Targeted mutation of the mouse grp94gene disrupts development and perturbs endoplasmic reticulum stress signaling

PLoS ONE

Volumn 5, Issue 5, 2010, Pages

  Mao, Changhui ^a   Wang, Miao ^a   Luo, Biquan ^a   Wey, Shiuan ^a   Dong, Dezheng ^a   Wesselschmidt, Robin ^b   Rawlings, Stephen ^a   Lee, Amy S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALNEXIN; CALRETICULIN; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH FACTOR; PROTEIN DISULFIDE ISOMERASE; X BOX BINDING PROTEIN 1; DNA BINDING PROTEIN; ENDOPLASMIN; HEAT SHOCK PROTEIN; MEMBRANE PROTEIN; MOLECULAR CHAPERONE GRP78; REGULATORY FACTOR X TRANSCRIPTION FACTORS; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR STRESS RESPONSE; CELLULAR STRESS SIGNAL; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE DISRUPTION; GENE INACTIVATION; GENE MUTATION; HETEROZYGOSITY; IMMUNOHISTOCHEMISTRY; LOSS OF FUNCTION MUTATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; ORGANOGENESIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ALLELE; ALTERNATIVE RNA SPLICING; ANIMAL; EMBRYO DEATH; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; GENE REPRESSION; GENE TARGETING; GENETICS; HETEROZYGOTE; HOMOZYGOTE; METABOLISM; MOUSE MUTANT; MUTATION; PATHOLOGY; PHYSIOLOGICAL STRESS; UPREGULATION;

MUS;

ALLELES; ALTERNATIVE SPLICING; ANIMALS; DNA-BINDING PROTEINS; EMBRYO LOSS; EMBRYONIC DEVELOPMENT; EMBRYONIC STEM CELLS; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; GENE TARGETING; HEAT-SHOCK PROTEINS; HETEROZYGOTE; HOMOZYGOTE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR CHAPERONES; MUTATION; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; SUPPRESSION, GENETIC; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 77956296890     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010852     Document Type: Article

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