Costunolide inhibits cyclooxygenase-2 expression induced by toll-like receptor 3 or 4 agonist

Toxicology and Environmental Health Sciences

Volumn 1, Issue 2, 2009, Pages 122-126

  Park, Se Jeong ^a   Yun, Sae Mi ^a   Lee, A Neum ^a   Ahn, Sang II ^a   Lee, Mi Yong ^a   Youn, Hyung Sun ^a  

^a Soonchunhyang University   (South Korea)

Author keywords

Costunolide; Cyclooxygenase 2; Nuclear factor B; Toll like receptor

Indexed keywords

EID: 77956344062     PISSN: 20059752     EISSN: 22337784     Source Type: Journal    
DOI: 10.1007/BF03216473     Document Type: Article

References (24)

1. Medzhitov, R. Toll-like receptors and innate immunity. Nat Rev Immunol1, 135-145 (2001).
2. O'Neill, L. A. TLRs: Professor Mechnikov, sit on your hat. Trends Immunol25, 687-693 (2004).
3. Vogel, S. N., Fitzgerald, K. A. & Fenton, M. J. TLRs: Differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol Interv3, 466-477 (2003).
4. Takeda, K. & Akira, S. Toll-like receptors in innate immunity. Int Immunol17, 1-14 (2005).
5. Lin, R., Heylbroeck, C., Pitha, P. M. & Hiscott, J. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biolbd18, 2986-2996 (1998).
6. Navarro, L. & David, M. p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide. J Biol Chem274, 35535-35538 (1999).
7. Kawai, T. et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol167, 5887-5894 (2001).
8. Gao, J. J. et al. Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: Pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene. J Immunol161, 4803-4810 (1998).
9. Pandey, M. M., Rastogi, S. & Rawat, A. K. Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant. J Ethnopharmacol110, 379-390 (2007).
10. Matsuda, H. et al. Effects of sesquiterpenes and amino acid-sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide-activated macrophages. Bioorg Med Chem11, 709-715 (2003).
11. Kang, J. S., Yoon, Y. D., Lee, K. H., Park, S. K. & Kim, H. M. Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264. 7 cells. Biochem Biophys Res Commun313, 171-177 (2004).
12. Lee, M. G., Lee, K. T., Chi, S. G. & Park, J. H. Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release. Biol Pharm Bull24, 303-306 (2001).
13. Chen, H. C., Chou, C. K., Lee, S. D., Wang, J. C. & Yeh, S. F. Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. Antiviral Res27, 99-109 (1995).
14. Ahn, S. I., Lee, J. K. & Youn, H. S. Inhibition of homodimerization of toll-like receptor 4 by 6-shogaol. Mol Cells27, 211-215 (2009).
15. Ahn, S. I. & Youn, H. S. Guggulsterone suppresses the activation of NF-κB and expression of COX-2 induced by toll-like receptor 2, 3, and 4 agonists. Food Sci Biotechnol17, 1294-1298 (2008).
16. Youn, H. S. et al. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: Molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol175, 3339-3346 (2005).
17. Youn, H. S., Saitoh, S. I., Miyake, K. & Hwang, D. H. Inhibition of homodimerization of Toll-like receptor 4 by curcumin. Biochem Pharmacol72, 62-69 (2006).
18. Simmons, D. L., Levy, D. B., Yannoni, Y. & Erikson, R. L. Identification of a phorbol ester-repressible vsrc-inducible gene. Proc Natl Acad Sci USA86, 1178-1182 (1989).
19. Vane, J. R., Bakhle, Y. S. & Botting, R. M. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol38, 97-120 (1998).
20. Murakami, A. & Ohigashi, H. Targeting NOX, INOS and COX-2 in inflammatory cells: Chemoprevention using food phytochemicals. Int J Cancer121, 2357-2363 (2007).
21. Kawai, T. & Akira, S. Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci1143, 1-20 (2008).
22. Kawai, T. & Akira, S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med13, 460-469 (2007).
23. Fitzgerald, K. A. et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol4, 491-496 (2003).
24. Meylan, E. et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappaB activation. Nat Immunol5, 503-507 (2004).