A basal-cell-like compartment in head and neck squamous cell carcinomas represents the invasive front of the tumor and is expressing MMP-9

Oral Oncology

Volumn 46, Issue 2, 2010, Pages 116-122

  Sterz, Carolina M ^a   Kulle, Carolin ^a   Dakic, Branka ^a   Makarova, Galina ^a   Böttcher, Martina C ^a   Bette, Michael ^b   Werner, Jochen A ^a   Mandic, Robert ^a  

^a UNIVERSITY HOSPITAL MARBURG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

ALDH1; Basal cell like cell (BCLC); Cancer stem cell (CSC); CD44; CK14; Head and neck cancer; HNSCC; Invasiveness; MMP 9

Indexed keywords

GELATINASE B; HERMES ANTIGEN; TUMOR MARKER; TUMOR MARKER ALDH1; TUMOR MARKER CK14; UNCLASSIFIED DRUG;

ARTICLE; BASAL CELL; CANCER INVASION; CANCER STEM CELL; CANCER TISSUE; CONTROLLED STUDY; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SQUAMOUS CELL CARCINOMA; TUMOR CELL; WESTERN BLOTTING; ZYMOGRAPHY;

ALDEHYDE DEHYDROGENASE; ANTIGENS, CD44; CARCINOMA, SQUAMOUS CELL; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; KERATIN-14; MALE; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; TUMOR CELLS, CULTURED;

EID: 74649086713     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2009.11.011     Document Type: Article

References (30)

1. Dobrossy L. Epidemiology of head and neck cancer: magnitude of the problem. Cancer Metast Rev 24 (2005) 9-17
2. charoenrat P., Rhys-Evans P.H., and Eccles S.A. Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 127 (2001) 813-820
3. Sternlicht M.D., and Werb Z. How matrix metalloproteinases regulate cell behavior. Ann Rev Cell Dev Biol 17 (2001) 463-516
4. Werner J.A., Rathcke I.O., and Mandic R. The role of matrix metalloproteinases in squamous cell carcinomas of the head and neck. Clin Exp Metast 19 (2002) 275-282
5. Miyajima Y., Nakano R., and Morimatsu M. Analysis of expression of matrix metalloproteinases-2 and -9 in hypopharyngeal squamous cell carcinoma by in situ hybridization. Ann Otol Rhinol Laryngol 104 (1995) 678-684
6. De S., Fenton J.E., and Jones A.S. Matrix metalloproteinases and their inhibitors in non-neoplastic otorhinolaryngological disease. J Laryngol Otol 119 (2005) 436-442
7. Weinberg R. The biology of cancer. 1-864. 2007. Garland Science. Ref. Type: Serial (Book, Monograph).
8. Reya T., Morrison S.J., Clarke M.F., and Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 414 (2001) 105-111
9. Klarmann G.J., Hurt E.M., Mathews L.A., Zhang X., Duhagon M.A., Mistree T., et al. Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature. Clin Exp Metast 26 (2009) 433-446
10. Prince M.E., Sivanandan R., Kaczorowski A., Wolf G.T., Kaplan M.J., Dalerba P., et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA 104 (2007) 973-978
11. Mandic R., Dunne A.A., Eikelkamp N., Ramaswamy A., Schulz S., Teymoortash A., et al. Expression of MMP-3, MMP-13, TIMP-2 and TIMP-3 in the VX2 carcinoma of the New Zealand white rabbit. Anticancer Res 22 (2002) 3281-3284
12. Dutta A., Sen T., Banerji A., Das S., and Chatterjee A. Studies on multifunctional effect of all-trans retinoic acid (ATRA) on matrix metalloproteinase-2 (MMP-2) and its regulatory molecules in human breast cancer cells (MCF-7). J Oncol 2009 (2009) 627840
13. Mandic R., Schamberger C.J., Muller J.F., Geyer M., Zhu L., Carey T.E., et al. Reduced cisplatin sensitivity of head and neck squamous cell carcinoma cell lines correlates with mutations affecting the COOH-terminal nuclear localization signal of p53. Clin Cancer Res 11 (2005) 6845-6852
14. Chen Y.C., Chen Y.W., Hsu H.S., Tseng L.M., Huang P.I., Lu K.H., et al. Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer. Biochem Biophys Res Commun 385 (2009) 307-313
15. Redondo-Munoz J., Ugarte-Berzal E., Garcia-Marco J.A., del Cerro M.H., Van den Steen P.E., Opdenakker G., et al. Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells. Blood 112 (2008) 169-178
16. Yan L., Borregaard N., Kjeldsen L., and Moses M.A. The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL. J Biol Chem 276 (2001) 37258-37265
17. Kamiguti A.S., Lee E.S., Till K.J., Harris R.J., Glenn M.A., Lin K., et al. The role of matrix metalloproteinase 9 in the pathogenesis of chronic lymphocytic leukaemia. Brit J Haematol 125 (2004) 128-140
18. Bonnet D., and Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3 (1997) 730-737
19. Visvader J.E., and Lindeman G.J. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8 (2008) 755-768
20. Valk-Lingbeek M.E., Bruggeman S.W., and van L.M. Stem cells and cancer; the polycomb connection. Cell 118 (2004) 409-418
21. Oliveira D.T., Sherriff M., and Odell E.W. Expression of CD44 variant exons by primary and metastatic oral squamous carcinomas. J Oral Pathol Med 27 (1998) 303-307
22. Andratschke M., Chaubal S., Pauli C., Mack B., Hagedorn H., and Wollenberg B. Soluble CD44v6 is not a sensitive tumor marker in patients with head and neck squamous cell cancer. Anticancer Res 25 (2005) 2821-2826
23. Mack B., and Gires O. CD44s and CD44v6 expression in head and neck epithelia. PLoS One 3 (2008) e3360
24. Sutinen M., Kainulainen T., Hurskainen T., Vesterlund E., Alexander J.P., Overall C.M., et al. Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis. Brit J Cancer 77 (1998) 2239-2245
25. Ondruschka C., Buhtz P., Motsch C., Freigang B., Schneider-Stock R., Roessner A., et al. Prognostic value of MMP-2, -9 and TIMP-1,-2 immunoreactive protein at the invasive front in advanced head and neck squamous cell carcinomas. Pathol Res Pract 198 (2002) 509-515
26. Vilen S.T., Nyberg P., Hukkanen M., Sutinen M., Ylipalosaari M., Bjartell A., et al. Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: Possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma. Exp Cell Res 314 (2007) 914-926
27. Hong S.D., Hong S.P., Lee J.I., and Lim C.Y. Expression of matrix metalloproteinase-2 and -9 in oral squamous cell carcinomas with regard to the metastatic potential. Oral Oncol 36 (2000) 207-213
28. Civenni G., and Sommer L. Chemokines in neuroectodermal development and their potential implication in cancer stem cell-driven metastasis. Semin Cancer Biol 19 (2009) 68-75
29. Jung A., Brabletz T., and Kirchner T. The migrating cancer stem cells model - a conceptual explanation of malignant tumour progression. Ernst Schering Found Symp Proc (2006) 109-124
30. Annabi B., Bouzeghrane M., Currie J.C., Hawkins R., Dulude H., Daigneault L., et al. A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis. Clin Exp Metast 22 (2005) 429-439