An immunohistochemical study of the distribution of p 16 protein in oral mucosa in smokers, non-smokers and in frictional keratosis

Medicina Oral, Patologia Oral y Cirugia Bucal

Volumn 15, Issue 5, 2010, Pages

  Tarakji, Bassel ^a   Kujan, Omar ^b   Nassani, Mohammad Z ^a  

^a UNIVERSITY OF ALEPPO   (Syrian Arab Republic)

^b AL BAATH UNIVERSITY   (Syrian Arab Republic)

Author keywords

Frictional keratosis; Immunohistochemical; Oral mucosa; p 16; Smokers

Indexed keywords

PROTEIN P16;

ARTICLE; BASAL CELL; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATOSIS; LAMINA PROPRIA; MOUTH MUCOSA; PROTEIN EXPRESSION; SMOKING; SQUAMOUS CELL; TISSUE DISTRIBUTION;

HUMANS; IMMUNOHISTOCHEMISTRY; LEUKOPLAKIA, ORAL; MOUTH MUCOSA; NEOPLASM PROTEINS; SMOKING;

EID: 77956406194     PISSN: 16984447     EISSN: 16986946     Source Type: Journal    
DOI: 10.4317/medoral.15.e681     Document Type: Article

References (18)

1. Wu CL, Roz L, McKown S, Sloan P, Read AP, Holland S, et al. DNA studies underestimate the major role of CDKN2A inactivation in oral and oropharyngeal squamous cell carcinomas. Genes Chromosomes Cancer. 1999;25:16-25.
2. Okami K, Reed AL, Cairns P, Koch WM, Westra WH, Wehage S, et al. Cyclin D1 amplification is independent of p16 inactivation in head and neck squamous cell carcinoma. Oncogene. 1999;18:3541-5.
3. Chen Q, Luo G, Li B, Samaranayake LP. Expression of p16 and CDK4 in oral premalignant lesions and oral squamous cell carcinomas: a semi-quantitative immunohistochemical study. J Oral Pathol Med. 1999;28:158-64.
4. Lai S, El-Naggar AK. Differential expression of key cell cycle genes (p16/cyclin D1/pRb) in head and neck squamous carcinomas. Lab Invest. 1999;79:255-60.
5. Nielsen GP, Stemmer-Rachamimov AO, Shaw J, Roy JE, Koh J, Louis DN. Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues. Lab Invest. 1999;79:1137-43. (Pubitemid 29444545)
6. Thomson PJ, Potten CS, Appleton DR. Mapping dynamic epithelial cell proliferative activity within the oral cavity of man: a new insight into carcinogenesis? Br J Oral Maxillofac Surg. 1999;37:377-83.
7. LaRue H, Allard P, Simoneau M, Normand C, Pfister C, Moore L, et al. P53 point mutations in initial superficial bladder cancer occur only in tumors from current or recent cigarette smokers. Carcinogenesis. 2000;21:101-6.
8. Thomson PJ, Potten CS, Appleton DR. Characterization of epithelial cell activity in patients with oral cancer. Br J Oral Maxillofac Surg. 1999;37:384-90.
9. Villablanca AC. Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol. 1998;84:2089-98.
10. Waggoner SE, Wang X. Effect of nicotine on proliferation of normal, malignant, and human papillomavirus-transformed human cervical cells. Gynecol Oncol. 1994;55:91-5.
11. Piepkorn M. The expression of p16(INK4a), the product of a tumor suppressor gene for melanoma, is upregulated in human melanocytes by UVB irradiation. J Am Acad Dermatol. 2000;42:741-5.
12. Kato H, Yoshikawa M, Fukai Y, Tajima K, Masuda N, Tsukada K, et al. An immunohistochemical study of p16, pRb, p21 and p53 proteins in human esophageal cancers. Anticancer Res. 2000;20:345-9.
13. Suzuki H, Fujioka Y. Deletion of the p16 gene and microsatellite instability in carcinoma arising in pleomorphic adenoma of the parotid gland. Diagn Mol Pathol. 1998;7:224-31.
14. Chen M, Chen ZQ, Cui PG, Yao X, Li YM, Li AS, et al. The methylation pattern of p16INK4a gene promoter in psoriatic epidermis and its clinical significance. Br J Dermatol. 2008;158:987-93.
15. Zindy F, Quelle DE, Roussel MF, Sherr CJ. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene. 1997;15:203-11.
16. Buajeeb W, Poomsawat S, Punyasingh J, Sanguansin S. Expression of p16 in oral cancer and premalignant lesions. J Oral Pathol Med. 2009;38:104-8.
17. de Sousa FA, Paradella TC, Carvalho YR, Rosa LE. Comparative analysis of cell proliferation ratio in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2009;14:e563-7.
18. Santos-García A, Abad-Hernández MM, Fonseca-Sánchez E, Cruz-Hernández JJ, Bullón-Sopelana A. Proteic expression of p53 and cellular proliferation in oral leukoplakias. Med Oral Patol Oral Cir Bucal. 2005;10:5-8;1-5.