Folding and rescue of a cystic fibrosis transmembrane conductance regulator trafficking mutant identified using human-murine chimeric proteins

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 27033-27044

  Da Paula, Ana Carina ^a,b   Sousa, Marisa ^a,b   Xu, Zhe ^c   Dawson, Elizabeth S ^d   Boyd, A Christopher ^d   Sheppard, David N ^c   Amaral, Margarida D ^a,b  

^a UNIVERSITY OF LISBON   (Portugal)

^b NATIONAL INSTITUTE OF HEALTH DR RICARDO JORGE   (Portugal)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; CHANNEL FUNCTIONS; CHIMERIC PROTEINS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; DIFFERENT DOMAINS; DISTANCE ANALYSIS; FUNCTIONAL PROPERTIES; GAIN INSIGHT; GENETIC DISEASE; NUCLEOTIDE-BINDING DOMAIN; POINT MUTATIONS; PROTEIN PROCESSING; REGULATORY DOMAIN; SINGLE MUTATION; STRUCTURAL MODELS;

AMINO ACIDS; ORGANIC ACIDS; PROTEINS;

MODEL STRUCTURES;

CHIMERIC PROTEIN; GLUTAMIC ACID; LEUCINE; LYSINE; MUTANT PROTEIN; PHENYLALANINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; MICE; MUTATION, MISSENSE; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS;

MURINAE;

EID: 77956240070     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.120352     Document Type: Article

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