Design of a non-glycosylated outer domain-derived HIV-1 gp120 immunogen that binds to CD4 and induces neutralizing antibodies

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 27100-27110

  Bhattacharyya, Sanchari ^a   Rajan, Roshan Elizabeth ^b   Swarupa, Yalla ^b   Rathore, Ujjwal ^a   Verma, Anjali ^b   Udaykumar, Ranga ^b   Varadarajan, Raghavan ^a,b  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPHYSICAL STUDIES; ENVELOPE GLYCOPROTEINS; GLYCOSYLATED; IMMUNOGENS; NEUTRALIZING ANTIBODIES; OUTER DOMAIN;

BINDING ENERGY; DESIGN; DISEASES; ESCHERICHIA COLI; IMMUNIZATION; VIRUSES;

ANTIBODIES;

ADJUVANT; CD4 ANTIGEN; EPITOPE; FREUND ADJUVANT; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; PROTEINASE; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ANTIGEN BINDING; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG DESIGN; ESCHERICHIA COLI; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNIZATION; IMMUNOGENICITY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN FOLDING; RABBIT; SERUM; VIRUS NEUTRALIZATION; VIRUS RESISTANCE; VIRUS STRAIN;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIGENS, CD4; BINDING SITES; EPITOPES; FEMALE; GLYCOSYLATION; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; IMMUNIZATION; MUTATION; PROTEIN FOLDING; RABBITS; RECOMBINANT PROTEINS;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS;

EID: 77956247505     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.152272     Document Type: Article

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