Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 (MDR1) gene

Epilepsy Research

Volumn 80, Issue 1, 2008, Pages 42-46

  Dericioglu, Nese ^a   Babaoglu, Melih O ^a   Yasar, Umit ^a   Bal, I Burak ^a   Bozkurt, Atila ^a   Saygi, Serap ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

ABCB1 (MDR1) gene; C3435T polymorphism; Epilepsy surgery; Multidrug resistance; Refractory epilepsy

Indexed keywords

MULTIDRUG RESISTANCE PROTEIN 1;

ADULT; ARTICLE; BRAIN SURGERY; CONTROLLED STUDY; DNA POLYMORPHISM; EPILEPSY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC CODE; GENOTYPE; HIPPOCAMPAL SCLEROSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIDRUG RESISTANCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION MAPPING; SEIZURE;

ADULT; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, MULTIPLE; EPILEPSY; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; P-GLYCOPROTEIN; POLYMORPHISM, GENETIC; RETROSPECTIVE STUDIES;

EID: 44749088921     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2008.03.004     Document Type: Article

References (24)

1. Ameyaw M.M., Regateiro F., Li T., Liu X., Tariq M., Mobarek A., Thornton N., Folayan G.O., Githang'a J., Indalo A., Ofori-Adjei D., Price-Evans D.A., and McLeod H.L. MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity. Pharmacogenetics 11 (2001) 217-221
2. Babaoglu M.O., Bayar B., Aynacioglu A.S., Kerb R., Abali H., Celik I., and Bozkurt A. Association of the ABCB1 3435C>T polymorphism with antiemetic efficacy of 5-hydroxytryptamine type 3 antagonists. Clin. Pharmacol. Ther. 78 (2005) 619-626
3. Benbadis S.R., and Allen Hauser W. An estimate of the prevalence of psychogenic non-epileptic seizures. Seizure 9 4 (2000) 280-281
4. Callen D.F., Baker E., Simmers R.N., Seshadri R., and Roninson I.B. Localization of the human multidrug resistance gene, MDR1, to 7q21.1. Hum. Genet. 77 (1987) 142-144
5. Dombrowski S.M., Desai S.Y., Marroni M., Cucullo L., Goodrich K., Bingaman W., Matberg M.R., Bengez L., and Janigro D. Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 42 12 (2001) 1501-1506
6. Drozdzik M., Bialecka M., Mysliwiec K., Honczarenko K., Stankiewicz J., and Sych Z. Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease. Pharmacogenetics 13 (2003) 259-263
7. Dupont W.D., and Plummer W.D. Power and sample size calculations for studies involving linear regression. Control Clin. Trials 19 (1998) 589-601
8. Hoffmeyer S., Burk O., von Richter O., Arnold H.P., Brockmöller J., Johne A., Cascorbi I., Gerloff T., Roots I., Eichelbaum M., and Brinkmann U. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 3473-3478
9. Hung C.C., Tai J.J., Lin C.J., Lee M.J., and Liou H.H. Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response. Pharmacogenomics 6 4 (2005) 411-417
10. Ishikawa T., Onishi Y., Hirano H., Oosumi K., Nagakura M., and Tarui S. Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1). Biol. Pharm. Bull. 27 (2004) 939-948
11. Kerb R., Aynacioglu A.S., Brockmöller J., Schlagenhaufer R., Bauer S., Szekeres T., Hamwi A., Fritzer-Szekeres M., Baumgartner C., Öngen H.Z., Güzelbey P., Roots I., and Brinkmann U. The predictive value of MDR1 CYP2C9 and CYP2C19 polymorphisms for phenytoin plasma levels. Pharmacogenom. J. 1 (2001) 204-210
12. Kim D.W., Kim M., Lee S.K., Kang R., and Lee S.Y. Lack of association between C3435T nucleotide MDR1 polymorphism and multidrug-resistant epilepsy. Seizure 15 5 (2006) 344-347
13. Kim Y.O., Kim M.K., Woo Y.J., Lee M.C., Kim J.H., Park K.W., Kim E.Y., Roh Y.I., and Kim C.J. Single nucleotide polymorphisms in the multidrug resistance 1 gene in Korean epileptics. Seizure 15 (2006) 67-72
14. Kimchi-Sarfaty C., Oh J.M., Kim I., Sauna Z.E., Calcagno A.M., Ambudkar S.V., and Gottesman M.M. A silent polymorphism in the MDR1 gene changes substrate specificity. Science 315 (2007) 525-528
15. Leschziner G.D., Andrew T., Leach J.P., Chadwick D., Coffey A.J., Balding D.J., Bentley D.R., Pirmohamed M., and Johnson M.R. Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach. Pharmacogenet. Genom. 17 (2007) 217-220
16. Loscher W., and Potschka H. Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J. Pharmacol. Exp. Ther. 301 (2002) 7-14
17. Shahwan A., Murphy K., Doherty C., Cavalleri G.L., Muckian C., Dicker P., McCarthy M., Kinirons P., Goldstein D., and Delanty N. The controversial association of ABCB1 polymorphisms in refractory epilepsy: an analysis of multiple SNPs in an Irish population. Epilepsy Res. 73 2 (2007) 192-198
18. Siddiqui A., Kerb R., Weale M.E., Brinkmann U., Smith A., Goldstein D.B., Wood N.W., and Sisodiya S.M. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N. Engl. J. Med. 348 (2003) 1442-1448
19. Sills G.J., Mohanraj R., Butler E., McCrindle S., Collier L., Wilson E.A., and Brodie M.J. Lack of association between C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. Epilepsia 46 5 (2005) 643-647
20. Sisodiya S.M., Lin W.R., Harding B.N., Sguier M.V., and Thom M. Drug resistance in epilepsy: human epilepsy. Novart. Found. Symp. 243 (2002) 167-174
21. Tan N.C.K., Heron S.E., Scheffer I.E., Pelekanos J.T., McMahon J.M., Vears D.F., Mulley J.C., and Berkovic S.F. Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy. Neurology 63 (2004) 1090-1092
22. Tishler D.M., Weinberg K.I., Hinton D.R., Barbaro N., Annett G.M., and Raffel C. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 36 (1995) 1-6
23. Tufan A., Babaoglu M.O., Akdogan A., Yasar U., Calguneri M., Kalyoncu U., Karadag O., Hayran M., Ertenli A.I., Bozkurt A., and Kiraz S. Association of drug transporter gene ABCB1 (MDR1) 3435C to T polymorphism with colchicine response in familial Mediterranean fever. J. Rheumatol. 34 7 (2007) 1540-1544
24. Zimprich F., Sunder-Plassmann R., Stogmann E., Gleiss A., Dal-Bianco A., Zimprich A., Plumer S., Baumgartner C., and Mannhalter C. Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy. Neurology 63 (2004) 1087-1089