The pharmacological treatment of bipolar disorder: The question of modern advances

Harvard Review of Psychiatry

Volumn 18, Issue 5, 2010, Pages 266-278

  Hirschowitz, Jack ^a   Kolevzon, Alexander ^a   Garakani, Amir ^a  

^a SILVER HILL HOSPITAL   (United States)

Author keywords

Anticonvulsant; antipsychotic; depression; lithium; maintenance; mania; manic; mood stabilizer

Indexed keywords

ARIPIPRAZOLE; ASENAPINE; CARBAMAZEPINE; CHLORDIAZEPOXIDE; CHLORPROMAZINE; CLONAZEPAM; CLOZAPINE; DIAZEPAM; FLUOXETINE PLUS OLANZAPINE; HALOPERIDOL; IMIPRAMINE; LAMOTRIGINE; LITHIUM; LORAZEPAM; OLANZAPINE; OXAZEPAM; OXCARBAZEPINE; PHENOTHIAZINE DERIVATIVE; PLACEBO; QUETIAPINE; RISPERIDONE; VALPROATE SEMISODIUM; VALPROIC ACID; ZIPRASIDONE;

BIPOLAR DEPRESSION; CLINICAL TRIAL; DRUG EFFICACY; DRUG PROTEIN BINDING; ELECTROENCEPHALOGRAM; FOCAL EPILEPSY; FOOD AND DRUG ADMINISTRATION; HAMILTON SCALE; HUMAN; MANIA; MEDLINE; MONOTHERAPY; MONTGOMERY ASBERG DEPRESSION RATING SCALE; PRIORITY JOURNAL; PSYCHOTHERAPY; RECOMMENDED DRUG DOSE; REVIEW; TEMPORAL LOBE EPILEPSY;

ANTIDEPRESSIVE AGENTS; ANTIMANIC AGENTS; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; HUMANS; LITHIUM COMPOUNDS;

EID: 77956511255     PISSN: 10673229     EISSN: 14657309     Source Type: Journal    
DOI: 10.3109/10673229.2010.507042     Document Type: Review

References (135)

1. Kline NS. Lithium comes into its own. Am J Psychiatry 1968;125:558-560
2. Blackwell B. Need for careful evaluation of lithium. Am J Psychiatry 1969;125:1131.
3. Kline N. Need for careful evaluation of lithium. Reply. Am J Psychiatry 1969;125:1131-1132
4. Jefferson J. Rediscovering the art of lithium therapy. Curr Psychiatry 2002;1:19-24.
5. Siegel D, Lopez J. Trends in antihypertensive drug use in the United States: do the JNC V recommendations affect prescribing? Fifth Joint National Commission on the Detection, Evaluation, and Treatment of High Blood Pressure. JAMA 1997;278:1745-1748
6. Hadorn DC, Baker D, Hodges JS, Hicks N. Rating the quality of evidence for clinical practice guidelines. J Clin Epidemiol 1996;49:749-754
7. Mayer-GrossW. Clinical Psychiatry London: Baillere, Tindall & Cassell, 1969.
8. Cade JF. Lithium salts in the treatment of psychotic excitement. Med J Aust 1949;36:349-352
9. Schou M, Juel-Nielsen N, Stromgren E, Voldby H. The treatment of manic psychoses by the administration of lithium salts. J Neurol Neurosurg Psychiatry 1954;17:250-260
10. Baastrup PC, Schou M. Prophylactic lithium? Lancet 1968;2:349-350
11. Goodwin FK, Jamison KR. Manic-depressive illness. New York: Oxford University Press, 1990.
12. Janicak PG, Davis JM, Preskorn SH, Ayd FJ Jr. Principles and practice of psychopharmacology. Baltimore, MD: Williams & Wilkins, 1993.
13. Moncrieff J. Lithium: evidence reconsidered. Br J Psychiatry 1997;171:113-119
14. Johnson G, Gershon S, Hekimian LJ. Controlled evaluation of lithium and chlorpromazine in the treatment of manic states: an interim report. Compr Psychiatry 1968;9:563-573
15. Maggs R. Treatment of manic illness with lithium carbonate. Br J Psychiatry 1963;109:56-65.
16. Goodwin FK, Murphy DL, Bunney WE Jr. Lithium-carbonate treatment in depression and mania. A longitudinal doubleblind study. Arch Gen Psychiatry 1969;21:486-496
17. Baastrup PC, Poulsen JC, Schou M, Thomsen K, Amdisen A. Prophylactic lithium: double blind discontinuation in manic-depressive and recurrent-depressive disorders. Lancet 1970;2:326-330
18. Melia PI. Prophylactic lithium: a double-blind trial in recurrent affective disorders. Br J Psychiatry 1970;116: 621-624
19. Suppes T, Baldessarini RJ, Faedda GL, Tohen M. Risk of recurrence following discontinuation of lithium treatment in bipolar disorder. Arch Gen Psychiatry 1991;48:1082-1088
20. Sargant W, Slater E. An introduction to physical methods of treatment in Psychiatry London: Livingstone, 1963.
21. Platman S. A comparison of lithium carbonate and chlorpromazine in mania. Am J Psychiatry 1970;127:351-353
22. Spring G, Schweid D, Gray C, Steinberg J, Horwitz M. A double-blind comparison of lithium and chlorpromazine in the treatment of manic states. Am J Psychiatry 1970;126:1306-1310
23. Librium and valium. Drug Ther Bull 1964;2:93-95
24. Chouinard G, Young SN, Annable L. Antimanic effect of clonazepam. Biol Psychiatry 1983;18:451-466
25. Takezaki H, Hanaoka M. The use of carbamazepine (Tegretol) in the control of manic-depressive psychosis and other manicdepressive states. Seishin Igaku 1971;13:173-183
26. Dalby MA. Antiepileptic and psychotropic effect of carbamazepine (Tegretol) in the treatment of psychomotor epilepsy. Epilepsia 1971;12:325-334
27. Lambert PA, Carraz G, Borselli S, Carbel S. Neuropsychotropic action of a new anti-epileptic agent: depamide. Ann Med Psychol (Paris) 1966;124:707-710
28. Ballenger JC, Post RM. Therapeutic effects of arbamazepine in affective illness: a preliminary report. Commun Psychopharmacol 1978;2:159-175
29. Ballenger JC, Post RM. Carbamazepine in manic depressive illness: a new treatment. Am J Psychiatry 1980;137:782-790
30. Keck PE, Perlis RH, Otto MW, Carpenter D, Ross R, Docherty JP. The Expert Consensus Guideline Series: treatment of bipolar disorder 2004. Postgrad Med Spec Rep 2004;Dec:1-120.
31. Calabrese JR, Delucchi GA. Spectrum of efficacy of valproate in 55 patients with rapid-cycling bipolar disorder. Am J Psychiatry 1990;147:431-434
32. Calabrese JR, Shelton MD, Rapport DJ, et al. A 20-month, double-blind, maintenance trial of lithium versus divalproex in rapid-cycling bipolar disorder. Am J Psychiatry 2005;162:2152-2161
33. Calabrese JR, Huffman RF, White RL, et al. Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trials. Bipolar Disord 2008;10:323-333
34. Calabrese JR, Keck PE Jr, Macfadden W, et al. A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression. Am J Psychiatry 2005;162:1351-1360
35. Thase ME, Macfadden W, Weisler RH, et al.; BOLDER II Study Group. Efficacy of quetiapine monotherapy in bipolar I and II depression: a double-blind, placebo-controlled study (the BOLDER II study). J Clin Psychopharmacol 2006;26:600-609
36. Endicott J, Rajagopalan K, Minkwitz M, Macfadden W; BOLDER Study Group. A randomized, double-blind, placebocontrolled study of quetiapine in the treatment of bipolar I and II depression: improvements in quality of life. Int Clin Psychopharmacol 2007;22:29-37.
37. Gijsman HJ, Geddes JR, Rendell JM, Nolen WA, Goodwin GM. Antidepressants for bipolar depression: a systematic review of randomized, controlled trials. Am J Psychiatry 2004;161:1537-1547
38. Sachs GS, Nierenberg AA, Calabrese JR, et al. Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med 2007;356:1711-1722
39. Koszewska I, Rybakowski JK. Antidepressant-induced mood conversions in bipolar disorder: a retrospective study of tricyclic versus non-tricyclic antidepressant drugs. Neuropsychobiology 2009;59:12-16
40. Grunze HC. Switching, induction of rapid cycling, and increased suicidality with antidepressants in bipolar patients: fact or overinterpretation? CNS Spectr 2008;13:790-795
41. Licht RW, Gijsman H, Nolen WA, Angst J. Are antidepressants safe in the treatment of bipolar depression? A critical evaluation of their potential risk to induce switch into mania or cycle acceleration. Acta Psychiatr Scand 2008;118:337-346
42. Geddes JR, Briess D. Bipolar disorder. Clin Evid (Online) 2007 Aug 1;2007. pii: 1014.
43. American Psychiatric Association. Practice guideline for the treatment of patients with bipolar disorder (revision). Am J Psychiatry 2002;159:1-50.
44. Goodwin GM. Consensus Group of the British Association for Psychopharmacology. Evidence-based guidelines for treating bipolar disorder: recommendations from the British Association for Psychopharmacology. J Psychopharmacol 2003;17:149-173
45. Fountoulakis KN, Vieta E. Treatment of bipolar disorder: a systematic review of available data and clinical perspectives. Int J Neuropsychopharmacol 2008;11:999-1029.
46. Bauer MS, Mitchner L. What is a "mood stabilizer "? An evidence-based response. Am J Psychiatry 2004;161:3-18.
47. Grunze H, Kasper S, Goodwin G, Bowden C, Möller HJ; WFSBP Task Force on Treatment Guidelines for Bipolar Disorders. The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders, part III: maintenance treatment. World J Biol Psychiatry 2004;5:120-135
48. Müller-Oerlinghausen B, Berghöfer A, Bauer M. Bipolar disorder. Lancet. 2002;359:241-247
49. Johnson G, Gershon S, Burdock EI, Floyd A, Hekimian L. Comparative effects of lithium and chlorpromazine in the treatment of acute manic states. Br J Psychiatry 1971;119:267-276
50. Prien RF, Caffey EM, Klett CJ. Relationship between serum lithium level and clinical response in acutemania treated with lithium. Br J Psychiatry 1972;120:409-414
51. Takahashi R, Sakuma A, Itoh K, et al. Comparison of efficacy of lithium carbonate and chlorpromazine in mania. Report of collaborative study group on treatment of mania in Japan. Arch Gen Psychiatry 1975;32:1310-1318
52. Shopsin B, Gershon S, Thompson H, Collins P. Psychoactive drugs in mania. A controlled comparison of lithium carbonate, chlorpromazine, and haloperidol. Arch Gen Psychiatry 1975;32:34-42.
53. Bowden CL, Brugger AM, Swann AC, et al. Efficacy of divalproex vs. lithium and placebo in the treatment of mania. Depakote Mania Study Group. JAMA 1994;271:918-924
54. Bowden CL, Grunze H, Mullen J, et al. A randomized, doubleblind, placebo-controlled efficacy and safety study of quetiapine or lithium as monotherapy for mania in bipolar disorder. J Clin Psychiatry 2005;66:111-121
55. Geddes JR, Burgess S, Hawton K, Jamison K, Goodwin GM. Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. Am J Psychiatry 2004;161:217-222
56. Burgess S, Geddes J, Hawton K, Townsend E, Jamison K, Goodwin G. Lithium for maintenance treatment of mood disorders. Cochrane Database Syst Rev 2001;(3):CD003013.
57. Mendels J. Lithium in the treatment of depression. Am J Psychiatry 1976;133:373-378
58. Goodwin FK, Murphy DL, Dunner DL, Bunney WE Jr. Lithium response in unipolar versus bipolar depression. Am J Psychiatry 1972;129:44-47
59. Baron M, Gershon ES, Rudy V, Jonas WZ, Buchsbaum M. Lithium carbonate response in depression. Prediction by unipolar/bipolar illness, average-evoked response, catechol-Omethyl transferase, and family history. Arch Gen Psychiatry 1975;32:1107-1111
60. Young AH, McElroy SL, Bauer M, et al. A double-blind, placebo-controlled study of quetiapine and lithium monotherapy in adults in the acute phase of bipolar depression (EMBOLDEN I). J Clin Psychiatry 2010;71:150-162
61. Malhi GS, Adams D, Cahill CM, Dodd S, Berk M. The management of individuals with bipolar disorder: a review of the evidence and its integration into clinical practice. Drugs 2009;69:2063-2101
62. Chou JC, Zito JM, Vitrai J, Craig TJ, Allingham BH, Czobor P. Neuroleptics in acute mania: a pharmacoepidemiologic study. Ann Pharmacother 1996;30:1396-1398
63. Perlis RH, Welge JA, Vornik LA, Hirschfeld RM, Keck PE Jr. Atypical antipsychotics in the treatment of mania: a metaanalysis of randomized, placebo-controlled trials. J Clin Psychiatry 2006;67:509-516
64. Tohen M, Sanger TM, McElroy SL, et al. Olanzapine versus placebo in the treatment of acute mania. Olanzapine HGEH Study Group. Am J Psychiatry 1999;156:702-709
65. Tohen M, Jacobs TG, Grundy SL, et al. Efficacy of olanzapine bin acute bipolar mania: a double-blind, placebo-controlled study. The Olanzapine HGGW Study Group. Arch Gen Psychiatry 2000;57:841-849
66. Berk M, Ichim L, Brook S. Olanzapine compared to lithium in mania: a double-blind randomized controlled trial. Int Clin Psychopharmacol 1999;14:339-343
67. Zajecka JM, Weisler R, Sachs G, Swann AC, Wozniak P, Sommerville KW. A comparison of the efficacy, safety, and tolerability of divalproex sodium and olanzapine in the treatment of bipolar disorder. J Clin Psychiatry 2002;63:1148-1155
68. Tohen M, Ketter TA, Zarate CA, et al. Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: a 47-week study. Am J Psychiatry 2003;160:1263-1271
69. Tohen M, Vieta E, Goodwin GM, et al. Olanzapine versus divalproex versus placebo in the treatment of mild to moderate mania: a randomized, 12-week, double-blind study. J Clin Psychiatry 2008;69:1776-1789
70. Aitchison K, Bienroth M, Cookson J, et al. A UK consensus on the administration of aripiprazole for the treatment of mania. J Psychopharmacol 2009;23:231-240
71. Young AH, Oren DA, Lowy A, et al. Aripiprazole monotherapy in acutemania: 12-week randomised placebo- and haloperidolcontrolled study. Br J Psychiatry 2009;194:40-48
72. Keck PE, Orsulak PJ, Cutler AJ, et al.; CN138-135 Study Group. Aripiprazole monotherapy in the treatment of acute bipolar I mania: a randomized, double-blind, placeboand lithium-controlled study. J Affect Disord 2009;112: 36-49.
73. Keck PE Jr, Versiani M, Potkin S, West SA, Giller E, Ice K. Ziprasidone in Mania Study Group. Ziprasidone in the treatment of acute bipolar mania: a three-week, placebocontrolled, double-blind, randomized trial. Am J Psychiatry 2003;160:741-748
74. Potkin SG, Keck PE JrSegal S, Ice K, English P. Ziprasidone in acute bipolar mania: a 21-day randomized, double-blind, placebo-controlled replication trial. J Clin Psychopharmacol 2005;25:301-310
75. Vieta E, Ramey T, Keller D, English P, Loebel A, Miceli J. Ziprasidone in the treatment of acute mania: a 12- week, placebo-controlled, haloperidol-referenced study. J Psychopharmacol 2010; 24:547-558
76. Post RM, Jimerson DC, Bunney WE Jr, Goodwin FK. Dopamine and mania: behavioral and biochemical effects of the dopamine receptor blocker pimozide. Psychopharmacology (Berl) 1980;67:297-305.
77. Christie JE, Whalley LJ, Hunter R, Bennie J, Fink G. Sulpiride treatment of acute mania with a comparison of the effects on plasma hormone concentrations of lithium and sulpiride treatment. J Affect Disord 1989;16:115-120
78. Sachs GS, Grossman F, Ghaemi SN, Okamoto A, Bowden CL. Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebocontrolled comparison of efficacy and safety. Am J Psychiatry 2002;159:1146-1154
79. TohenM, Chengappa KNR, Suppes T, et al. Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy. Arch Gen Psychiatry 2002;59:62-69
80. Yatham LN, Grossman F, Augustyns I, Vieta E, Ravindran A. Mood stabilisers plus risperidone or placebo in the treatment of acute mania. International, double-blind, randomized controlled trial. Br J Psychiatry 2003;182:141-147
81. Sachs G, Chengappa KN, Suppes T, et al. Quetiapine with lithium or divalproex for the treatment of bipolar mania: a randomized, double-blind, placebo-controlled study. Bipolar Disord 2004;6:213-223
82. Tohen M, Greil W, Calabrese JR, et al. Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12- onth, randomized, double-blind, controlled clinical trial. Am J Psychiatry 2005;162:1281-1290
83. TohenM, Calabrese JR, Sachs GS, et al. Randomized, placebocontrolled trial of olanzapine as maintenance therapy inpatients with bipolar I disorder responding to acute treatment with olanzapine. Am J Psychiatry 2006;163:247-256
84. Keck PE Jr, Calabrese JR, McQuade RD, et al.; Aripiprazole Study Group. A randomized, double-blind, placebo-controlled 26-week trial of aripiprazole in recently manic patients with bipolar I disorder. J Clin Psychiatry 2006;67:626-637
85. Keck PE Jr, Calabrese JR, McIntyre RS, et al.; Aripiprazole Study Group. Aripiprazole monotherapy for maintenance therapy in bipolar I disorder: a 100-week, double-blind study versus placebo. J Clin Psychiatry 2007;68:1480-1491
86. Vieta E, Suppes T, Eggens I, Persson I, Paulsson B, Brecher M. Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord 2008;109:251-263
87. Suppes T, Vieta E, Liu S, Brecher M, Paulsson B; Trial 127 Investigators. Maintenance treatment for patients with bipolar I disorder: results from a North American study of quetiapine in combination with lithium or divalproex (trial 127). Am J Psychiatry 2009;166:476-488
88. Brown EB, McElroy SL, Keck PE Jr, et al. A 7-week, randomized, double-blind trial of olanzapine/fluoxetine combination versus lamotrigine in the treatment of bipolar I depression. J Clin Psychiatry 2006;67:1025-1033
89. Brown E, Dunner DL, McElroy SL, et al. Olanzapine/ fluoxetine combination vs. lamotrigine in the 6-month treatment of bipolar I depression. Int J Neuropsychopharmacol 2009;12:773-782
90. Keck PE Jr, Corya SA, Altshuler LL, et al. Analyses of treatment-emergent mania with olanzapine/fluoxetine combination in the treatment of bipolar depression. J Clin Psychiatry 2005;66:611-616
91. Curtin F, Schulz P. Clonazepam and lorazepam in acute mania: a Bayesian meta-analysis. J Affect Disord 2004;78: 201-208
92. Bradwejn J, Shriqui C, Koszycki D, Meterissian G. Doubleblind comparison of the effects of clonazepam and lorazepam in acute mania. J Clin Psychopharmacol 1990;10:403-408
93. Clark H, Berk M, Brook S. Clonazepam vs. lithium in mania: a controlled single blind randomised trial. Hum Psychopharmacol 1997;12:325-328
94. Edwards R, Stephenson U, Flewett T. Clonazepam in acute mania: a double blind trial. Aust N Z J Psychiatry 1991;25:238-242
95. Aronson TA, Shukla S, Hirschowitz J. Clonazepam treatment of five lithium-refractory patients with bipolar disorder. Am J Psychiatry 1989;146:77-80.
96. Bowden CL. Efficacy of divalproex vs. lithium and placebo in mania. Reply. JAMA 1994;272:1006.
97. Bowden CL, Calabrese JR, McElroy SL, et al. A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group. Arch Gen Psychiatry 2000;57:481-489
98. Gyulai L, Bowden CL, McElroy SL, et al. Maintenance efficacy of divalproex in the prevention of bipolar depression. Neuropsychopharmacology 2003;28:1374-1382
99. MacritchieK,Geddes JR, Scott J,HaslamD, de LimaM,Goodwin G. Valproate for acute mood episodes in bipolar disorder. Cochrane Database Syst Rev 2003;(1):CD004052.
100. Bowden CL, Swann AC, Calabrese JR, et al. A randomized, placebo-controlled, multicenter study of divalproex sodium extended release in the treatment of acute mania. J Clin Psychiatry 2006;67:1501-1510
101. Vasudev K, Goswami U, Kohli K. Carbamazepine and valproate monotherapy: feasibility, relative safety and efficacy, and therapeutic drug monitoring in manic disorder. Psychopharmacology (Berl) 2000;150:15-23.
102. Tohen M, Vieta E, Goodwin GM, et al. Olanzapine versus divalproex versus placebo in the treatment of mild to moderate mania: a randomized, 12-week, double-blind study. J Clin Psychiatry 2008;69:1776-1789
103. Tohen M, Baker RW, Altshuler LL, et al. Olanzapine versus divalproex in the treatment of acute mania. Am J Psychiatry 2002;159:1011-1017
104. Macritchie KA GJ, Scott J, Haslam DR, Goodwin GM. Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder. Cochrane Database Syst Rev 2001;(3):CD003196.
105. Bond DJ, Lam RW, Yatham LN. Divalproex sodium versus placebo in the treatment of acute bipolar depression: a systematic review and meta-analysis. J Affect Disord 2009;Dec 29 [Epub ahead of print].
106. Okuma T, Inanaga K, Otsuki S, et al. Comparison of the antimanic efficacy of carbamazepine and chlorpromazine: a double-blind controlled study. Psychopharmacology 1979;66:211-217
107. Lerer B, Moore N, Meyendorff E, Cho SR, Gershon S. Carbamazepine versus lithium in mania: a double-blind study. J Clin Psychiatry 1987;48:89-93.
108. Lusznat RM, Murphy DP, Nunn CM. Carbamazepine vs. lithium in the treatment and prophylaxis of mania. Br J Psychiatry 1988;153:198-204.
109. Brown D, Silverstone T, Cookson J. Carbamazepine compared to haloperidol in acutemania. Int Clin Psychopharmacol 1989;4:229-238
110. Okuma T, Yamashita I, Takahashi R, et al. Comparison of the antimanic efficacy of carbamazepine and lithium carbonate by double-blind controlled study. Pharmacopsychiatry 1990;23:143-150
111. Small JG, KlapperMH, Milstein V, et al. Carbamazepine compared with lithium in the treatment of mania. Arch Gen Psychiatry 1991;48:915-921
112. Emrich HM, Dose M, Vonzerssen D. The use of sodium valproate, carbamazepine and oxcarbazepine in patients with affective disorders. J Affect Disord 1985;8:243-250
113. Emrich HM. Studies with oxcarbazepine (trileptal) in acute mania. Int Clin Psychopharmacol 1990;5:83-88
114. Wagner KD, Kowatch RA, Emslie GJ, et al. A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents. Am J Psychiatry 2006;163:1179-1186
115. Okuma T, Inanaga K, Otsuki S, et al. A preliminary doubleblind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness. Psychopharmacology (Berl) 1981;73:95-96
116. Coxhead N, Silverstone T, Cookson J. Carbamazepine versus lithium in the prophylaxis of bipolar affective disorder. Acta Psychiatr Scand 1992;85:114-118
117. Simhandl C, Denk E, Thau K. The comparative efficacy of carbamazepine low and high serum level and lithium carbonate in the prophylaxis of affective disorders. J Affect Disord 1993;28:221-231
118. Vasudev A, Macritchie K, Watson S, Geddes JR, Young AH. Oxcarbazepine in the maintenance treatment of bipolar disorder. Cochrane Database Syst Rev 2008;(1):CD005171.
119. Vieta E, Cruz N, García-Campayo J, et al. A double-blind, randomized, placebo-controlled prophylaxis trial of oxcarbazepine as adjunctive treatment to lithium in the long-term treatment of bipolar I and II disorder. Int J Neuropsychopharmacol 2008;11:445-452
120. Juruena MF, Ottoni GL, Machado-Vieira R, et al. Bipolar I and II disorder residual symptoms: oxcarbazepine and carbamazepine as add-on treatment to lithium in a double-blind, randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:94-99
121. Ichim L, BerkM, Brook S. Lamotrigine compared with lithium in mania: a double-blind randomized controlled trial. Ann Clin Psychiatry 2000;12:5-10.
122. Calabrese JR, Suppes T, Bowden CL, et al. A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapidcycling bipolar disorder. Lamictal 614 Study Group. J Clin Psychiatry 2000;61:841-850
123. Calabrese JR, Bowden CL, Sachs G, et al.; Lamictal 605 Study Group. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry 2003;64: 1013-1024
124. Goodwin GM, Bowden CL, Calabrese JR, et al. A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder. J Clin Psychiatry 2004;65:432-441
125. Calabrese JR, Bowden CL, Sachs GS, Ascher JA, Monaghan E, Rudd GD. A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiatry 1999;60: 79-88.
126. Calabrese JR, Keck PE Jr, McElroy SL, Shelton MD. A pilot study of topiramate as monotherapy in the treatment of acute mania. J Clin Psychopharmacol 2001;21:340-342
127. Vasudev K, Macritchie K, Geddes J, Watson S, Young A. Topiramate for acute affective episodes in bipolar disorder. Cochrane Database Syst Rev 2006;(1):CD003384.
128. Frye MA, Ketter TA, Kimbrell TA, et al. A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharmacol 2000;20:607-614
129. Pande AC, Crockatt JG, Janney CA, Werth JL, Tsaroucha G. Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Gabapentin Bipolar Disorder Study Group. Bipolar Disord 2000;2:249-255
130. Grunze H, Erfurth A, Marcuse A, Amann B, Normann C, Walden J. Tiagabine appears not to be efficacious in the treatment of acute mania. J Clin Psychiatry 1999;60:759-762
131. Young AH, Geddes JR, Macritchie K, Rao SN, Watson S, Vasudev A. Tiagabine in the treatment of acute affective episodes in bipolar disorder: efficacy and acceptability. Cochrane Database Syst Rev 2006;(3):CD004694.
132. Grof P, Alda M, Grof E, Fox D, Cameron P. The challenge of predicting response to stabilising lithium treatment. The importance of patient selection. Br J Psychiatry 1993;163(suppl 21):16-19
133. PassmoreMJ, Garnham J,Duffy A, et al. Phenotypic spectra of bipolar disorder in responders to lithium versus lamotrigine. Bipolar Disord 2003;5:110-114
134. Angell M. The truth about the drug companies: how they deceive us and what to do about it. New York: Random House, 2005.
135. Antes G, Chalmers I. Under-reporting of clinical trials is unethical. Lancet 2003;361:978-979