Intracellular bimodal nanoparticles based on quantum dots for high-field MRI at 21.1 T

Magnetic Resonance in Medicine

Volumn 64, Issue 3, 2010, Pages 871-882

  Rosenberg, Jens T ^a,b   Kogot, Joshua M ^c   Lovingood, Derek D ^c   Strouse, Geoffrey F ^c   Grant, Samuel C ^a,b  

^a FAMU FSU COLLEGE OF ENGINEERING   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

^c FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Bimodal contrast agent; Cellular MRI; DOTA Dy; High field MRI; Quantum dots

Indexed keywords

BIOCOMPATIBILITY; FLUORESCENCE; GRAPHENE QUANTUM DOTS; III-V SEMICONDUCTORS; INDIUM PHOSPHIDE; INDIUM SULFIDE; MAGNETIC FIELDS; MAGNETIC RESONANCE IMAGING; MEDICAL IMAGING; NANOCRYSTALS; NANOMAGNETICS; NANOPARTICLES; NANOSTRUCTURED MATERIALS; SEMICONDUCTING INDIUM PHOSPHIDE; SULFUR COMPOUNDS;

CELL-PENETRATING PEPTIDE; CELLULAR MRIS; CONTRAST AGENT; FLUORESCENCE DETECTION; FLUORESCENT IMAGES; HIGH FIELD MRI; HIGH MAGNETIC FIELDS; MR CONTRAST AGENTS;

SEMICONDUCTOR QUANTUM DOTS;

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; CAAKA 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; CAAKA 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID DYSPROSIUM; DYSPROSIUM; INDIUM PHOSPHIDE; INORGANIC COMPOUND; NANOPARTICLE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; QUANTUM DOT; QUANTUM DOT CAAKA 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID DYSPROSIUM; UNCLASSIFIED DRUG; ZINC SULFIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL SELECTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; GENETIC TRANSFECTION; IMAGE ANALYSIS; MAGNETIC FIELD; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; X RAY FLUORESCENCE;

EID: 77956366065     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22441     Document Type: Article

References (64)

1. Vaughan T, DelaBarre L, Snyder C, Tian J, Akgun C, Shrivastava D, Liu W, Olson C, Adriany G, Strupp J, Andersen P, Gopinath A, van de Moortele PF, Garwood M, Ugurbil K. 9.4T human MRI: preliminary results. Magn Reson Med 2006;56:1274-1282. (Pubitemid 44865309)
2. Scarabino T, Giannatempo GM, Popolizio T, Tosetti M, d'Alesio V, Esposito F, Di Salle F, Di Costanzo A, Bertolino A, Maggialetti A, Salvolini U. 3.0-T functional brain imaging: a 5-year experience. Radiol Med 2007;112:97-112.
3. van de Ven RC, Hogers B, van den Maagdenberg AM, de Groot HJ, Ferrari MD, Frants RR, Poelmann RE, van der Weerd L, Kiihne SR. T(1) relaxation in in vivo mouse brain at ultra-high field. Magn Reson Med 2007;58:390-395.
4. Fu R, Brey WW, Shetty K, Gor'kov P, Saha S, Long JR, Grant SC, Chekmenev EY, Hu J, Gan Z, Sharma M, Zhang F, Logan TM, Bruschweller R, Edison A, Blue A, Dixon IR, Markiewicz WD, Cross TA. Ultra-wide bore 900 MHz high-resolution NMR at the national high magnetic field laboratory. J Magn Reson 2005;177:1-8.
5. Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 2005;307:538-544. (Pubitemid 40165671)
6. Service RF. Materials and biology: nanotechnology takes aim at cancer. Science 2005;310:1132-1134.
7. Bruchez M Jr, Moronne M, Gin P, Weiss S, Alivisatos AP. Seminiconductor nanocrystals as fluorescent biological labels. Science 1998;281:2013-2016. (Pubitemid 28475485)
8. Bulte JW, Kraitchman DL. Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed 2004;17:484-499. (Pubitemid 39549426)
9. Bulte JW, Duncan ID, Frank JA. In vivo magnetic resonance tracking of magnetically labeled cells after transplantation. J Cereb Blood Flow Metab 2002;22:899-907.
10. Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L. Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 1990;175:489-493. (Pubitemid 20135290)
11. Aime S, Nano R. Factors determining the proton T1 relaxivity in solutions containing Gd-DTPA. Invest Radiol 1988;23(suppl 1):S264-266.
12. Terreno E, Geninatti Crich S, Belfiore S, Biancone L, Cabella C, Esposito G, Manazza AD, Aime S. Effect of the intracellular localization of a Gd-based imaging probe on the relaxation enhancement of water protons. Magn Reson Med 2006;55:491-497. (Pubitemid 43352546)
13. Aime S, Dastru W, Crich SG, Gianolio E, Mainero V. Innovative magnetic resonance imaging diagnostic agents based on paramagnetic Gd(III) complexes. Biopolymers 2002;66:419-428. (Pubitemid 36433536)
14. Aime S, Cabella C, Colombatto S, Geninatti Crich S, Gianolio E, Maggioni F. Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations. J Magn Reson Imaging 2002;16:394-406. (Pubitemid 35167875)
15. Woods M, Botta M, Avedano S, Wang J, Sherry AD. Towards the rational design of MRI contrast agents: a practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange. Dalton Trans 2005;24:3829-3837. (Pubitemid 43022752)
16. Aime S, Botta M, Fasano M, Mauro F, Paoletti S, Anelli PL, Uggeri F, Virtuani M. NMR evidence of a long exchange lifetime for the coordinated water in ln(III)-bis(methyl amide)-DTPA complexes (Ln=Gd, dy). Inorganic Chem 1994;33:4707-4711.
17. 1H magnetic resonance spectroscopic studies of transcellular sodium distribution in the dog brain in vivo. Magn Reson Med 1993;30:11-17.
18. Vander Elst L, Zhang S, Sherry AD, Laurent S, Botteman F, Muller RN. Dy-complexes as high field T2 contrast agents: influence of water exchange rates. Acad Radiol2002;9(suppl 2):S297-299.
19. Vander Elst L, Roch A, Gillis P, Laurent S, Botteman F, Bulte JW, Muller RN. Dy-DTPA derivatives as relaxation agents for very high field MRI: the beneficial effect of slow water exchange on the transverse relaxivities. Magn Reson Med 2002;47:1121-1130. (Pubitemid 34587403)
20. Bulte JW, Wu C, Brechbiel MW, Brooks RA, Vymazal J, Holla M, Frank JA. Dysprosium-DOTA-PAMAM dendrimers as macromolecular T2 contrast agents: preparation and relaxometry. Invest Radiol 1998;33:841-845.
21. Freed JH. Dynamic effects of pair correlation-functions on spin relaxation by translational diffusion in liquids, 2: finite jumps and independent T1 processes. J Chem Phys 1978;68:4034-4037.
22. Gillis P, Roch A, Brooks RA. Corrected equations for susceptibility- induced T2-shortening. J Magn Reson 1999;137:402-407.
23. Bertini I, Capozzi F, Luchinat C, Nicastro G, Xia ZC. Water proton relaxation for some lanthanide aqua ions in solution. J Phys Chem 1993;97:6351-6354.
24. Mulder WJ, Strijkers GJ, Briley-Saboe KC, Frias JC, Aguinaldo JG, Vucic E, Amirbekian V, Tang C, Chin PT, Nicolay K, Fayad ZA. Molecular imaging of macrophages in atherosclerotic plaques using bimodal PEG-micelles. Magn Reson Med 2007;58:1164-1170.
25. Prinzen L, Miserus RJ, Dirksen A, Hackeng TM, Deckers N, Bitsch NJ, Megens RT, Douma K, Heemskerk JW, Kooi ME, Frederik PM, Slaaf DW, van Zandvoort MA, Reutelingsperger CP. Optical and magnetic resonance imaging of cell death and platelet activation using annexin a5-functionalized quantum dots. Nano Lett 2007;7:93-100.
26. Mulder WJ, Koole R, Brandwijk RJ, Storm G, Chin PT, Strijkers GJ, de Mello Donega C, Nicolay K, Griffioen AW. Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe. Nano Lett 2006;6:1-6.
27. Tan WB, Zhang Y. Multi-functional chitosan nanoparticles encapsulating quantum dots and gd-DTPA as imaging probes for bio-applications. J Nanosci Nanotechnol 2007;7:2389-2393.
28. Wang S, Jarrett BR, Kauzlarich SM, Louie AY. Core/shell quantum dots with high relaxivity and photoluminescence for multimodality imaging. J Am Chem Soc 2007;129:3848-3856.
29. Santra S, Yang H, Stanley JT, Holloway PH, Moudgil BM, Walter G, Mericle RA. Rapid and effective labeling of brain tissue using TAT-conjugated CdS:Mn/ZnS quantum dots. Chem Commun (Camb) 2005;25:3144-3146.
30. Xie R, Battaglia D, Peng X. Colloidal InP nanocrystals as efficient emitters covering blue to near-infrared. J Am Chem Soc 2007;129:15432-15433.
31. Bottrill M, Kwok L, Long NJ. Lanthanides in magnetic resonance imaging. Chem Soc Rev 2006;35:557-571.
32. Bharali DJ, Lucey DW, Jayakumar H, Pudavar HE, Prasad PN. Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy. J Am Chem Soc 2005;127:11364-11371.
33. Flora SJS. Possible health hazards associated with the use of toxic metals in semiconductor industries. J Occup Health 2000;42:105.
34. Yamazaki K, Tanaka A, Hirata M, Omura M, Makita Y, Inoue N, Sugio K, Sugimachi K. Long term pulmonary toxicity of indium arsenide and indium phosphide instilled intratracheally in hamsters. J Occup Health 2000;42:169.
35. Oda K. Toxicity of a low level of indium phosphide (InP) in rats after intratracheal instillation. Ind Health 1997;35:61-68.
36. Uemura T, Oda K, Omae K, Takebayashi T, Nomiyama T, Ishizuka C, Hosoda K, Sakurai H, Yamazaki K, Kabe I. Effects of intracheally administered indium phosphide on male Fischer 344 rats. J Occup Health 1997;39:205.
37. Omura M, Yamazaki K, Tanaka A, Hirata M, Makita Y, Inoue N. Changes in the testicular damage caused by indium arsenide and indium phosphide in hamsters during two years after intratracheal instillations. J Occup Health 2000;42:196.
38. Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Itty Ipe B, Bawendi MG, Frangioni JV. Renal clearance of quantum dots. Nat Biotechnol 2007;25:1165-1170.
39. Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, Nakayama A, Parker JA, Mihaljevic T, Laurence RG, Dor DM, Cohn LH, Bawendi MG, Frangioni JV. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol 2004;22:93-97.
40. Grabarek Z, Gergely J. Zero-length crosslinking procedure with the use of active esters. Anal Biochem 1990;185:131-135.
41. Gerbec JA, Magana D, Washington A, Strouse GF. Microwave-enhanced reaction rates for nanoparticle synthesis. J Am Chem Soc 2005;127:15791-15800.
42. Haubold S, Haase M, Kornowski A, Weller H. Strongly luminescent InP/ZnS core-shell nanoparticles. Chem Phys Chem 2001;2:331-334.
43. Talapin DV, Rogach AL, Kornowski A, Haase M, Weller H. Highly luminescent monodisperse CdSe and CdSe/ZnS nanocrystals synthesized in a hexadecylamine-trioctylphosphine oxide-trioctylphospine mixture. Nano Lett 2001;1:207-211.
44. Cao YW, Banin U. Growth and properties of semiconductor core/shell nanocrystals with InAs cores. J Am Chem Soc 2000;122:9692-9702.
45. Shi L, Rosenzweig N, Rosenzweig Z. Luminescent quantum dots fluorescence resonance energy transfer-based probes for enzymatic activity and enzyme inhibitors. Anal Chem 2007;79:208-214.
46. Khalil IA, Kogure K, Akita H, Harashima H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol Rev 2006;58:32-45.
47. Clark P. Bi-exponential proton transverse relaxation rate (R2) image analysis using RF field intensity-weighted spin density projection: potential for R2 measurement of iron-loaded liver Magn Reson Imaging 2003;21:519-530.
48. Brekke C, Morgan SC, Lowe AS, Meade TJ, Price J, Williams SCR, Modo M. The in vitro effects of a bimodal contrast agent on cellular functions and relaxometry. NMR Biomed 2007;20:77-89.
49. Strijkers GJ, Hak S, Kok MB, Springer CS Jr, Nicolay K. Three-compartment T(1) relaxation model for intracellular paramagnetic contrast agents. Magn Reson Med 2009;61:1049-1058.
50. Mulder WJ, Castermans K, van Beijnum JR, Oude Egbrink MG, Chin PT, Fayad ZA, Lowik CW, Kaijzel EL, Que I, Storm G, Strijkers GJ, Griffioen AW, Nicolay K. Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots. Angiogenesis 2009;12:17-24.
51. Koole R, van Schooneveld MM, Hilhorst J, Castermans K, Cormode DP, Strijkers GJ, de Mello Donega C, Vanmaekelbergh D, Griffioen AW, Nicolay K, Fayad ZA, Meijerink A, Mulder WJ. Paramagnetic lipid-coated silica nanoparticles with a fluorescent quantum dot core: a new contrast agent platform for multimodality imaging. Bioconjug Chem 2008;19:2471-2479.
52. Mulder WJ, Strijkers GJ, van Tilborg GA, Griffioen AW, Nicolay K. Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging NMR. Biomed 2006;19:142-164.
53. van Tilborg GA, Mulder WJ, Chin PT, Storm G, Reutelingsperger CP, Nicolay K, Strijkers GJ. Annexin A5-conjugated quantum dots with a paramagnetic lipidic coating for the multimodal detection of apoptotic cells. Bioconjug Chem 2006;17:865-868.
54. Moore A, Medarova Z, Potthast A, Dai G. In vivo targeting of underglycosylated MUC-1 tumor antigen using a multimodal imaging probe. Cancer Res 2004;64:1821-1827.
55. Lisy MR, Hartung A, Lang C, Schuler D, Richter W, Reichenbach JR, Kaiser WA, Hilger I. Fluorescent bacterial magnetic nanoparticles as bimodal contrast agents. Invest Radiol 2007;42:235-241.
56. Kok MB, Hak S, Mulder WJ, van der Schaft DW, Strijkers GJ, Nicolay K. Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T(1) and T(2) relaxivity. Magn Reson Med 2009;61:1022-1032.
57. Fawell S, Seery J, Daikh Y, Moore C, Chen LL, Pepinsky B, Barsoum J. Tat-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci USA 1994;91:664-668.
58. Mann DA, Frankel AD. Endocytosis and targeting of exogenous HIV-1 tat protein. EMBO J 1991;10:1733-1739.
59. Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol 2000;18:410-414.
60. Ruan G, Agrawal A, Marcus AI, Nie S. Imaging and tracking of tat peptide-conjugated quantum dots in living cells: new insights into nanoparticle uptake, intracellular transport, and vesicle shedding. J Am Chem Soc 2007;129:14759-14766.
61. Bulte JW, Zhang S, van Gelderen P, Herynek V, Jordan EK, Duncan ID, Frank JA. Neurotransplantation of magnetically labeled oligodendrocyte progenitors: magnetic resonance tracking of cell migration and myelination. Proc Natl Acad Sci USA 1999;96:15256-15261.
62. Aime S, Barge A, Cabella C, Crich SG, Gianolio E. Targeting cells with MR imaging probes based on paramagnetic gd(III) chelates. Curr Pharm Biotechnol 2004;5:509-518.
63. Frank JA, Anderson SA, Kalsih H, Jordan EK, Lewis BK, Yocum GT, Arbab AS. Methods for magnetically labeling stem and other cells for detection by in vivo magnetic resonance imaging. Cytotherapy 2004;6:621-625.
64. Jung CW, Jacobs P. Physical and chemical properties of superparamagnetic iron oxide MR contrast agents: ferumoxides, ferumoxtran, ferumoxsil. Magn Reson Imaging 1995;13:661-674.