In vivo disruption of TGF-β Signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Luo, Xiaolin ^a   Ding, Qiurong ^a   Wang, Min ^a   Li, Zhigang ^a   Mao, Kairui ^b   Sun, Bing ^b   Pan, Yi ^a   Wang, Zhenzhen ^a   Zang, Ying Qin ^a   Chen, Yan ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 17; INTERLEUKIN 6; OVALBUMIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; URETHAN; SMAD7 PROTEIN, MOUSE;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CLARA CELL; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE DISRUPTION; GENE EXPRESSION PROFILING; IMMUNOCOMPETENT CELL; IN VIVO STUDY; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LUNG CANCER; LUNG CARCINOGENESIS; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; TH2 CELL; TISSUE HOMOGENATE; TRANSGENIC MOUSE; ANIMAL; ASTHMA; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENE THERAPY; GENETICS; LUNG TUMOR; METABOLISM; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA;

ANIMALIA; MUS; MUS MUSCULUS;

ANIMALS; ASTHMA; CYTOKINES; DISEASE MODELS, ANIMAL; GENE THERAPY; INFLAMMATION; LUNG NEOPLASMS; MICE; MICE, TRANSGENIC; OVALBUMIN; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA; URETHANE;

EID: 77956300060     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010149     Document Type: Article

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