Identification and analysis of amino acid mutations in porin IB that mediate intermediate-level resistance to penicillin and tetracycline in Neisseria gonorrhoeae

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 9, 2002, Pages 2811-2820

  Olesky, Melanie ^a   Hobbs, Marcia ^a   Nicholas, Robert A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ASPARTIC ACID; GLYCINE; LYSINE; PENICILLIN DERIVATIVE; PORIN; PORIN 1B; TETRACYCLINE; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CHIMERA; GENBANK; GENE LOCUS; GENE MUTATION; NEISSERIA GONORRHOEAE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS;

EID: 0036719736     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.9.2811-2820.2002     Document Type: Article

References (45)

1. One single lysine residue is responsible for the special interaction between polyphosphate and the outer membrane porin PhoE of Escherichia coli
2. Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae
3. Confirmation of association of protein I serotype of Neisseria gonorrhoeae with ability to cause disseminated infection
4. Genetic locus (nmp-1) affecting the principal outer membrane protein of Neisseria gonorrhoeae
5. The genetics of the gonococcus
6. Genetics of protein I of Neisseria gonorrhoeae: Construction of hybrid porins
7. 1998 Guidelines for treatment of sexually transmitted diseases
8. Fluoroquinolone resistance in Neisseria gonorrhoeae, Hawaii, 1999, and decreased susceptibility to azithromycin in N. gonorrhoeae, Missouri, 1999
9. Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid
10. In vivo modification of porin activity conferring antibiotic resistance to Enterobacter aerogenes
11. Variation within serovars of Neisseria gonorrhoeae detected by structural analysis of outer-membrane protein PIB and by pulsed-field gel electrophoresis
12. Crystal structures explain functional properties of two E. coli porins
13. A new mechanism of antibiotic resistance in Enterobacteriaceae induced by a structural modification of the major porin
14. Structural and evolutionary inference from molecular variation in Neisseria porins
15. Penicillin-binding proteins of penicillin-susceptible and intrinsically resistant Neisseria gonorrhoeae
16. Penicillin-binding protein 2 genes of non-β-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae
17. Species-specific uptake of DNA by gonococci is mediated by a 10-base-pair sequence
18. Genetics of resistance in a non-β-lactamase-producing gonococcus with relatively high-level penicillin resistance
19. Genetic diversity and mosaicism at the por locus of Neisseria gonorrhoeae
20. Gonococcal resistance to β-lactams and tetracycline involves mutation in loop 3 of the porin encoded at the penB locus
21. Factors influencing the specific interaction of Neisseria gonorrhoeae with transforming DNA
22. Use of a non-selective transformation technique to construct a multiply restriction/modification-deficient mutant of Neisseria gonorrhoeae
23. Cell envelope alterations in antibiotic-sensitive and-resistant strains of Neisseria gonorrhoeae
24. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system
25. Relationship between outer membrane alterations and susceptibility to antimicrobial agents in isogenic strains of Klebsiella pneumoniae
26. Site-directed mutagenesis by overlap extension using the polymerase chain reaction
27. Molecular typing of Neisseria gonorrhoeae causing repeated infections: Evolution of porin during passage within a community
28. Structural and functional alterations of a colicin-resistant mutant of OmpF porin from Escherichia coli
29. Neisseria gonorrhoeae. I. Virulence genetically linked to colonial variation
30. Outer membrane protein composition and colonial morphology of Neisseria gonorrhoeae strain P9
31. Structural and functional characterization of OmpF porin mutants selected for larger pore size. I. Crystallographic analysis
32. In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum cephalosporins
33. Isolation and characterization of OmpC porin mutants with altered pore properties
34. High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant
35. Regulation of the permeability of the gonococcal cell envelope by the mtr system
36. Structural and functional characterization of OmpF porin mutants selected for larger pore size. II. Functional characterization
37. Loss of low-level antibiotic resistance in Neisseria gonorrhoeae due to env mutations
38. Genetic mapping of linked antibiotic resistance loci in Neisseria gonorrhoeae
39. Inheritance of low-level resistance to penicillin, tetracycline, and chloramphenicol in Neisseria gonorrhoeae
40. Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae
41. A comprehensive comparison of multiple sequence alignment programs
42. Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa
43. The structure of porin from Rhodobacter capsulatus at 1.8 Å resolution
44. Associations between serotype and susceptibility to antibiotics of Neisseria gonorrhoeae
45. Crystal structure of omp32, the anion-selective porin from Comamonas acidovorans, in complex with a periplasmic peptide at 2.1 Å resolution