메뉴 건너뛰기




Volumn 10, Issue 8, 2010, Pages 1187-1195

Multigene assays and isolated tumor cells for early breast cancer treatment: Time for bionetworks

Author keywords

breast cancer; cancer genomes; multigene assays; node negative; systems biology

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; TRASTUZUMAB;

EID: 77956247826     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/era.10.91     Document Type: Review
Times cited : (90)

References (71)
  • 1
    • 77955635233 scopus 로고    scopus 로고
    • Cancer statistics
    • 10.3322/caac.20073 (2010) (Epub ahead of print).
    • Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J. Clin. DOI: doi: 10.3322/caac.20073 (2010) (Epub ahead of print).
    • (2010) CA Cancer J. Clin.
    • Jemal, A.1    Siegel, R.2    Xu, J.3    Ward, E.4
  • 2
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomized trials
    • Early Breast Cancer Trialists' Collaborative Group EBCTCG
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials. Lancet 365, 1687-1717 (2005).
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 3
    • 69449090120 scopus 로고    scopus 로고
    • Panel members thresholds for therapies: Highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009
    • Goldhirsch A, Ingle JN, Gelber RD, Coates AS, Thürlimann B, Senn HJ; Panel members. Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009. Ann. Oncol. 20(8), 1319-1329 (2009).
    • (2009) Ann. Oncol. , vol.20 , Issue.8 , pp. 1319-1329
    • Goldhirsch, A.1    Ingle, J.N.2    Gelber, R.D.3    Coates, A.S.4    Thürlimann, B.5    Senn, H.J.6
  • 4
    • 70349472886 scopus 로고    scopus 로고
    • New but not improved Incorporating comparative-effectiveness information into FDA labeling
    • Stafford RS, Wagner TH, Lavori PW. New, but not improved? Incorporating comparative-effectiveness information into FDA labeling. N. Engl. J. Med. 361(13), 1230-1233 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.13 , pp. 1230-1233
    • Stafford, R.S.1    Wagner, T.H.2    Lavori, P.W.3
  • 6
    • 68849115626 scopus 로고    scopus 로고
    • Micrometastases or isolated tumor cells and the outcome of breast cancer
    • De Boer M, van Deurzen CH, van Dijck JA et al. Micrometastases or isolated tumor cells and the outcome of breast cancer. N. Engl. J. Med. 361(7), 653-663 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.7 , pp. 653-663
    • De Boer, M.1    Van Deurzen, C.H.2    Van Dijck, J.A.3
  • 7
    • 70449641339 scopus 로고    scopus 로고
    • Isolated tumor cells in breast cancer
    • Roukos DH. Isolated tumor cells in breast cancer. N. Engl. J. Med. 361, 1994-1995 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1994-1995
    • Roukos, D.H.1
  • 8
    • 36349035978 scopus 로고    scopus 로고
    • The prognostic significance of micrometastases in breast cancer: A SEER population-based analysis
    • Chen SL, Hoehne FM, Giuliano AE. The prognostic significance of micrometastases in breast cancer: a SEER population-based analysis. Ann. Surg. Oncol. 14(12), 3378-3384 (2007).
    • (2007) Ann. Surg. Oncol. , vol.14 , Issue.12 , pp. 3378-3384
    • Chen, S.L.1    Hoehne, F.M.2    Giuliano, A.E.3
  • 9
    • 0033546902 scopus 로고    scopus 로고
    • Role of immunohistochemical detection of lymph-node metastases in management of breast cancer
    • Cote RJ, Peterson HF, Chaiwun B et al. Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. Lancet 354, 896-900 (1999).
    • (1999) Lancet , vol.354 , pp. 896-900
    • Cote, R.J.1    Peterson, H.F.2    Chaiwun, B.3
  • 10
    • 0026794242 scopus 로고
    • Prognostic significance of breast cancer axillary lymph node micrometastases assessed by two special techniques: Revaluation with longer follow-up
    • De Mascarel I, Bonichon F, Coindre JM, Trojani M. Prognostic significance of breast cancer axillary lymph node micrometastases assessed by two special techniques: revaluation with longer follow-up. Br. J. Cancer 66, 523-527 (1992).
    • (1992) Br. J. Cancer , vol.66 , pp. 523-527
    • De Mascarel, I.1    Bonichon, F.2    Coindre, J.M.3    Trojani, M.4
  • 11
    • 42949155840 scopus 로고    scopus 로고
    • Occult axillary node metastases in breast cancer are prognostically significant: Results in 368 node-negative patients with 20-year follow-up
    • Tan LK, Giri D, Hummer AJ et al. Occult axillary node metastases in breast cancer are prognostically significant: results in 368 node-negative patients with 20-year follow-up. J. Clin. Oncol. 26, 1803-1809 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1803-1809
    • Tan, L.K.1    Giri, D.2    Hummer, A.J.3
  • 12
    • 20144375982 scopus 로고    scopus 로고
    • Size of breast cancer metastases in axillary lymph nodes: Clinical relevance of minimal lymph node involvement
    • Colleoni M, Rotmensz N, Peruzzotti G et al. Size of breast cancer metastases in axillary lymph nodes: clinical relevance of minimal lymph node involvement. J. Clin. Oncol. 23, 1379-1389 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 1379-1389
    • Colleoni, M.1    Rotmensz, N.2    Peruzzotti, G.3
  • 13
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB et al. Molecular portraits of human breast tumours. Nature 406, 747-752 (2000).
    • (2000) Nature. , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 14
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • USA
    • Sorlie T, Perou CM, Tibshirani R et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl Acad. Sci. USA 98, 10869-10874 (2001).
    • (2001) Proc. Natl Acad. Sci. , vol.98 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 15
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • USA
    • Sorlie T, Tibshirani R, Parker J et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl Acad. Sci. USA 100, 8418-18412 (2003).
    • (2003) Proc. Natl Acad. Sci. , vol.100 , pp. 8418-18412
    • Sorlie, T.1    Tibshirani, R.2    Parker, J.3
  • 16
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated node-negative breast cancer
    • Paik S, Shak S, Tang G et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. 351, 2817-2826 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 17
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • Van de Vijver MJ, He YD, Van't Veer LJ et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347, 1999-2009 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1999-2009
    • Van De Vijver, M.J.1    He, Y.D.2    Vant Veer, L.J.3
  • 18
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N. Engl. J. Med. 360(8), 790-800 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.8 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 19
    • 33746887084 scopus 로고    scopus 로고
    • Molecular signatures predict outcomes of breast cancer
    • O'Shaughnessy JA. Molecular signatures predict outcomes of breast cancer. N. Engl. J. Med. 355(6), 615-617 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , Issue.6 , pp. 615-617
    • O'Shaughnessy, J.A.1
  • 20
    • 62449163752 scopus 로고    scopus 로고
    • Twenty-one-gene assay: Challenges and promises in translating personal genomics and whole-genome scans into personalized treatment of breast cancer
    • Roukos DH. Twenty-one-gene assay: challenges and promises in translating personal genomics and whole-genome scans into personalized treatment of breast cancer. J. Clin. Oncol. 27(8), 1337-1338 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.8 , pp. 1337-1338
    • Roukos, D.H.1
  • 21
    • 41649109849 scopus 로고    scopus 로고
    • Use of gene signatures to improve risk estimation in cancer
    • Huang CC, Bredel M. Use of gene signatures to improve risk estimation in cancer. JAMA 299(13), 1605-1606 (2008).
    • (2008) JAMA , vol.299 , Issue.13 , pp. 1605-1606
    • Huang, C.C.1    Bredel, M.2
  • 22
    • 33746910265 scopus 로고    scopus 로고
    • Concordance among gene-expression-based predictors for breast cancer
    • Fan C, Oh DS, Wessels L et al. Concordance among gene-expression-based predictors for breast cancer. N. Engl. J. Med. 355, 560-569 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 560-569
    • Fan, C.1    Oh, D.S.2    Wessels, L.3
  • 24
    • 79959802526 scopus 로고    scopus 로고
    • National comprehensive cancer network
    • ional Comprehensive Cancer Network PA, USA
    • National Comprehensive Cancer Network. Guidelines for Treatment of Cancer by Site. National Comprehensive Cancer Network, PA, USA (2009).
    • (2009) Guidelines for Treatment of Cancer by Site
  • 25
    • 73349119689 scopus 로고    scopus 로고
    • High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive node-negative tumors 1 cm or smaller
    • Gonzalez-Angulo AM, Litton JK, Broglio KR et al. High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, node-negative tumors 1 cm or smaller. J. Clin. Oncol. 27(34), 5700-5706 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.34 , pp. 5700-5706
    • Gonzalez-Angulo, A.M.1    Litton, J.K.2    Broglio, K.R.3
  • 26
    • 73349142700 scopus 로고    scopus 로고
    • Clinical relevance of HER2 overexpression/ amplification in patients with small tumor size and node-negative breast cancer
    • Curigliano G, Viale G, Bagnardi V et al. Clinical relevance of HER2 overexpression/ amplification in patients with small tumor size and node-negative breast cancer. J. Clin. Oncol. 27(34), 5693-5699 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.34 , pp. 5693-5699
    • Curigliano, G.1    Viale, G.2    Bagnardi, V.3
  • 27
    • 33344478381 scopus 로고    scopus 로고
    • Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
    • Joensuu H, Kellokumpu-Lehtinen P-L, Bono P et al. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N. Engl. J. Med. 354(8), 809-820 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , Issue.8 , pp. 809-820
    • Joensuu, H.1    Kellokumpu-Lehtinen, P.-L.2    Bono, P.3
  • 28
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N. Engl. J. Med. 353(16), 1659-1672 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , Issue.16 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 29
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med. 353(16), 1673-1684 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , Issue.16 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 30
    • 34248658992 scopus 로고    scopus 로고
    • BCIRG 006: 2nd interim analysis Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab with docetaxel carboplatin and trastuzumab in HER2/neu positive early breast cancer patients
    • Presented at:San Antonio, TX, USA, 14-17 December
    • Slamon D, Eiermann W, Robert N et al. BCIRG 006: 2nd interim analysis Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab with docetaxel, carboplatin and trastuzumab in HER2/neu positive early breast cancer patients. Presented at: 29th Annual San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 14-17 December 2006.
    • (2006) 29th Annual San Antonio Breast Cancer Symposium
    • Slamon, D.1    Eiermann, W.2    Robert, N.3
  • 31
    • 34548444589 scopus 로고    scopus 로고
    • Adjuvant trastuzumab in the treatment of HER-2-positive early breast cancer: A meta-analysis of published randomized trials
    • Viani G, Afonso S, Stefano E et al. Adjuvant trastuzumab in the treatment of HER-2-positive early breast cancer: a meta-analysis of published randomized trials. BMC Cancer 7, 153 (2007).
    • (2007) BMC Cancer , vol.7 , pp. 153
    • Viani, G.1    Afonso, S.2    Stefano, E.3
  • 32
    • 76749112093 scopus 로고    scopus 로고
    • From tumor size and HER2 status to systems oncology for very early breast cancer treatment
    • Roukos DH, Ziogas D. From tumor size and HER2 status to systems oncology for very early breast cancer treatment. Expert Rev. Anticancer Ther. 10(2), 123-128 (2010).
    • (2010) Expert Rev. Anticancer Ther. , vol.10 , Issue.2 , pp. 123-128
    • Roukos, D.H.1    Ziogas, D.2
  • 33
    • 68849123389 scopus 로고    scopus 로고
    • Case records of the Massachusetts General Hospital case 25-2009 a 36-year-old woman with hormone-receptor-positive breast cancer
    • Burstein HJ, Souter I, D'Alessandro HA, Sgroi DC. Case records of the Massachusetts General Hospital. Case 25-2009. A 36-year-old woman with hormone-receptor-positive breast cancer. N. Engl. J. Med. 361(7), 699-707 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.7 , pp. 699-707
    • Burstein, H.J.1    Souter, I.2    D'Alessandro, H.A.3    Sgroi, D.C.4
  • 35
    • 0036561908 scopus 로고    scopus 로고
    • Modelling the molecular circuitry of cancer
    • Hahn WC, Weinberg RA. Modelling the molecular circuitry of cancer. Nat. Rev. Cancer 2(5), 331-341 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.5 , pp. 331-341
    • Hahn, W.C.1    Weinberg, R.A.2
  • 36
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100(1), 57-70 (2000).
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 37
    • 33846326304 scopus 로고    scopus 로고
    • Genetic screening for signal transduction in the era of network biology
    • Friedman A, Perrimon N. Genetic screening for signal transduction in the era of network biology. Cell 128, 225-231 (2007).
    • (2007) Cell , vol.128 , pp. 225-231
    • Friedman, A.1    Perrimon, N.2
  • 38
    • 66749095489 scopus 로고    scopus 로고
    • Personalized cancer diagnostics and therapeutics
    • Roukos DH. Personalized cancer diagnostics and therapeutics. Expert Rev. Mol. Diagn. 9(3), 227-229 (2009).
    • (2009) Expert Rev. Mol. Diagn. , vol.9 , Issue.3 , pp. 227-229
    • Roukos, D.H.1
  • 39
    • 66749140976 scopus 로고    scopus 로고
    • Mea Culpa with cancer-targeted therapy: New thinking and new agents design for novel causal networks-based personalized biomedicine
    • Roukos DH. Mea Culpa with cancer-targeted therapy: new thinking and new agents design for novel, causal networks-based, personalized biomedicine. Expert Rev. Mol. Diagn. 9(3), 217-221 (2009).
    • (2009) Expert Rev. Mol. Diagn. , vol.9 , Issue.3 , pp. 217-221
    • Roukos, D.H.1
  • 40
    • 0019183253 scopus 로고
    • On the nature of susceptibility to cancer the presidential address
    • Miller DG. On the nature of susceptibility to cancer. The presidential address. Cancer 46, 1307-1318 (1980).
    • (1980) Cancer , vol.46 , pp. 1307-1318
    • Miller, D.G.1
  • 41
    • 38449094794 scopus 로고    scopus 로고
    • Oncogenic transformation and experimental models of human cancer
    • Schinzel AC, Hahn WC. Oncogenic transformation and experimental models of human cancer. Front. Biosci. 13, 71-84 (2008).
    • (2008) Front. Biosci. , vol.13 , pp. 71-84
    • Schinzel, A.C.1    Hahn, W.C.2
  • 42
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood LD, Parsons DW, Jones S. The genomic landscapes of human breast and colorectal cancers. Science 318(5853), 1108-1113 (2007).
    • (2007) Science , vol.318 , Issue.5853 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3
  • 43
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321(5897), 1801-1806 (2008).
    • (2008) Science , vol.321 , Issue.5897 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 44
    • 53649106195 scopus 로고    scopus 로고
    • Next-generation DNA sequencing
    • Shendure J, Ji H. Next-generation DNA sequencing. Nat. Biotechnol. 26, 1135-1145 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , pp. 1135-1145
    • Shendure, J.1    Ji, H.2
  • 45
    • 77950607162 scopus 로고    scopus 로고
    • Bionetworks-based personalized medicine versus comparative-effectiveness research or harmonization of both in cancer management
    • Roukos DH. Bionetworks-based personalized medicine versus comparative-effectiveness research or harmonization of both in cancer management? Expert Rev. Mol. Diagn. 10(3), 247-250 (2010).
    • (2010) Expert Rev. Mol. Diagn. , vol.10 , Issue.3 , pp. 247-250
    • Roukos, D.H.1
  • 46
  • 47
    • 70349969478 scopus 로고    scopus 로고
    • Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
    • Shah SP, Morin RD, Khattra J et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 461(7265), 809-813 (2009).
    • (2009) Nature , vol.461 , Issue.7265 , pp. 809-813
    • Shah, S.P.1    Morin, R.D.2    Khattra, J.3
  • 48
    • 72949119310 scopus 로고    scopus 로고
    • Complex landscapes of somatic rearrangement in human breast cancer genomes
    • Stephens PJ, McBride DJ, Lin ML et al. Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature 462(7276), 1005-1010 (2009).
    • (2009) Nature , vol.462 , Issue.7276 , pp. 1005-1010
    • Stephens, P.J.1    McBride, D.J.2    Lin, M.L.3
  • 49
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alteration across human cancers
    • Beroukhim R, Mermel CH, Porter D et al. The landscape of somatic copy-number alteration across human cancers. Nature 463(7283), 899-905 (2010).
    • (2010) Nature , vol.463 , Issue.7283 , pp. 899-905
    • Beroukhim, R.1    Mermel, C.H.2    Porter, D.3
  • 50
    • 66249090533 scopus 로고    scopus 로고
    • Systems biology: When it is time to die
    • Bastiaens P. Systems biology: when it is time to die. Nature 459(7245), 334-335 (2009).
    • (2009) Nature , vol.459 , Issue.7245 , pp. 334-335
    • Bastiaens, P.1
  • 51
    • 57649124192 scopus 로고    scopus 로고
    • Reverse engineering the genotype-phenotype map with natural genetic variation
    • Rockman MV. Reverse engineering the genotype-phenotype map with natural genetic variation. Nature 456, 738-744 (2008).
    • (2008) Nature , vol.456 , pp. 738-744
    • Rockman, M.V.1
  • 52
    • 62449169427 scopus 로고    scopus 로고
    • Mathematics emergence of connectivity in networks
    • Bohman T. Mathematics. Emergence of connectivity in networks. Science 323(5920), 1438-1439 (2009).
    • (2009) Science , vol.323 , Issue.5920 , pp. 1438-1439
    • Bohman, T.1
  • 53
    • 74749106342 scopus 로고    scopus 로고
    • Novel clinico-genome network modeling for revolutionizing genotype-phenotype-based personalized cancer care
    • Roukos DH. Novel clinico-genome network modeling for revolutionizing genotype-phenotype-based personalized cancer care. Expert Rev. Mol. Diagn. 10(1), 33-48 (2010).
    • (2010) Expert Rev. Mol. Diagn , vol.10 , Issue.1 , pp. 33-48
    • Roukos, D.H.1
  • 54
    • 70249134919 scopus 로고    scopus 로고
    • Molecular networks as sensors and drivers of common human diseases
    • Schadt EE. Molecular networks as sensors and drivers of common human diseases. Nature 461(7261), 218-223 (2009).
    • (2009) Nature , vol.461 , Issue.7261 , pp. 218-223
    • Schadt, E.E.1
  • 55
    • 77949613884 scopus 로고    scopus 로고
    • Systems medicine: A real approach for future personalized oncology
    • Roukos DH. Systems medicine: a real approach for future personalized oncology? Pharmacogenomics 11(3), 283-287 (2010).
    • (2010) Pharmacogenomics , vol.11 , Issue.3 , pp. 283-287
    • Roukos, D.H.1
  • 56
    • 77951094805 scopus 로고    scopus 로고
    • Big science: The cancer genome challenge
    • Ledford H. Big science: the cancer genome challenge. Nature 464(7291), 972-974 (2010).
    • (2010) Nature , vol.464 , Issue.7291 , pp. 972-974
    • Ledford, H.1
  • 57
    • 77950412216 scopus 로고    scopus 로고
    • The human genome at ten
    • The human genome at ten. Nature 464(7289), 649-650 (2010).
    • (2010) Nature , vol.464 , Issue.7289 , pp. 649-650
  • 58
    • 77951139631 scopus 로고    scopus 로고
    • Genome remodelling in a basal-like breast cancer metastasis and xenograft
    • Ding L, Ellis MJ, Li S et al. Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 464(7291), 999-1005 (2010).
    • (2010) Nature , vol.464 , Issue.7291 , pp. 999-1005
    • Ding, L.1    Ellis, M.J.2    Li, S.3
  • 59
    • 63249084150 scopus 로고    scopus 로고
    • Radiation therapy for breast cancer
    • Roukos DH. Radiation therapy for breast cancer. N. Engl. J. Med. 360(13), 1362 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.13 , pp. 1362
    • Roukos, D.H.1
  • 60
    • 77955626568 scopus 로고    scopus 로고
    • Beyond HER2 and trastuzumab: Heterogeneity systems biology and cancer origin research may guide the future for personalized treatment of very early but aggressive breast cancer
    • Roukos DH. Beyond HER2 and trastuzumab: heterogeneity, systems biology, and cancer origin research may guide the future for personalized treatment of very early but aggressive breast cancer. J. Clin. Oncol. 28(17), e279-e280 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.17
    • Roukos, D.H.1
  • 61
    • 60449118127 scopus 로고    scopus 로고
    • Personal genomics and genome-wide association studies: Novel discoveries but limitations for practical personalized medicine
    • Roukos DH. Personal genomics and genome-wide association studies: novel discoveries but limitations for practical personalized medicine. Ann. Surg. Oncol. 16(3), 772-773 (2009).
    • (2009) Ann. Surg. Oncol. , vol.16 , Issue.3 , pp. 772-773
    • Roukos, D.H.1
  • 62
    • 60449099750 scopus 로고    scopus 로고
    • Human genetic and structural genomic variation: Would genome-wide association studies be the solution for cancer complexity like Alexander the Great for the Gordian Knot
    • Roukos DH, Ziogas D. Human genetic and structural genomic variation: would genome-wide association studies be the solution for cancer complexity like Alexander the Great for the 'Gordian Knot'? Ann. Surg. Oncol. 16(3), 774-775 (2009).
    • (2009) Ann. Surg. Oncol. , vol.16 , Issue.3 , pp. 774-775
    • Roukos, D.H.1    Ziogas, D.2
  • 63
    • 67649211353 scopus 로고    scopus 로고
    • Genetics and personal genomics for personalized breast cancer surgery: Progress and challenges in research and clinical practice
    • Ziogas D, Roukos DH. Genetics and personal genomics for personalized breast cancer surgery: progress and challenges in research and clinical practice. Ann. Surg. Oncol. 16(7), 1771-1782 (2009).
    • (2009) Ann. Surg. Oncol. , vol.16 , Issue.7 , pp. 1771-1782
    • Ziogas, D.1    Roukos, D.H.2
  • 64
    • 85047686032 scopus 로고    scopus 로고
    • Genome-wide association studies: How predictable is a persons cancer risk
    • Roukos DH. Genome-wide association studies: how predictable is a person's cancer risk? Expert Rev. Anticancer Ther. 9(4), 389-392 (2009).
    • (2009) Expert Rev. Anticancer Ther. , vol.9 , Issue.4 , pp. 389-392
    • Roukos, D.H.1
  • 65
    • 62149146888 scopus 로고    scopus 로고
    • Genome-wide association studies and aggressive surgery toward individualized prevention, and improved local control and overall survival for gastric cancer
    • Roukos DH. Genome-wide association studies and aggressive surgery toward individualized prevention, and improved local control and overall survival for gastric cancer. Ann. Surg. Oncol. 16(4), 795-798 (2009).
    • (2009) Ann. Surg. Oncol. , vol.16 , Issue.4 , pp. 795-798
    • Roukos, D.H.1
  • 66
    • 77950440741 scopus 로고    scopus 로고
    • Has the revolution arrived
    • Collins F. Has the revolution arrived? Nature 464(7289), 674-675 (2010).
    • (2010) Nature , vol.464 , Issue.7289 , pp. 674-675
    • Collins, F.1
  • 67
    • 77950456427 scopus 로고    scopus 로고
    • Multiple personal genomes await
    • Venter JC. Multiple personal genomes await. Nature 464(7289), 676-677 (2010).
    • (2010) Nature , vol.464 , Issue.7289 , pp. 676-677
    • Venter, J.C.1
  • 68
    • 77955591497 scopus 로고    scopus 로고
    • Complete genome sequencing and network modeling to overcome trastuzumab resistance
    • Roukos DH. Complete genome sequencing and network modeling to overcome trastuzumab resistance. Pharmacogenomics 11(8), 1039-1043 (2010).
    • (2010) Pharmacogenomics , vol.11 , Issue.8 , pp. 1039-1043
    • Roukos, D.H.1
  • 69
    • 77955596399 scopus 로고    scopus 로고
    • Next-generation genome sequencing-based biomarkers: Concerns and challenges for medical practice
    • 110.2217/BMM.10.70 In press).
    • Roukos DH. Next-generation, genome sequencing-based biomarkers: concerns and challenges for medical practice. Biomarkers Med. 4(4), DOI: 110.2217/BMM.10.70 (2010) (In press).
    • (2010) Biomarkers Med. , vol.4 , Issue.4
    • Roukos, D.H.1
  • 70
    • 77956250186 scopus 로고    scopus 로고
    • Individual genomes and personalized medicine: Life diversity and complexity
    • Katsios C, Roukos DH. Individual genomes and personalized medicine: life diversity and complexity. Per. Med. 7(4), 347-350 (2010).
    • (2010) Per. Med. , vol.7 , Issue.4 , pp. 347-350
    • Katsios, C.1    Roukos, D.H.2
  • 71
    • 77954697543 scopus 로고    scopus 로고
    • Genotype-phenotype map and molecular networks: A promising solution in overcoming colorectal cancer resistance to targeted treatment
    • Roukos DH, Katsios C, Liakakos T. Genotype-phenotype map and molecular networks: a promising solution in overcoming colorectal cancer resistance to targeted treatment. Expert Rev. Mol. Diagn. 10(5), 541-545 (2010).
    • (2010) Expert Rev. Mol. Diagn. , vol.10 , Issue.5 , pp. 541-545
    • Roukos, D.H.1    Katsios, C.2    Liakakos, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.