Sources of variation in factor VIII, von Willebrand factor and fibrinogen measurements: Implications for detecting deficiencies and increased plasma levels

Thrombosis Research

Volumn 126, Issue 3, 2010, Pages

  Bach, Juergen ^a   Haubelt, Hanne ^a   Hellstern, Peter ^a  

^a Academic City Hospital   (Germany)

Author keywords

Factor VIII; Fibrinogen; Freezing and thawing; High sensitivity C reactive protein; Inflammation; Von Willebrand factor

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 8; C REACTIVE PROTEIN; CITRIC ACID; FIBRINOGEN; VON WILLEBRAND FACTOR;

ADULT; AGED; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD SAMPLING; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FEMALE; FREEZING; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; QUANTITATIVE ANALYSIS; THAWING;

ADOLESCENT; ADULT; AFIBRINOGENEMIA; AGED; ANTICOAGULANTS; BIOLOGICAL MARKERS; BLOOD COAGULATION TESTS; BLOOD SPECIMEN COLLECTION; C-REACTIVE PROTEIN; CITRATES; FACTOR VIII; FEMALE; FIBRINOGEN; FREEZING; GERMANY; HEMOPHILIA A; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROTEIN STABILITY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; VON WILLEBRAND DISEASES; VON WILLEBRAND FACTOR; YOUNG ADULT;

EID: 77956265230     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2010.05.029     Document Type: Article

References (58)

1. D. Lillicrap, S.C. Nair, A. Srivastava, F. Rodeghiero, I. Pabinger, and A.B. Federich Laboratory issues in bleeding disorders Haemophilia 12 suppl 3 2006 68 75
2. M. Greaves, and H.G. Watson Approach to the diagnosis and management of mild bleeding disorders J Thromb Haemost 5 suppl 1 2007 167 174
3. T. Koster, F.R. Rosendaal, P.H. Reitsma, P.A. van der Velden, E. Briët, and J.P. Vandenbroucke and fibrinogen levels as risk factors for venous thrombosis. A case-control study of plasma levels and DNS polymorphisms - the Leiden Thrombophilia Study (LETS) Thromb Haemost 71 1994 719 722
4. T. Koster, A.D. Blann, E. Briët, J.P. Vandenbroucke, and F.R. Rosendaal Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis Lancet 345 1995 152 155
5. J. ÓDonnell, E.G.D. Tuddenham, R. Manning, G. Kemball-Cook, D. Johnson, and M. Laffan High prevalence of elevated factor VIII levels in patients referred to thrombophilia screening: Role of increased synthesis and relationship of the acute phase reaction Thromb Haemost 77 1997 825 828
6. R.A. Kraaijenhagen, P.S. ińt Anker, M.M.W. Koopman, P.H. Reitsma, M.H. Prins, and A. van den Ende High plasma concentration of factor VIII is a major risk factor for venous thromboembolism Thromb Haemost 83 2000 5 9
7. P.A. Kyrle, E. Minar, M. Hirschl, C. Bialonczyk, M. Stain, and B. Schneider High plasma levels of factor VIII and the risk of recurrent venous thromboembolism N Engl J Med 343 2000 457 462
8. A.W. Tsai, M. Cushman, W.D. Rosamond, S.R. Heckbert, R.P. Tracy, and N. Aleksic Coagulation factors, inflammation markers, and venous thromboembolism: The longitudinal investigation of thromboembolism etiology (LITE) Am J Med 113 2002 636 642
9. A. Van Hylckama Vlieg, and F.R. Rosendaal High levels of fibrinogen are associated with the risk of deep venous thrombosis mainly in the elderly J Thromb Haemost 1 2003 2677 2678
10. C. Legnani, C. Benilde, C. Michela, F. Mirella, G. Giuliana, and P. Gualtiero High plasma levels of factor VIII and risk of recurrence of venous thromboembolism Br J Haematol 124 2004 504 510
11. B. Cosmi, M. Legnani, M. Cini, E. Favaretto, and G. Palareti D-dimer and factor VIII are independent risk factor for recurrence after anticoagulation withdrawal for a first episode of deep vein thrombosis Thromb Res 122 2008 610 617
12. B. Luxembourg, J. Schmitt, M. Humpich, M. Glowatzki, D. Dressler, and E. Seifried Cardiovascular risk factors in idiopathic compared to risk-associated venous thromboembolism: A focus on fibrinogen, factor VIII, and high-sensitivity C-reactive protein (hs-CRP) Thromb Haemost 102 2009 668 675
13. F. Ceciliani, A. Giordano, and V. Spagnolo The systemic reaction during inflammation: the acute-phase proteins Protein Pept Lett 9 2002 211 223
14. I. Martinelli Von Willebrand factor and factor VIII as risk factors for arterial and venous thrombosis Semin Hematol 42 2005 49 55
15. The Fibrinogen Studies Collaboration Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154, 211 adults in 31 prospective studies Am J Epidemiol 166 2007 867 879
16. M. Woodward, H. Tunstall-Pedoe, A. Rumley, and G.D.O. Lowe Does fibrinogen add to prediction of cardiovascular disease? Results from the Scottish Heart Health Extended Cohort Study Br J Haematol 146 2009 442 446
17. S.G. Wannamethee, P.H. Whincup, A.G. Shaper, A. Rumley, L. Lennon, and G.D. Lowe Circulating inflammatory and haemostatic biomarkers are associated with risk of myocardial infarction and coronary death, but not with angina pectoris, in older men J Thromb Haemost 7 2009 1605 1611
18. P.S. Wells, N.J. Langlois, M.A. Webster, J. Jaffey, and J.A. Anderson Elevated factor VIII is a risk factor for idiopathic venous thromboembolism in Canada - is it necessary to define a new upper reference range for factor VIII? Thromb Haemost 93 2005 842 846
19. C.M. Schambeck, K. Hinney, I. Haubitz, M. Taleghani, D. Wahler, and F. Keller Familial clustering of high factor VIII levels in patients with venous thromboembolism Arterioscler Thromb Vasc Biol 21 2001 289 292
20. T. Quiroga, M. Goycoolea, O. Panes, E. Aranda, C. Martínez, and S. Belmont High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. A prospective study of 280 patients and 299 controls Haematologica 92 2007 357 365
21. S. Lethagen, A. Hillarp, C. Ekholm, E. Mattson, C. Halldén, and B. Friberg Distribution of von Willebrand factor levels in young women with and without bleeding symptoms. Influence of ABO blood group and promoter haplotypes Thromb Haemost 99 2008 1013 1018
22. S. Runkel, H. Haubelt, W. Hitzler, and P. Hellstern The quality of plasma collected by automated apheresis and of recovered plasma from leukodepleted whole blood Transfusion 45 2005 427 432
23. H. Beeck, T. Becker, S.T. Kiessig, R. Kaeser, K. Wolter, and P. Hellstern The influence of citrate concentration on the quality of plasma obtained by automated plasmapheresis: a prospective study Transfusion 39 1999 1266 1270
24. S. Rosén, M. Andersson, M. Blombäck, U. Hägglund, M.J. Larrieu, and M. Wolf Clinical application of a chromogenic substrate method for determination of factor VIII activity Thromb Haemost 54 1985 818 823
25. J.M. Bland, and D.G. Altman Statistical methods for assessing agreement between two methods of clinical measurement Lancet 1 1986 307 310
26. E.J. Favarolo, S. Soltani, and J. McDonald Potential laboratory misdiagnosis of hemophilia and von Willebrand disorder owing to cold activation of blood samples for testing Am J Clin Pathol 122 2004 686 692
27. M. Böhm, S. Täschner, E. Kretzschmar, R. Gerlach, E.J. Favarolo, and I. Scharrer Cold storage of citrated whole blood induces drastic time-dependent losses in factor VIII and von Willebrand factor: potential for misdiagnosis of haemophilia and von Willebrand disease Blood Coagul Fibrinolysis 17 2006 39 45
28. T.W. Barrowcliffe, M.S. Tydeman, T.B.L. Kirkwood, and D.P. Thomas Standardization of factor VIII - III. Establishment of a stable reference plasma for factor VIII-related activities Thromb Haemost 50 1983 690 696
29. th International Standard (97/586) Thromb Haemost 85 2001 634 638
30. A.R. Hubbard, and A.B. Heath Standardization of factor VIII and von Willebrand factor in plasma: calibration of the WHO 5th International Standard (02/150) J Thromb Haemost 2 2004 1380 1384
31. M. Zürcher, I. Sulzer, G. Barizzi, B. Lämmle, and L. Alberio Stability of coagulation assays performed in plasma from citrated whole blood transported at ambient temperature Thromb Haemost 99 2008 416 426
32. B. Woodhams, O. Girardot, M.J. Blanco, G. Colesse, and Y. Gourmelin Stability of coagulation proteins in frozen plasma Blood Coagul Fibrinolysis 12 2001 229 236
33. M. Lamboo, D.C.W. Poland, J.C.J. Eikenboom, M.S. Harvey, E. Groot, and A. Brand Coagulation parameters of thawed fresh-frozen plasma during storage at different temperatures Transfus Med 17 2007 182 186
34. D. Aronson, and P. Chang Activated factor VIII in therapeutic preparations: analysis by ultracentrifugation Vox Sang 71 1996 142 149
35. P. Hellstern, J. Bach, H. Haubelt, W.E. Hitzler, S. Mathis, and A. Vogt The impact of the intensity of automated plasmapheresis and the speed of deep-freezing on the quality of plasma Transfusion 41 2001 1601 1605
36. G. Rock, P. Tittley, and V. Fuller Effect of citrate anticoagulants on factor VIII levels in plasma Transfusion 28 1988 248 252
37. M. Andrew, P. Vegh, M. Johnston, J. Bowker, F. Ofosu, and L. Mitchell Maturation of the hemostatic system during childhood Blood 80 1992 1998 2005
38. M.M. Flanders, R.A. Crist, W.L. Roberts, and G.M. Rodgers Pediatric reference intervals for seven common coagulation assays Clin Chem 51 2005 1738 1742
39. S. Kitchen, and M. Makris N. Key, M. Makris, D. ÓShaughnessy, D. Lillycrap, Reference ranges Practical Hemostasis and Thrombosis 2009 Wiley-Blackwell Chapel Hill 297 304
40. M. Schleef, E. Strobel, A. Dick, J. Frank, W. Schramm, and M. Spannagl Relationship between ABO and secretor genotype with plasma levels of factor VIII and von Willebrand factor in thrombosis patients and control individuals Br J Haematol 128 2004 100 107
41. J.C.J. Eikenboom, G. Castaman, P.W. Kamphuisen, F.R. Rosendaal, and R.M. Bertina The factor VIII/von Willebrand factor ratio discriminates between reduced synthesis and increased clearance of von Willebrand factor Thromb Haemost 87 2002 252 257
42. P.W. Kamphuisen, J.C.J. Eikenboom, F.R. Rosendaal, T. Koster, A.D. Blann, and H.L. Vos High factor VIII antigen levels increase the risk of venous thrombosis but are not associated with polymorphisms in the von Willebrand factor and factor VIII gene Br J Haematol 115 2001 156 158
43. F. Haverkate, S.G. Thompson, and F. Duckert Haemostasis factors in angina pectoris: relation to gender, age and acute-phase reaction Thromb Haemost 73 1995 561 567
44. J. ÓDonnell, A.D. Mumford, R.A. Manning, and M. Laffan Elevation of FVIII:C in venous thromboembolism is persistent and independent of the acute phase response Thromb Haemost 83 2000 10 13
45. A. Gatt, J.J. van Veen, A. Bowyer, A.M. Woodley, P. Cooper, and S. Kitchen Wide variation in thrombin generation in patients with atrial fibrillation and therapeutic International normalized Ratio is not due to inflammation Br J Haematol 142 2008 946 952
46. A. Passaro, S. Calzavarini, S. Volpato, P. Caruso, A. Poli, and R. Fellin Reduced factor VII and factor VIII levels and prolonged thrombin-generation times during a healthy diet in middle-aged women with mild to moderate cardiovascular disease risk J Thromb Haemost 6 2008 2088 2094
47. C. Ay, K. Thom, F. Abu-Hamdeh, B. Horvath, P. Quehenberger, and C. Male Determinants of factor VIII plasma levels in carriers of haemophilia A and in control women Haemophilia 16 2010 111 117
48. G. Lippi, M. Franchini, G. Targher, G. Poli, and G.C. Guidi The significance of evaluating conventional inflammatory markers in von Willebrand factor measurement Clin Chim Acta 381 2007 167 170
49. M. Woodward, A. Rumley, P. Welsh, S. MacMahon, and G. Lowe A comparison of the association between seven hemostatic or inflammatory variables and coronary heart disease J Thromb Haemost 5 2007 795 800
50. M. Verhovsek, K.A. Moffat, and C.P.M. Hayward Laboratory testing for fibrinogen abnormalities Am J Hematol 83 2008 928 931
51. A. Rumley, M. Woodward, A. Hoffmeister, W. Koenig, and G.D.O. Lowe Comparison of plasma fibrinogen by Clauss, prothrombin time-derived, and immunonephelometric assays in a general population: implications for risk stratification by thirds of fibrinogen Blood Coagul Fibrinolysis 14 2003 197 201
52. T.B. Ledue, D.L. Weiner, J.D. Sipe, S.D. Poulin, M.F. Collins, and N. Rifai analytical evaluation of particle-enhanced immunonephelometric assays for C-reactive protein, serum amyloid A and mannose-binding protein in human serum Ann Clin Biochem 35 1998 745 753
53. E.S. Ford, W.H. Giles, G.L. Myers, and D.M. Mannino Population distribution of high-sensitivity C-reactive protein among US men: findings from National Health and Nutrition Examination Survey 1999-2000 Clin Chem 49 2003 686 690
54. M. Rifai, and P.M. Ridker Population distribution of C-reactive protein in apparently healthy men and women in the United States: implication for clinical interpretation [Technical Brief] Clin Chem 49 2003 666 669
55. M. Visser, L.M. Bouter, G.M. McQuillan, M.H. Wener, and T.B. Harris Elevated C-reactive protein levels in overweight and obese adults JAMA 282 1999 2131 2135
56. P.W. Kamphuisen, J.C.J. Eikenboom, H.L. Vos, R. Pablo, A. Sturk, and R.M. Bertina Increased levels of factor VIII and fibrinogen in patients with venous thrombosis are not caused by acute phase reactions Thromb Haemost 81 1999 680 683
57. R.L. Lundblad, H.S. Kingdon, K.G. Mann, and G.C. White Issues with the assay of factor VIII activity in plasma and factor VIII concentrates Thromb Haemost 84 2000 942 948
58. S.E. Rodgers, E.M. Duncan, M. Sobieraj-Teague, and J.V. Lloyd Evaluation of three automated chromogenic FVIII kits for the diagnosis of mild discrepant haemophilia A Int J Lab Hem 31 2008 180 188