Early identification of sepsis

Current Infectious Disease Reports

Volumn 12, Issue 5, 2010, Pages 329-335

  Gonsalves, Mateus Demarchi ^a   Sakr, Yasser ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Biomarkers; Cytokines; Early diagnosis; Hybridization; Microarrays; Multiplex; Polymerase chain reaction; Procalcitonin; Sepsis

Indexed keywords

ANTIBIOTIC AGENT; BETA 1,3 GLUCAN; C REACTIVE PROTEIN; GALACTOMANNAN; LEPTIN; LEUKOTRIENE B4; LEUKOTRIENE C4; LEUKOTRIENE D4; LIPOPOLYSACCHARIDE BINDING PROTEIN; PROCALCITONIN; VASCULOTROPIN;

ANAMNESIS; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIGEN DETECTION; BACTERIAL ENDOCARDITIS; BACTERIUM CULTURE; BACTERIUM DETECTION; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE MARKER; EARLY DIAGNOSIS; FUNGAL DETECTION; FUNGEMIA; HUMAN; HYBRIDIZATION; IMMUNE RESPONSE; MICROARRAY ANALYSIS; MULTIPLEX POLYMERASE CHAIN REACTION; POLYMERASE CHAIN REACTION; PREDICTION; RELIABILITY; REVIEW; SENSITIVITY AND SPECIFICITY; SEPSIS;

EID: 77956262855     PISSN: 15233847     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11908-010-0122-3     Document Type: Review

References (51)

1. GS Martin DM Mannino S Eaton, et al. 2003 The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 348 1546 1554 10.1056/NEJMoa022139 12700374
2. JL Vincent J Rello J Marshall, et al. 2009 International study of the prevalence and outcomes of infection in intensive care units JAMA 302 2323 2329 10.1001/jama.2009.1754 1:CAS:528:DC%2BD1MXhsFCjsr3L 19952319
3. RP Dellinger JM Carlet H Masur, et al. 2004 Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock Crit Care Med 32 858 873 10.1097/01.CCM.0000117317.18092.E4 15090974
4. JM Hyatt PS McKinnon GS Zimmer, et al. 1995 The importance of pharmacokinetic/pharmacodynamic surrogate markers to outcome. Focus on antibacterial agents Clin Pharmacokinet 28 143 160 10.2165/00003088-199528020- 00005 1:CAS:528:DyaK2MXktVejtbY%3D 7736689
5. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992, 20:864-874.
6. MM Levy MP Fink JC Marshall, et al. 2003 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference Crit Care Med 31 1250 1256 10.1097/01.CCM.0000050454.01978.3B 12682500
7. T Calandra J Cohen 2005 The international sepsis forum consensus conference on definitions of infection in the intensive care unit Crit Care Med 33 1538 1548 10.1097/01.CCM.0000168253.91200.83 16003060
8. Sakr Y, Reinhart K: Biomarkers of host response; diagnostic purposes. In Sepsis Handbook. Edited by Dellinger RP, Carlet JM. Paris: bioMérieux Editions; 2008:94-103. This chapter provides a concise review of biomarkers of host response that could be used in the diagnosis of sepsis.
9. L Bouadma CE Luyt F Tubach, et al. 2010 Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial Lancet 375 463 474 10.1016/S0140- 6736(09)61879-1 1:CAS:528:DC%2BC3cXhs1altLo%3D 20097417 The study presents the results of a multicenter trial on the use of PCT to guide antibiotic therapy. The authors also comprehensively summarize previous trials on the same subject
10. M Christ-Crain D Stolz R Bingisser, et al. 2006 Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial Am J Respir Crit Care Med 174 84 93 10.1164/rccm.200512-1922OC 1:CAS:528: DC%2BD28XntF2ltbo%3D 16603606
11. H Westh G Lisby F Breysse, et al. 2009 Multiplex real-time PCR and blood culture for identification of bloodstream pathogens in patients with suspected sepsis Clin Microbiol Infect 15 544 551 10.1111/j.1469-0691.2009.02736.x 1:CAS:528:DC%2BD1MXhtVamu7fJ 19392905
12. N Mancini S Carletti N Ghidoli, et al. 2010 The era of molecular and other non-culture-based methods in diagnosis of sepsis Clin Microbiol Rev 23 235 251 10.1128/CMR.00043-09 1:CAS:528:DC%2BC3cXks1Skur8%3D 20065332 This article provides a detailed review of the molecular and nonculture-based methods used in diagnosis of sepsis. Recent and commercially available assays are summarized
13. A Rea-Neto NC Youssef F Tuche, et al. 2008 Diagnosis of ventilator-associated pneumonia: a systematic review of the literature Crit Care 12 R56 10.1186/cc6877 18426596 This article reviews the current methods used in the diagnosis of ventilator-associated pneumonia. A clinically oriented approach is also described and may be helpful in the diagnosis of sepsis from other causes
14. RP Peters MA van Agtmael SA Danner, et al. 2004 New developments in the diagnosis of bloodstream infections Lancet Infect Dis 4 751 760 10.1016/S1473-3099(04)01205-8 1:CAS:528:DC%2BD2MXisV2ltQ%3D%3D 15567125
15. S Shang Z Chen X Yu 2001 Detection of bacterial DNA by PCR and reverse hybridization in the 16S rRNA gene with particular reference to neonatal septicemia Acta Paediatr 90 179 183 10.1080/080352501300049389 1:STN:280:DC%2BD3M7nsVKntQ%3D%3D 11236048
16. F Fenollar D Raoult 2007 Molecular diagnosis of bloodstream infections caused by non-cultivable bacteria Int J Antimicrob Agents 30 Suppl 1 S7 S15 10.1016/j.ijantimicag.2007.06.024 1:CAS:528:DC%2BD2sXhtFeitLvK 17707613
17. L Klingspor J Loeffler 2009 Aspergillus PCR formidable challenges and progress Med Mycol 47 Suppl 1 S241 S247 10.1080/13693780802616823 1:CAS:528:DC%2BD1MXms1OnsLk%3D 19253138
18. S Ahmad Z Khan AS Mustafa, et al. 2002 Seminested PCR for diagnosis of candidemia: comparison with culture, antigen detection, and biochemical methods for species identification J Clin Microbiol 40 2483 2489 10.1128/JCM.40.7.2483- 2489.2002 1:CAS:528:DC%2BD38XlvVSrtrk%3D 12089267
19. MS Moreira-Oliveira Y Mikami M Miyaji, et al. 2005 Diagnosis of candidemia by polymerase chain reaction and blood culture: prospective study in a high-risk population and identification of variables associated with development of candidemia Eur J Clin Microbiol Infect Dis 24 721 726 10.1007/s10096-005-0041-7 1:CAS:528:DC%2BD2MXht1Oqsb7F 16328556
20. L Klingspor S Jalal 2006 Molecular detection and identification of Candida and Aspergillus spp. from clinical samples using real-time PCR Clin Microbiol Infect 12 745 753 1:CAS:528:DC%2BD28XosFamu7o%3D 16842569
21. E Hardak M Yigla I Avivi, et al. 2009 Impact of PCR-based diagnosis of invasive pulmonary aspergillosis on clinical outcome Bone Marrow Transplant 44 595 599 10.1038/bmt.2009.65 1:CAS:528:DC%2BD1MXhtl2hsrrE 19308034
22. RP Peters MA van Agtmael S Gierveld, et al. 2007 Quantitative detection of Staphylococcus aureus and Enterococcus faecalis DNA in blood to diagnose bacteremia in patients in the intensive care unit J Clin Microbiol 45 3641 3646 10.1128/JCM.01056-07 1:CAS:528:DC%2BD2sXhsVWrtLrF 17881553
23. MM Sanchez-Jimenez N Cardona-Castro 2004 Validation of a PCR for diagnosis of typhoid fever and salmonellosis by amplification of the hilA gene in clinical samples from Colombian patients J Med Microbiol 53 875 878 10.1099/jmm.0.45630-0 1:CAS:528:DC%2BD2cXovFOlsL4%3D 15314194
24. MJ Rebollo GR San Juan D Folgueira, et al. 2006 Blood and urine samples as useful sources for the direct detection of tuberculosis by polymerase chain reaction Diagn Microbiol Infect Dis 56 141 146 10.1016/j.diagmicrobio.2006.03. 018 1:CAS:528:DC%2BD28XhtVCrtb%2FM 16698218
25. JH Song H Cho MY Park, et al. 1993 Detection of Salmonella typhi in the blood of patients with typhoid fever by polymerase chain reaction J Clin Microbiol 31 1439 1443 1:CAS:528:DyaK3sXltFSjsr0%3D 8314983
26. C Schabereiter-Gurtner M Nehr P Apfalter, et al. 2008 Evaluation of a protocol for molecular broad-range diagnosis of culture-negative bacterial infections in clinical routine diagnosis J Appl Microbiol 104 1228 1237 10.1111/j.1365-2672.2007.03648.x 1:CAS:528:DC%2BD1cXmtFGqtrk%3D 18028360
27. LE Lehmann KP Hunfeld T Emrich, et al. 2008 A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples Med Microbiol Immunol 197 313 324 10.1007/s00430-007-0063-0 1:CAS:528:DC%2BD1cXmsVaqtro%3D 18008085
28. M Marín P Muñoz M Sánchez, et al. 2007 Molecular diagnosis of infective endocarditis by real-time broad-range polymerase chain reaction (PCR) and sequencing directly from heart valve tissue Medicine (Baltimore) 86 195 202 10.1097/MD.0b013e31811f44ec
29. RE Rothman MD Majmudar GD Kelen, et al. 2002 Detection of bacteremia in emergency department patients at risk for infective endocarditis using universal 16S rRNA primers in a decontaminated polymerase chain reaction assay J Infect Dis 186 1677 1681 10.1086/345367 1:CAS:528:DC%2BD38Xps1KrtL0%3D 12447747
30. HA El Mahallawy HH Shaker H Ali Helmy, et al. 2006 Evaluation of pan-fungal PCR assay and Aspergillus antigen detection in the diagnosis of invasive fungal infections in high risk paediatric cancer patients Med Mycol 44 733 739 10.1080/13693780600939955 17127630
31. T Vollmer M Stormer K Kleesiek, et al. 2008 Evaluation of novel broad-range real-time PCR assay for rapid detection of human pathogenic fungi in various clinical specimens J Clin Microbiol 46 1919 1926 10.1128/JCM.02178-07 1:CAS:528:DC%2BD1cXotFGhs7g%3D 18385440
32. JA Van Burik D Myerson RW Schreckhise, et al. 1998 Panfungal PCR assay for detection of fungal infection in human blood specimens J Clin Microbiol 36 1169 1175 9574670
33. MR Millar G Johnson M Wilks, et al. 2008 Molecular diagnosis of vascular access device-associated infection in children being treated for cancer or leukaemia Clin Microbiol Infect 14 213 220 10.1111/j.1469-0691.2007.01909.x 1:CAS:528:DC%2BD1cXjs1CgurY%3D 18093238
34. RP Peters T Mohammadi CM Vandenbroucke-Grauls, et al. 2004 Detection of bacterial DNA in blood samples from febrile patients: underestimated infection or emerging contamination? FEMS Immunol Med Microbiol 42 249 253 10.1016/j.femsim.2004.05.009 1:CAS:528:DC%2BD2cXnsFSku70%3D 15364111
35. S Yang P Ramachandran A Hardick, et al. 2008 Rapid PCR-based diagnosis of septic arthritis by early Gram-type classification and pathogen identification J Clin Microbiol 46 1386 1390 10.1128/JCM.02305-07 1:CAS:528: DC%2BD1cXltFejsrc%3D 18305128
36. N Mancini D Clerici R Diotti, et al. 2008 Molecular diagnosis of sepsis in neutropenic patients with haematological malignancies J Med Microbiol 57 601 604 10.1099/jmm.0.47732-0 18436593
37. RF Louie Z Tang TE Albertson, et al. 2008 Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia Crit Care Med 36 1487 1492 10.1097/CCM.0b013e31816f487c 1:CAS:528:DC%2BD1cXltlSgtr4%3D 18434904
38. CE Corless M Guiver R Borrow, et al. 2001 Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR J Clin Microbiol 39 1553 1558 10.1128/JCM.39.4.1553-1558.2001 1:STN:280: DC%2BD3Mvnt1yiuw%3D%3D 11283086
39. D Volokhov A Rasooly K Chumakov, et al. 2002 Identification of Listeria species by microarray-based assay J Clin Microbiol 40 4720 4728 10.1128/JCM.40.12.4720-4728.2002 1:CAS:528:DC%2BD38Xps1ygtrs%3D 12454178
40. DM Leinberger U Schumacher IB Autenrieth, et al. 2005 Development of a DNA microarray for detection and identification of fungal pathogens involved in invasive mycoses J Clin Microbiol 43 4943 4953 10.1128/JCM.43.10.4943-4953.2005 1:CAS:528:DC%2BD2MXhtFGqtrnN 16207946
41. S Shang G Chen Y Wu, et al. 2005 Rapid diagnosis of bacterial sepsis with PCR amplification and microarray hybridization in 16S rRNA gene Pediatr Res 58 143 148 10.1203/01.PDR.0000169580.64191.8B 1:CAS:528:DC%2BD2MXlsVyjtrw%3D 15985688
42. K Uchida T Yayama Y Kokubo, et al. 2009 Direct detection of pathogens in osteoarticular infections by polymerase chain reaction amplification and microarray hybridization J Orthop Sci 14 471 483 10.1007/s00776-009-1373-4 1:CAS:528:DC%2BD1MXht1WhtLvI 19802657
43. SM Yoo SY Lee KH Chang, et al. 2009 High-throughput identification of clinically important bacterial pathogens using DNA microarray Mol Cell Probes 23 171 177 10.1016/j.mcp.2009.03.004 1:CAS:528:DC%2BD1MXms1Ohtbg%3D 19374946
44. Y Liu JX Han HY Huang, et al. 2005 Development and evaluation of 16S rDNA microarray for detecting bacterial pathogens in cerebrospinal fluid Exp Biol Med (Maywood ) 230 587 591 1:CAS:528:DC%2BD2MXpslOmsrs%3D
45. EM Marlowe JJ Hogan JF Hindler, et al. 2003 Application of an rRNA probe matrix for rapid identification of bacteria and fungi from routine blood cultures J Clin Microbiol 41 5127 5133 10.1128/JCM.41.11.5127-5133.2003 1:CAS:528:DC%2BD3sXpvVyhsLY%3D 14605149
46. S Poppert A Essig B Stoehr, et al. 2005 Rapid diagnosis of bacterial meningitis by real-time PCR and fluorescence in situ hybridization J Clin Microbiol 43 3390 3397 10.1128/JCM.43.7.3390-3397.2005 1:CAS:528: DC%2BD2MXntlSltrg%3D 16000464
47. M Hogardt K Trebesius AM Geiger, et al. 2000 Specific and rapid detection by fluorescent in situ hybridization of bacteria in clinical samples obtained from cystic fibrosis patients J Clin Microbiol 38 818 825 1:CAS:528: DC%2BD3cXht1ejtL8%3D 10655391
48. K Trebesius L Leitritz K Adler, et al. 2000 Culture independent and rapid identification of bacterial pathogens in necrotising fasciitis and streptococcal toxic shock syndrome by fluorescence in situ hybridisation Med Microbiol Immunol 188 169 175 10.1007/s004300000035 1:CAS:528: DC%2BD3cXjvFCgtrY%3D 10917153
49. CD Pfeiffer JP Fine N Safdar 2006 Diagnosis of invasive aspergillosis using a galactomannan assay: a meta-analysis Clin Infect Dis 42 1417 1427 10.1086/503427 1:CAS:528:DC%2BD28Xlt1Cqu74%3D 16619154
50. Z Odabasi G Mattiuzzi E Estey, et al. 2004 Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome Clin Infect Dis 39 199 205 10.1086/421944 1:CAS:528: DC%2BD2cXovVejtbs%3D 15307029
51. C Pazos J Ponton A Del Palacio 2005 Contribution of (1->3)-beta-D- glucan chromogenic assay to diagnosis and therapeutic monitoring of invasive aspergillosis in neutropenic adult patients: a comparison with serial screening for circulating galactomannan J Clin Microbiol 43 299 305 10.1128/JCM.43.1.299- 305.2005 1:CAS:528:DC%2BD2MXhtF2nu74%3D 15634986