-
1
-
-
0023887476
-
An assessment of clinically useful measures of the consequences of treatment
-
Laupacis, A., Sackett, D. L. & Roberts, R. S. An assessment of clinically useful measures of the consequences of treatment. N. Engl. J. Med. 318, 1728-1734 (1988).
-
(1988)
N. Engl. J. Med.
, vol.318
, pp. 1728-1734
-
-
Laupacis, A.1
Sackett, D.L.2
Roberts, R.S.3
-
2
-
-
77649126524
-
Heart disease and stroke statistics-2010 update: A report from the American Heart Association
-
Lloyd-Jones, D. et al. Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 121, e46-e215 (2010).
-
(2010)
Circulation
, vol.121
-
-
Lloyd-Jones, D.1
-
3
-
-
34249775519
-
Combining multiple approaches for the secondary prevention of vascular events after stroke: A quantitative modeling study
-
Hackam, D. G. & Spence, J. D. Combining multiple approaches for the secondary prevention of vascular events after stroke: a quantitative modeling study. Stroke 38, 1881-1885 (2007).
-
(2007)
Stroke
, vol.38
, pp. 1881-1885
-
-
Hackam, D.G.1
Spence, J.D.2
-
4
-
-
34347363803
-
Has Ontarios Stroke System really made a difference?
-
Lewis, M., Trypuc, J., Lindsay, P., OCallaghan, C. & Dishaw, A. Has Ontarios Stroke System really made a difference? Healthc. Q. 9, 50-59 (2006).
-
(2006)
Healthc. Q.
, vol.9
, pp. 50-59
-
-
Lewis, M.1
Trypuc, J.2
Lindsay, P.3
Ocallaghan, C.4
Dishaw, A.5
-
5
-
-
44449107747
-
Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack
-
Adams, R. J. et al. Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack. Stroke 39, 1647-1652 (2008).
-
(2008)
Stroke
, vol.39
, pp. 1647-1652
-
-
Adams, R.J.1
-
6
-
-
0034645547
-
Short-term prognosis after emergency department diagnosis of TIA
-
Johnston, S. C., Gress, D. R., Browner, W. S. & Sidney, S. Short-term prognosis after emergency department diagnosis of TIA. JAMA 284, 2901-2906 (2000).
-
(2000)
JAMA
, vol.284
, pp. 2901-2906
-
-
Johnston, S.C.1
Gress, D.R.2
Browner, W.S.3
Sidney, S.4
-
7
-
-
67650034775
-
Population-based study of risk and predictors of stroke in the first few hours after a TIA
-
Chandratheva, A., Mehta, Z., Geraghty, O. C., Marquardt, L. & Rothwell, P. M. Population-based study of risk and predictors of stroke in the first few hours after a TIA. Neurology 72, 1941-1947 (2009).
-
(2009)
Neurology
, vol.72
, pp. 1941-1947
-
-
Chandratheva, A.1
Mehta, Z.2
Geraghty, O.C.3
Marquardt, L.4
Rothwell, P.M.5
-
8
-
-
35248869805
-
Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (eXPReSS study): A prospective population-based sequential comparison
-
Rothwell, P. M. et al. effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (eXPReSS study): a prospective population-based sequential comparison. Lancet 370, 1432-1442 (2007).
-
(2007)
Lancet
, vol.370
, pp. 1432-1442
-
-
Rothwell, P.M.1
-
9
-
-
77951749588
-
Multicenter external validation of the ABCD2 score in triaging TIA patients
-
Tsivgoulis, G. et al. Multicenter external validation of the ABCD2 score in triaging TIA patients. Neurology 74, 1351-1357 (2010).
-
(2010)
Neurology
, vol.74
, pp. 1351-1357
-
-
Tsivgoulis, G.1
-
10
-
-
70349239307
-
Does ABCD2 score below 4 allow more time to evaluate patients with a transient ischemic attack?
-
Amarenco, P. et al. Does ABCD2 score below 4 allow more time to evaluate patients with a transient ischemic attack? Stroke 40, 3091-3095 (2009).
-
(2009)
Stroke
, vol.40
, pp. 3091-3095
-
-
Amarenco, P.1
-
11
-
-
70349174819
-
Stroke: Using the ABCD system to evaluate transient ischemic attack
-
Giles, M. F. & Rothwell, P. M. Stroke: using the ABCD system to evaluate transient ischemic attack. Nat. Rev. Neurol. 5, 470-471 (2009).
-
(2009)
Nat. Rev. Neurol.
, vol.5
, pp. 470-471
-
-
Giles, M.F.1
Rothwell, P.M.2
-
12
-
-
77950274089
-
Systematic review and pooled analysis of published and unpublished validations of the ABCD and ABCD2 transient ischemic attack risk scores
-
Giles, M. F. & Rothwell, P. M. Systematic review and pooled analysis of published and unpublished validations of the ABCD and ABCD2 transient ischemic attack risk scores. Stroke 41, 667-673 (2010).
-
(2010)
Stroke
, vol.41
, pp. 667-673
-
-
Giles, M.F.1
Rothwell, P.M.2
-
13
-
-
52049092321
-
Primary prevention of stroke by healthy lifestyle
-
Chiuve, S. e. et al. Primary prevention of stroke by healthy lifestyle. Circulation 118, 947-954 (2008).
-
(2008)
Circulation
, vol.118
, pp. 947-954
-
-
Chiuve, S.E.1
-
15
-
-
0033144604
-
Passive smoking as well as active smoking increases the risk of acute stroke
-
Bonita, R., Duncan, J., Truelsen, R., Jackson, R. T. & Beaglehole, R. Passive smoking as well as active smoking increases the risk of acute stroke. Tob. Control 8, 156-160 (1999).
-
(1999)
Tob. Control
, vol.8
, pp. 156-160
-
-
Bonita, R.1
Duncan, J.2
Truelsen, R.3
Jackson, R.T.4
Beaglehole, R.5
-
16
-
-
0018141860
-
Effect of passive smoking on angina pectoris
-
Aronow, W. S. Effect of passive smoking on angina pectoris. N. Engl. J. Med. 299, 21-24 (1978).
-
(1978)
N. Engl. J. Med.
, vol.299
, pp. 21-24
-
-
Aronow, W.S.1
-
17
-
-
77950208330
-
Smoking cessation for hospitalized smokers: An evaluation of the "ottawa Model"
-
Reid, R. D. et al. Smoking cessation for hospitalized smokers: an evaluation of the "Ottawa Model". Nicotine Tob. Res. 12, 11-18 (2010).
-
(2010)
Nicotine Tob. Res.
, vol.12
, pp. 11-18
-
-
Reid, R.D.1
-
19
-
-
33745611449
-
Efficacy of varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: A randomized controlled trial
-
Jorenby, D. e. et al. Efficacy of varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA 296, 56-63 (2006).
-
(2006)
JAMA
, vol.296
, pp. 56-63
-
-
Jorenby, D.E.1
-
20
-
-
74949122161
-
Efficacy and safety of varenicline for smoking cessation in patients with cardiovascular disease: A randomized trial
-
Rigotti, N. A. et al. efficacy and safety of varenicline for smoking cessation in patients with cardiovascular disease: a randomized trial. Circulation 121, 221-229 (2010).
-
(2010)
Circulation
, vol.121
, pp. 221-229
-
-
Rigotti, N.A.1
-
21
-
-
0015985626
-
Stopping smoking after myocardial infarction
-
Burt, A. et al. Stopping smoking after myocardial infarction. Lancet 1, 304-306 (1974).
-
(1974)
Lancet
, vol.1
, pp. 304-306
-
-
Burt, A.1
-
22
-
-
0026631267
-
Treatment of obesity
-
Garrow, J. S. Treatment of obesity. Lancet 340, 409-413 (1992).
-
(1992)
Lancet
, vol.340
, pp. 409-413
-
-
Garrow, J.S.1
-
23
-
-
74549208859
-
Exercise as stroke prophylaxis
-
Reimers, C. D., Knapp, G. & Reimers, A. K. Exercise as stroke prophylaxis. Dtsch. Arztebl. Int. 106, 715-721 (2009).
-
(2009)
Dtsch. Arztebl. Int.
, vol.106
, pp. 715-721
-
-
Reimers, C.D.1
Knapp, G.2
Reimers, A.K.3
-
24
-
-
61849141217
-
Biological mechanisms of stroke prevention by physical activity in type 2 diabetes
-
Agosti, V., Graziano, S., Artiaco, L. & Sorrentino, G. Biological mechanisms of stroke prevention by physical activity in type 2 diabetes. Acta Neurol. Scand. 119, 213-223 (2009).
-
(2009)
Acta Neurol. Scand.
, vol.119
, pp. 213-223
-
-
Agosti, V.1
Graziano, S.2
Artiaco, L.3
Sorrentino, G.4
-
25
-
-
77951769435
-
Excess body weight and incidence of stroke: Meta-analysis of prospective studies with 2 million participants
-
Strazzullo, P. et al. excess body weight and incidence of stroke: meta-analysis of prospective studies with 2 million participants. Stroke 41, e418-e426 (2010).
-
(2010)
Stroke
, vol.41
-
-
Strazzullo, P.1
-
26
-
-
0348222671
-
Inflammation: The link between insulin resistance, obesity and diabetes
-
Dandona, P., Aljada, A. & Bandyopadhyay, A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol. 25, 4-7 (2004).
-
(2004)
Trends Immunol.
, vol.25
, pp. 4-7
-
-
Dandona, P.1
Aljada, A.2
Bandyopadhyay, A.3
-
27
-
-
77950488227
-
Orange juice neutralizes the proinflammatory effect of a high-fat, highcarbohydrate meal and prevents endotoxin increase and Toll-like receptor expression
-
Ghanim, H. et al. Orange juice neutralizes the proinflammatory effect of a high-fat, highcarbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am. J. Clin. Nutr. 91, 940-949 (2010).
-
(2010)
Am. J. Clin. Nutr.
, vol.91
, pp. 940-949
-
-
Ghanim, H.1
-
28
-
-
77951968184
-
Macronutrient intake induces oxidative and inflammatory stress: Potential relevance to atherosclerosis and insulin resistance
-
Dandona, P., Ghanim, H., Chaudhuri, A., Dhindsa, S. & Kim, S. S. Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance. Exp. Mol. Med. 42, 245-253 (2010).
-
(2010)
Exp. Mol. Med.
, vol.42
, pp. 245-253
-
-
Dandona, P.1
Ghanim, H.2
Chaudhuri, A.3
Dhindsa, S.4
Kim, S.S.5
-
29
-
-
0021989139
-
The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger
-
Stunkard, A. J. & Messick, S. The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J. Psychosom. Res. 29, 71-83 (1985).
-
(1985)
J. Psychosom. Res.
, vol.29
, pp. 71-83
-
-
Stunkard, A.J.1
Messick, S.2
-
30
-
-
0141720388
-
Calorie restriction and aging: Review of the literature and implications for studies in humans
-
Heilbronn, L. K. & Ravussin, E. Calorie restriction and aging: review of the literature and implications for studies in humans. Am. J. Clin. Nutr. 78, 361-369 (2003).
-
(2003)
Am. J. Clin. Nutr.
, vol.78
, pp. 361-369
-
-
Heilbronn, L.K.1
Ravussin, E.2
-
31
-
-
33847764645
-
Aging, adiposity, and calorie restriction
-
Fontana, L. & Klein, S. Aging, adiposity, and calorie restriction. JAMA 297, 986-994 (2007).
-
(2007)
JAMA
, vol.297
, pp. 986-994
-
-
Fontana, L.1
Klein, S.2
-
32
-
-
0017841253
-
Impact of Westernization on the nutrition of Japanese: Changes in physique, cancer, longevity and centenarians
-
Kagawa, Y. Impact of Westernization on the nutrition of Japanese: changes in physique, cancer, longevity and centenarians. Prev. Med. 7, 205-217 (1978).
-
(1978)
Prev. Med.
, vol.7
, pp. 205-217
-
-
Kagawa, Y.1
-
33
-
-
61449183682
-
Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
-
Sacks, F. M. et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N. Engl. J. Med. 360, 859-873 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 859-873
-
-
Sacks, F.M.1
-
34
-
-
77950515150
-
Dietary intervention to reverse carotid atherosclerosis
-
Shai, I. et al. Dietary intervention to reverse carotid atherosclerosis. Circulation 121, 1200-1208 (2010).
-
(2010)
Circulation
, vol.121
, pp. 1200-1208
-
-
Shai, I.1
-
35
-
-
85046916367
-
Dietary cholesterol and egg yolks: Not for patients at risk of vascular disease
-
in press
-
Spence, J. D., Jenkins, D. J. & Davignon, J. Dietary cholesterol and egg yolks: not for patients at risk of vascular disease. Can. J. Cardiol. (in press).
-
Can. J. Cardiol.
-
-
Spence, J.D.1
Jenkins, D.J.2
Davignon, J.3
-
36
-
-
0032955055
-
Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: Final report of the Lyon Diet Heart Study
-
de Lorgeril, M. et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 99, 779-785 (1999).
-
(1999)
Circulation
, vol.99
, pp. 779-785
-
-
De Lorgeril, M.1
-
37
-
-
0037207464
-
Rebuilding the food pyramid
-
Willett, W. C. & Stampfer, M. J. Rebuilding the food pyramid. Sci. Am. 288, 64-71 (2003).
-
(2003)
Sci. Am.
, vol.288
, pp. 64-71
-
-
Willett, W.C.1
Stampfer, M.J.2
-
38
-
-
33645757846
-
Trans fatty acids and cardiovascular disease
-
Mozaffarian, D., Katan, M. B., Ascherio, A., Stampfer, M. J. & Willett, W. C. Trans fatty acids and cardiovascular disease. N. Engl. J. Med. 354, 1601-1613 (2006).
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 1601-1613
-
-
Mozaffarian, D.1
Katan, M.B.2
Ascherio, A.3
Stampfer, M.J.4
Willett, W.C.5
-
39
-
-
77953943136
-
Removing industrial trans fat from foods
-
Mozaffarian, D. & Stampfer, M. J. Removing industrial trans fat from foods. BMJ 340, c1826 (2010).
-
(2010)
BMJ
, vol.340
-
-
Mozaffarian, D.1
Stampfer, M.J.2
-
40
-
-
0029022932
-
Mediterranean diet and public health: Personal reflections
-
Keys, A. Mediterranean diet and public health: personal reflections. Am. J. Clin. Nutr. 61, 1321S-1323S (1995).
-
(1995)
Am. J. Clin. Nutr.
, vol.61
-
-
Keys, A.1
-
41
-
-
47549110641
-
Weight loss with a lowcarbohydrate, Mediterranean, or low-fat diet
-
Shai, I. et al. Weight loss with a lowcarbohydrate, Mediterranean, or low-fat diet. N. Engl. J. Med. 359, 229-241 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 229-241
-
-
Shai, I.1
-
42
-
-
1842331509
-
Plasma homocysteine as a risk factor for vascular disease
-
Graham, I. M. et al. Plasma homocysteine as a risk factor for vascular disease. JAMA 277, 1775-1781 (1997).
-
(1997)
JAMA
, vol.277
, pp. 1775-1781
-
-
Graham, I.M.1
-
43
-
-
1842370239
-
Plasma homocysteine levels and mortality in patients with coronary artery disease
-
Nygd, O. et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N. Engl. J. Med. 337, 230-236 (1997).
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 230-236
-
-
Nygd, O.1
-
44
-
-
0037497965
-
Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoe-deficient mice
-
Zhou, J. et al. effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoe-deficient mice. Atherosclerosis 168, 255-262 (2003).
-
(2003)
Atherosclerosis
, vol.168
, pp. 255-262
-
-
Zhou, J.1
-
45
-
-
33645796222
-
Homocysteine lowering and cardiovascular events after acute myocardial infarction
-
Bonaa, K. H. et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N. Engl. J. Med. 354, 1578-1588 (2006).
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 1578-1588
-
-
Bonaa, K.H.1
-
46
-
-
33645777279
-
Homocysteine trials-clear outcomes for complex reasons
-
Loscalzo, J. Homocysteine trials-clear outcomes for complex reasons. N. Engl. J. Med. 354, 1629-1632 (2006).
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 1629-1632
-
-
Loscalzo, J.1
-
47
-
-
27644521579
-
Vitamin Intervention for Stroke Prevention trial: An efficacy analysis
-
Spence, J. D., Bang, H., Chambless, L. E. & Stampfer, M. J. Vitamin Intervention For Stroke Prevention trial: an efficacy analysis. Stroke 36, 2404-2409 (2005).
-
(2005)
Stroke
, vol.36
, pp. 2404-2409
-
-
Spence, J.D.1
Bang, H.2
Chambless, L.E.3
Stampfer, M.J.4
-
48
-
-
33645753544
-
Homocysteine lowering with folic acid and B vitamins in vascular disease
-
Lonn, e. et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N. Engl. J. Med. 354, 1567-1577 (2006).
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 1567-1577
-
-
Lonn, E.1
-
49
-
-
0036843983
-
Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults
-
Rajan, S. et al. Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults. J. Am. Geriatr. Soc. 50, 1789-1795 (2002).
-
(2002)
J. Am. Geriatr. Soc.
, vol.50
, pp. 1789-1795
-
-
Rajan, S.1
-
50
-
-
34547743420
-
Homocysteine-lowering therapy: A role in stroke prevention?
-
Spence, J. D. Homocysteine-lowering therapy: a role in stroke prevention? Lancet Neurol. 7, 830-838 (2007).
-
(2007)
Lancet Neurol.
, vol.7
, pp. 830-838
-
-
Spence, J.D.1
-
51
-
-
26444612124
-
Culprit factors for the failure of wellconducted warfarin therapy to prevent ischemic events in patients with atrial fibrillation: The role of homocysteine
-
Poli, D. et al. Culprit factors for the failure of wellconducted warfarin therapy to prevent ischemic events in patients with atrial fibrillation: the role of homocysteine. Stroke 36, 2159-2163 (2005).
-
(2005)
Stroke
, vol.36
, pp. 2159-2163
-
-
Poli, D.1
-
52
-
-
77951645401
-
Effect of B-vitamin therapy on progression of diabetic nephropathy: A randomized controlled trial
-
House, A. A. et al. Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial. JAMA 303, 1603-1609 (2010).
-
(2010)
JAMA
, vol.303
, pp. 1603-1609
-
-
House, A.A.1
-
53
-
-
33845472466
-
The effect of mesna on plasma total homocysteine concentration in hemodialysis patients
-
Urquhart, B. L., Freeman, D. J., Spence, J. D. & House, A. A. The effect of mesna on plasma total homocysteine concentration in hemodialysis patients. Am. J. Kidney Dis. 49, 109-117 (2007).
-
(2007)
Am. J. Kidney Dis.
, vol.49
, pp. 109-117
-
-
Urquhart, B.L.1
Freeman, D.J.2
Spence, J.D.3
House, A.A.4
-
54
-
-
14044269477
-
The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings
-
Herrmann, W., Obeid, R., Schorr, H. & Geisel, J. The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings. Curr. Drug Metab. 6, 47-53 (2005).
-
(2005)
Curr. Drug Metab.
, vol.6
, pp. 47-53
-
-
Herrmann, W.1
Obeid, R.2
Schorr, H.3
Geisel, J.4
-
55
-
-
71749120426
-
Determinants of plasma methylmalonic acid in a large population: Implications for assessment of vitamin B12 status
-
Vogiatzoglou, A. et al. Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status. Clin. Chem. 55, 2198-2206 (2009).
-
(2009)
Clin. Chem.
, vol.55
, pp. 2198-2206
-
-
Vogiatzoglou, A.1
-
56
-
-
33748361787
-
Nutrition and stroke prevention
-
Spence, J. D. Nutrition and stroke prevention. Stroke 37, 2430-2435 (2006).
-
(2006)
Stroke
, vol.37
, pp. 2430-2435
-
-
Spence, J.D.1
-
57
-
-
59649103167
-
Vitamin B-12 and cognition in the elderly
-
Smith, A. D. & Refsum, H. Vitamin B-12 and cognition in the elderly. Am. J. Clin. Nutr. 89, 707S-711S (2009).
-
(2009)
Am. J. Clin. Nutr.
, vol.89
-
-
Smith, A.D.1
Refsum, H.2
-
58
-
-
9144248446
-
Hypertension treatment and control in five european countries, Canada, and the United States
-
Wolf-Maier, K. et al. Hypertension treatment and control in five european countries, Canada, and the United States. Hypertension 43, 10-17 (2004).
-
(2004)
Hypertension
, vol.43
, pp. 10-17
-
-
Wolf-Maier, K.1
-
59
-
-
16844384024
-
Blood pressure control and risk of stroke: A population-based prospective cohort study
-
Li, C., Engstrom, G., Hedblad, B., Berglund, G. & Janzon, L. Blood pressure control and risk of stroke: a population-based prospective cohort study. Stroke 36, 725-730 (2005).
-
(2005)
Stroke
, vol.36
, pp. 725-730
-
-
Li, C.1
Engstrom, G.2
Hedblad, B.3
Berglund, G.4
Janzon, L.5
-
60
-
-
0003953636
-
-
(eds Laragh, J. H. & Brenner, B.) Raven Press, New York
-
Spence, J. D. In Hypertension: Pathophysiology, Diagnosis, and Management (eds Laragh, J. H. & Brenner, B.) 741-753 (Raven Press, New York, 1995).
-
(1995)
Hypertension: Pathophysiology, Diagnosis, and Management
, pp. 741-753
-
-
Spence, J.D.1
-
62
-
-
0021925301
-
Prevalence and control of hypertension in an Ontario county
-
Birkett, N. J., Donner, A. P. & Maynard, M. Prevalence and control of hypertension in an Ontario county. Can. Med. Assoc. J. 132, 1019-1024 (1985).
-
(1985)
Can. Med. Assoc. J.
, vol.132
, pp. 1019-1024
-
-
Birkett, N.J.1
Donner, A.P.2
Maynard, M.3
-
63
-
-
0022513557
-
Antihypertensive drugs and prevention of atherosclerotic stroke
-
Spence, J. D. Antihypertensive drugs and prevention of atherosclerotic stroke. Stroke 17, 808-810 (1986).
-
(1986)
Stroke
, vol.17
, pp. 808-810
-
-
Spence, J.D.1
-
64
-
-
0022453546
-
Do family physicians need medical assistants to detect and manage hypertension?
-
Bass, M. J., McWhinney, I. R. & Donner, A. Do family physicians need medical assistants to detect and manage hypertension? CMAJ 134, 1247-1255 (1986).
-
(1986)
CMAJ
, vol.134
, pp. 1247-1255
-
-
Bass, M.J.1
McWhinney, I.R.2
Donner, A.3
-
65
-
-
0032737636
-
Physiologic tailoring of therapy for resistant hypertension: 20 years experience with stimulated renin profiling
-
Spence, J. D. Physiologic tailoring of therapy for resistant hypertension: 20 years experience with stimulated renin profiling. Am. J. Hypertens. 12, 1077-1083 (1999).
-
(1999)
Am. J. Hypertens.
, vol.12
, pp. 1077-1083
-
-
Spence, J.D.1
-
66
-
-
0016423806
-
Stimulated renin: A screening test for hypertension
-
Wallach, L., Nyarai, I. & Dawson, K. G. Stimulated renin: a screening test for hypertension. Ann. Intern. Med 82, 27-34 (1975).
-
(1975)
Ann. Intern. Med
, vol.82
, pp. 27-34
-
-
Wallach, L.1
Nyarai, I.2
Dawson, K.G.3
-
67
-
-
0022615449
-
Effect of non-steroidal anti-inflammatory drugs on control of hypertension by beta-blockers and diuretics
-
Wong, D. G., Spence, J. D., Lamki, L. & McDonald, J. W. Effect of non-steroidal anti-inflammatory drugs on control of hypertension by beta-blockers and diuretics. Lancet 1, 997-1001 (1986).
-
(1986)
Lancet
, vol.1
, pp. 997-1001
-
-
Wong, D.G.1
Spence, J.D.2
Lamki, L.3
McDonald, J.W.4
-
68
-
-
67649361948
-
Plasma Renin test-guided drug treatment algorithm for correcting patients with treated but uncontrolled hypertension: A randomized controlled trial
-
Egan, B. M. et al. Plasma Renin test-guided drug treatment algorithm for correcting patients with treated but uncontrolled hypertension: a randomized controlled trial. Am. J. Hypertens. 22, 792-801 (2009).
-
(2009)
Am. J. Hypertens.
, vol.22
, pp. 792-801
-
-
Egan, B.M.1
-
69
-
-
77951601349
-
Physiologic tailoring of treatment in resistant hypertension
-
Spence, J. D. Physiologic tailoring of treatment in resistant hypertension. Curr. Cardiol. Rev. 6, 213-219 (2010).
-
(2010)
Curr. Cardiol. Rev.
, vol.6
, pp. 213-219
-
-
Spence, J.D.1
-
70
-
-
0036242751
-
Treatment options for renovascular hypertension
-
Spence, J. D. Treatment options for renovascular hypertension. Expert Opin. Pharmacother. 3, 411-416 (2002).
-
(2002)
Expert Opin. Pharmacother.
, vol.3
, pp. 411-416
-
-
Spence, J.D.1
-
71
-
-
33646672176
-
Racial and geographic differences in awareness, treatment, and control of hypertension: The Reasons for Geographic and Racial Differences in Stroke study
-
Howard, G. et al. Racial and geographic differences in awareness, treatment, and control of hypertension: the Reasons for Geographic And Racial Differences in Stroke study. Stroke 37, 1171-1178 (2006).
-
(2006)
Stroke
, vol.37
, pp. 1171-1178
-
-
Howard, G.1
-
72
-
-
0029926802
-
Lipids and stroke: A paradox resolved
-
Hachinski, V. et al. Lipids and stroke: a paradox resolved. Arch. Neurol. 53, 303-308 (1996).
-
(1996)
Arch. Neurol.
, vol.53
, pp. 303-308
-
-
Hachinski, V.1
-
73
-
-
33746895436
-
High-dose atorvastatin after stroke or transient ischemic attack
-
Amarenco, P. et al. High-dose atorvastatin after stroke or transient ischemic attack. N. Engl. J. Med. 355, 549-559 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 549-559
-
-
Amarenco, P.1
-
74
-
-
58149343413
-
Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: A secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial
-
Sillesen, H. et al. Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Stroke 39, 3297-3302 (2008).
-
(2008)
Stroke
, vol.39
, pp. 3297-3302
-
-
Sillesen, H.1
-
75
-
-
41649107358
-
Simvastatin with or without ezetimibe in familial hypercholesterolemia
-
Kastelein, J. J. et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N. Engl. J. Med. 358, 1431-1443 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 1431-1443
-
-
Kastelein, J.J.1
-
76
-
-
55549132673
-
Is carotid intima-media thickness a reliable clinical predictor?
-
Spence, J. D. Is carotid intima-media thickness a reliable clinical predictor? Mayo Clin. Proc. 83, 1299-1300 (2008).
-
(2008)
Mayo Clin. Proc.
, vol.83
, pp. 1299-1300
-
-
Spence, J.D.1
-
77
-
-
55549092294
-
The importance of distinguishing between diffuse carotid intima medial thickening and focal plaque
-
Spence, J. D. The importance of distinguishing between diffuse carotid intima medial thickening and focal plaque. Can. J. Cardiol. 24, 61C-64C (2008).
-
(2008)
Can. J. Cardiol.
, vol.24
-
-
Spence, J.D.1
-
78
-
-
75149166553
-
Correlation between carotid intimal/medial thickness and atherosclerosis. A point of view from pathology
-
Finn, A. V., Kolodgie, F. D. & Virmani, R. Correlation between carotid intimal/medial thickness and atherosclerosis. A point of view from pathology. Arterioscler. Thromb. Vasc. Biol. 30, 177-181 (2009).
-
(2009)
Arterioscler. Thromb. Vasc. Biol.
, vol.30
, pp. 177-181
-
-
Finn, A.V.1
Kolodgie, F.D.2
Virmani, R.3
-
79
-
-
72049129430
-
Extended-release niacin or ezetimibe and carotid intima-media thickness
-
Taylor, A. J. et al. Extended-release niacin or ezetimibe and carotid intima-media thickness. N. Engl. J Med. 361, 2113-2122 (2009).
-
(2009)
N. Engl. J Med.
, vol.361
, pp. 2113-2122
-
-
Taylor, A.J.1
-
80
-
-
77953133727
-
Treating arteries instead of risk factors. A paradigm change in management of atherosclerosis
-
Spence, J. D. & Hackam, D. G. Treating arteries instead of risk factors. A paradigm change in management of atherosclerosis. Stroke 41, 1193-1199 (2010).
-
(2010)
Stroke
, vol.41
, pp. 1193-1199
-
-
Spence, J.D.1
Hackam, D.G.2
-
81
-
-
76149138463
-
Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosis
-
Spence, J. D. et al. Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosis. Arch. Neurol. 67, 180-186 (2010).
-
(2010)
Arch. Neurol.
, vol.67
, pp. 180-186
-
-
Spence, J.D.1
-
82
-
-
77956341472
-
Adding ezetimibe to statin halts progression of carotid plaque [abstract]
-
Spence, J. D. Adding ezetimibe to statin halts progression of carotid plaque [abstract]. Basic Clin. Pharmacol. Toxicol. 107 (Suppl. 1), 2194 (2010).
-
(2010)
Basic Clin. Pharmacol. Toxicol.
, vol.107
, Issue.SUPPL. 1
, pp. 2194
-
-
Spence, J.D.1
-
83
-
-
72149087737
-
Effect of intensive glycemic control on cardiovascular outcomes and all-cause mortality in type 2 diabetes: Overview and metaanalysis of five trials
-
Tkac, I. Effect of intensive glycemic control on cardiovascular outcomes and all-cause mortality in type 2 diabetes: overview and metaanalysis of five trials. Diabetes Res. Clin. Pract. 86, S57-S62 (2009).
-
(2009)
Diabetes Res. Clin. Pract.
, vol.86
-
-
Tkac, I.1
-
84
-
-
33745661675
-
Glycemic control and macrovascular disease in types 1 and 2 diabetes mellitus: Meta-analysis of randomized trials
-
Stettler, C. et al. Glycemic control and macrovascular disease in types 1 and 2 diabetes mellitus: meta-analysis of randomized trials. Am. Heart J. 152, 27-38 (2006).
-
(2006)
Am. Heart J.
, vol.152
, pp. 27-38
-
-
Stettler, C.1
-
85
-
-
77951735232
-
Effects of intensive blood-pressure control in type 2 diabetes mellitus
-
Cushman, W. C. et al. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N. Engl. J. Med. 362, 1575-1585 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 1575-1585
-
-
Cushman, W.C.1
-
86
-
-
33947539408
-
Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke: Results from PROactive (PROspective pioglitAzone Clinical Trial in macroVascular events 04)
-
Wilcox, R. et al. Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke: results from PROactive (PROspective pioglitAzone Clinical Trial In macroVascular events 04). Stroke 38, 865-873 (2007).
-
(2007)
Stroke
, vol.38
, pp. 865-873
-
-
Wilcox, R.1
-
87
-
-
26244453309
-
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial in macroVascular events): A randomised controlled trial
-
Dormandy, J. A. et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular events): a randomised controlled trial. Lancet 366, 1279-1289 (2005).
-
(2005)
Lancet
, vol.366
, pp. 1279-1289
-
-
Dormandy, J.A.1
-
89
-
-
0033606533
-
Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: A randomised controlled trial. ASA and Carotid endarterectomy (ACe) Trial Collaborators
-
Taylor, D. W. et al. Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomised controlled trial. ASA and Carotid endarterectomy (ACe) Trial Collaborators. Lancet 353, 2179-2184 (1999).
-
(1999)
Lancet
, vol.353
, pp. 2179-2184
-
-
Taylor, D.W.1
-
90
-
-
63749128221
-
Low-dose aspirin, coxibs, and other NSAIDS: A clinical mosaic emerges
-
Patrono, C. & Baigent, C. Low-dose aspirin, coxibs, and other NSAIDS: a clinical mosaic emerges. Mol. Interv. 9, 31-39 (2009).
-
(2009)
Mol. Interv.
, vol.9
, pp. 31-39
-
-
Patrono, C.1
Baigent, C.2
-
91
-
-
33646596912
-
Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (eSPRIT): Randomised controlled trial
-
Halkes, P. H., van Gijn, J., Kappelle, L. J., Koudstaal, P. J. & Algra, A. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (eSPRIT): randomised controlled trial. Lancet 367, 1665-1673 (2006).
-
(2006)
Lancet
, vol.367
, pp. 1665-1673
-
-
Halkes, P.H.1
Van Gijn, J.2
Kappelle, L.J.3
Koudstaal, P.J.4
Algra, A.5
-
92
-
-
0030590746
-
A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIe). CAPRIe Steering Committee
-
[No authors listed]
-
[No authors listed] A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIe). CAPRIe Steering Committee. Lancet 348, 1329-1339 (1996).
-
(1996)
Lancet
, vol.348
, pp. 1329-1339
-
-
-
93
-
-
51449116270
-
Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
-
Sacco, R. L. et al. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N. Engl. J. Med. 359, 1238-1251 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 1238-1251
-
-
Sacco, R.L.1
-
94
-
-
77950627212
-
Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): A randomised, open-label, blinded-endpoint trial
-
Wong, K. S. et al. Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial. Lancet Neurol. 9, 489-497 (2010).
-
(2010)
Lancet Neurol.
, vol.9
, pp. 489-497
-
-
Wong, K.S.1
-
95
-
-
4444229924
-
Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: The Clopidogrel in Unstable angina to prevent Recurrent ischemic events (CURe) Trial
-
Fox, K. A. et al. Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic events (CURe) Trial. Circulation 110, 1202-1208 (2004).
-
(2004)
Circulation
, vol.110
, pp. 1202-1208
-
-
Fox, K.A.1
-
96
-
-
62649164844
-
A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
-
Juurlink, D. N. et al. A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ 180, 713-718 (2009).
-
(2009)
CMAJ
, vol.180
, pp. 713-718
-
-
Juurlink, D.N.1
-
97
-
-
70149107498
-
Ticagrelor-is there need for a new player in the antiplatelet-therapy field?
-
Schomig, A. Ticagrelor-is there need for a new player in the antiplatelet-therapy field? N. Engl. J. Med. 361, 1108-1111 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1108-1111
-
-
Schomig, A.1
-
98
-
-
70149101223
-
Ticagrelor versus clopidogrel in patients with acute coronary syndromes
-
Wallentin, L. et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 361, 1045-1057 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1045-1057
-
-
Wallentin, L.1
-
99
-
-
69849106857
-
Stroke: Atrial fibrillation, stroke prevention therapy and aging
-
Spence, J. D. Stroke: atrial fibrillation, stroke prevention therapy and aging. Nat. Rev. Cardiol. 6, 448-450 (2009).
-
(2009)
Nat. Rev. Cardiol.
, vol.6
, pp. 448-450
-
-
Spence, J.D.1
-
100
-
-
58149269939
-
Atrial fibrillation detected by mobile cardiac outpatient telemetry in cryptogenic TIA or stroke
-
Tayal, A. H. et al. Atrial fibrillation detected by mobile cardiac outpatient telemetry in cryptogenic TIA or stroke. Neurology 71, 1696-1701 (2008).
-
(2008)
Neurology
, vol.71
, pp. 1696-1701
-
-
Tayal, A.H.1
-
101
-
-
77953007620
-
Occult atrial fibrillation in ischemic stroke: Seek and you shall find
-
Tayal, A. H. & Callans, D. J. Occult atrial fibrillation in ischemic stroke: seek and you shall find. Neurology 74, 1662-1663 (2010).
-
(2010)
Neurology
, vol.74
, pp. 1662-1663
-
-
Tayal, A.H.1
Callans, D.J.2
-
102
-
-
34548231003
-
Frequent atrial premature beats predict paroxysmal atrial fibrillation in stroke patients: An opportunity for a new diagnostic strategy
-
Wallmann, D. et al. Frequent atrial premature beats predict paroxysmal atrial fibrillation in stroke patients: an opportunity for a new diagnostic strategy. Stroke 38, 2292-2294 (2007).
-
(2007)
Stroke
, vol.38
, pp. 2292-2294
-
-
Wallmann, D.1
-
103
-
-
55649107701
-
Cryptogenic stroke and patent foramen ovale: Clinical clues to paradoxical embolism
-
Ozdemir, A. O., Tamayo, A., Munoz, C., Dias, B. & Spence, J. D. Cryptogenic stroke and patent foramen ovale: clinical clues to paradoxical embolism. J. Neurol. Sci. 275, 121-127 (2008).
-
(2008)
J. Neurol. Sci.
, vol.275
, pp. 121-127
-
-
Ozdemir, A.O.1
Tamayo, A.2
Munoz, C.3
Dias, B.4
Spence, J.D.5
-
104
-
-
40449120615
-
Genetic determinants of response to warfarin during initial anticoagulation
-
Schwarz, U. I. et al. Genetic determinants of response to warfarin during initial anticoagulation. N. Engl. J Med. 358, 999-1008 (2008).
-
(2008)
N. Engl. J Med.
, vol.358
, pp. 999-1008
-
-
Schwarz, U.I.1
-
105
-
-
70349306707
-
Dabigatran versus warfarin in patients with atrial fibrillation
-
Connolly, S. J. et al. Dabigatran versus warfarin in patients with atrial fibrillation. N. Engl. J Med. 361, 1139-1151 (2009).
-
(2009)
N. Engl. J Med.
, vol.361
, pp. 1139-1151
-
-
Connolly, S.J.1
-
106
-
-
33847662941
-
Intestinal drug transporter expression and the impact of grapefruit juice in humans
-
Glaeser, H. et al. Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin. Pharmacol. Ther. 81, 362-370 (2007).
-
(2007)
Clin. Pharmacol. Ther.
, vol.81
, pp. 362-370
-
-
Glaeser, H.1
-
107
-
-
33846585054
-
Left atrial appendage exclusion for stroke prevention in patients with nonrheumatic atrial fibrillation
-
Onalan, O. & Crystal, E. Left atrial appendage exclusion for stroke prevention in patients with nonrheumatic atrial fibrillation. Stroke 38, 624-630 (2007).
-
(2007)
Stroke
, vol.38
, pp. 624-630
-
-
Onalan, O.1
Crystal, E.2
-
108
-
-
67649214861
-
Carotid artery stenting has increased rates of post-procedure stroke, death, and resource utilization than does carotid endarterectomy in the United States, 2005
-
McPhee, J. T., Schanzer, A., Messina, L. M. & Eslami, M. H. Carotid artery stenting has increased rates of post-procedure stroke, death, and resource utilization than does carotid endarterectomy in the United States, 2005. J. Vasc. Surg. 50, 238-239 (2008).
-
(2008)
J. Vasc. Surg.
, vol.50
, pp. 238-239
-
-
McPhee, J.T.1
Schanzer, A.2
Messina, L.M.3
Eslami, M.H.4
-
109
-
-
74049129866
-
Low risk of ipsilateral stroke in patients with asymptomatic carotid stenosis on best medical treatment: A prospective, population-based study
-
Marquardt, L., Geraghty, O. C., Mehta, Z. & Rothwell, P. M. Low risk of ipsilateral stroke in patients with asymptomatic carotid stenosis on best medical treatment: a prospective, population-based study. Stroke 41, e11-e17 (2010).
-
(2010)
Stroke
, vol.41
-
-
Marquardt, L.1
Geraghty, O.C.2
Mehta, Z.3
Rothwell, P.M.4
-
110
-
-
70349659460
-
Medical (nonsurgical) intervention alone is now best for prevention of stroke associated with asymptomatic severe carotid stenosis: Results of a systematic review and analysis
-
Abbott, A. L. Medical (nonsurgical) intervention alone is now best for prevention of stroke associated with asymptomatic severe carotid stenosis: results of a systematic review and analysis. Stroke 40, e573-e583 (2009).
-
(2009)
Stroke
, vol.40
-
-
Abbott, A.L.1
-
111
-
-
77949464348
-
Carotid stenting: More risky than endarterectomy and often no better than medical treatment alone
-
Rothwell, P. M. Carotid stenting: more risky than endarterectomy and often no better than medical treatment alone. Lancet 375, 957-959 (2010).
-
(2010)
Lancet
, vol.375
, pp. 957-959
-
-
Rothwell, P.M.1
-
112
-
-
77954204134
-
Stenting versus endarterectomy for treatment of carotid-artery stenosis
-
Brott, T. G. et al. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N. Engl. J. Med. 363, 11-23 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 11-23
-
-
Brott, T.G.1
-
113
-
-
77953476898
-
Asymptomatic embolisation for prediction of stroke in the Asymptomatic Carotid emboli Study (ACeS): A prospective observational study
-
doi:10.1016/S1474-4422(10)70120-4
-
Markus, H. S. et al. Asymptomatic embolisation for prediction of stroke in the Asymptomatic Carotid emboli Study (ACeS): a prospective observational study. Lancet Neurol. doi:10.1016/S1474-4422(10)70120-4.
-
Lancet Neurol.
-
-
Markus, H.S.1
-
114
-
-
0034716822
-
Impaired cerebral vasoreactivity and risk of stroke in patients with asymptomatic carotid artery stenosis
-
Silvestrini, M. et al. Impaired cerebral vasoreactivity and risk of stroke in patients with asymptomatic carotid artery stenosis. JAMA 283, 2122-2127 (2000).
-
(2000)
JAMA
, vol.283
, pp. 2122-2127
-
-
Silvestrini, M.1
-
115
-
-
44949248164
-
Identifying vulnerable carotid plaques by noninvasive imaging
-
Kwee, R. M. et al. Identifying vulnerable carotid plaques by noninvasive imaging. Neurology 70, 2401-2409 (2008).
-
(2008)
Neurology
, vol.70
, pp. 2401-2409
-
-
Kwee, R.M.1
-
116
-
-
84964308706
-
Silent embolic infarcts on computed tomography brain scans and risk of ipsilateral hemispheric events in patients with asymptomatic internal carotid artery stenosis
-
Kakkos, S. K. et al. Silent embolic infarcts on computed tomography brain scans and risk of ipsilateral hemispheric events in patients with asymptomatic internal carotid artery stenosis. J. Vasc. Surg. 49, 902-909 (2009).
-
(2009)
J. Vasc. Surg.
, vol.49
, pp. 902-909
-
-
Kakkos, S.K.1
-
117
-
-
77953587135
-
Association of plaque echostructure and cardiovascular risk factors with symptomatic carotid artery disease
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Giannoukas, A. D., Sfyroeras, G. S., Griffin, M., Saleptsis, V. & Nicolaides, A. N. Association of plaque echostructure and cardiovascular risk factors with symptomatic carotid artery disease. J. Cardiovasc. Surg. (Torino) 51, 245-251 (2010).
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(2010)
J. Cardiovasc. Surg. (Torino)
, vol.51
, pp. 245-251
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Giannoukas, A.D.1
Sfyroeras, G.S.2
Griffin, M.3
Saleptsis, V.4
Nicolaides, A.N.5
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