Methyl gallate inhibits the production of interleukin-6 and nitric oxide via down-regulation of extracellular-signal regulated protein kinase in RAW 264.7 Cells

American Journal of Chinese Medicine

Volumn 38, Issue 5, 2010, Pages 973-983

  Chae, Hee Sung ^a   Kang, Ok Hwa ^a   Choi, Jang Gi ^a   Oh, You Chang ^a   Lee, Young Seob ^a   Brice, Obiang Obounou ^a   Chong, Myong Soo ^a   Lee, Ki Nam ^a   Shin, Dong Won ^b   Kwon, Dong Yeul ^a  

^a Wonkwang University   (South Korea)

^b Sunchon National University   (South Korea)

Author keywords

ERK; Methyl Gallate; NO

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2; GALLIC ACID METHYL ESTER; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BEHAVIOR, ANIMAL; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUGS, CHINESE HERBAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GALLIC ACID; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED ICR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PAIN; PHOSPHORYLATION; PLANT TUMORS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 77956428865     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X10008391     Document Type: Article

References (27)

1. Ahn, Y.J., C.O. Lee, J.H. Kweon, J.W. Ahn and J.H. Park. Growth-inhibitory effects of Galla Rhoisderived tannins on intestinal bacteria. J. Appl. Microbiol. 84: 439-443, 1998.
2. Bae, E.A., M.J. Han, N.J. Kim and D.H. Kim. Anti-Helicobacter pylori activity of herbal medicines. Biol. Pharm. Bull. 21: 990-992, 1998.
3. Chen, C.C. and J.K. Wang. p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Mol. Pharmacol. 55: 481-488, 1999.
4. Collier, H.O., L.C. Dinneen, C.A. Johnson and C. Schneider. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br. J. Pharmacol. Chemother. 32: 295-310, 1968.
5. Doherty, N.S., T.H. Beaver, K.Y. Chan, J.E. Coutant and G.L. Westrich. The role of prostaglandins in the nociceptive response induced by intraperitoneal injection of zymosan in mice. Br. J. Pharmacol. 91: 39-47, 1987.
6. Evans, C.H. Nitric oxide: what role does it play in inflammation and tissue destruction? Agents Actions Suppl. 47: 107-116, 1995.
7. Förstermann, U. and H. Kleinert. Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn Schmiedebergs Arch. Pharmacol. 352: 351-364, 1995.
8. Hawkey, C.J. COX-2 inhibitors. Lancet 353: 307-314, 1999.
9. Ho, F.M., C.C. Lai, L.J. Huang, T.C. Kuo, C.M. Chao and W.W. Lin. The anti-inflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages. Br. J. Pharmacol. 141: 1037-1047, 2004.
10. Kane, C.J., J.H. Menna, C.C. Sung and Y.C. Yeh. Methyl gallate, methyl-3,4,5-trihydoxybenzoate, is a potent and highly specific inhibitor of herpes simplex virus in vitro. II. Antiviral activity of methyl gallate and its derivatives. Biosci. Rep. 8: 95-102, 1988.
11. Kim, K.W., K.T. Ha, C.S. Park, U.H. Jin, H.W. Chang, I.S. Lee and C.H. Kim. Polygonum cuspidatum, compared with baicalin and berberine, inhibits inducible nitric oxide synthase and cyclooxygenase-2 gene expressions in RAW 264.7 macrophages. Vascul. Pharmacol. 47: 99-107, 2007.
12. Kim, M.W., S.M. Ju, K.J. Kim, Y.G. Yun, D.M. Han, W.S. Kim and B.H. Jeon. Study on the antileukemic effect of Galla Rhois. Kor. J. Orient. Physiol. Pathol. 19: 234-241, 2005.
13. Kim, S. J., M. Jin, E. Lee, T.C. Moon, Z. Quan, J.H. Yang, K.H. Son, K.U. Kim, J.K. Son and H.W. Chang. Effects of methyl gallate on arachidonic acid metabolizing enzymes: cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch. Pharm. Res. 29: 874-878, 2006.
14. Koyanagi, M., K. Egashira, M. Kubo-Inoue, M. Usui, S. Kitamoto, H. Tomita, H. Shimokawa and A. Takeshita. Role of transforming growth factor-beta1 in cardiovascular inflammatory changes induced by chronic inhibition of nitric oxide synthesis. Hypertension 35: 86-90, 2000. (Pubitemid 30054242)
15. Masferrer, J.L., B.S. Zweifel, P.T. Manning, S.D. Hauser, K.M. Leahy, W.G. Smith, P.C. Isakson and K. Seibert. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. USA 91: 3228-3232, 1994.
16. Meade, E.A., W.L. Smith and D.L. DeWitt. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268: 6610-6617, 1993.
17. Nakamura, H., A. Shimoda, K. Ishii and T. Kadokawa. Central and peripheral analgesic action of non-acidic non-steroidal anti-inflammatory drugs in mice and rats. Arch. Int. Pharmacodyn. Ther. 282: 16-25, 1986.
18. Nathan, C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6: 3051-3064, 1992.
19. Nick, J.A., S.K. Young, L.K. Brown, N.J. Avdi, P.G. Arndt, B.T. Suratt, M.S. Janes, P.M. Henson and G.S. Worthen. Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation. J. Immunol. 164: 2151-2159, 2000.
20. Palmer, R.M., D.S. Ashton and S. Moncada. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333: 664-666, 1988.
21. Raj, P.P. Advances in the practice of medicine: contributions of pain management. Ann. Acad. Med. Singapore 25: 152-159, 1996.
22. Robinson, M.J. and M.H. Cobb. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9: 180-186, 1997.
23. Sanghera, J.S., S.L. Weinstein, M. Aluwalia, J. Girn and S.L. Pelech. Activation of multiple prolinedirected kinases by bacterial lipopolysaccharide in murine macrophages. J. Immunol. 156: 4457-4465, 1996.
24. Vale, M.L., V.M. Benevides, D. Sachs, G.A. Brito, F.A. da Rocha, S. Poole, S.H. Ferreira, F.Q. Cunha and R.A.S. Ribeiro. Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. Br. J. Pharmacol. 143: 833-844, 2004.
25. Wang, X., J.L. Martindale, Y. Liu and N.J. Holbrook. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem. J. 333: 291-300, 1998.
26. Xia, Z., M. Dickens, J. Raingeaud, R.J. Davis and M.E. Greenberg. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331, 1995.
27. Zhao, L., P.A. Weber, J.R. Smith, M.L. Comerford and G.T. Elliott. Role of inducible nitric oxide synthase in pharmacological " preconditioning" with monophosphoryl lipid A. J. Mol. Cell Cardiol. 29: 1567-1576, 1997.