A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity

Vaccine

Volumn 26, Issue 37, 2008, Pages 4849-4859

  Fukuiwa, Tatsuya ^a,b,c   Sekine, Shinichi ^a,b   Kobayashi, Ryoki ^a,b   Suzuki, Hideaki ^a,b   Kataoka, Kosuke ^d   Gilbert, Rebekah S ^a,b   Kurono, Yuichi ^c   Boyaka, Prosper N ^e   Krieg, Arthur M ^f   McGhee, Jerry R ^a,b   Fujihashi, Kohtaro ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

^e OHIO STATE UNIVERSITY   (United States)

^f PFIZER INC   (United States)

Author keywords

Cytokines; Dendritic cells; Nasal immunization

Indexed keywords

ADJUVANT; COMPLEMENTARY DNA; CPG OLIGODEOXYNUCLEOTIDE; FLT3 LIGAND; IMMUNOGLOBULIN A ANTIBODY; MESSENGER RNA; OVALBUMIN; SECRETORY IMMUNOGLOBULIN;

AGED; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOKINE RESPONSIVE ELEMENT; DENDRITIC CELL; DRUG EFFICACY; FEMALE; FLOW CYTOMETRY; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; MOUSE; MUCOSAL IMMUNITY; NASOPHARYNGEAL ASSOCIATED LYMPHORETICULAR TISSUE; NONHUMAN; OPEN READING FRAME; PLASMA CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETICULOENDOTHELIAL SYSTEM; TARGET CELL; TH1 CELL; TH2 CELL;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; CYTOKINES; DENDRITIC CELLS; DNA, COMPLEMENTARY; FEMALE; IMMUNOGLOBULIN A; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; NASAL MUCOSA; NASOPHARYNX; OLIGODEOXYRIBONUCLEOTIDES; OVALBUMIN; PLASMIDS;

EID: 49749093403     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.06.091     Document Type: Article

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