The importance of vascular endothelial growth factor in the healing of acute tympanic membrane perforation

American Journal of Otolaryngology - Head and Neck Medicine and Surgery

Volumn 31, Issue 5, 2010, Pages 309-314

  Cho, Kyu Sup ^a   Lee, Dong Gun ^a   Shin, Dong Hoon ^a   Park, Young Dae ^a   Chon, Kyong Myong ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EARDRUM PERFORATION; FEMALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; WOUND HEALING;

ANIMALS; DEXAMETHASONE; FEMALE; FIBROBLAST GROWTH FACTOR 2; GLUCOCORTICOIDS; IMMUNOHISTOCHEMISTRY; RATS; RATS, SPRAGUE-DAWLEY; TYMPANIC MEMBRANE; TYMPANIC MEMBRANE PERFORATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 77956226524     PISSN: 01960709     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjoto.2009.03.005     Document Type: Article

References (20)

1. Johnson A.P., Smallman L.A., and Kent S.E. The mechanism of healing of tympanic membrane perforations. A two-dimensional histological study in guinea pigs Acta Otolaryngol 109 1990 406 415
2. Ozkaptan Y., Gerek M., and Simsek S. Effects of fibroblast growth factor on the healing process of tympanic membrane perforations in an animal model Eur Arch Otorhinolaryngol 254 Suppl 1 1997 S2 S5
3. Ramalho J.R., and Bento R.F. Healing of subacute tympanic membrane perforations in chinchillas treated with epidermal growth factor and pentoxifylline Otol Neurotol 27 2006 720 727
4. Guneri E.A., Tekin S., and Yilmaz O. The effects of hyaluronic acid, epidermal growth factor, and mitomycin in an experimental model of acute traumatic tympanic membrane perforation Otol Neurotol 24 2003 371 376
5. Mondain M., and Ryan A. Epidermal growth factor and fibroblast growth factor are induced in guinea-pig tympanic membrane following traumatic perforation Acta Otolaryngol 115 1995 50 54
6. Koba R., and Kawabata I. Immunohistochemical study of transforming growth factor-α expression in normal and perforated tympanic membrane Ann Otol Rhinol Laryngol 104 1995 793 797
7. Tarnawski A.S. Cellular and molecular mechanisms of gastrointestinal ulcer healing Dig Dis Sci 50 suppl 2005 S24 S33
8. Milani S., and Calabro A. Role of growth factors and their receptors in gastric ulcer healing Microsc Res Techniq 53 2001 360 371
9. Ferrara N. Vascular endothelial growth factor Trends Cardiovasc Med 3 1993 244 250
10. Corral C.J., Siddiqui A., and Wu L. Vascular endothelial growth factor is more important than basic fibroblastic growth factor during ischemic wound healing Arch Surg 134 1999 200 205
11. Gan L., Fagerholm P., and Palmblad J. Vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in the regulation of corneal neovascularization and wound healing Acta Ophthalmol Scand 82 2004 557 563
12. Knutsson J., Bagger-Sjoback D., and von Unge M. Distribution of different collagen types in the rat's tympanic membrane and its suspending structures Otol Neurotol 28 2007 486 491
13. Wang W.Q., Wang Z.M., and Chi F.L. Spontaneous healing of various tympanic membrane perforations in the rat Acta Otolaryngol 124 2004 1141 1144
14. Ishimoto S., and Ishibashi T. Induction of growth factor expression is reduced during healing of tympanic membrane perforations in glucocorticoid- treated rats Ann Otol Rhinol Laryngol 111 2002 947 953
15. Sheikh A.Y., Gibson J.J., and Rollins M.D. Effect of hyperoxia on vascular endothelial growth factor levels in a wound model Arch Surg 135 2000 1293 1297
16. Ishibashi T., Shinogami M., and Ishimoto S.I. Induction of KGF, basic FGF, and TGFalpha mRNA expression during healing of experimental TM perforations Acta Otolaryngol 118 1998 701 704
17. Vrabec J.T., Schwaber M.K., and Davidson J.M. Evaluation of basic fibroblast growth factor in tympanic membrane repair Laryngoscope 104 1994 1059 1064
18. Buyten J., Kaufman G., and Ryan M. Effects of ciprofloxacin/dexamethasone and ofloxacin on tympanic membrane perforation healing Otol Neurotol 28 2007 887 890
19. Ma Y., Zhao H., and Zhou X. Topical treatment with growth factors for tympanic membrane perforations: progress towards clinical application Acta Otolaryngol 122 2002 586 599
20. Thomas K.A. Vascular endothelial growth factor: a potent and selective angiogenic agent J Biol Chem 271 1996 603 606