Exposure to dogs is associated with a decreased tumour necrosis factor-α-producing capacity in early life

Clinical and Experimental Allergy

Volumn 40, Issue 10, 2010, Pages 1498-1506

  Lappalainen, M H J ^a   Huttunen, K ^a,b   Roponen, M ^a   Remes, S ^c   Hirvonen, M R ^a,b   Pekkanen, J ^a,b  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

animal exposure; cytokine; dog; IFN ; IL 10; IL 5; IL 8; immune development; TNF

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 5; INTERLEUKIN 8; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; STAPHYLOCOCCUS ENTEROTOXIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CARE; ARTICLE; BLOOD SAMPLING; CAT; CORRELATIONAL STUDY; CYTOKINE PRODUCTION; DOG; ENZYME LINKED IMMUNOSORBENT ASSAY; HORSE; HUMAN; INFANT; MAJOR CLINICAL STUDY; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; QUESTIONNAIRE; UMBILICAL CORD BLOOD; VENOUS BLOOD;

ANIMALS; CATS; CYTOKINES; DOGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FETAL BLOOD; HUMANS; INFANT; INFANT, NEWBORN; PETS; PREGNANCY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77956529439     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2010.03566.x     Document Type: Article

References (33)

1. Holt PG. Developmental factors as determinants of risk for infections and atopy in childhood. Eur Respir Rev 2005 14 : 69 73.
2. Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Holt PG. Development of allergen-specific T-cell memory in atopic and normal children. Lancet 1999 353 : 196 200.
3. Braun-Fahrlander C, Riedler J, Herz U et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002 347 : 869 877.
4. Lappalainen MH, Roponen M, Hyvarinen A et al. Exposure to environmental bacteria may have differing effects on tumour necrosis factor-alpha and interleukin-6-producing capacity in infancy. Clin Exp Allergy 2008 38 : 1483 1492.
5. Bufford JD, Reardon CL, Li Z et al. Effects of dog ownership in early childhood on immune development and atopic diseases. Clin Exp Allergy 2008 38 : 1635 1643.
6. Gern JE, Reardon CL, Hoffjan S et al. Effects of dog ownership and genotype on immune development and atopy in infancy. J Allergy Clin Immunol 2004 113 : 307 314.
7. Riedler J, Braun-Fahrlander C, Eder W et al. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001 358 : 1129 1133.
8. Ege MJ, Bieli C, Frei R et al. Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol 2006 117 : 817 823.
9. Al-Mousawi MS, Lovel H, Behbehani N, Arifhodzic N, Woodcock A, Custovic A. Asthma and sensitization in a community with low indoor allergen levels and low pet-keeping frequency. J Allergy Clin Immunol 2004 114 : 1389 1394.
10. Melen E, Wickman M, Nordvall SL, van Hage-Hamsten M, Lindfors A. Influence of early and current environmental exposure factors on sensitization and outcome of asthma in pre-school children. Allergy 2001 56 : 646 652.
11. Hugg TT, Jaakkola MS, Ruotsalainen R, Pushkarev V, Jaakkola JJ. Exposure to animals and the risk of allergic asthma: a population-based cross-sectional study in Finnish and Russian children. Environ Health 2008 7 : 28.
12. Litonjua AA, Milton DK, Celedon JC, Ryan L, Weiss ST, Gold DR. A longitudinal analysis of wheezing in young children: the independent effects of early life exposure to house dust endotoxin, allergens, and pets. J Allergy Clin Immunol 2002 110 : 736 742.
13. Remes ST, Iivanainen K, Koskela H, Pekkanen J. Which factors explain the lower prevalence of atopy amongst farmers' children? Clin Exp Allergy 2003 33 : 427 434.
14. Ownby DR, Johnson CC, Peterson EL. Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA 2002 288 : 963 972.
15. Anyo G, Brunekreef B, de Meer G, Aarts F, Janssen NA, van Vliet P. Early, current and past pet ownership: associations with sensitization, bronchial responsiveness and allergic symptoms in school children. Clin Exp Allergy 2002 32 : 361 366.
16. Waser M, von Mutius E, Riedler J et al. Exposure to pets, and the association with hay fever, asthma, and atopic sensitization in rural children. Allergy 2005 60 : 177 184.
17. Simpson A, John SL, Jury F et al. Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment. Am J Respir Crit Care Med 2006 174 : 386 392.
18. Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet 1999 354 (Suppl. 2) : SII12 15.
19. Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 2001 357 : 752 756.
20. Hesselmar B, Aberg B, Eriksson B, Bjorksten B, Aberg N. High-dose exposure to cat is associated with clinical tolerance-a modified Th2 immune response? Clin Exp Allergy 2003 33 : 1681 1685.
21. Roponen M, Hyvarinen A, Hirvonen MR, Keski-Nisula L, Pekkanen J. Change in IFN-gamma-producing capacity in early life and exposure to environmental microbes. J Allergy Clin Immunol 2005 116 : 1048 1052.
22. Lappalainen M, Roponen M, Pekkanen J, Huttunen K, Hirvonen MR. Maturation of cytokine-producing capacity from birth to 1 yr of age. Pediatr Allergy Immunol 2009 20 : 714 725.
23. Karvonen AM, Hyvarinen A, Roponen M et al. Confirmed moisture damage at home, respiratory symptoms and atopy in early life: a birth-cohort study. Pediatrics 2009 124 : e329 338.
24. von Mutius E, Schmid S. The PASTURE project: EU support for the improvement of knowledge about risk factors and preventive factors for atopy in Europe. Allergy 2006 61 : 407 413.
25. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology 1990 1 : 43 6.
26. Pfefferle P, Büchele G, Blümer N et al. Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy-The PASTURE-STUDY. J Allergy Clin Immunol 2010 125 : 108 115.
27. Heinrich J, Gehring U, Douwes J et al. Pets and vermin are associated with high endotoxin levels in house dust. Clin Exp Allergy 2001 31 : 1839 1845.
28. Park JH, Spiegelman DL, Gold DR, Burge HA, Milton DK. Predictors of airborne endotoxin in the home. Environ Health Perspect 2001 109 : 859 864.
29. Campo P, Kalra HK, Levin L et al. Influence of dog ownership and high endotoxin on wheezing and atopy during infancy. J Allergy Clin Immunol 2006 118 : 1271 1278.
30. Remes ST, Castro-Rodriguez JA, Holberg CJ, Martinez FD, Wright AL. Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy. J Allergy Clin Immunol 2001 108 : 509 515.
31. Chen CM, Morgenstern V, Bischof W et al. Dog ownership and contact during childhood and later allergy development. Eur Respir J 2008 31 : 963 967.
32. Wright AL. Early dog exposure: potential pathways to allergic disease. Clin Exp Allergy 2008 38 : 1568 1571.
33. Ege MJ, Herzum I, Buchele G et al. Prenatal exposure to a farm environment modifies atopic sensitization at birth. J Allergy Clin Immunol 2008 122 : 407 412, 412 e401-404.