Liver regeneration by small hepatocyte-like progenitor cells after necrotic injury by carbon tetrachloride in retrorsine-exposed rats

Experimental and Molecular Pathology

Volumn 89, Issue 2, 2010, Pages 92-98

  Best, D Hunter ^a,b   Coleman, William B ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Carbon tetrachloride; Liver regeneration; Oval cells; Pyrrolizidine alkaloid; Small hepatocyte like progenitor cells

Indexed keywords

CARBON TETRACHLORIDE; RETRORSINE; PYRROLIZIDINE ALKALOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL EXPANSION; CELL PROLIFERATION; CONTROLLED STUDY; LIVER CELL; LIVER NECROSIS; LIVER REGENERATION; LIVER STRUCTURE; MALE; NONHUMAN; RAT; STEM CELL; ANIMAL; CYTOLOGY; DRUG EFFECTS; FISCHER 344 RAT; LIVER RESECTION; NECROSIS; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; TOXIC HEPATITIS; TOXICITY;

ANIMALS; CARBON TETRACHLORIDE; DRUG-INDUCED LIVER INJURY; HEPATECTOMY; HEPATOCYTES; LIVER REGENERATION; MALE; NECROSIS; PYRROLIZIDINE ALKALOIDS; RANDOM ALLOCATION; RATS; RATS, INBRED F344; STEM CELLS;

ANIMALIA; RATTUS;

EID: 77956440352     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2010.06.007     Document Type: Article

References (30)

1. Alison M., et al. Wholesale hepatocytic differentiation in the rat from ductular oval cells, the progeny of biliary stem cells. J. Hepatol. 1997, 26:343-352.
2. Avril A., et al. Mature hepatocytes are the source of small hepatocyte-like progenitor cells in the retrorsine model of liver injury. J. Hepatol. 2004, 41:737-743.
3. Best D.H., Coleman W.B. Treatment with 2-AAF blocks the small hepatocyte-like progenitor cell response in retrorsine-exposed rats. J. Hepatol. 2007, 46:1055-1063.
4. Best D.H., Coleman W.B. Bile duct destruction by 4, 4'-diaminodiphenylmethane does not block the small hepatocyte-like progenitor cell response in retrorsine-exposed rats. Hepatology 2007, 46:1611-1619.
5. Best D.H., Coleman W.B. Cells of origin of small hepatocyte-like progenitor cells in the retrorsine model of rat liver injury and regeneration. J. Hepatol. 2008, 48:369-371.
6. Czaja, M.J., 1998. Liver regeneration following hepatic injury. In: Strain, A.J., Diehl, A.M. (Eds.), Liver Growth and Repair. New York, Chapman and Hall, 28-49.
7. Coleman W.B., Best D.H. Cellular responses in experimental liver injury: Possible cellular origins of regenerative stem-like progenitor cells. Hepatology 2005, 41:1173-1176.
8. Evarts R.P., et al. A precursor-product relationship exists between oval cells and hepatocytes in rat liver. Carcinogenesis 1987, 8:1737-1740.
9. Farber J.L., El-Mofty S.K. The biochemical pathology of liver cell necrosis. Am. J. Pathol. 1975, 81:237-250.
10. Fausto N. Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 2004, 39:1477-1487.
11. Fausto N., Campbell J.S. The role of hepatocytes and oval cells in liver regeneration and repopulation. Mech. Dev. 2003, 120:117-130.
12. Fausto N., et al. Liver regeneration. Hepatology 2006, 43:S45-S53.
13. Gordon G.J., et al. Liver regeneration in rats with retrorsine-induced hepatocellular injury proceeds through a novel cellular response. Am. J. Pathol. 2000, 156:607-619.
14. Hayes M.A., et al. Initiation and selection of resistant hepatocyte nodules in rats given the pyrrolizidine alkaloids lasiocarpine and senecionine. Cancer Res. 1985, 45:3726-3734.
15. Kanz M.F., et al. A minimally toxic dose of methylene dianiline injures biliary epithelial cells in rats. Toxicol. Appl. Pharmacol. 1998, 150:414-426.
16. Laconi E., et al. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am. J. Pathol. 1998, 153:319-329.
17. Laconi E., et al. Transplantation of normal hepatocytes modulates the development of chronic liver lesions induced by a pyrrolizidine alkaloid, lasiocarpine. Carcinogenesis 1995, 16:139-142.
18. Laconi S., et al. Liver regeneration in response to partial hepatectomy in rats treated with retrorsine: a kinetic study. J. Hepatol. 1999, 31:1069-1074.
19. Lemire J.M., et al. Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine. Am. J. Pathol. 1991, 139:535-552.
20. Michalopoulos G.K. Liver regeneration. J. Cell. Physiol. 2007, 213:286-300.
21. Paku S., et al. 2-acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: confocal and electron microscopic studies. Hepatology 2004, 39:1353-1361.
22. Panduro A., et al. Changes in albumin, alpha-fetoprotein and collagen gene transcription in CCl4-induced hepatic fibrosis. Hepatology 1988, 8:259-266.
23. Petersen B.E., et al. Bile ductular damage induced by methylene dianiline inhibits oval cell activation. Am. J. Pathol. 1997, 151:905-909.
24. Petersen B.E., et al. Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats. Hepatology 1998, 27:1030-1038.
25. Pichard V., Ferry N. Origin of small hepatocyte-like progenitor in retrorsine-treated rats. J. Hepatol. 2008, 48:368-369.
26. Sell S. The role of progenitor cells in repair of liver injury and in liver transplantation. Wound Repair Regen 2001, 9:467-482.
27. Sell S., et al. Rapid development of large numbers of alpha-fetoprotein-containing "oval" cells in the liver of rats fed N-2-fluorenylacetamide in a choline-devoid diet. Gann 1981, 72:479-487.
28. Tatematsu M., et al. Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy. Am. J. Pathol. 1984, 114:418-430.
29. Taub R. Liver regeneration: from myth to mechanism. Nat. Rev. Mol. Cell Biol. 2004, 5:836-847.
30. Webber E.M., et al. Transforming growth factor-alpha expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor-alpha and hepatocyte growth factor. Hepatology 1993, 18:1422-1431.