humans. J Pharmacol Exp Ther 258:588-593.
    • (1991) J Pharmacol Exp Ther , vol.258 , pp. 588-593
    • Biaggioni, I.1    Paul, S.2    Puckett, A.3    Arzubiaga, C.4
  • 7
    • 1242329170 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1
    • Blakey GE, Lockton JA, Perrett J, Norwood P, Russell M, Aherne Z and Plume J (2004) Pharmacokinetic and pharmacodynamic assessment of a five-probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1. Br J Clin Pharmacol 57:162-169.
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 162-169
    • Blakey, G.E.1    Lockton, J.A.2    Perrett, J.3    Norwood, P.4    Russell, M.5    Aherne, Z.6    Plume, J.7
  • 8
    • 33748946044 scopus 로고    scopus 로고
    • Prediction of in vivo drug-drug interactions from in vitro data: Factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4
    • Brown HS, Galetin A, Hallifax D and Houston JB (2006) Prediction of in vivo drug-drug interactions from in vitro data: factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4. Clin Pharmacokinet 45:1035-1050.
    • (2006) Clin Pharmacokinet , vol.45 , pp. 1035-1050
    • Brown, H.S.1    Galetin, A.2    Hallifax, D.3    Houston, J.B.4
  • 9
    • 27444445468 scopus 로고    scopus 로고
    • Prediction of in vivo drug-drug interactions from in vitro data: Impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant
    • Brown HS, Ito K, Galetin A and Houston JB (2005) Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant. Br J Clin Pharmacol 60:508-518.
    • (2005) Br J Clin Pharmacol , vol.60 , pp. 508-518
    • Brown, H.S.1    Ito, K.2    Galetin, A.3    Houston, J.B.4
  • 11
    • 0021254927 scopus 로고
    • Effects of combined alcohol and benzodiazepine: A review
    • Chan AW (1984) Effects of combined alcohol and benzodiazepine: a review. Drug Alcohol Depend 13:315-341.
    • (1984) Drug Alcohol Depend , vol.13 , pp. 315-341
    • Chan, A.W.1
  • 15
    • 0032428779 scopus 로고    scopus 로고
    • In vitro assessment of human cytochrome P450
    • Clarke SE (1998) In vitro assessment of human cytochrome P450. Xenobiotica 28:1167-1202.
    • (1998) Xenobiotica , vol.28 , pp. 1167-1202
    • Clarke, S.E.1
  • 16
    • 0028838078 scopus 로고
    • Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: Possible mechanism for terfenadine-associated cardiotoxicity
    • Crumb WJ, Jr., Wible B, Arnold DJ, Payne JP and Brown AM (1995) Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity. Mol Pharmacol 47:181-190.
    • (1995) Mol Pharmacol , vol.47 , pp. 181-190
    • Crumb Jr., W.J.1    Wible, B.2    Arnold, D.J.3    Payne, J.P.4    Brown, A.M.5
  • 18
    • 27444442823 scopus 로고    scopus 로고
    • Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics
    • Culm-Merdek KE, Von Moltke LL, Harmatz JS and Greenblatt DJ (2005) Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics. Br J Clin Pharmacol 60:486-493.
    • (2005) Br J Clin Pharmacol , vol.60 , pp. 486-493
    • Culm-Merdek, K.E.1    Von Moltke, L.L.2    Harmatz, J.S.3    Greenblatt, D.J.4
  • 20
    • 1942455344 scopus 로고    scopus 로고
    • Potential for drug interactions involving cytochromes P450 2D6 and 3A4 on general adult psychiatric and functional elderly psychiatric wards
    • Davies SJ, Eayrs S, Pratt P and Lennard MS (2004) Potential for drug interactions involving cytochromes P450 2D6 and 3A4 on general adult psychiatric and functional elderly psychiatric wards. Br J Clin Pharmacol 57:464-472.
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 464-472
    • Davies, S.J.1    Eayrs, S.2    Pratt, P.3    Lennard, M.S.4
  • 21
    • 33746299419 scopus 로고    scopus 로고
    • Antidepressant-drug interactions are potentially but rarely clinically significant
    • De Vane CL (2006) Antidepressant-drug interactions are potentially but rarely clinically significant. Neuropsychopharmacol 31:1594-1604.
    • (2006) Neuropsychopharmacol , vol.31 , pp. 1594-1604
    • De Vane, C.L.1
  • 24
    • 33846607427 scopus 로고    scopus 로고
    • Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach
    • Fuhr U, Jetter A and Kirchheiner J (2007) Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach. Clin Pharmacol Ther 81:270-283.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 270-283
    • Fuhr, U.1    Jetter, A.2    Kirchheiner, J.3
  • 25
    • 29944446485 scopus 로고    scopus 로고
    • Prediction of time-dependent CYP3A4 drug-drug interactions: Impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition
    • Galetin A, Burt H, Gibbons L and Houston JB (2006) Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition. Drug Metab Dispos 34:166-175.
    • (2006) Drug Metab Dispos , vol.34 , pp. 166-175
    • Galetin, A.1    Burt, H.2    Gibbons, L.3    Houston, J.B.4
  • 26
    • 35348880290 scopus 로고    scopus 로고
    • Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs
    • Galetin A, Hinton LK, Burt H, Obach RS and Houston JB (2007) Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs. Curr Drug Metab 8:685-693.
    • (2007) Curr Drug Metab , vol.8 , pp. 685-693
    • Galetin, A.1    Hinton, L.K.2    Burt, H.3    Obach, R.S.4    Houston, J.B.5
  • 27
    • 33747599176 scopus 로고    scopus 로고
    • Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: Impact on prediction of first-pass metabolism
    • Galetin A and Houston JB (2006) Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: impact on prediction of first-pass metabolism. J Pharmacol Exp Ther 318:1220-1229.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1220-1229
    • Galetin, A.1    Houston, J.B.2
  • 28
    • 23044500208 scopus 로고    scopus 로고
    • CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions
    • Galetin A, Ito K, Hallifax D and Houston JB (2005) CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions. J Pharmacol Exp Ther 314:180-190.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 180-190
    • Galetin, A.1    Ito, K.2    Hallifax, D.3    Houston, J.B.4
  • 29
    • 33645391461 scopus 로고    scopus 로고
    • Drug-drug interactions among recently hospitalised patients - Frequent but mostly clinically insignificant
    • Glintborg B, Andersen SE and Dalhoff K (2005) Drug-drug interactions among recently hospitalised patients - frequent but mostly clinically insignificant. Eur J Clin Pharmacol 61:675-681.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 675-681
    • Glintborg, B.1    Andersen, S.E.2    Dalhoff, K.3
  • 31
    • 1842636952 scopus 로고    scopus 로고
    • Fluvoxamine drastically increases concentrations and effects of tizanidine: A potentially hazardous interaction
    • Granfors MT, Backman JT, Neuvonen M, Ahonen J and Neuvonen PJ (2004b) Fluvoxamine drastically increases concentrations and effects of tizanidine: a potentially hazardous interaction. Clin Pharmacol Ther 75:331-341.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 331-341
    • Granfors, M.T.1    Backman, J.T.2    Neuvonen, M.3    Ahonen, J.4    Neuvonen, P.J.5
  • 32
    • 54449098492 scopus 로고    scopus 로고
    • Preparation of scientific reports on pharmacokinetic drug interaction studies
    • Greenblatt DJ (2008) Preparation of scientific reports on pharmacokinetic drug interaction studies. J Clin Psychopharmacol 28:369-373.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 369-373
    • Greenblatt, D.J.1
  • 37
    • 65949100844 scopus 로고    scopus 로고
    • Drug-drug interactions: Clinical perspectives
    • Rodrigues AD ed, Informa Healthcare, New York
    • Greenblatt DJ and Von Moltke LL (2008) Drug-drug interactions: clinical perspectives, in Drug-Drug Interactions (Rodrigues AD ed) pp 643-664, Informa Healthcare, New York.
    • (2008) Drug-Drug Interactions , pp. 643-664
    • Greenblatt, D.J.1    Von Moltke, L.L.2
  • 42
    • 0038826450 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and drug disposition
    • Davis KL and American College of Neuropsychopharmacology eds, Lippincott Williams & Wilkins, Philadelphia
    • Greenblatt DJ, Von Moltke LL, Harmatz JS and Shader RI (2002) Pharmacokinetics, pharmacodynamics, and drug disposition, in Neuropsychopharmacology the Fifth Generation of Progress (Davis KL and American College of Neuropsychopharmacology eds) pp 507-524, Lippincott Williams & Wilkins, Philadelphia.
    • (2002) Neuropsychopharmacology the Fifth Generation of Progress , pp. 507-524
    • Greenblatt, D.J.1    Von Moltke, L.L.2    Harmatz, J.S.3    Shader, R.I.4
  • 43
    • 0032872510 scopus 로고    scopus 로고
    • Human cytochromes and some newer antidepressants: Kinetics, metabolism, and drug interactions
    • Greenblatt DJ, Von Moltke LL, Harmatz JS and Shader RI (1999) Human cytochromes and some newer antidepressants: kinetics, metabolism, and drug interactions. J Clin Psychopharmacol 19(supp. 1):23S-35S.
    • (1999) J Clin Psychopharmacol , vol.19 , Issue.SUPPL. 1
    • Greenblatt, D.J.1    Von Moltke, L.L.2    Harmatz, J.S.3    Shader, R.I.4
  • 45
    • 0032924934 scopus 로고    scopus 로고
    • Cytochrome P-450 3A4: Regulation and role in drug metabolism
    • Guengerich FP (1999) Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol 39:1-17.
    • (1999) Annu Rev Pharmacol Toxicol , vol.39 , pp. 1-17
    • Guengerich, F.P.1
  • 47
    • 0036001244 scopus 로고    scopus 로고
    • Change from the CYP2D6 extensive metabolizer to the poor metabolizer phenotype during treatment with bupropion
    • Guzey C, Norstrom A and Spigset O (2002) Change from the CYP2D6 extensive metabolizer to the poor metabolizer phenotype during treatment with bupropion. Ther Drug Monit 24:436-437.
    • (2002) Ther Drug Monit , vol.24 , pp. 436-437
    • Guzey, C.1    Norstrom, A.2    Spigset, O.3
  • 48
    • 0036219021 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: An update
    • Hemeryck A and Belpaire FM (2002) Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: an update. Curr Drug Metab 3:13-37.
    • (2002) Curr Drug Metab , vol.3 , pp. 13-37
    • Hemeryck, A.1    Belpaire, F.M.2
  • 50
    • 0026671408 scopus 로고
    • Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin
    • Honig PK, Woosley RL, Zamani K, Conner DP and Cantilena LR, Jr. (1992) Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin. Clin Pharmacol Ther 52:231-238.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 231-238
    • Honig, P.K.1    Woosley, R.L.2    Zamani, K.3    Conner, D.P.4    Cantilena Jr., L.R.5
  • 51
    • 0027768575 scopus 로고
    • Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics
    • Honig PK, Wortham DC, Hull R, Zamani K, Smith JE and Cantilena LR (1993a) Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics. J Clin Pharmacol 33:1201-1206.
    • (1993) J Clin Pharmacol , vol.33 , pp. 1201-1206
    • Honig, P.K.1    Wortham, D.C.2    Hull, R.3    Zamani, K.4    Smith, J.E.5    Cantilena, L.R.6
  • 52
    • 0028343588 scopus 로고
    • Comparison of the effect of the macrolide antibiotics erythromycin, clarithromycin, and azithromycin on terfenadine steadystate pharmacokinetics and electrocardiographic parameters
    • Honig PK, Wortham DC, Zamani K and Cantilena LR (1994) Comparison of the effect of the macrolide antibiotics erythromycin, clarithromycin, and azithromycin on terfenadine steadystate pharmacokinetics and electrocardiographic parameters. Drug Invest 7:148-156.
    • (1994) Drug Invest , vol.7 , pp. 148-156
    • Honig, P.K.1    Wortham, D.C.2    Zamani, K.3    Cantilena, L.R.4
  • 55
    • 33846577441 scopus 로고    scopus 로고
    • Drug interaction studies: Study design, data analysis, and implications for dosing and labeling
    • Huang SM, Temple R, Throckmorton DC and Lesko LJ (2007) Drug interaction studies: study design, data analysis, and implications for dosing and labeling. Clin Pharmacol Ther 81:298-304.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 298-304
    • Huang, S.M.1    Temple, R.2    Throckmorton, D.C.3    Lesko, L.J.4
  • 56
    • 1942455361 scopus 로고    scopus 로고
    • Database analyses for the prediction of in vivo drug-drug interactions from in vitro data
    • Ito K, Brown HS and Houston JB (2004) Database analyses for the prediction of in vivo drug-drug interactions from in vitro data. Br J Clin Pharmacol 57:473-486.
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 473-486
    • Ito, K.1    Brown, H.S.2    Houston, J.B.3
  • 57
    • 0038311984 scopus 로고    scopus 로고
    • Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes
    • Ito K, Ogihara K, Kanamitsu S and Itoh T (2003) Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes. Drug Metab Dispos 31:945-954.
    • (2003) Drug Metab Dispos , vol.31 , pp. 945-954
    • Ito, K.1    Ogihara, K.2    Kanamitsu, S.3    Itoh, T.4
  • 58
    • 0029738965 scopus 로고    scopus 로고
    • Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine
    • Jeppesen U, Gram LF, Vistisen K, Loft S, Poulsen HE and Brøsen K (1996a) Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. Eur J Clin Pharmacol 51:73-78.
    • (1996) Eur J Clin Pharmacol , vol.51 , pp. 73-78
    • Jeppesen, U.1    Gram, L.F.2    Vistisen, K.3    Loft, S.4    Poulsen, H.E.5    Brøsen, K.6
  • 60
    • 0031006546 scopus 로고    scopus 로고
    • The use of other drugs to allow a lower dosage of cyclosporin to be used. Therapeutic and pharmacoeconomic considerations
    • Jones TE (1997) The use of other drugs to allow a lower dosage of cyclosporin to be used. Therapeutic and pharmacoeconomic considerations. Clin Pharmacokinet 32:357-367.
    • (1997) Clin Pharmacokinet , vol.32 , pp. 357-367
    • Jones, T.E.1
  • 61
    • 0033994866 scopus 로고    scopus 로고
    • Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: Use of maximum unbound concentration of inhibitor at the inlet to the liver
    • Kanamitsu S, Ito K and Sugiyama Y (2000) Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver. Pharm Res 17:336-343.
    • (2000) Pharm Res , vol.17 , pp. 336-343
    • Kanamitsu, S.1    Ito, K.2    Sugiyama, Y.3
  • 62
    • 0026783029 scopus 로고
    • Effects of benzodiazepine administration on A1 adenosine receptor binding in-vivo and ex-vivo
    • Kaplan GB, Cotreau MM and Greenblatt DJ (1992a) Effects of benzodiazepine administration on A1 adenosine receptor binding in-vivo and ex-vivo. J Pharm Pharmacol 44:700-703.
    • (1992) J Pharm Pharmacol , vol.44 , pp. 700-703
    • Kaplan, G.B.1    Cotreau, M.M.2    Greenblatt, D.J.3
  • 63
  • 64
    • 0027887282 scopus 로고
    • Caffeine treatment and withdrawal in mice: Relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding
    • Kaplan GB, Greenblatt DJ, Kent MA and Cotreau-Bibbo MM (1993) Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding. J Pharmacol Exp Ther 266:1563-1572.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 1563-1572
    • Kaplan, G.B.1    Greenblatt, D.J.2    Kent, M.A.3    Cotreau-Bibbo, M.M.4
  • 67
    • 0030949860 scopus 로고    scopus 로고
    • Common noncompartmental pharmacokinetic variables: Are they normally or log-normally distributed?
    • Lacey LF, Keene ON, Pritchard JF and Bye A (1997) Common noncompartmental pharmacokinetic variables: are they normally or log-normally distributed? J Biopharm Stat 7:171-178.
    • (1997) J Biopharm Stat , vol.7 , pp. 171-178
    • Lacey, L.F.1    Keene, O.N.2    Pritchard, J.F.3    Bye, A.4
  • 68
    • 0036908935 scopus 로고    scopus 로고
    • Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping
    • Lee JI, Chaves-Gnecco D, Amico JA, Kroboth PD, Wilson JW and Frye RF (2002) Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping. Clin Pharmacol Ther 72:718-728.
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 718-728
    • Lee, J.I.1    Chaves-Gnecco, D.2    Amico, J.A.3    Kroboth, P.D.4    Wilson, J.W.5    Frye, R.F.6
  • 69
    • 33745395225 scopus 로고    scopus 로고
    • CYP induction-mediated drug interactions: In vitro assessment and clinical implications
    • Lin JH (2006) CYP induction-mediated drug interactions: in vitro assessment and clinical implications. Pharm Res 23:1089-1116.
    • (2006) Pharm Res , vol.23 , pp. 1089-1116
    • Lin, J.H.1
  • 70
    • 0034570768 scopus 로고    scopus 로고
    • Sense and nonsense in the prediction of drug-drug interactions
    • Lin JH (2000) Sense and nonsense in the prediction of drug-drug interactions. Curr Drug Metab 1:305-331.
    • (2000) Curr Drug Metab , vol.1 , pp. 305-331
    • Lin, J.H.1
  • 71
    • 18744383066 scopus 로고    scopus 로고
    • Co-prescription of cytochrome P450 2D6/3A4 inhibitor-substrate pairs in clinical practice. A retrospective analysis of data from Norwegian primary pharmacies
    • Molden E, Garcia BH, Braathen P and Eggen AE (2005) Co-prescription of cytochrome P450 2D6/3A4 inhibitor-substrate pairs in clinical practice. A retrospective analysis of data from Norwegian primary pharmacies. Eur J Clin Pharmacol 61:119-125.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 119-125
    • Molden, E.1    Garcia, B.H.2    Braathen, P.3    Eggen, A.E.4
  • 74
    • 28844476587 scopus 로고    scopus 로고
    • In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach
    • Obach RS, Walsky RL, Venkatakrishnan K, Houston JB and Tremaine LM (2005) In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach. Clin Pharmacol Ther 78:582-592.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 582-592
    • Obach, R.S.1    Walsky, R.L.2    Venkatakrishnan, K.3    Houston, J.B.4    Tremaine, L.M.5
  • 76
    • 0024535104 scopus 로고
    • Urinary excretion of 6 beta-hydroxycortisol and the time course measurement of enzyme induction in man
    • Ohnhaus EE, Breckenridge AM and Park BK (1989) Urinary excretion of 6 beta-hydroxycortisol and the time course measurement of enzyme induction in man. Eur J Clin Pharmacol 36:39-46.
    • (1989) Eur J Clin Pharmacol , vol.36 , pp. 39-46
    • Ohnhaus, E.E.1    Breckenridge, A.M.2    Park, B.K.3
  • 77
    • 34547641389 scopus 로고    scopus 로고
    • General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs
    • Ohno Y, Hisaka A and Suzuki H (2007) General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs. Clin Pharmacokinet 46:681-696.
    • (2007) Clin Pharmacokinet , vol.46 , pp. 681-696
    • Ohno, Y.1    Hisaka, A.2    Suzuki, H.3
  • 78
    • 34548049514 scopus 로고    scopus 로고
    • Effect of the treatment period with erythromycin on cytochrome P450 3A activity in humans
    • Okudaira T, Kotegawa T, Imai H, Tsutsumi K, Nakano S and Ohashi K (2007) Effect of the treatment period with erythromycin on cytochrome P450 3A activity in humans. J Clin Pharmacol 47:871-876.
    • (2007) J Clin Pharmacol , vol.47 , pp. 871-876
    • Okudaira, T.1    Kotegawa, T.2    Imai, H.3    Tsutsumi, K.4    Nakano, S.5    Ohashi, K.6
  • 81
    • 36949032109 scopus 로고    scopus 로고
    • Quantitative correlations among CYP3A sensitive substrates and inhibitors: Literature analysis
    • Ragueneau-Majlessi I, Boulenc X, Rauch C, Hachad H and Levy RH (2007) Quantitative correlations among CYP3A sensitive substrates and inhibitors: literature analysis. Curr Drug Metab 8:810-814.
    • (2007) Curr Drug Metab , vol.8 , pp. 810-814
    • Ragueneau-Majlessi, I.1    Boulenc, X.2    Rauch, C.3    Hachad, H.4    Levy, R.H.5
  • 82
    • 0027718143 scopus 로고
    • Effects of terfenadine and its metabolites on a delayed rectifier K+ channel cloned from human heart
    • Rampe D, Wible B, Brown AM and Dage RC (1993) Effects of terfenadine and its metabolites on a delayed rectifier K+ channel cloned from human heart. Mol Pharmacol 44:1240-1245.
    • (1993) Mol Pharmacol , vol.44 , pp. 1240-1245
    • Rampe, D.1    Wible, B.2    Brown, A.M.3    Dage, R.C.4
  • 84
    • 33947587274 scopus 로고    scopus 로고
    • Simulation and prediction of in vivo drug metabolism in human populations from in vitro data
    • Rostami-Hodjegan A and Tucker GT (2007) Simulation and prediction of in vivo drug metabolism in human populations from in vitro data. Nat Rev Drug Discov 6:140-148.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 140-148
    • Rostami-Hodjegan, A.1    Tucker, G.T.2
  • 86
    • 0032444641 scopus 로고    scopus 로고
    • Human cytochrome P450s: Selectivity and measurement in vivo
    • Smith DA, Abel SM, Hyland R and Jones BC (1998a) Human cytochrome P450s: selectivity and measurement in vivo. Xenobiotica 28:1095-1128.
    • (1998) Xenobiotica , vol.28 , pp. 1095-1128
    • Smith, D.A.1    Abel, S.M.2    Hyland, R.3    Jones, B.C.4
  • 87
    • 0032414615 scopus 로고    scopus 로고
    • Molecular genetics of the human cytochrome P450 monooxygenase superfamily
    • Smith G, Stubbins MJ, Harries LW and Wolf CR (1998b) Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica 28:1129-1165.
    • (1998) Xenobiotica , vol.28 , pp. 1129-1165
    • Smith, G.1    Stubbins, M.J.2    Harries, L.W.3    Wolf, C.R.4
  • 89
    • 0037803539 scopus 로고    scopus 로고
    • How useful is the "cocktail approach" for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo?
    • Tanaka E, Kurata N and Yasuhara H (2003) How useful is the "cocktail approach" for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo? J Clin Pharm Ther 28:157-165.
    • (2003) J Clin Pharm Ther , vol.28 , pp. 157-165
    • Tanaka, E.1    Kurata, N.2    Yasuhara, H.3
  • 90
    • 0032700543 scopus 로고    scopus 로고
    • Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: Effect of ketoconazole
    • Tsunoda SM, Velez RL, Von Moltke LL and Greenblatt DJ (1999) Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole. Clin Pharmacol Ther 66:461-471.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 461-471
    • Tsunoda, S.M.1    Velez, R.L.2    Von Moltke, L.L.3    Greenblatt, D.J.4
  • 91
    • 0034824312 scopus 로고    scopus 로고
    • Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential - Towards a consensus
    • Tucker GT, Houston JB and Huang SM (2001) Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential - towards a consensus. Br J Clin Pharmacol 52:107-117.
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 107-117
    • Tucker, G.T.1    Houston, J.B.2    Huang, S.M.3
  • 92
    • 0034004083 scopus 로고    scopus 로고
    • Effects of the antifungal agents on oxidative drug metabolism: Clinical relevance
    • Venkatakrishnan K, Von Moltke LL and Greenblatt DJ (2000) Effects of the antifungal agents on oxidative drug metabolism: clinical relevance. Clin Pharmacokinet 38:111-180.
    • (2000) Clin Pharmacokinet , vol.38 , pp. 111-180
    • Venkatakrishnan, K.1    Von Moltke, L.L.2    Greenblatt, D.J.3
  • 93
    • 0034770465 scopus 로고    scopus 로고
    • Human drug metabolism and the cytochromes P450: Application and relevance of in vitro models
    • Venkatakrishnan K, Von Moltke LL and Greenblatt DJ (2001) Human drug metabolism and the cytochromes P450: application and relevance of in vitro models. J Clin Pharmacol 41:1149-1179.
    • (2001) J Clin Pharmacol , vol.41 , pp. 1149-1179
    • Venkatakrishnan, K.1    Von Moltke, L.L.2    Greenblatt, D.J.3
  • 94
    • 0142010701 scopus 로고    scopus 로고
    • Drug metabolism and drug interactions: Application and clinical value of in vitro models
    • Venkatakrishnan K, Von Moltke LL, Obach RS and Greenblatt DJ (2003) Drug metabolism and drug interactions: application and clinical value of in vitro models. Curr Drug Metab 4:423-459.
    • (2003) Curr Drug Metab , vol.4 , pp. 423-459
    • Venkatakrishnan, K.1    Von Moltke, L.L.2    Obach, R.S.3    Greenblatt, D.J.4
  • 96
    • 0028194864 scopus 로고
    • Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake- inhibitor antidepressants, and by quinidine and ketoconazole: A model system to predict drug interactions in vivo
    • Von Moltke LL, Greenblatt DJ, Cotreau-Bibbo MM, Duan SX, Harmatz JS and Shader RI (1994a) Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo. J Pharmacol Exp Ther 268:1278-1283.
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 1278-1283
    • Von Moltke, L.L.1    Greenblatt, D.J.2    Cotreau-Bibbo, M.M.3    Duan, S.X.4    Harmatz, J.S.5    Shader, R.I.6
  • 97
    • 0028898816 scopus 로고
    • Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: Comparison with other selective serotonin reuptake inhibitor antidepressants
    • Von Moltke LL, Greenblatt DJ, Court MH, Duan SX, Harmatz JS and Shader RI (1995) Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants. J Clin Psychopharmacol 15:125-131.
    • (1995) J Clin Psychopharmacol , vol.15 , pp. 125-131
    • Von Moltke, L.L.1    Greenblatt, D.J.2    Court, M.H.3    Duan, S.X.4    Harmatz, J.S.5    Shader, R.I.6
  • 101
    • 6944221357 scopus 로고    scopus 로고
    • Drug-drug interactions for UDP-glucuronosyltransferase substrates: A pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
    • Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, Peterkin V, Koup JR and Ball SE (2004) Drug-drug interactions for UDP- glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos 32:1201-1208.
    • (2004) Drug Metab Dispos , vol.32 , pp. 1201-1208
    • Williams, J.A.1    Hyland, R.2    Jones, B.C.3    Smith, D.A.4    Hurst, S.5    Goosen, T.C.6    Peterkin, V.7    Koup, J.R.8    Ball, S.E.9
  • 103
    • 0035215519 scopus 로고    scopus 로고
    • Fluvoxamine-theophylline interaction: Gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2
    • Yao C, Kunze KL, Kharasch ED, Wang Y, Trager WF, Ragueneau I and Levy RH (2001) Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2. Clin Pharmacol Ther 70:415-424.
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 415-424
    • Yao, C.1    Kunze, K.L.2    Kharasch, E.D.3    Wang, Y.4    Trager, W.F.5    Ragueneau, I.6    Levy, R.H.7
  • 104
    • 0344519718 scopus 로고    scopus 로고
    • Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19
    • Yao C, Kunze KL, Trager WF, Kharasch ED and Levy RH (2003) Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19. Drug Metab Dispos 31:565-571.
    • (2003) Drug Metab Dispos , vol.31 , pp. 565-571
    • Yao, C.1    Kunze, K.L.2    Trager, W.F.3    Kharasch, E.D.4    Levy, R.H.5
  • 106
    • 1642494659 scopus 로고    scopus 로고
    • "Cocktail" approaches and strategies in drug development: Valuable tool or flawed science?
    • Zhou H, Tong Z and McLeod JF (2004) "Cocktail" approaches and strategies in drug development: valuable tool or flawed science? J Clin Pharmacol 44:120-134.
    • (2004) J Clin Pharmacol , vol.44 , pp. 120-134
    • Zhou, H.1    Tong, Z.2    McLeod, J.F.3
  • 107
    • 45249121177 scopus 로고    scopus 로고
    • Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
    • Zhou SF (2008) Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. Curr Drug Metab 9:310-322.
    • (2008) Curr Drug Metab , vol.9 , pp. 310-322
    • Zhou, S.F.1


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