The Apolipoprotein A-I level is downregulated in the granulosa cells of patients with polycystic ovary syndrome and affects steroidogenesis

Journal of Proteome Research

Volumn 9, Issue 9, 2010, Pages 4329-4336

  Choi, Dong Hee ^a   Lee, Woo Sik ^b   Won, Miae ^c   Park, Mira ^c   Park, Ho Oak ^c   Kim, Eunju ^c   Lee, Kyoung Ah ^c   Bae, Jeehyeon ^c  

^a Department of Obstetrics and Gynecology   (South Korea)

^b Gangnam CHA Hospital   (South Korea)

^c CHA University   (South Korea)

Author keywords

ApoA I; granulosa cell; ovary; PCOS; proteomics; steroidogenesis

Indexed keywords

APOLIPOPROTEIN A1; PROGESTERONE;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GRANULOSA CELL; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEOMICS; STEROIDOGENESIS; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION; WESTERN BLOTTING;

ADULT; APOLIPOPROTEIN A-I; BLOTTING, WESTERN; CELL LINE; CHROMATOGRAPHY, LIQUID; DOWN-REGULATION; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GRANULOSA CELLS; HUMANS; POLYCYSTIC OVARY SYNDROME; PROGESTERONE; PROTEOME; PROTEOMICS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 77956335783     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100008e     Document Type: Article

References (43)

1. Ehrmann, D. A. Polycystic ovary syndrome N. Engl. J. Med. 2005, 352 (12) 1223-1236
2. Legro, R. S.; Kunselman, A. R.; Dunaif, A. Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome Am. J. Med. 2001, 111 (8) 607-613
3. Wild, S.; Pierpoint, T.; Jacobs, H.; McKeigue, P. Long-term consequences of polycystic ovary syndrome: Results of a 31 year follow-up study Hum. Fertil. (Abingdon, U.K.) 2000, 3 (2) 101-105
4. Jansen, E.; Laven, J. S.; Dommerholt, H. B.; Polman, J.; van Rijt, C.; van den Hurk, C.; Westland, J.; Mosselman, S.; Fauser, B. C. Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients Mol. Endocrinol. 2004, 18 (12) 3050-3063
5. Diao, F. Y.; Xu, M.; Hu, Y.; Li, J.; Xu, Z.; Lin, M.; Wang, L.; Zhou, Y.; Zhou, Z.; Liu, J.; Sha, J. The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray J. Mol. Endocrinol. 2004, 33 (1) 59-72
6. Oksjoki, S.; Soderstrom, M.; Inki, P.; Vuorio, E.; Anttila, L. Molecular profiling of polycystic ovaries for markers of cell invasion and matrix turnover Fertil. Steril. 2005, 83 (4) 937-944
7. Wood, J. R.; Nelson, V. L.; Ho, C.; Jansen, E.; Wang, C. Y.; Urbanek, M.; McAllister, J. M.; Mosselman, S.; Strauss, J. F., III The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis J. Biol. Chem. 2003, 278 (29) 26380-26390
8. Wood, J. R.; Dumesic, D. A.; Abbott, D. H.; Strauss, J. F., III Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis J. Clin. Endocrinol. Metab. 2007, 92 (2) 705-713
9. Kenigsberg, S.; Bentov, Y.; Chalifa-Caspi, V.; Potashnik, G.; Ofir, R.; Birk, O. S. Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients Mol. Hum. Reprod. 2009, 15 (2) 89-103
10. Matharoo-Ball, B.; Hughes, C.; Lancashire, L.; Tooth, D.; Ball, G.; Creaser, C.; Elgasim, M.; Rees, R.; Layfield, R.; Atiomo, W. Characterization of biomarkers in polycystic ovary syndrome (PCOS) using multiple distinct proteomic platforms J. Proteome Res. 2007, 6 (8) 3321-3328
11. Ma, X.; Fan, L.; Meng, Y.; Hou, Z.; Mao, Y. D.; Wang, W.; Ding, W.; Liu, J. Y. Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome Mol. Hum. Reprod. 2007, 13 (8) 527-535
12. Adams, J.; Franks, S.; Polson, D. W.; Mason, H. D.; Abdulwahid, N.; Tucker, M.; Morris, D. V.; Price, J.; Jacobs, H. S. Multifollicular ovaries: Clinical and endocrine features and response to pulsatile gonadotropin releasing hormone Lancet 1985, 2 (8469-8470) 1375-1379
13. Franks, S.; Mason, H.; Willis, D. Follicular dynamics in the polycystic ovary syndrome Mol. Cell. Endocrinol. 2000, 163 (1-2) 49-52
14. Hillier, S. G. Gonadotropic control of ovarian follicular growth and development Mol. Cell. Endocrinol. 2001, 179 (1-2) 39-46
15. Franks, S.; Stark, J.; Hardy, K. Follicle dynamics and anovulation in polycystic ovary syndrome Hum. Reprod. Update 2008, 14 (4) 367-378
16. Lithell, H.; Nillius, S. J.; Bergh, T.; Selinus, I. Metabolic profile in obese women with the polycystic ovary syndrome Int. J. Obes. 1987, 11 (1) 1-8
17. Legro, R. S.; Blanche, P.; Krauss, R. M.; Lobo, R. A. Alterations in low-density lipoprotein and high-density lipoprotein subclasses among Hispanic women with polycystic ovary syndrome: Influence of insulin and genetic factors Fertil. Steril. 1999, 72 (6) 990-995
18. Yilmaz, M.; Biri, A.; Karakoc, A.; Toruner, F.; Bingol, B.; Cakir, N.; Tiras, B.; Ayvaz, G.; Arslan, M. The effects of rosiglitazone and metformin on insulin resistance and serum androgen levels in obese and lean patients with polycystic ovary syndrome J. Endocrinol. Invest. 2005, 28 (11) 1003-1008
19. Valkenburg, O.; Steegers-Theunissen, R. P.; Smedts, H. P.; Dallinga-Thie, G. M.; Fauser, B. C.; Westerveld, E. H.; Laven, J. S. A more atherogenic serum lipoprotein profile is present in women with polycystic ovary syndrome: A case-control study J. Clin. Endocrinol. Metab. 2008, 93 (2) 470-476
20. Plump, A. S.; Erickson, S. K.; Weng, W.; Partin, J. S.; Breslow, J. L.; Williams, D. L. Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production J. Clin. Invest. 1996, 97 (11) 2660-2671
21. Azhar, S.; Tsai, L.; Medicherla, S.; Chandrasekher, Y.; Giudice, L.; Reaven, E. Human granulosa cells use high density lipoprotein cholesterol for steroidogenesis J. Clin. Endocrinol. Metab. 1998, 83 (3) 983-991
22. Richards, J. S. Hormonal control of gene expression in the ovary Endocr. Rev. 1994, 15 (6) 725-751
23. Conti, M. Specificity of the cyclic adenosine 3′,5′- monophosphate signal in granulosa cell function Biol. Reprod. 2002, 67 (6) 1653-1661
24. Salmassi, A.; Zhang, Z.; Schmutzler, A. G.; Koch, K.; Buck, S.; Jonat, W.; Mettler, L. Expression of mRNA and protein of macrophage colony-stimulating factor and its receptor in human follicular luteinized granulosa cells Fertil. Steril. 2005, 83 (2) 419-425
25. Mortz, E.; Krogh, T. N.; Vorum, H.; Gorg, A. Improved silver staining protocols for high sensitivity protein identification using matrix-assisted laser desorption/ionization-time of flight analysis Proteomics 2001, 1 (11) 1359-1363
26. Bahk, Y. Y.; Kim, S. A.; Kim, J. S.; Euh, H. J.; Bai, G. H.; Cho, S. N.; Kim, Y. S. Antigens secreted from Mycobacterium tuberculosis: Identification by proteomics approach and test for diagnostic marker Proteomics 2004, 4 (11) 3299-3307
27. Welsh, T. H., Jr.; Jia, X. C.; Hsueh, A. J. Forskolin and phosphodiesterase inhibitors stimulate rat granulosa cell differentiation Mol. Cell. Endocrinol. 1984, 37 (1) 51-60
28. Legro, R. S.; Kunselman, A. R.; Dodson, W. C.; Dunaif, A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women J. Clin. Endocrinol. Metab. 1999, 84 (1) 165-169
29. Shaw, L. J.; Bairey Merz, C. N.; Azziz, R.; Stanczyk, F. Z.; Sopko, G.; Braunstein, G. D.; Kelsey, S. F.; Kip, K. E.; Cooper-Dehoff, R. M.; Johnson, B. D.; Vaccarino, V.; Reis, S. E.; Bittner, V.; Hodgson, T. K.; Rogers, W.; Pepine, C. J. Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: Results from the National Institutes of Health-National Heart, Lung, and Blood Institute sponsored Women's Ischemia Syndrome Evaluation J. Clin. Endocrinol. Metab. 2008, 93 (4) 1276-1284
30. Westerveld, H. E.; Hoogendoorn, M.; de Jong, A. W.; Goverde, A. J.; Fauser, B. C.; Dallinga-Thie, G. M. Cardiometabolic abnormalities in the polycystic ovary syndrome: Pharmacotherapeutic insights Pharmacol. Ther. 2008, 119 (3) 223-241
31. Lo, J. C.; Feigenbaum, S. L.; Yang, J.; Pressman, A. R.; Selby, J. V.; Go, A. S. Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome J. Clin. Endocrinol. Metab. 2006, 91 (4) 1357-1363
32. Barter, P. J.; Ballantyne, C. M.; Carmena, R.; Castro Cabezas, M.; Chapman, M. J.; Couture, P.; de Graaf, J.; Durrington, P. N.; Faergeman, O.; Frohlich, J.; Furberg, C. D.; Gagne, C.; Haffner, S. M.; Humphries, S. E.; Jungner, I.; Krauss, R. M.; Kwiterovich, P.; Marcovina, S.; Packard, C. J.; Pearson, T. A.; Reddy, K. S.; Rosenson, R.; Sarrafzadegan, N.; Sniderman, A. D.; Stalenhoef, A. F.; Stein, E.; Talmud, P. J.; Tonkin, A. M.; Walldius, G.; Williams, K. M. Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: Report of the thirty-person/ten-country panel J. Intern. Med. 2006, 259 (3) 247-258
33. Rajkhowa, M.; Neary, R. H.; Kumpatla, P.; Game, F. L.; Jones, P. W.; Obhrai, M. S.; Clayton, R. N. Altered composition of high density lipoproteins in women with the polycystic ovary syndrome J. Clin. Endocrinol. Metab. 1997, 82 (10) 3389-3394
34. Dejager, S.; Pichard, C.; Giral, P.; Bruckert, E.; Federspield, M. C.; Beucler, I.; Turpin, G. Smaller LDL particle size in women with polycystic ovary syndrome compared to controls Clin. Endocrinol. (Oxford, U.K.) 2001, 54 (4) 455-462
35. Macut, D.; Damjanovic, S.; Panidis, D.; Spanos, N.; Glisic, B.; Petakov, M.; Rousso, D.; Kourtis, A.; Bjekic, J.; Milic, N. Oxidised low-density lipoprotein concentration: Early marker of an altered lipid metabolism in young women with PCOS Eur. J. Endocrinol. 2006, 155 (1) 131-136
36. Hermann, M.; Lindstedt, K. A.; Foisner, R.; Morwald, S.; Mahon, M. G.; Wandl, R.; Schneider, W. J.; Nimpf, J. Apolipoprotein A-I production by chicken granulosa cells FASEB J. 1998, 12 (10) 897-903
37. Pascher, E.; Chari, S.; Sturm, G. Expression of mRNA for ovarian steroid-stimulating factor (apolipoprotein A-I and apolipoprotein A-I-like protein) in human granulosa cells Exp. Clin. Endocrinol. Diabetes 1997, 105 (2) 122-124
38. Glass, C.; Pittman, R. C.; Weinstein, D. B.; Steinberg, D. Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-I of rat plasma high density lipoprotein: Selective delivery of cholesterol ester to liver, adrenal, and gonad Proc. Natl. Acad. Sci. U.S.A. 1983, 80 (17) 5435-5439
39. Jakimiuk, A. J.; Weitsman, S. R.; Brzechffa, P. R.; Magoffin, D. A. Aromatase mRNA expression in individual follicles from polycystic ovaries Mol. Hum. Reprod. 1998, 4 (1) 1-8
40. Ishii, T.; Hasegawa, T.; Pai, C. I.; Yvgi-Ohana, N.; Timberg, R.; Zhao, L.; Majdic, G.; Chung, B. C.; Orly, J.; Parker, K. L. The roles of circulating high-density lipoproteins and trophic hormones in the phenotype of knockout mice lacking the steroidogenic acute regulatory protein Mol. Endocrinol. 2002, 16 (10) 2297-2309
41. Chandras, C.; Ragoobir, J.; Barrett, G. E.; Bruckdorfer, K. R.; Graham, A.; Abayasekara, D. R.; Michael, A. E. Roles for prostaglandins in the steroidogenic response of human granulosa cells to high-density lipoproteins Mol. Cell. Endocrinol. 2004, 222 (1-2) 1-8
42. Doldi, N.; Gessi, A.; Destefani, A.; Calzi, F.; Ferrari, A. Polycystic ovary syndrome: Anomalies in progesterone production Hum. Reprod. 1998, 13 (2) 290-293
43. Magoffin, D. A. Ovarian enzyme activities in women with polycystic ovary syndrome Fertil. Steril. 2006, 86 (Suppl. 1) S9-S11