High factor VIII antigen levels increase the risk of venous thrombosis but are not associated with polymorphisms in the von Willebrand factor and factor VIII gene

British Journal of Haematology

Volumn 115, Issue 1, 2001, Pages 156-158

  Kamphuisen, Pieter W ^a   Eikenboom, Jeroen C J ^a   Rosendaal, Frits R ^a   Koster, Ted ^a   Blann, Andrew D ^b   Vos, Hans L ^a   Bertina, Rogier M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

Factor VIII; Polymorphisms; Venous thrombosis; Von Willebrand factor

Indexed keywords

ANTIGEN; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 ANTIGEN; SILVER; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK; VEIN THROMBOSIS;

BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FACTOR VIII; HUMANS; LOGISTIC MODELS; POLYMORPHISM, GENETIC; REGRESSION ANALYSIS; RISK; VENOUS THROMBOSIS; VON WILLEBRAND FACTOR;

EID: 0034778588     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.03089.x     Document Type: Article

References (12)

1. Von Willebrand factor, soluble P-selectin, tissue plasminogen activator and plasminogen activator inhibitor in atherosclerosis
2. High concentrations of factor VIII and thrombosis: Is the factor VIII-binding domain of von Willebrand factor implicated?
3. Familial clustering of factor VIII and von Willebrand factor levels
4. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis
5. High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism
6. High plasma levels of factor VIII and the risk of recurrent venous thromboembolism
7. Haemophilia A diagnosis by analysis of a hypervariable dinucleotide repeat within the factor VIII gene
8. Haemophilia A diagnosis by simultaneous analysis of two variable dinucleotide tandem repeats within the factor VIII gene
9. Analysis of the F8 gene in individuals with high plasma factor VIII: C levels and associated venous thrombosis
10. High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: Role of increased synthesis and relationship to the acute phase reaction
11. The role of von Willebrand factor multimerization and propeptide cleavage in the binding and stabilization of factor VIII
12. Characterization of the von Willebrand factor gene (VWF) in von Willebrand disease type III patients from 24 families of Swedish and Finnish origin