Peripheral 4-1BB signaling negatively regulates NK cell development through IFN-γ

Journal of Immunology

Volumn 185, Issue 3, 2010, Pages 1404-1411

  Choi, Beom K ^a   Kim, Young H ^a   Kim, Chang H ^a   Kim, Moon S ^a   Kim, Kwang H ^a   Oh, Ho S ^a   Lee, Myoung J ^a   Lee, Don K ^a   Vinay, Dass S ^b   Kwon, Byoung S ^a,b  

^a National Cancer Center   (South Korea)

^b TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD137 ANTIGEN; GAMMA INTERFERON; EPITOPE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CD8+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IN VIVO STUDY; INNATE IMMUNITY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR IMMUNITY; ADENOCARCINOMA; ANIMAL; BAGG ALBINO MOUSE; BONE MARROW CELL; C57BL MOUSE; CELL DIFFERENTIATION; COLON TUMOR; COMPARATIVE STUDY; DOWN REGULATION; GENETICS; IMMUNOLOGY; KIDNEY TUMOR; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; THYMOMA; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; ANTIGENS, CD137; BONE MARROW CELLS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOWN-REGULATION; FEMALE; IMMUNITY, INNATE; IMMUNODOMINANT EPITOPES; INTERFERON-GAMMA; KIDNEY NEOPLASMS; KILLER CELLS, NATURAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; THYMOMA;

EID: 77956414971     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000850     Document Type: Article

References (32)

1. Hurtado, J. C., S. H. Kim, K. E. Pollok, Z. H. Lee, and B. S. Kwon. 1995. Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28. J. Immunol. 155: 3360-3367.
2. Vinay, D. S., B. K. Choi, J. S. Bae, W. Y. Kim, B. M. Gebhardt, and B. S. Kwon. 2004. CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses. J. Immunol. 173: 4218-4229.
3. Choi, B. K., J. S. Bae, E. M. Choi, W. J. Kang, S. Sakaguchi, D. S. Vinay, and B. S. Kwon. 2004. 4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells. J. Leukoc. Biol. 75: 785-791.
4. Choi, B. K., Y. H. Kim, P. M. Kwon, S. C. Lee, S. W. Kang, M. S. Kim, M. J. Lee, and B. S. Kwon. 2009. 4-1BB functions as a survival factor in dendritic cells. J. Immunol. 182: 4107-4115.
5. Pan, P. Y., P. Gu, Q. Li, D. Xu, K. Weber, and S. H. Chen. 2004. Regulation of dendritic cell function by NK cells: mechanisms underlying the synergism in the combination therapy of IL-12 and 4-1BB activation. J. Immunol. 172: 4779-4789.
6. Shuford,W.W., K. Klussman, D. D. Tritchler, D. T. Loo, J. Chalupny, A.W. Siadak, T. J. Brown, J. Emswiler, H. Raecho, C. P. Larsen, et al. 1997. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med. 186: 47-55.
7. Lee, H.W., S. J. Park, B. K. Choi, H. H. Kim, K. O. Nam, and B. S. Kwon. 2002. 4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1. J. Immunol. 169: 4882-4888.
8. Vinay, D. S., and B. S. Kwon. 1998. Role of 4-1BB in immune responses. Semin. Immunol. 10: 481-489.
9. Melero, I., S. Hervas-Stubbs, M. Glennie, D. M. Pardoll, and L. Chen. 2007. Immunostimulatory monoclonal antibodies for cancer therapy. Nat. Rev. Cancer 7: 95-106.
10. Lee, S. W., Y. Park, T. So, B. S. Kwon, H. Cheroutre, R. S. Mittler, and M. Croft. 2008. Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat. Immunol. 9: 917-926.
11. Kwon, B. S., J. C. Hurtado, Z. H. Lee, K. B. Kwack, S. K. Seo, B. K. Choi, B. H. Koller, G. Wolisi, H. E. Broxmeyer, and D. S. Vinay. 2002. Immune responses in 4-1BB (CD137)-deficient mice. J. Immunol. 168: 5483-5490.
12. Lee, S. W., A. T. Vella, B. S. Kwon, and M. Croft. 2005. Enhanced CD4 T cell responsiveness in the absence of 4-1BB. J. Immunol. 174: 6803-6808.
13. Lee, S. W., S. Salek-Ardakani, R. S. Mittler, and M. Croft. 2009. Hypercostimulation through 4-1BB distorts homeostasis of immune cells. J. Immunol. 182: 6753-6762.
14. Kasahara, T., J. Y. Djeu, S. F. Dougherty, and J. J. Oppenheim. 1983. Capacity of human large granular lymphocytes (LGL) to produce multiple lymphokines: interleukin 2, interferon, and colony stimulating factor. J. Immunol. 131: 2379-2385.
15. Melero, I., W. W. Shuford, S. A. Newby, A. Aruffo, J. A. Ledbetter, K. E. Hellström, R. S. Mittler, and L. Chen. 1997. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat. Med. 3: 682-685.
16. Choi, B. K., Y. H. Kim, W. J. Kang, S. K. Lee, K. H. Kim, S. M. Shin, W. M. Yokoyama, T. Y. Kim, and B. S. Kwon. 2007. Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy. Cancer Res. 67: 8891-8899.
17. Wilcox, R. A., D. B. Flies, G. Zhu, A. J. Johnson, K. Tamada, A. I. Chapoval, S. E. Strome, L. R. Pease, and L. Chen. 2002. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J. Clin. Invest. 109: 651-659.
18. Wilcox, R. A., K. Tamada, S. E. Strome, and L. Chen. 2002. Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity. J. Immunol. 169: 4230-4236.
19. Richards, J. O., X. Chang, B. W. Blaser, M. A. Caligiuri, P. Zheng, and Y. Liu. 2006. Tumor growth impedes natural-killer-cell maturation in the bone marrow. Blood 108: 246-252.
20. Richards, J., B. McNally, X. Fang, M. A. Caligiuri, P. Zheng, and Y. Liu. 2008. Tumor growth decreases NK and B cells as well as common lymphoid progenitor. PLoS ONE 3: e3180.
21. Kim, S., K. Iizuka, H. S. Kang, A. Dokun, A. R. French, S. Greco, and W. M. Yokoyama. 2002. In vivo developmental stages in murine natural killer cell maturation. Nat. Immunol. 3: 523-528.
22. Shimozato, O., J. R. Ortaldo, K. L. Komschlies, and H. A. Young. 2002. Impaired NK cell development in an IFN-gamma transgenic mouse: aberrantly expressed IFN-gamma enhances hematopoietic stem cell apoptosis and affects NK cell differentiation. J. Immunol. 168: 1746-1752.
23. Seo, S. K., J. H. Choi, Y. H. Kim, W. J. Kang, H. Y. Park, J. H. Suh, B. K. Choi, D. S. Vinay, and B. S. Kwon. 2004. 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat. Med. 10: 1088-1094.
24. Choi, B. K., T. Asai, D. S. Vinay, Y. H. Kim, and B. S. Kwon. 2006. 4-1BBmediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms. Cytokine 34: 233-242.
25. Kasahara, T., J. J. Hooks, S. F. Dougherty, and J. J. Oppenheim. 1983. Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets. J. Immunol. 130: 1784-1789.
26. Liu, Y., and C. A. Janeway, Jr. 1990. Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance. J. Exp. Med. 172: 1735-1739.
27. Yang, L., I. Dybedal, D. Bryder, L. Nilsson, E. Sitnicka, Y. Sasaki, and S. E. Jacobsen. 2005. IFN-gamma negatively modulates self-renewal of repopulating human hemopoietic stem cells. J. Immunol. 174: 752-757.
28. Young, H. A., D. M. Klinman, D. A. Reynolds, K. J. Grzegorzewski, A. Nii, J. M. Ward, R. T. Winkler-Pickett, J. R. Ortaldo, J. J. Kenny, and K. L. Komschlies. 1997. Bone marrow and thymus expression of interferon-gamma results in severe B-cell lineage reduction, T-cell lineage alterations, and hematopoietic progenitor deficiencies. Blood 89: 583-595.
29. Niu, L., S. Strahotin, B. Hewes, B. Zhang, Y. Zhang, D. Archer, T. Spencer, D. Dillehay, B. Kwon, L. Chen, et al. 2007. Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice. J. Immunol. 178: 4194-4213. (Pubitemid 46492370)
30. Porritt, H. E., K. Gordon, and H. T. Petrie. 2003. Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice. J. Exp. Med. 198: 957-962.
31. Hackett, J., Jr., M. Bennett, and V. Kumar. 1985. Origin and differentiation of natural killer cells. I. Characteristics of a transplantable NK cell precursor. J. Immunol. 134: 3731-3738.
32. Baessler, T., J. E. Charton, B. J. Schmiedel, F. Grünebach, M. Krusch, A. Wacker, H. G. Rammensee, and H. R. Salih. 2010. CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells. Blood 115: 3058-3069.