Phosphorylation of AATYK1 by Cdk5 Suppresses Its Tyrosine Phosphorylation

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Tsutsumi, Koji ^a   Takano, Tetsuya ^a   Endo, Ryo ^a   Fukuda, Mitsunori ^b   Ohshima, Toshio ^c   Tomomura, Mineko ^d   Hisanaga, Shin ichi ^a  

^a TOKYO METROPOLITAN UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c WASEDA UNIVERSITY   (Japan)

^d MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS ASSOCIATED TYROSINE KINASE 1; CYCLIN DEPENDENT KINASE 5; NERVE GROWTH FACTOR; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SERINE; TYROSINE; UNCLASSIFIED DRUG; AATK PROTEIN, MOUSE; APOPTOSIS REGULATORY PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN TISSUE; CELL STRAIN COS7; CELL STRAIN HEK293; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GROWTH CONE; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; ANIMAL; BRAIN; CELL CULTURE; CELL STRAIN COS1; CERCOPITHECUS; METABOLISM; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BRAIN; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIN-DEPENDENT KINASE 5; ENDOSOMES; MICE; NEURONS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; SRC-FAMILY KINASES; TYROSINE;

EID: 77956305951     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010260     Document Type: Article

References (38)

1. Tomomura M, Morita N, Yoshikawa F, Konishi A, Akiyama H, et al. (2007) Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. Neuroscience 148: 510-521.
2. Gaozza E, Baker SJ, Vora RK, Reddy EP (1997) AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells. Oncogene 15: 3127-3135.
3. Raghunath M, Patti R, Bannerman P, Lee CM, Baker S, et al. (2000) A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. Brain Res Mol Brain Res 77: 151-162.
4. Wang H, Brautigan DL (2002) A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. J Biol Chem 277: 49605-49612.
5. Kesavapany S, Lau KF, Ackerley S, Banner SJ, Shemilt SJ, et al. (2003) Identification of a novel, membrane-associated neuronal kinase, cyclindependent kinase 5/p35-regulated kinase. J Neurosci 23: 4975-4983.
6. Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T (2004) Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling. Genes Cells 9: 219-232.
7. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (2002) The protein kinase complement of the human genome. Science 298: 1912-1934.
8. Tomomura M, Furuichi T (2005) Apoptosis-associated tyrosine kinase (AATYK) has differential Ca2+-dependent phosphorylation states in response to survival and apoptotic conditions in cerebellar granule cells. J Biol Chem 280: 35157-35163.
9. Tomomura M, Hasegawa Y, Hashikawa T, Tomomura A, Yuzaki M, et al. (2003) Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain. Brain Res Mol Brain Res 112: 103-112.
10. Dhavan R, Tsai LH (2001) A decade of CDK5. Nat Rev Mol Cell Biol 2: 749-759.
11. Hisanaga S, Saito T (2003) The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator. Neurosignals 12: 221-229.
12. Cruz JC, Tsai LH (2004) Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol Med 10: 452-458.
13. Hawasli AH, Bibb JA (2007) Alternative roles for Cdk5 in learning and synaptic plasticity. Biotechnol J 2: 941-948.
14. Lai KO, Ip NY (2009) Recent advances in understanding the roles of Cdk5 in synaptic plasticity. Biochim Biophys Acta 1792: 741-745.
15. Honma N, Asada A, Takeshita S, Enomoto M, Yamakawa E, et al. (2003) Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. Biochem Biophys Res Commun 310: 398-404.
16. Tsutsumi K, Tomomura M, Furuichi T, Hisanaga S (2008) Palmitoylationdependent endosomal localization of AATYK1A and its interaction with Src. Genes Cells 13: 949-964.
17. Paglini G, Peris L, Diez-Guerra J, Quiroga S, Caceres A (2001) The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic. EMBO Rep 2: 1139-1144.
18. Asada A, Yamamoto N, Gohda M, Saito T, Hayashi N, et al. (2008) Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes. J Neurochem 106: 1325-1336.
19. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, et al. (1999) Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402: 615-622.
20. Lisé MF, Wong TP, Trinh A, Hines RM, Liu L, Kang R, Hines DJ, Lu J, Goldenring JR, Wang YT, El-Husseini A (2006) Involvement of myosin Vb in glutamate receptor trafficking. J Biol Chem 281: 3669-3678.
21. Harada T, Morooka T, Ogawa S, Nishida E (2001) ERK induces p35, a neuronspecific activator of Cdk5, through induction of Egr1. Nat Cell Biol 3: 453-459.
22. Sano M, Kato K, Totsuka T, Katoh-Semba R (1988) A convenient bioassay for NGF using a new subline of PC12 pheochromocytoma cells (PC12D). Brain Res 459: 404-406.
23. Jin E, Nosaka K, Sano M (2007) NGF-dependent formation of ruffles in PC12D cells required a different pathway from that for neurite outgrowth. Neurochem Int 51: 216-226.
24. Wang H, Brautigan DL (2006) Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase. Mol Cell Proteomics 5: 2124-2130.
25. Chibalina MV, Seaman MN, Miller CC, Kendrick-Jones J, Buss F (2007) Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment. J Cell Sci 120: 4278-4288.
26. Inoue T, Kon T, Ohkura R, Yamakawa H, Ohara O, et al. (2008) BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking. Genes Cells 13: 483-495.
27. Shirane M, Nakayama KI (2006) Protrudin induces neurite formation by directional membrane trafficking. Science 314: 818-821.
28. Sann S, Wang Z, Brown H, Jin Y (2009) Roles of endosomal trafficking in neurite outgrowth and guidance. Trends Cell Biol 19: 317-324.
29. Tan TC, Valova VA, Malladi CS, Graham ME, Berven LA, et al. (2003) Cdk5 is essential for synaptic vesicle endocytosis. Nat Cell Biol 5: 701-710.
30. Tomizawa K, Ohta J, Matsushita M, Moriwaki A, Li ST, et al. (2002) Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. J Neurosci 22: 2590-2597.
31. Tomizawa K, Sunada S, Lu YF, Oda Y, Kinuta M, et al. (2003) Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrinmediated endocytosis of synaptic vesicles. J Cell Biol 163: 813-824.
32. Nikolic M, Dudek H, Kwon YT, Ramos YF, Tsai LH (1996) The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes Dev 10: 816-825.
33. Yamada M, Saito T, Sato Y, Kawai Y, Sekigawa A, et al. (2007) Cdk5-p39 is a labile complex with the similar substrate specificity to Cdk5-p35. J Neurochem 102: 1477-1487.
34. Fukuda M (2003) Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. J Biol Chem 278: 15373-15380.
35. Tsuboi T, Fukuda M (2006) Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells. J Cell Sci 119: 2196-2203.
36. Saito T, Onuki R, Fujita Y, Kusakawa G, Ishiguro K, et al. (2003) Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation. J Neurosci 23: 1189-1197.
37. Ohshima T, Ward JM, Huh CG, Longenecker G, Veeranna, et al. (1996) Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci USA 93: 11173-11178.
38. Ohshima T, Suzuki H, Morimura T, Ogawa M, Mikoshiba K (2007) Modulation of Reelin signaling by Cyclin-dependent kinase 5. Brain Res 1140: 84-95.