Regulation of bone formation using rapamycin-induced BMP2 expression system: Influence of implanted cell number

Molecular and Cellular Toxicology

Volumn 6, Issue 2, 2010, Pages 187-194

  Lim, Dong Jin ^a   Park, Bae Keun ^b   Jang, Won Gu ^a   Lee, Kkot Nim ^a   Franceschi, Renny ^c   Kim, Sun Hun ^a   Lee, Shee Eun ^a   Koh, Jeong Tae ^a  

^a Chonnam National University   (South Korea)

^b Yonsei University Wonju College of Medicine   (South Korea)

^c UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

Author keywords

BMP2; Bone formation; Gene therapy; Rapamycin; Retrovirus

Indexed keywords

EID: 77956570481     PISSN: 1738642X     EISSN: 20928467     Source Type: Journal    
DOI: 10.1007/s13273-010-0026-1     Document Type: Article

References (21)

1. B. L. Hogan 1996 Bone morphogenetic proteins: multifunctional regulators of vertebrate development Genes Dev 10 1580 1594 10.1101/gad.10.13.1580 1:CAS:528:DyaK28Xkt1CksL4%3D 8682290
2. D. Chen M. Zhao G. R. Mundy 2004 Bone morphogenetic proteins Growth Factors 22 233 241 10.1080/08977190412331279890 1:CAS:528:DC%2BD2MXhtFWrsQ%3D%3D 15621726 (Pubitemid 40136452)
3. R. T. Franceschi 2005 Biological approaches to bone regeneration by gene therapy J Dent Res 84 1093 1103 10.1177/154405910508401204 1:CAS:528: DC%2BD28Xps1arsg%3D%3D 16304438 (Pubitemid 43827776)
4. G. N. King N. King A. T. Cruchley J. M. Wozney F. J. Hughes 1997 Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects J Dent Res 76 1460 1470 10.1177/ 00220345970760080801 1:CAS:528:DyaK2sXltFCit78%3D 9240382
5. M. J. Bitgood A. P. McMahon 1995 Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo Dev Biol 172 126 138 10.1006/dbio.1995.0010 1:CAS:528:DyaK2MXptFGru7Y%3D 7589793
6. P. H. Francis M. K. Richardson P. M. Brickell C. Tickle 1994 Bone morphogenetic proteins and a signal-ling pathway that controls patterning in the developing chick limb Development 120 209 218 1:CAS:528:DyaK2cXmsFWmtLw%3D 8119128
7. G. R. Martin 1998 The roles of FGFs in the early development of vertebrate limbs Genes Dev 12 1571 1586 10.1101/gad.12.11.1571 1:CAS:528:DyaK1cXjslKqtr0%3D 9620845
8. P. H. Krebsbach K. Gu R. T. Franceschi R. B. Rutherford 2000 Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo Hum Gene Ther 11 1201 1210 10.1089/10430340050015248 1:CAS:528: DC%2BD3cXjsF2gsLo%3D 10834621 (Pubitemid 30331585)
9. J. R. Lieberman, et al. 1999 The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats J Bone Joint Surg Am 81 905 917 1:STN:280:DyaK1MzlsFSktw%3D%3D 10428121
10. K. D. Riew N. M. Wright S. Cheng L. V. Avioli J. Lou 1998 Induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene in a rabbit spinal fusion model Calcif Tissue Int 63 357 360 10.1007/s002239900540 1:CAS:528:DyaK1cXmsVegs7w%3D 9744997 (Pubitemid 28443422)
11. R. B. Rutherford, et al. 2010 Bone morphogenetic proteintransduced human fibroblasts convert to osteoblasts and form bone in vivo Tissue Eng 8 441 452 10.1089/107632702760184709
12. I. K. Moutsatsos, et al. 2001 Exogenously regulated stem cell-mediated gene therapy for bone regeneration Mol Ther 3 449 461 10.1006/mthe.2001.0291 1:CAS:528:DC%2BD38XhvFKisrg%3D 11319905 (Pubitemid 32509838)
13. H. Peng, et al. 2004 Development of a self-inactivating teton retroviral vector expressing bone morphogenetic protein 4 to achieve regulated bone formation Mol Ther 9 885 894 10.1016/j.ymthe.2004.02.023 1:CAS:528: DC%2BD2cXkvVegsrk%3D 15194055 (Pubitemid 38878134)
14. J. T. Koh, et al. 2006 Use of a stringent dimerizer-regulated gene expression system for controlled BMP2 delivery Mol Ther 14 684 691 10.1016/j.ymthe.2006.05.021 1:CAS:528:DC%2BD28XhtVGju7jO 16905364 (Pubitemid 44507713)
15. T. Katagiri, et al. 1994 Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage J Cell Biol 127 1755 1766 10.1083/jcb.127.6.1755 1:CAS:528:DyaK2cXmvFemtLs%3D 7798324 (Pubitemid 24380911)
16. X. Jiao, et al. 2007 Heparan sulfate proteoglycans (HSPGs) modulate BMP2 osteogenic bioactivity in C2C12 cells J Biol Chem 282 1080 1086 10.1074/jbc.M513414200 1:CAS:528:DC%2BD2sXit1KmtQ%3D%3D 17020882 (Pubitemid 47076568)
17. J. Nickel M. K. Dreyer T. Kirsch W. Sebald 2001 The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists J Bone Joint Surg Am 83-ASuppl1 S7 14
18. B. C. Carofino J. R. Lieberman 2008 Gene therapy applications for fracture-healing J Bone Joint Surg Am 90 Suppl1 99 110 10.2106/JBJS.G.01546 18292364 (Pubitemid 351329128)
19. G. A. Helm T. D. Alden J. P. Sheehan D. Kallmes 2000 Bone morphogenetic proteins and bone morpho-genetic protein gene therapy in neurological surgery: a review Neurosurgery 46 1213 1222 10.1097/00006123-200005000-00038 1:STN:280:DC%2BD3c3msFGgtg%3D%3D 10807254
20. J. T. Koh, et al. 2008 Combinatorial gene therapy with BMP2/7 enhances cranial bone regeneration J Dent Res 87 845 849 10.1177/154405910808700906 1:CAS:528:DC%2BD1cXhtFWitLjJ 18719211
21. J. K. Heinonen R. J. Lahti 1981 A new and convenient colorimetric determination of inorganic orthophosphate and its application to the assay of inorganic pyrophosphatase Anal Biochem 113 313 317 10.1016/0003-2697(81)90082-8 1:CAS:528:DyaL3MXksFKqsr0%3D 6116463 (Pubitemid 11012541)