Dopamine β-hydroxylase-deficient mice have normal densities of D 2 dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding

Synapse

Volumn 64, Issue 9, 2010, Pages 699-703

  Skinbjerg, Mette ^a,b,c   Seneca, Nicholas ^a   Liow, Jeih San ^a   Hong, Jinsoo ^a   Weinshenker, David ^d   Pike, Victor W ^a   Halldin, Christer ^b   Sibley, David R ^c   Innis, Robert B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

11C MNPA; D2 dopamine receptor; Dopamine hydroxylase; High affinity state; PET

Indexed keywords

CARBON 11; DOPAMINE 2 RECEPTOR; DOPAMINE BETA MONOOXYGENASE; METHYLSPIPERONE H 3; PROPYLNORAPOMORPHINE; PROPYLNORAPOMORPHINE C 11; PSYCHOSTIMULANT AGENT; RADIOLIGAND; SPIPERONE DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG; 3-N-METHYLSPIPERONE; APOMORPHINE; DOPAMINE RECEPTOR STIMULATING AGENT; N-N-PROPYLNORAPOMORPHINE; RADIOPHARMACEUTICAL AGENT; SPIPERONE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME DEFICIENCY; GENE DELETION; HYPERSENSITIVITY; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LIGAND BINDING; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DENSITY; RECEPTOR SENSITIVITY; ANALOGS AND DERIVATIVES; ANIMAL; BINDING COMPETITION; CEREBELLUM; DEFICIENCY; DIAGNOSTIC USE; DRUG EFFECTS; FEMALE; GENETICS; KINETICS; MALE; METABOLISM; NEOSTRIATUM; RADIOASSAY; SCINTISCANNING;

ANIMALS; APOMORPHINE; BINDING, COMPETITIVE; CEREBELLUM; DOPAMINE AGONISTS; DOPAMINE BETA-HYDROXYLASE; FEMALE; KINETICS; MALE; MICE; MICE, KNOCKOUT; NEOSTRIATUM; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RECEPTORS, DOPAMINE D2; SPIPERONE;

EID: 77956495257     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20781     Document Type: Article

References (17)

1. 3H]propyl- norapomorphine to dopamine receptors in living mouse striatum: Occupancy by endogenous dopamine and guanosine triphosphate-free G protein. J Cereb Blood Flow Metab 22:596-604.
2. 11C]MNPA. Synapse 63:378-389.
3. 11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab 23:1096-1112.
4. 2 receptors: Evidence for identical binding sites. Eur J Pharmacol 303:123-128.
5. (2) receptor in vitro. Synapse 63:998-1009.
6. 3H]raclopride are indistinguishably inhibited by D2 agonists and antagonists ex vivo. Nucl Med Biol 35:11-17.
7. Schank JR, Ventura R, Puglisi-Allegra S, Alcaro A, Cole CD, Liles LC, Seeman P, Weinshenker D. 2006. Dopamine beta-hydroxylase knockout mice have alterations in dopamine signaling and are hypersensitive to cocaine. Neuropsychopharmacology 31:2221-2230. (Pubitemid 44413199)
8. Seeman P, Tallerico T, Ko F, Tenn C, Kapur S. 2002. Amphetamine- sensitized animals show a marked increase in dopamine D2 high receptors occupied by endogenous dopamine, even in the absence of acute challenges. Synapse 46:235-239.
9. 2High states, implying many paths to psychosis. Proc Natl Acad Sci USA 102:3513-3518.
10. Seidel J, Vaquero JJ, Green MV. 2003. Resolution uniformity and sensitivity of the NIH ATLAS small animal PET scanner: Comparison to simulated LSO scanners without depth-of-interaction capability. IEEE Trans Nucl Sci 50:1347-1350.
11. 11C]MNPA. Synapse 62:756-763.
12. Sibley DR, De Lean A, Creese I. 1982. Anterior pituitary dopamine receptors. Demonstration of interconvertible high and low affinity states of the D-2 dopamine receptor. J Biol Chem 257:6351-6361.
13. 3 dopamine receptors. Synapse 63:462-475.
14. 11C]MNPA. J Label Compd Radiopharm 52:158-165.
15. Thomas SA, Marck BT, Palmiter RD, Matsumoto AM. 1998. Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase. J Neurochem 70:2468-2476.
16. Weinshenker D, Miller NS, Blizinsky K, Laughlin ML, Palmiter RD. 2002. Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animals. Proc Natl Acad Sci USA 99:13873-13877.
17. Weinshenker D, Schroeder JP. 2007. There and back again: A tale of norepinephrine and drug addiction. Neuropsychopharmacology 32:1433-1451. (Pubitemid 46920149)