TNF-alpha induced PMN apoptosis in whole human blood: Protective effect of SSR180575, a potent and selective peripheral benzodiazepine ligand

Biochemical and Biophysical Research Communications

Volumn 399, Issue 4, 2010, Pages 475-479

  Leducq Alet, N ^a   Vin, V ^a   Savi, P ^a   Bono, F ^a  

^a SANOFI   (France)

Author keywords

Apoptosis; PBR; PMN; Rh TNF ; SSR180575; Surrogate marker

Indexed keywords

7 CHLORO N,N,5 TRIMETHYL 4 OXO 3 PHENYL 3,5 DIHYDRO 4H PYRIDAZINO[4,5 B]INDOL 1 ACETAMIDE; APOPTOSIS INHIBITOR; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; SSR 180575; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; ACETAMIDE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; INDOLE DERIVATIVE; LIGAND; SSR180575;

APOPTOSIS; ARTICLE; BLOOD; CELL PROTECTION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

ACETAMIDES; APOPTOSIS; BENZODIAZEPINES; CELLS, CULTURED; CYTOPROTECTION; HUMANS; INDOLES; LIGANDS; NEUTROPHILS; RECEPTORS, GABA-A; TUMOR NECROSIS FACTOR-ALPHA; GABA-A RECEPTOR AGONISTS;

EID: 77956264153     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.07.011     Document Type: Article

References (34)

1. Joseph-Liauzun E., Delmas P., Shire D., Ferrara P. Topological analysis of the peripheral benzodiazepine receptor in yeast mitochondrial membranes supports a five-transmembrane structure. J. Biol. Chem. 1998, 273:2146-2152.
2. Braestrup C., Albrechtsen R., Squires R.F. High densities of benzodiazepine receptors in human cortical areas. Nature 1977, 269:702-704.
3. Anholt R.R., Pedersen P.L., De Souza E.B., Snyder S.H. The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J. Biol. Chem. 1986, 261:576-583.
4. Carayon P., Portier M., Dussossoy D., Bord A., Petitpretre G., Canat X., Le Fur G., Casellas P. Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage. Blood 1996, 87:3170-3178.
5. Syapin P.J., Cole R., De Vellis J., Noble E.P. Benzodiazepine binding characteristics of embryonic rat brain neurons grown in culture. J. Neurochem. 1985, 45:1797-1801.
6. Le Fur G., Perrier M.L., Vaucher N., Imbault F., Flamier A., Benavides J., Uzan A., Renault C., Dubroeucq M.C., Gueremy C. Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide. I. In vitro studies. Life Sci. 1983, 32:1839-1847.
7. Veenman L., Gavish M. The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development. Pharmacol. Ther. 2006, 110:503-524.
8. Bono F., Lamarche I., Prabonnaud V., Le Fur G., Herbert J.M. Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities. Biochem. Biophys. Res. Commun. 1999, 265:457-461.
9. Leducq N., Bono F., Sulpice T., Vin V., Janiak P., Fur G.L., O'Connor S.E., Herbert J.M. Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion. J. Pharmacol. Exp. Ther. 2003, 306:828-837.
10. Szabo I., Zoratti M. The mitochondrial permeability transition pore may comprise VDAC molecules. I. Binary structure and voltage dependence of the pore. FEBS Lett. 1993, 330:201-205.
11. Gavish M., Katz Y., Bar-Ami S., Weizman R. Biochemical, physiological, and pathological aspects of the peripheral benzodiazepine receptor. J. Neurochem. 1992, 58:1589-1601.
12. McEnery M.W., Snowman A.M., Trifiletti R.R., Snyder S.H. Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc. Natl Acad. Sci. USA 1992, 89:3170-3174.
13. Zamzami N., Larochette N., Kroemer G. Mitochondrial permeability transition in apoptosis and necrosis. Cell Death Differ. 2005, 12(Suppl. 2):1478-1480.
14. Gavish M., Bachman I., Shoukrun R., Katz Y., Veenman L., Weisinger G., Weizman A. Enigma of the peripheral benzodiazepine receptor. Pharmacol. Rev. 1999, 51:629-650.
15. Hans G., Wislet-Gendebien S., Lallemend F., Robe P., Rogister B., Belachew S., Nguyen L., Malgrange B., Moonen G., Rigo J.M. Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression. Biochem. Pharmacol. 2005, 69:819-830.
16. Chelli B., Lena A., Vanacore R., Pozzo E.D., Costa B., Rossi L., Salvetti A., Scatena F., Ceruti S., Abbracchio M.P., Gremigni V., Martini C. Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells. Biochem. Pharmacol. 2004, 68:125-134.
17. Chelli B., Falleni A., Salvetti F., Gremigni V., Lucacchini A., Martini C. Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue. Biochem. Pharmacol. 2001, 61:695-705.
18. Li J., Wang J., Zeng Y. Peripheral benzodiazepine receptor ligand, PK11195 induces mitochondria cytochrome c release and dissipation of mitochondria potential via induction of mitochondria permeability transition. Eur. J. Pharmacol. 2007, 560:117-122.
19. Maaser K., Hopfner M., Jansen A., Weisinger G., Gavish M., Kozikowski A.P., Weizman A., Carayon P., Riecken E.O., Zeitz M., Scherubl H. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br. J. Cancer 2001, 85:1771-1780.
20. Gonzalez-Polo R.A., Carvalho G., Braun T., Decaudin D., Fabre C., Larochette N., Perfettini J.L., Djavaheri-Mergny M., Youlyouz-Marfak I., Codogno P., Raphael M., Feuillard J., Kroemer G. PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor. Oncogene 2005, 24:7503-7513.
21. Banker D.E., Cooper J.J., Fennell D.A., Willman C.L., Appelbaum F.R., Cotter F.E. PK11195, a peripheral benzodiazepine receptor ligand, chemosensitizes acute myeloid leukemia cells to relevant therapeutic agents by more than one mechanism. Leuk. Res. 2002, 26:91-106.
22. Le Fur G., Vaucher N., Perrier M.L., Flamier A., Benavides J., Renault C., Dubroeucq M.C., Gueremy C., Uzan A. Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies. Life Sci. 1983, 33:449-457.
23. Strohmeier R., Roller M., Sanger N., Knecht R., Kuhl H. Modulation of tamoxifen-induced apoptosis by peripheral benzodiazepine receptor ligands in breast cancer cells. Biochem. Pharmacol. 2002, 64:99-107.
24. Ferzaz B., Brault E., Bourliaud G., Robert J.P., Poughon G., Claustre Y., Marguet F., Liere P., Schumacher M., Nowicki J.P., Fournier J., Marabout B., Sevrin M., George P., Soubrie P., Benavides J., Scatton B. SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]i ndole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair. J. Pharmacol. Exp. Ther. 2002, 301:1067-1078.
25. Vin V., Leducq N., Bono F., Herbert J.M. Binding characteristics of SSR180575, a potent and selective peripheral benzodiazepine ligand. Biochem. Biophys. Res. Commun. 2003, 310:785-790.
26. Kunduzova O.R., Escourrou G., De La Farge F., Salvayre R., Seguelas M.H., Leducq N., Bono F., Herbert J.M., Parini A. Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion. J. Am. Soc. Nephrol. 2004, 15:2152-2160.
27. Canat X., Carayon P., Bouaboula M., Cahard D., Shire D., Roque C., Le Fur G., Casellas P. Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells. Life Sci. 1993, 52:107-118.
28. Joo H.K., Oh S.C., Cho E.J., Park K.S., Lee J.Y., Lee E.J., Lee S.K., Kim H.S., Park J.B., Jeon B.H. Midazolam inhibits tumor necrosis factor-alpha-induced endothelial activation: involvement of the peripheral benzodiazepine receptor. Anesthesiology 2009, 110:106-112.
29. Riccardi C., Nicoletti I. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat. Protoc. 2006, 1:1458-1461.
30. Li W., Hardwick M.J., Rosenthal D., Culty M., Papadopoulos V. Peripheral-type benzodiazepine receptor overexpression and knockdown in human breast cancer cells indicate its prominent role in tumor cell proliferation. Biochem. Pharmacol. 2007, 73:491-503.
31. Hunakova L., Bodo J., Chovancova J., Sulikova G., Pastorekova S., Sedlak J. Expression of new prognostic markers, peripheral-type benzodiazepine receptor and carbonic anhydrase IX, in human breast and ovarian carcinoma cell lines. Neoplasma 2007, 54:541-548.
32. Pretner E., Amri H., Li W., Brown R., Lin C.S., Makariou E., Defeudis F.V., Drieu K., Papadopoulos V. Cancer-related overexpression of the peripheral-type benzodiazepine receptor and cytostatic anticancer effects of Ginkgo biloba extract (EGb 761). Anticancer Res. 2006, 26:9-22.
33. Cossarizza A., Mussini C., Mongiardo N., Borghi V., Sabbatini A., De Rienzo B., Franceschi C. Mitochondria alterations and dramatic tendency to undergo apoptosis in peripheral blood lymphocytes during acute HIV syndrome. Aids 1997, 11:19-26.
34. Lokensgard J.R., Hu S., Hegg C.C., Thayer S.A., Gekker G., Peterson P.K. Diazepam inhibits HIV-1 Tat-induced migration of human microglia. J. Neurovirol. 2001, 7:481-486.