Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice

Cancer Chemotherapy and Pharmacology

Volumn 66, Issue 5, 2010, Pages 819-827

  Letari, Ornella ^a   Booth, Catherine ^b   Bonazzi, Albino ^a   Garofalo, Paolo ^a   Makovec, Francesco ^a   Rovati, Lucio C ^a   Caselli, Gianfranco ^a  

^a Rotta Research Laboratorium   (Italy)

^b Epistem Ltd   (United Kingdom)

Author keywords

Cancer; Chemotherapy; CR3294; Diarrhea; Mucositis

Indexed keywords

BENZAMIDINE DERIVATIVE; CR 3294; CYTOKINE; FLUOROURACIL; N [4 [[(PENTYLAMINO)THIOXOMETHYL]AMINO]PHENYL]ETHANIMIDAMIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL ISOLATION; CELL PROLIFERATION; CHEMOLUMINESCENCE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DIARRHEA; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; GASTROINTESTINAL MUCOSITIS; HUMAN; HUMAN CELL; IMMUNOASSAY; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; INTESTINE CRYPT; MALE; MOUSE; MUCOSA INFLAMMATION; NEUTROPHIL; NONHUMAN; NUDE MOUSE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SOLID TUMOR; TUMOR GROWTH; TUMOR XENOGRAFT;

AMIDINES; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CYTOKINES; DIARRHEA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; FLUOROURACIL; INHIBITORY CONCENTRATION 50; INTESTINAL MUCOSA; LUMINESCENCE; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MUCOSITIS; REACTIVE OXYGEN SPECIES; THIOUREA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77956228663     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-1224-1     Document Type: Article

References (40)

1. M Duncan G Grant 2003 Oral and intestinal mucositis-causes and possible treatments Aliment Pharmacol Ther 18 853 874 10.1046/j.1365-2036.2003.01784.x 1:STN:280:DC%2BD3srjs1egtw%3D%3D 14616150
2. ST Sonis LS Elting D Keefe DE Peterson M Schubert M Hauer-Jensen BN Bekele J Raber-Durlacher JP Donnelly EB Rubenstein 2004 Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients Cancer 100 1995 2025 10.1002/cncr.20162 15108222
3. EB Rubenstein DE Peterson M Schubert D Keefe D McGuire J Epstein LS Elting PC Fox C Cooksley ST Sonis 2004 Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis Cancer 100 2026 2046 10.1002/cncr.20163 15108223
4. CG Leichman TR Fleming FM Muggia CM Tangen B Ardalan JH Doroshow FJ Meyers RF Holcombe GR Weiss A Mangalik 1995 Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study J Clin Oncol 13 1303 1311 1:STN:280:DyaK2M3ntFamsg%3D%3D 7751875
5. RJ Arnold N Gabrail M Raut R Kim JC Sung Y Zhou 2005 Clinical implications of chemotherapy-induced diarrhea in patients with cancer J Support Oncol 3 227 232 15915825
6. K Wisinski A Benson III 2007 Chemotherapy-induced mucositis: focusing on diarrhea J Support Oncol 5 270 271 1:CAS:528:DC%2BD2sXnvFGjtrw%3D 17624051
7. ML Rothenberg NJ Meropol EA Poplin CE Van S Wadler 2001 Mortality associated with irinotecan plus bolus fluorouracil/leucovorin: summary findings of an independent panel J Clin Oncol 19 3801 3807 1:CAS:528:DC%2BD3MXnsVKqsb0%3D 11559717
8. JM Bowen 2008 Prevention and treatment of regimen-related mucosal toxicity Recent Patents Anticancer Drug Discov 3 68 75 10.2174/ 157489208784638802 1:CAS:528:DC%2BD1cXotF2nsbo%3D
9. DM Keefe ST Sonis JM Bowen 2008 Emerging drugs for chemotherapy-induced mucositis Expert Opin Emerg Drugs 13 511 522 10.1517/14728214.13.3.511 1:CAS:528:DC%2BD1cXhtVGksbvO 18764726
10. M Tafani L Schito T Anwar M Indelicato P Sale VM Di E Morgante R Beraldi F Makovec O Letari G Caselli C Spadafora B Pucci MA Russo 2008 Induction of autophagic cell death by a novel molecule is increased by hypoxia Autophagy 4 1042 1053 1:CAS:528:DC%2BD1MXmtlaksQ%3D%3D 18927491
11. Makovec F, Zanzola S, Artusi R, Rovati LC (2007) Benzamidine derivatives having anti-inflammatory and immunosuppressive activity. Patent No. US7,202,277
12. ST Sonis 2004 The pathobiology of mucositis Nat Rev Cancer 4 277 284 10.1038/nrc1318 1:CAS:528:DC%2BD2cXis1Gmt78%3D 15057287
13. RM Logan RJ Gibson JM Bowen AM Stringer ST Sonis DM Keefe 2008 Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis Cancer Chemother Pharmacol 62 33 41 10.1007/s00280-007-0570-0 1:CAS:528:DC%2BD1cXks1Krsb8%3D 17703303
14. RF Leitao RA Ribeiro EA Bellaguarda FD Macedo LR Silva RB Oria ML Vale FQ Cunha GA Brito 2007 Role of nitric oxide on pathogenesis of 5-fluorouracil induced experimental oral mucositis in hamster Cancer Chemother Pharmacol 59 603 612 10.1007/s00280-006-0301-y 1:CAS:528:DC%2BD2sXhvVeitbs%3D 16944152
15. N Al-Dasooqi RJ Gibson JM Bowen DM Keefe 2009 Matrix metalloproteinases: key regulators in the pathogenesis of chemotherapy-induced mucositis? Cancer Chemother Pharmacol 64 1 9 10.1007/s00280-009-0984-y 1:CAS:528: DC%2BD1MXlt1KjsLk%3D 19305997
16. (1988) UKCCCR guidelines for the welfare of animals in experimental neoplasia. Br J Cancer 58:109-113
17. HR Withers MM Elkind 1970 Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation Int J Radiat Biol Relat Stud Phys Chem Med 17 261 267 10.1080/09553007014550291 1:STN:280:DyaE3c3hsVSnsw%3D%3D 4912514
18. Potten CS, Hendry JH (1985) The microcolony assay in mouse small intestine. In: Potten CS, Hendry JH (eds) Cell clones. Churchill Livingstone, Edinburgh, pp 50-60
19. CS Potten M Rezvani JH Hendry JV Moore D Major 1981 The correction of intestinal microcolony counts for variation in size Int J Radiat Biol Relat Stud Phys Chem Med 40 321 326 10.1080/09553008114551251 1:STN:280: DyaL38%2FivF2gtg%3D%3D 7026475
20. Merritt AJ, Jones LS, Potten CS (1996) Apoptosis in murine intestinal crypts. In: Cotter TG, Martin SJ (eds) Techniques in apoptosis. Portland Press, London, pp 269-300
21. CS Potten G Owen SA Roberts 1990 The temporal and spatial changes in cell proliferation within the irradiated crypts of the murine small intestine Int J Radiat Biol 57 185 199 10.1080/09553009014550431 1:STN:280:DyaK3c7htFelsw%3D%3D 1967288
22. DM Keefe MM Schubert LS Elting ST Sonis JB Epstein JE Raber-Durlacher CA Migliorati DB McGuire RD Hutchins DE Peterson 2007 Updated clinical practice guidelines for the prevention and treatment of mucositis Cancer 109 820 831 10.1002/cncr.22484 1:CAS:528:DC%2BD2sXjsVKns7o%3D 17236223
23. ST Sonis KE O'Donnell R Popat C Bragdon S Phelan D Cocks JB Epstein 2004 The relationship between mucosal cyclooxygenase-2 (COX-2) expression and experimental radiation-induced mucositis Oral Oncol 40 170 176 10.1016/S1368-8375(03)00148-9 1:CAS:528:DC%2BD3sXhtVSjsrzK 14693241
24. CK Murphy EG Fey BA Watkins V Wong D Rothstein ST Sonis 2008 Efficacy of superoxide dismutase mimetic M40403 in attenuating radiation-induced oral mucositis in hamsters Clin Cancer Res 14 4292 4297 10.1158/1078-0432.CCR-07-4669 1:CAS:528:DC%2BD1cXnvFyks7Y%3D 18594012
25. G Facorro MM Sarrasague H Torti A Hager JS Avalos M Foncuberta G Kusminsky 2004 Oxidative study of patients with total body irradiation: effects of amifostine treatment Bone Marrow Transplant 33 793 798 10.1038/sj.bmt.1704427 1:CAS:528:DC%2BD2cXisl2qsb8%3D 14990982
26. S Braun C Hanselmann MG Gassmann U auf dem Keller C Born-Berclaz K Chan YW Kan S Werner 2002 Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound Mol Cell Biol 22 5492 5505 10.1128/MCB.22.15.5492-5505.2002 1:CAS:528:DC%2BD38XltlGntrc%3D 12101242
27. RV Lalla MM Schubert RJ Bensadoun D Keefe 2006 Anti-inflammatory agents in the management of alimentary mucositis Support Care Cancer 14 558 565 10.1007/s00520-006-0050-9 16565821
28. JM Bowen AM Stringer RJ Gibson AS Yeoh S Hannam DM Keefe 2007 VSL#3 probiotic treatment reduces chemotherapy-induced diarrhea and weight loss Cancer Biol Ther 9 1449 1454
29. CL Smith MS Geier R Yazbeck DM Torres RN Butler GS Howarth 2008 Lactobacillus fermentum BR11 and fructo-oligosaccharide partially reduce jejunal inflammation in a model if intestinal mucositis in rats Nutr Cancer 60 757 767 10.1080/01635580802192841 1:CAS:528:DC%2BD1MXjvV2ntg%3D%3D 19005975
30. EJ Whitford AG Cummins RN Butler LD Prisciandaro JK Fauser R Yazbeck A Lawrence KY Cheah TH Wright KA Lymn GS Howarth 2009 Effects of Streptococcus thermophilus TH-4 on intestinal mucositis induced by the chemotherapeutic agent, 5-Fluorouracil (5-FU) Cancer Biol Ther 8 6 505 512 1:CAS:528: DC%2BD1MXotV2qu7g%3D
31. KY Cheah GS Howarth R Yazbeck TH Wright EJ Whitford C Payne RN Butler SE Bastian 2009 Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis Cancer Biol Ther 8 382 390 1:CAS:528: DC%2BD1MXotV2qtb0%3D 19305141
32. WC You CC Hsieh JT Huang 2009 Effect of extracts from indigowood root (Isatis indigotica Fort.) on immune responses in radiation-induced mucositis J Altern Complement Med 15 771 778 10.1089/acm.2008.0322 19534614
33. K Ijiri CS Potten 1987 Further studies on the response of intestinal crypt cells of different hierarchical status to eighteen different cytotoxic agents Br J Cancer 55 113 123 1:CAS:528:DyaL2sXhvVymurw%3D 3814484
34. CL Farrell JV Bready KL Rex JN Chen CR DiPalma KL Whitcomb S Yin DC Hill B Wiemann CO Starnes AM Havill ZN Lu SL Aukerman GF Pierce A Thomason CS Potten TR Ulich DL Lacey 1998 Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality Cancer Res 58 933 939 1:CAS:528:DyaK1cXhsFersrY%3D 9500453
35. PM Hwang F Bunz J Yu C Rago TA Chan MP Murphy GF Kelso RA Smith KW Kinzler B Vogelstein 2001 Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells Nat Med 7 1111 1117 10.1038/nm1001-1111 1:CAS:528:DC%2BD3MXns12kt78%3D 11590433
36. T Yorimitsu DJ Klionsky 2005 Autophagy: molecular machinery for self-eating Cell Death Differ 12 Suppl 2 1542 1552 10.1038/sj.cdd.4401765 1:CAS:528:DC%2BD2MXhtFCjt7%2FJ 16247502
37. LB Saltz 2003 Understanding and managing chemotherapy-induced diarrhea J Support Oncol 1 35 46 1:CAS:528:DC%2BD3sXntV2ktb4%3D 15352641
38. AB Benson III JA Ajani RB Catalano C Engelking SM Kornblau JA Martenson Jr R McCallum EP Mitchell TM O'Dorisio EE Vokes S Wadler 2004 Recommended guidelines for the treatment of cancer treatment-induced diarrhea J Clin Oncol 22 2918 2926 10.1200/JCO.2004.04.132 1:CAS:528:DC%2BD2cXpsVWktbs%3D 15254061
39. CS Potten 1996 Protection of the small intestinal clonogenic stem cells from radiation-induced damage by pretreatment with interleukin 11 also increases murine survival time Stem Cells 14 452 459 10.1002/stem.140452 1:CAS:528:DyaK28XkvFOns74%3D 8843547
40. RJ Gibson JM Bowen DM Keefe 2005 Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor-bearing DA rats Int J Cancer 116 464 470 10.1002/ijc.21082 1:CAS:528:DC%2BD2MXmtl2ku74%3D 15800945