Spatial distribution of factor xa, thrombin, and fibrin(ogen) on thrombi at venous shear

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Berny, Michelle A ^a,b   Munnix, Imke C A ^a   Auger, Jocelyn M ^c   Schols, Saskia E M ^a   Cosemans, Judith M E M ^a   Panizzi, Peter ^d,e   Bock, Paul E ^e   Watson, Steve P ^c   McCarty, Owen J T ^b   Heemskerk, Johan W M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b Oregon Health and Science University Department of Biomedical Engineering   (United States)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; FERROUS CHLORIDE; FIBRINOGEN; THROMBIN; FIBRIN; PHOSPHATIDYLSERINE; THROMBOPLASTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; FIBRIN DEPOSITION; FIBRIN FORMATION; FLUORESCENCE MICROSCOPY; HUMAN; MESENTERIC VEIN; MOUSE; NONHUMAN; SHEAR RATE; SHEAR STRESS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOGENESIS; VEIN THROMBOSIS; ANIMAL; PATHOLOGY; PERFUSION; PROTEIN BINDING; THROMBOCYTE;

ANIMALS; BLOOD PLATELETS; CALCIUM SIGNALING; FACTOR XA; FIBRIN; FIBRINOGEN; HUMANS; MICE; PERFUSION; PHOSPHATIDYLSERINES; PLATELET AGGREGATION; PROTEIN BINDING; THROMBIN; THROMBOPLASTIN; VENOUS THROMBOSIS;

EID: 77956396233     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010415     Document Type: Article

References (43)

1. Furie B, Furie BC (2005) Thrombus formation in vivo. J Clin Invest 115: 3355-3362.
2. Munnix IC, Kuijpers MJ, Auger J, Thomassen CM, Panizzi P, et al. (2007) Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation. Arterioscler Thromb Vasc Biol 27: 2484-2490.
3. Nesbitt WS, Westein E, Tovar-Lopez FJ, Tolouei E, Mitchell A, et al. (2009) A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med 15: 665-673.
4. Dubois C, Panicot-Dubois L, Gainor JF, Furie BC, Furie B (2007) Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation, a laser injury model. J Clin Invest 117: 953-960.
5. Kuijpers MJ, Munnix IC, Cosemans JM, Vlijmen BV, Reutelingsperger CP, et al. (2008) Key role of platelet procoagulant activity in tissue factor-and collagen-dependent thrombus formation in arterioles and venules in vivo differential sensitivity to thrombin inhibition. Microcirculation 15: 269-282.
6. Butenas S, Branda RF, van't Veer C, Cawthern KM, Mann KG (2001) Platelets and phospholipids in tissue factor-initiated thrombin generation. Thromb Haemost 86: 660-667.
7. Dachary-Prigent J, Pasquet JM, Freyssinet JM, Nurden AT (1995) Calcium involvement in aminophospholipid exposure and microparticle formation during platelet activation, a study using Ca2+-ATPase inhibitors. Biochemistry 34: 11625-11634.
8. Leon C, Alex M, Klocke A, Morgenstern E, Moosbauer C, et al. (2004) Platelet ADP receptors contribute to the initiation of intravascular coagulation. Blood 103: 594-600.
9. Vanschoonbeek K, Feijge MAH, van Kampen RJW, Kenis H, Hemker HC, et al. (2004) Initiating and potentiating roles of platelets in tissue factor-induced thrombin generation in the presence of plasma: subject-dependent variation in thrombogram characteristics. J Thromb Haemost 2: 476-484.
10. Tracy PB, Eide LL, Mann KG (1985) Human prothrombinase complex assembly and function on isolated peripheral blood cell populations. J Biol Chem 260: 2119-2124.
11. Zwaal RF, Schroit AJ (1997) Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 89: 1121-1132.
12. Heemskerk JW, Bevers EM, Lindhout T (2002) Platelet activation and blood coagulation. Thromb Haemost 88: 186-193.
13. Beguin S, Kumar R (1997) Thrombin, fibrin and platelets, a resonance loop in which von Willebrand factor is a necessary link. Thromb Haemost 78: 590-594.
14. Inauen W, Baumgartner HR, Bombeli T, Haeberli A, Straub PW (1990) Dose-and shear rate-dependent effects of heparin on thrombogenesis induced by rabbit aorta subendothelium exposed to flowing human blood. Arteriosclerosis 10: 607-615.
15. Weiss HJ, Turitto VT, Baumgartner HR (1986) Role of shear rate and platelets in promoting fibrin formation on rabbit subendothelium. Studies utilizing patients with quantitative and qualitative platelet defects. J Clin Invest 78: 1072-1082.
16. Bock PE (1992) Active-site-selective labeling of blood coagulation proteinases with fluorescence probes by the use of thioester peptide chloromethyl ketones. II. Properties of thrombin derivatives as reporters of prothrombin fragment 2 binding and specificity of the labeling approach for other proteinases. J Biol Chem 267: 14974-19481.
17. Panizzi P, Friedrich R, Fuentes-Prior P, Kroh HK, Briggs J, et al. (2006) Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions. J Biol Chem 281: 1169-1178.
18. Siljander PR, Munnix IC, Smethurst PA, Deckmyn H, Lindhout T, et al. (2004) Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood. Blood 103: 1333-1341.
19. van Lier M, Verhoef S, Cauwenberghs S, Heemskerk JW, Akkerman JW, et al. (2008) Role of membrane cholesterol in platelet calcium signalling in response to VWF and collagen under stasis and flow. Thromb Haemost 99: 1068-1078.
20. Auger JM, Kuijpers MJE, Senis YA, Watson SP, Heemskerk JWM (2005) Adhesion of human and mouse platelets to collagen under shear: a unifying model. FASEB J 19: 825-827.
21. Hemker HC, Giesen PLA, Ramjee M, Wagenvoord R, Béguin S (2000) The thrombogram: monitoring thrombin generation in platelet rich plasma. Thromb Haemost 83: 589-591.
22. Kalia N, Auger JM, Atkinson B, Watson SP (2008) Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo. Microcirculation 15: 325-335.
23. Celi A, Merrill-Skoloff G, Gross P, Falati S, Sim DS, et al. (2003) Thrombus formation: direct real-time observation and digital analysis of thrombus assembly in a living mouse by confocal and widefield intravital microscopy. J Thromb Haemost 1: 60-68.
24. Ahmad SS, London FS, Walsh PN (2003) Binding studies of the enzyme (factor IXa) with the cofactor (factor VIIIa) in the assembly of factor-X activating complex on the activated platelet surface. J Thromb Haemost 1: 2348-2355.
25. Ahmad SS, London FS, Walsh PN (2003) The assembly of the factor X-activating complex on activated human platelets. J Thromb Haemost 1: 48-59.
26. Kamath P, Krishnaswamy S (2008) Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase. J Biol Chem 283: 30164-30173.
27. Kaneko N, Matsuda R, Hosoda S, Kajita T, Ohta Y (1996) Measurement of plasma annexin V by ELISA in the early detection of acute myocardial infarction. Clin Chim Acta 251: 65-80.
28. Masuda J, Takayama E, Satoh A, Ida M, Shinohara T, et al. (2004) Levels of annexin IV and V in the plasma of pregnant and postpartum women. Thromb Haemost 91: 1129-1136.
29. Adams TE, Huntington JA (2006) Thrombin-cofactor interactions: structural insights into regulatory mechanisms. Arterioscler Thromb Vasc Biol 26: 1738-1745.
30. Berny MA, White TC, Tucker EI, Bush-Pelc LA, Di Cera E, et al. (2008) Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist. Arterioscler Thromb Vasc Biol 28: 329-334.
31. Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR (1999) Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest 103: 879-887.
32. Mosesson MW (2005) Fibrinogen and fibrin structure and functions. J Thromb Haemost 3: 1890-1894.
33. Fredenburgh JC, Stafford AR, Leslie BA, Weitz JI (2008) Bivalent binding to gammaA/gamma'-fibrin engages both exosites of thrombin and protects it from inhibition by the antithrombin-heparin complex. J Biol Chem 283: 2470-2477.
34. Meh DA, Siebenlist KR, Mosesson MW (1996) Identification and character-ization of the thrombin binding sites on fibrin. J Biol Chem 271: 23121-23125.
35. Lovely RS, Falls LA, Al-Mondhiry HA, Chambers CE, Sexton GJ, et al. (2002) Association of gammaA/gamma' fibrinogen levels and coronary artery disease. Thromb Haemost 88: 26-31.
36. Mosesson MW, Finlayson JS, Umfleet RA (1972) Human fibrinogen heterogeneities. 3. Identification of chain variants. J Biol Chem 247: 5223-5227.
37. Pospisil CH, Stafford AR, Fredenburgh JC, Weitz JI (2003) Evidence that both exosites on thrombin participate in its high affinity interaction with fibrin. J Biol Chem 278: 21584-21591.
38. Weitz JI, Leslie B, Hudoba M (1998) Thrombin binds to soluble fibrin degradation products where it is protected from inhibition by heparin-antithrombin but susceptible to inactivation by antithrombin-independent inhibitors. Circulation 97: 544-552.
39. Furie B, Furie BC (2007) In vivo thrombus formation. J Thromb Haemost 5 Suppl 1: 12-17.
40. Coller BS (1980) Interaction of normal, thrombasthenic, and Bernard-Soulier platelets with immobilized fibrinogen: defective platelet-fibrinogen interaction in thrombasthenia. Blood 55: 169-178.
41. Nachman RL, Leung LL (1982) Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen. J Clin Invest 69: 263-269.
42. Ni H, Denis CV, Subbarao S, Degen JL, Sato TN, et al. (2000) Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest 106: 385-392.
43. Ni H, Papalia JM, Degen JL, Wagner DD (2003) Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain. Blood 102: 3609-3614.