Microsatellite instability with promoter methylation and silencing of hMLH1 can regionally occur during progression of gastric carcinoma

Cancer Letters

Volumn 297, Issue 2, 2010, Pages 244-251

  Ling, Zhi Qiang ^a,b   Tanaka, Aiko ^a,c   Li, Pei ^a,d   Nakayama, Takahisa ^a   Fujiyama, Yoshihide ^a   Hattori, Takanori ^a   Sugihara, Hiroyuki ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b ZHEJIANG CANCER HOSPITAL   (China)

^c Kohka Public Hospital   (Japan)

^d ZHENGZHOU UNIVERSITY   (China)

Author keywords

Gastric carcinoma; HMLH1; Intratumoral heterogeneity; Microsatellite instability; Promoter methylation; Tumor progression

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GROWTH; DISEASE SEVERITY; FEMALE; GENE SILENCING; GENETIC HETEROGENEITY; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; METHYLATION; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; DNA METHYLATION; DNA REPAIR; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; PATHOLOGY; STOMACH TUMOR; VERY ELDERLY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; AGED, 80 AND OVER; DNA METHYLATION; DNA REPAIR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; STOMACH NEOPLASMS;

MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 77956398232     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.05.017     Document Type: Article

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