Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia

PLoS ONE

Volumn 5, Issue 5, 2010, Pages

  Baron, Rebecca M ^a   Lopez Guzman, Silvia ^a   Riascos, Dario F ^a,b   Macias, Alvaro A ^a   Layne, Matthew D ^c   Cheng, Guiying ^d   Harris, Cailin ^a   Chung, Su Wol ^a,e   Reeves, Raymond ^f   von Andrian, Ulrich H ^d   Perrella, Mark A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b PONTIFICIA UNIVERSIDAD JAVERIANA   (Colombia)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e University of Ulsan   (South Korea)

^f WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; DISTAMYCIN A; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HIGH MOBILITY GROUP A PROTEIN; HIGH MOBILITY GROUP A1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PADGEM PROTEIN; UNCLASSIFIED DRUG; CYTOKINE; ENDOTOXIN; HIGH MOBILITY GROUP A1A PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTOXEMIA; HEPATITIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PNEUMONIA; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; TISSUE LEVEL; TRANSACTIVATION; ANIMAL; AT RICH SEQUENCE; C57BL MOUSE; CATTLE; CELL COMMUNICATION; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; GENETICS; HUMAN; INFLAMMATION; LIVER; LUNG; METABOLISM; NEUTROPHIL; PATHOLOGY; PROTEIN BINDING;

MURINAE;

ANIMALS; AT RICH SEQUENCE; CATTLE; CELL COMMUNICATION; CYTOKINES; DISTAMYCINS; ENDOTHELIAL CELLS; ENDOTOXEMIA; ENDOTOXINS; HMGA1A PROTEIN; HUMANS; INFLAMMATION; LIVER; LUNG; MALE; MICE; MICE, INBRED C57BL; NEUTROPHILS; NF-KAPPA B; P-SELECTIN; PROMOTER REGIONS, GENETIC; PROTEIN BINDING;

EID: 77956280193     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010656     Document Type: Article

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