Tiagabine appears not to be efficacious in the treatment of acute mania

Journal of Clinical Psychiatry

Volumn 60, Issue 11, 1999, Pages 759-762

  Grunze, Heinz ^a,c   Erfurth, Andreas ^a   Marcuse, Alain ^a   Amann, Benedikt ^a   Normann, Claus ^b   Walden, Jörg ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LITHIUM; NEUROLEPTIC AGENT; TIAGABINE; VALPROIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; FEMALE; HUMAN; MALE; MANIA; NAUSEA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEIZURE; VOMITING;

EID: 0032733148     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.v60n1107     Document Type: Article

References (23)

1. Emrich HM, von Zerssen D, Kissling W, et al. On a possible role of GABA in mania: therapeutic efficacy of sodium valproate. Adv Biochem Psychopharmacol 1981;26:287-296
2. Petty F. GABA and mood disorders: a brief review and hypothesis. J Affect Disord 1995;34:275-281
3. Gerner RH, Fairbanks L, Anderson GM, et al. CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls. Am J Psychiatry 1984;141:1533-1540
4. Emrich HM, Wolf R. Valproate treatment of mania. Prog Neuropsychopharmacol Biol Psychiatry 1992;16:691-701
5. Suzdak PD, Jansen JA. A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor Epilepsia 1995;36:612-626
6. Leach JP, Sills GJ, Majid A, et al. Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes. Seizure 1996;5:229-234
7. Dalby NO, Nielsen EB. Tiagabine exerts an anti-epileptogenic effect in amygdala kindling epileptogenesis in the rat. Neurosci Lett 1997;229: 135-137
8. Weiss SR, Post RM. Kindling: separate vs shared mechanisms in affective disorders and epilepsy. Neuropsychobiology 1998;38:167-180
9. Hu RQ, Davies JA. Tiagabine hydrochloride, an inhibitor of gamma-aminobutyric acid (GABA) uptake, induces cortical depolarizations in vitro. Brain Res 1997;753:260-268
10. Perucca E, Gram L, Avanzini G, el al. Antiepileptic drugs as a cause of worsening of seizures. Epilepsia 1998;39:5-17
11. Post RM, Ketter TA, Denicoff K, et al. The place of anticonvulsant therapy in bipolar illness. Psychopharmacology (Berl) 1996;128:115-129
12. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association; 1994
13. Bech P, Rafaelsen OJ, Kramp P, et al. The Mania Rating Scale: scale construction and inter-observer agreement. Neuropharmacology 1978;17: 430-431
14. Keck PE Jr, McElroy SL, Bennett JA. Health-economic implications of the onset of action of antimanic agents. J Clin Psychiatry 1996;57(suppl 13):13-18
15. Lau AH, Gustavson LE, Sperelakis R. et al. Pharmacokinetics and safety of tiagabine in subjects with various degrees of hepatic function. Epilepsia 1997;38:445-451
16. Brodie MJ. Tiagabine pharmacology in profile. Epilepsia 1995;36 (6, suppl):7-9
17. Kaufman KR. Adjunctive tiagabine treatment of psychiatric disorders: three cases. Ann Clin Psychiatry 1998;10:181-184
18. Schapel G, Chadwick D. Tiagabine and non-convulsive status epilepticus. Seizure 1996;5:153-156
19. Eckardt KM, Steinhoff BJ. Nonconvulsive status epilepticus in two patients receiving tiagabine treatment. Epilepsia 1998;39:671-674
20. Maes M, Calabrese J, Jayathilake K, et al. Effects of subchronic treatment with valproate on L-5-HTP-induced cortisol responses in mania: evidence for increased central serotonergic neurotransmission. Psychiatry Res 1997;71:67-76
21. Rainnie D. Chronic clozapine treatment in vivo alters serotonergic modulation of synaptic transmission in the basolateral amygdala. Soc Neurosci Abstr 1998;24:677
22. Suppes T, McElroy SL, Gilbert J, et al. Clozapine in the treatment of dysphoric mania. Biol Psychiatry 1992;32:270-280
23. Calabrese JR, Kimmel SE, Woyshville MJ, et al. Clozapine for treatment-refractory mania. Am J Psychiatry 1996;153:759-764