Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: Role of epistatic mutations

Biochemistry

Volumn 49, Issue 37, 2010, Pages 8062-8070

  Tomberg, Joshua ^a   Unemo, Magnus ^b   Davies, Christopher ^c   Nicholas, Robert A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; SEWAGE TREATMENT PLANTS; STRUCTURAL ANALYSIS;

BREAK-POINTS; CEFIXIME; CEFTRIAXONE; INTERMEDIATE RESISTANCE; MINIMUM INHIBITORY CONCENTRATION; NEISSERIA GONORRHOEAE; PENICILLIN- BINDING PROTEINS; STRUCTURAL MECHANISMS; WILD TYPES; WILD-TYPE LEVELS; WILD-TYPE STRAIN;

GENES;

BETA LACTAM; CEFIXIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 2; PENICILLIN G; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; PENICILLIN DERIVATIVE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; GENE MUTATION; GENETIC EPISTASIS; MINIMUM INHIBITORY CONCENTRATION; NEISSERIA GONORRHOEAE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MUTATION;

NEISSERIA GONORRHOEAE;

ANTI-BACTERIAL AGENTS; CEFIXIME; CEFTRIAXONE; CEPHALOSPORINS; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; NEISSERIA GONORRHOEAE; PENICILLIN-BINDING PROTEINS; PENICILLINS;

EID: 77956565733     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101167x     Document Type: Article

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